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  1. Article ; Online: Physical activity, sleep, and quality of life of patients with asthma during the COVID-19 pandemic.

    Daşdemir, Kübra Ayşe / Suner-Keklik, Sinem

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2021  Volume 59, Issue 7, Page(s) 1484–1490

    Abstract: Objective: There is limited information in literature on how coronavirus disease-2019 (COVID-19) pandemic period affects people with asthma. This study aimed to compare levels of physical activity, stress, and fear and quality of life and sleep quality ... ...

    Abstract Objective: There is limited information in literature on how coronavirus disease-2019 (COVID-19) pandemic period affects people with asthma. This study aimed to compare levels of physical activity, stress, and fear and quality of life and sleep quality between patients with asthma and healthy individuals during the pandemic.
    Methods: Twenty-two patients with asthma and 22 healthy individuals aged between 18 and 65 years were included. Physical activity level using "International Physical Activity Questionnaire"; stress level, using "Perceived Stress Scale-14"; fear level, using "Fear of COVID-19 Scale"; sleep quality, using "Pittsburgh Sleep Quality Index"; and quality of life, using "World Health Organization Quality of Life" were evaluated.
    Results: Total physical activity level, vigorous physical activity level, and walking score of patients with asthma were lower than healthy individuals (
    Conclusion: During pandemic, patients with asthma are more inactive than healthy individuals regardless of the presence of a chronic disease; pandemic negatively affected stress, fear levels, sleep, and quality of life. To minimize the effects of restrictions and psychological burden caused by pandemic and to encourage patients with asthma to perform physical activities, conducting studies to control stress levels and increasing quality of life and sleep of all individuals are important.
    MeSH term(s) Adolescent ; Adult ; Aged ; Asthma/epidemiology ; Asthma/psychology ; COVID-19 ; Exercise ; Humans ; Middle Aged ; Pandemics ; Quality of Life/psychology ; Sleep ; Young Adult
    Language English
    Publishing date 2021-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2021.1931303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Correction to: Diagnostic utility of a targeted next-generation sequencing gene panel in the clinical suspicion of systemic autoinflammatory diseases: a multi-center study.

    Karacan, İlker / Balamir, Ayşe / Uğurlu, Serdal / Aydın, Aslı Kireçtepe / Everest, Elif / Zor, Seyit / Önen, Merve Özkılınç / Daşdemir, Selçuk / Özkaya, Ozan / Sözeri, Betül / Tufan, Abdurrahman / Yıldırım, Deniz Gezgin / Yüksel, Selçuk / Ayaz, Nuray Aktay / Ömeroğlu, Rukiye Eker / Öztürk, Kübra / Çakan, Mustafa / Söylemezoğlu, Oğuz / Şahin, Sezgin /
    Barut, Kenan / Adroviç, Amra / Seyahi, Emire / Özdoğan, Huri / Kasapçopur, Özgür / Turanlı, Eda Tahir

    Rheumatology international

    2019  Volume 39, Issue 5, Page(s) 921

    Abstract: The second affiliation of the corresponding author Eda Tahir Turanlı was incorrectly published as İstanbul Medeniyet University instead of Istanbul Technical University. ...

    Abstract The second affiliation of the corresponding author Eda Tahir Turanlı was incorrectly published as İstanbul Medeniyet University instead of Istanbul Technical University.
    Language English
    Publishing date 2019-03-15
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-019-04280-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1639: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Diagnostic utility of a targeted next-generation sequencing gene panel in the clinical suspicion of systemic autoinflammatory diseases: a multi-center study.

    Karacan, İlker / Balamir, Ayşe / Uğurlu, Serdal / Aydın, Aslı Kireçtepe / Everest, Elif / Zor, Seyit / Önen, Merve Özkılınç / Daşdemir, Selçuk / Özkaya, Ozan / Sözeri, Betül / Tufan, Abdurrahman / Yıldırım, Deniz Gezgin / Yüksel, Selçuk / Ayaz, Nuray Aktay / Ömeroğlu, Rukiye Eker / Öztürk, Kübra / Çakan, Mustafa / Söylemezoğlu, Oğuz / Şahin, Sezgin /
    Barut, Kenan / Adroviç, Amra / Seyahi, Emire / Özdoğan, Huri / Kasapçopur, Özgür / Turanlı, Eda Tahir

    Rheumatology international

    2019  Volume 39, Issue 5, Page(s) 911–919

    Abstract: Systemic autoinflammatory diseases (sAIDs) are a heterogeneous group of disorders, having monogenic inherited forms with overlapping clinical manifestations. More than half of patients do not carry any pathogenic variant in formerly associated disease ... ...

    Abstract Systemic autoinflammatory diseases (sAIDs) are a heterogeneous group of disorders, having monogenic inherited forms with overlapping clinical manifestations. More than half of patients do not carry any pathogenic variant in formerly associated disease genes. Here, we report a cross-sectional study on targeted Next-Generation Sequencing (NGS) screening in patients with suspected sAIDs to determine the diagnostic utility of genetic screening. Fifteen autoinflammation/immune-related genes (ADA2-CARD14-IL10RA-LPIN2-MEFV-MVK-NLRC4-NLRP12-NLRP3-NOD2-PLCG2-PSTPIP1-SLC29A3-TMEM173-TNFRSF1A) were used to screen 196 subjects from adult/pediatric clinics, each with an initial clinical suspicion of one or more sAID diagnosis with the exclusion of typical familial Mediterranean fever (FMF) patients. Following the genetic screening, 140 patients (71.4%) were clinically followed-up and re-evaluated. Fifty rare variants in 41 patients (20.9%) were classified as pathogenic or likely pathogenic and 32 of those variants were located on the MEFV gene. We detected pathogenic or likely pathogenic variants compatible with the final diagnoses and inheritance patterns in 14/140 (10%) of patients for the following sAIDs: familial Mediterranean fever (n = 7), deficiency of adenosine deaminase 2 (n = 2), mevalonate kinase deficiency (n = 2), Muckle-Wells syndrome (n = 1), Majeed syndrome (n = 1), and STING-associated vasculopathy with onset in infancy (n = 1). Targeted NGS panels have impact on diagnosing rare monogenic sAIDs for a group of patients. We suggest that MEFV gene screening should be first-tier genetic testing especially in regions with high carrier rates. Clinical utility of multi-gene testing in sAIDs was as low as expected, but extensive genome-wide familial analyses in combination with exome screening would enlighten additional genetic factors causing disease.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adenosine Deaminase/deficiency ; Adenosine Deaminase/genetics ; Adolescent ; Adult ; Agammaglobulinemia/diagnosis ; Agammaglobulinemia/genetics ; Anemia, Dyserythropoietic, Congenital/diagnosis ; Anemia, Dyserythropoietic, Congenital/genetics ; CARD Signaling Adaptor Proteins/genetics ; Calcium-Binding Proteins/genetics ; Child ; Child, Preschool ; Cryopyrin-Associated Periodic Syndromes/diagnosis ; Cryopyrin-Associated Periodic Syndromes/genetics ; Cytoskeletal Proteins/genetics ; Familial Mediterranean Fever/diagnosis ; Familial Mediterranean Fever/genetics ; Female ; Genetic Testing ; Hereditary Autoinflammatory Diseases/diagnosis ; Hereditary Autoinflammatory Diseases/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Immunologic Deficiency Syndromes/diagnosis ; Immunologic Deficiency Syndromes/genetics ; Intercellular Signaling Peptides and Proteins/genetics ; Male ; Mevalonate Kinase Deficiency/diagnosis ; Mevalonate Kinase Deficiency/genetics ; Middle Aged ; Nucleoside Transport Proteins/genetics ; Osteomyelitis/diagnosis ; Osteomyelitis/genetics ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Pyrin/genetics ; Sequence Analysis, DNA ; Severe Combined Immunodeficiency/diagnosis ; Severe Combined Immunodeficiency/genetics ; Young Adult
    Chemical Substances Adaptor Proteins, Signal Transducing ; CARD Signaling Adaptor Proteins ; Calcium-Binding Proteins ; Cytoskeletal Proteins ; Intercellular Signaling Peptides and Proteins ; MEFV protein, human ; NLRC4 protein, human ; Nucleoside Transport Proteins ; PSTPIP1 protein, human ; Pyrin ; SLC29A3 protein, human ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; mevalonate kinase (EC 2.7.1.36) ; ADA2 protein, human (EC 3.5.4.4) ; Adenosine Deaminase (EC 3.5.4.4)
    Language English
    Publishing date 2019-02-19
    Publishing country Germany
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-019-04252-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1639: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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