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  1. Article ; Online: Potential of Control Conditions for Nonspecific Treatment Effects in Noninferiority Trials.

    Budde, Henning / Amatriain-Fernández, Sandra / Trautmann, Sebastian

    JAMA psychiatry

    2023  Volume 80, Issue 5, Page(s) 522–523

    MeSH term(s) Humans ; Research Design ; Equivalence Trials as Topic ; Control Groups
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.0102
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  2. Article: Potential of control conditions for nonspecific treatment effects in noninferiority trials

    Budde, Henning / Amatriain-Fernández, Sandra / Trautmann, Sebastian

    JAMA Psychiatry

    2023  Volume 80, Issue 5, Page(s) 522–523

    Abstract: No abstract available. ...

    Title translation Potenzial von Kontrollbedingungen für unspezifische Behandlungseffekte in Nichtunterlegenheitsstudien.
    Abstract No abstract available.
    Keywords Achtsamkeitsbasierte Stressreduktion ; Angststörungen ; Anxiety Disorders ; Experiment Controls ; Experimentelle Kontrolle ; Intervention ; Methodologie ; Methodology ; Mindfulness-Based Stress Reduction ; Serotonin Reuptake Inhibitors ; Serotonin-Wiederaufnahme-Hemmer ; Therapieergebnisse ; Treatment Outcomes
    Language English
    Document type Article
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.0102
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  3. Article ; Online: Effects of chronic exercise on the inhibitory control of children and adolescents: A systematic review and meta-analysis.

    Amatriain-Fernández, Sandra / Ezquerro García-Noblejas, Milagros / Budde, Henning

    Scandinavian journal of medicine & science in sports

    2021  Volume 31, Issue 6, Page(s) 1196–1208

    Abstract: Inhibitory control is a main component of executive functions that relate to the ability to control prepotent responses and to resist interferences. Deficits in inhibitory control have been associated with numerous disorders, but exercise has become a ... ...

    Abstract Inhibitory control is a main component of executive functions that relate to the ability to control prepotent responses and to resist interferences. Deficits in inhibitory control have been associated with numerous disorders, but exercise has become a promising approach to benefit this domain. This systematic review and meta-analysis aims to provide synthesized information and effect size calculations of the benefits of chronic exercise interventions on the inhibitory control of healthy children and adolescents. A systematic search of PubMed, PsycINFO, MEDLINE, ERIC, SPORTDiscus, and PsycArticles identified 4166 articles to be screened for eligibility. A total of 10 studies (3138 participants) met the inclusion criteria. A random-effects analysis model was performed in three variables: accuracy, reaction time and combined scores. The results showed a very small but statistically significant effect in accuracy (d = 0.14, 95% CI 0.01 to 0.27, P =.04), and two almost null effects (statistically non-significant), in the reaction time (d = 0.03, 95% CI -0.10 to 0.16, P =.62) and the combined scores (d = 0.06, 95% CI -0.03 to 0.15, P =.17). Despite the high number of studies that reported positive outcomes, this meta-analysis found only modest benefits in the inhibitory control of healthy children and adolescents after they participated in different chronic exercise interventions. The strict inclusion criteria of this study and the high variability in the designs of the exercise interventions included, among other reasons, might explain the obtained results.
    MeSH term(s) Adolescent ; Bias ; Child ; Executive Function/physiology ; Exercise/physiology ; Female ; Humans ; Inhibition, Psychological ; Male ; Neuropsychological Tests ; Reaction Time/physiology ; Stroop Test
    Language English
    Publishing date 2021-03-10
    Publishing country Denmark
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1077418-x
    ISSN 1600-0838 ; 0905-7188
    ISSN (online) 1600-0838
    ISSN 0905-7188
    DOI 10.1111/sms.13934
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  4. Article: Physical Activity, Boredom and Fear of COVID-19 Among Adolescents in Germany.

    Bösselmann, Vincent / Amatriain-Fernández, Sandra / Gronwald, Thomas / Murillo-Rodríguez, Eric / Machado, Sergio / Budde, Henning

    Frontiers in psychology

    2021  Volume 12, Page(s) 624206

    Abstract: Background: The effectiveness of physical activity (PA) as an intervention against anxiety disorders and depression is undeniable in clinical psychology. Therefore, the question arose whether these effects also occur when a fear stimulus, like the COVID- ...

    Abstract Background: The effectiveness of physical activity (PA) as an intervention against anxiety disorders and depression is undeniable in clinical psychology. Therefore, the question arose whether these effects also occur when a fear stimulus, like the COVID-19 pandemic, affects otherwise healthy adolescents. Boredom is closely linked to symptoms of fear and anxiety, but the connection between PA, boredom and fear is partly unclear.
    Methods: A cross-sectional online study was conducted that involved 122 students. Participants were 13-19 years old (
    Results: The reported fear of COVID-19 significantly correlates with total PA, quantity of strenuous PA, and boredom. Furthermore, a significant regression equation was found. The variables boredom, PA, and age contribute significantly to predicting the fear of COVID-19 [
    Conclusion: Our results indicate that there is an association between PA, boredom and the quarantine experience of adolescents. Students who were physically more active, especially with strenuous intensity, did not feel bored and showed less fear of COVID-19.
    Language English
    Publishing date 2021-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.624206
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  5. Article ; Online: Benefits of physical activity and physical exercise in the time of pandemic.

    Amatriain-Fernández, Sandra / Murillo-Rodríguez, Eric Simón / Gronwald, Thomas / Machado, Sergio / Budde, Henning

    Psychological trauma : theory, research, practice and policy

    2020  Volume 12, Issue S1, Page(s) S264–S266

    Abstract: Physical activity and physical exercise are key factors to help the population to mitigate the effects that the current pandemic is causing on the mental and physical health of citizens worldwide. In such an extreme situation, it is highly recommended to ...

    Abstract Physical activity and physical exercise are key factors to help the population to mitigate the effects that the current pandemic is causing on the mental and physical health of citizens worldwide. In such an extreme situation, it is highly recommended to be physically active. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
    MeSH term(s) COVID-19/psychology ; Exercise/psychology ; Health Status ; Humans ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2497028-1
    ISSN 1942-969X ; 1942-9681
    ISSN (online) 1942-969X
    ISSN 1942-9681
    DOI 10.1037/tra0000643
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  6. Article: Systematic Review of Meta-Analyses: Exercise Effects on Depression in Children and Adolescents.

    Wegner, Mirko / Amatriain-Fernández, Sandra / Kaulitzky, Andrea / Murillo-Rodriguez, Eric / Machado, Sergio / Budde, Henning

    Frontiers in psychiatry

    2020  Volume 11, Page(s) 81

    Abstract: Background: Depression is a common threat to children and adolescents in terms of affecting psychosocial development and increasing their risk of suicide. Apart from conventional treatments for depression, physical exercise has become a promising ... ...

    Abstract Background: Depression is a common threat to children and adolescents in terms of affecting psychosocial development and increasing their risk of suicide. Apart from conventional treatments for depression, physical exercise has become a promising alternative. This paper aims to systematically review the existing meta-analyses that focus on the impact of physical exercise on clinical and nonclinical depression in children and adolescents.
    Methods: A systematic literature search was conducted using PsycINFO, PsycARTICLES, MedLine, PubMed, and hand searching. Risk of bias analysis, effect sizes calculations, and evaluation of the methodological characteristics (AMSTAR 2) were carried out.
    Results: Four meta-analyses met the inclusion criteria. After analysing the overlap, the total sample contained 30 single studies (mostly including gender mixed samples) and 2,110 participants (age range 5-20 years). The medium duration of the interventions was 11.5 weeks. The sessions had a medium length of 41 min, and the frequency of implementation was three sessions per week. The most implemented intervention type was aerobic exercise, while control groups mainly continued with their regular routine, among other related options. The overall mean effect of physical exercise on depression was medium (
    Conclusion: The small to medium but consistently positive effects that were found in the present study place physical exercise as a promising and helpful alternative for children and adolescents with clinical and nonclinical depression. The limited literature focused on children and adolescents in comparison with adult samples points to the need for further research.
    Language English
    Publishing date 2020-03-06
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.00081
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  7. Article: Physical activity, boredom and fear of COVID-19 among adolescents in Germany

    Bösselmann, Vincent / Amatriain-Fernández, Sandra / Gronwald, Thomas / Murillo-Rodríguez, Eric / Machado, Sergio / Budde, Henning

    Frontiers in Psychology

    2021  

    Abstract: Background: The effectiveness of physical activity (PA) as an intervention against anxiety disorders and depression is undeniable in clinical psychology. Therefore, the question arose whether these effects also occur when a fear stimulus, like the COVID- ... ...

    Title translation Körperliche Aktivität, Langeweile und Angst vor COVID-19 bei Jugendlichen in Deutschland (DeepL)
    Abstract Background: The effectiveness of physical activity (PA) as an intervention against anxiety disorders and depression is undeniable in clinical psychology. Therefore, the question arose whether these effects also occur when a fear stimulus, like the COVID-19 pandemic, affects otherwise healthy adolescents. Boredom is closely linked to symptoms of fear and anxiety, but the connection between PA, boredom and fear is partly unclear. Methods: A cross-sectional online study was conducted that involved 122 students. Participants were 13-19 years old (M-age = 15.83, SD = 1.73). The survey was available online from April 27th to May 3rd, 2020. At this time, schools in Germany had already been closed for 6 weeks. A self-report questionnaire was used to measure physical activity, boredom, and fear of COVID-19. A multiple linear regression model was conducted. Results: The reported fear of COVID-19 significantly correlates with total PA, quantity of strenuous PA, and boredom. Furthermore, a significant regression equation was found. The variables boredom, PA, and age contribute significantly to predicting the fear of COVID-19 [R-2 = 0.127, F(3,118) = 6.876, p < 0.000], among adolescents. Conclusion: Our results indicate that there is an association between PA, boredom and the quarantine experience of adolescents. Students who were physically more active, especially with strenuous intensity, did not feel bored and showed less fear of COVID-19.
    Keywords Adolescent Characteristics ; Angst ; Anxiety ; Boredom ; COVID-19 ; Fear ; Furcht ; Jugendlichenmerkmale ; Körperliche Aktivität ; Langeweile ; Physical Activity ; Quarantine ; Quarantäne
    Language English
    Document type Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.624206
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  8. Article: Physical Exercise Potentials Against Viral Diseases Like COVID-19 in the Elderly.

    Amatriain-Fernández, Sandra / Gronwald, Thomas / Murillo-Rodríguez, Eric / Imperatori, Claudio / Solano, Alexandre Francisco / Latini, Alexandra / Budde, Henning

    Frontiers in medicine

    2020  Volume 7, Page(s) 379

    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00379
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  9. Article: It's About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health.

    Yalçin, Müge / Mundorf, Annakarina / Thiel, Freya / Amatriain-Fernández, Sandra / Kalthoff, Ida Schulze / Beucke, Jan-Carl / Budde, Henning / Garthus-Niegel, Susan / Peterburs, Jutta / Relógio, Angela

    Frontiers in physiology

    2022  Volume 13, Page(s) 873237

    Abstract: A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping machinery known as the circadian clock (biological clock), which enables to anticipate, respond, and adapt to environmental influences such as the daily light and ... ...

    Abstract A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping machinery known as the circadian clock (biological clock), which enables to anticipate, respond, and adapt to environmental influences such as the daily light and dark cycles. Proper functioning of the clock plays a pivotal role in the temporal regulation of a wide range of cellular, physiological, and behavioural processes. The disruption of circadian rhythms was found to be associated with the onset and progression of several pathologies including sleep and mental disorders, cancer, and neurodegeneration. Thus, the role of the circadian clock in health and disease, and its clinical applications, have gained increasing attention, but the exact mechanisms underlying temporal regulation require further work and the integration of evidence from different research fields. In this review, we address the current knowledge regarding the functioning of molecular circuits as generators of circadian rhythms and the essential role of circadian synchrony in a healthy organism. In particular, we discuss the role of circadian regulation in the context of behaviour and cognitive functioning, delineating how the loss of this tight interplay is linked to pathological development with a focus on mental disorders and neurodegeneration. We further describe emerging new aspects on the link between the circadian clock and physical exercise-induced cognitive functioning, and its current usage as circadian activator with a positive impact in delaying the progression of certain pathologies including neurodegeneration and brain-related disorders. Finally, we discuss recent epidemiological evidence pointing to an important role of the circadian clock in mental health.
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.873237
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  10. Article ; Online: Can regular physical exercise be a treatment for panic disorder? A systematic review.

    Machado, Sergio / Telles, George / Magalhaes, Franklin / Teixeira, Diogo / Amatriain-Fernández, Sandra / Budde, Henning / Imperatori, Claudio / Murillo-Rodriguez, Eric / Monteiro, Diogo / Telles Correia, Diogo / Sá Filho, Alberto Souza

    Expert review of neurotherapeutics

    2022  Volume 22, Issue 1, Page(s) 53–64

    Abstract: Introduction: In the last few decades, exercise has been explored as a potential tool to reduce symptoms experienced by patients with panic disorder (PD). This systematic review aims to assess the effects of regular exercise interventions on panic ... ...

    Abstract Introduction: In the last few decades, exercise has been explored as a potential tool to reduce symptoms experienced by patients with panic disorder (PD). This systematic review aims to assess the effects of regular exercise interventions on panic severity, global anxiety, and depression symptoms of these patients.
    Areas covered: A search was conducted on PubMed, ISI Web of Science, and Cochrane Central Register of Controlled Trials using search terms related to PD and exercise. Eight trials were included, Furthermore, regular exercise programs presented different methodological characteristics. There is o clear evidence indicating that regular exercise programs (at least two 20-minute sessions per week for at least 6 weeks) reduce panic-related symptoms. Regular exercise is effective in improving global anxiety measures and depression.
    Expert opinion: Continuous aerobic exercise is the main type of intervention in the literature, generally providing a limited prescription. Currently, it is recommended the interval training, with intense and shorter stimuli, and long-term duration trials. However, despite the use of self-selected intensities and control based on the internal load be interesting as recommendation to increase adherence, careful is needed regarding training prescription due to scarce evidence.
    MeSH term(s) Anxiety ; Anxiety Disorders ; Exercise ; Exercise Therapy ; Humans ; Panic Disorder/therapy ; Quality of Life
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2112534-X
    ISSN 1744-8360 ; 1473-7175
    ISSN (online) 1744-8360
    ISSN 1473-7175
    DOI 10.1080/14737175.2021.2005581
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