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Article ; Online: Re-imaging healthcare delivery in the era of COVID-19.

Dwyer, Karen M / Axtens, Michael J / Egger, Garry / Stevens, John

2022 Volume 52, Issue 11, Page(s) 1998–2000

Abstract: The COVID-19 pandemic has exposed the deficiencies of the current healthcare system in terms of a disconnect between primary and tertiary care and increasing subspecialisation, the focus on acute episodic care rather than on prevention in a time where ... ...

Abstract	The COVID-19 pandemic has exposed the deficiencies of the current healthcare system in terms of a disconnect between primary and tertiary care and increasing subspecialisation, the focus on acute episodic care rather than on prevention in a time where chronic disease prevails and an inefficient use of healthcare resources. Herein, we present the case for an alternative model of healthcare delivery - shared medical appointments - which are efficient, effective and empowering and can be transitioned to the virtual environment successfully. We highlight the barriers to implementation and how these can be overcome.
MeSH term(s)	Humans ; COVID-19 ; Pandemics/prevention & control ; Delivery of Health Care
Language	English
Publishing date	2022-09-16
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.15931
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Licking microstructure and hedonic changes after flavour preference learning in rats.

Riordan, John Edmond / Dwyer, Dominic Michael

Quarterly journal of experimental psychology (2006)

2019 Volume 72, Issue 12, Page(s) 2717–2725

Abstract: Pairing a neutral flavour conditioned stimulus (CS) with a nutrient reward will create a learned preference for that CS. Prior studies suggest that this is accompanied by an increase in the hedonic value of the CS, although the reliability of this effect ...

Abstract	Pairing a neutral flavour conditioned stimulus (CS) with a nutrient reward will create a learned preference for that CS. Prior studies suggest that this is accompanied by an increase in the hedonic value of the CS, although the reliability of this effect is yet to be fully established. Here, flavour CS+s were mixed with either 16% sucrose or maltodextrin (with control CS-s mixed with 2% solutions of the same carbohydrate). While a reliable preference for the CS+ was seen in every case, and there was a learned increase in lick cluster size when all conditions were considered together, this difference was significant in only one experimental condition considered alone. A meta-analysis of these results and similar published licking microstructure analysis studies found that the Cohen's
MeSH term(s)	Animals ; Behavior, Animal/physiology ; Choice Behavior/physiology ; Learning/physiology ; Pleasure/physiology ; Rats ; Taste Perception/physiology
Language	English
Publishing date	2019-06-21
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	219170-2
ISSN	1747-0226 ; 0033-555X ; 1747-0218
ISSN (online)	1747-0226
ISSN	0033-555X ; 1747-0218
DOI	10.1177/1747021819857052
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Article ; Online: How will the artificial intelligence algorithm work within the constraints of this healthcare system?

Stretton, Brandon / Koovor, Joshua G / Hains, Lewis / Kleinig, Oliver / Tan, Sheryn / Gupta, Aashray K / Ittimani, Mana / Dwyer, Andrew / McNeil, Keith / Chan, WengOnn / Cusack, Michael / O'Callaghan, Patrick G / Maddison, John / Bacchi, Stephen

Internal medicine journal

2024 Volume 54, Issue 1, Page(s) 190–191

MeSH term(s)	Humans ; Artificial Intelligence ; Algorithms ; Delivery of Health Care
Language	English
Publishing date	2024-01-24
Publishing country	Australia
Document type	Letter
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.16308
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A preliminary investigation of cognitive intolerance and neuroimaging among adolescents returning to school after concussion.

Baker, John G / Willer, Barry S / Dwyer, Michael G / Leddy, John J

Brain injury

2020 Volume 34, Issue 6, Page(s) 818–827

Abstract: Primary objective: To introduce the concept of cognitive intolerance. A test is proposed to measure this concept and pilot data are presented to support this measure and future research to develop this concept into a construct. ...

Abstract	Primary objective: To introduce the concept of cognitive intolerance. A test is proposed to measure this concept and pilot data are presented to support this measure and future research to develop this concept into a construct.
MeSH term(s)	Adolescent ; Anisotropy ; Brain ; Brain Concussion/complications ; Brain Concussion/diagnostic imaging ; Cognition ; Diffusion Tensor Imaging ; Female ; Humans ; Male ; Neuroimaging ; Schools ; White Matter/diagnostic imaging
Language	English
Publishing date	2020-04-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639115-1
ISSN	1362-301X ; 0269-9052
ISSN (online)	1362-301X
ISSN	0269-9052
DOI	10.1080/02699052.2020.1749932
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Article ; Online: Assessing antimicrobial and metal resistance genes in Escherichia coli from domestic groundwater supplies in rural Ireland.

Andrade, Luisa / P Ryan, Michael / P Burke, Liam / Hynds, Paul / Weatherill, John / O'Dwyer, Jean

Environmental pollution (Barking, Essex : 1987)

2023 Volume 333, Page(s) 121970

Abstract: Natural ecosystems can become significant reservoirs and/or pathways for antimicrobial resistance (AMR) dissemination, with the potential to affect nearby microbiological, animal, and ultimately human communities. This is further accentuated in ... ...

Abstract	Natural ecosystems can become significant reservoirs and/or pathways for antimicrobial resistance (AMR) dissemination, with the potential to affect nearby microbiological, animal, and ultimately human communities. This is further accentuated in environments that provide direct human exposure, such as drinking water. To date, however, few studies have investigated AMR dissemination potential and the presence of co-selective stressors (e.g., metals/metalloids) in groundwater environments of human health significance. Accordingly, the present study analysed samples from rural (drinking) groundwater supplies (i.e., private wells) in the Republic of Ireland, where land use is dominated by livestock grazing activities. In total, 48 Escherichia coli isolates tested phenotypically for antimicrobial susceptibility in an earlier study were further subject to whole genome sequencing (WGS) and corresponding water samples were further analysed for trace metal/metalloid concentrations. Eight isolates (i.e., 16.7%) were genotypically resistant to antimicrobials, confirming prior phenotypic results through the identification of ten antimicrobial resistance genes (ARGs); namely: aph(3″)-lb (strA; n=7), aph(6)-Id (strA; n = 6), blaTEM (n = 6), sul2 (n = 6), tetA (n = 4), floR (n = 2), dfrA5 (n = 1), tetB (n = 1), and tetY (n = 1). Additional bioinformatic analysis revealed that all ARGs were plasmid-borne, except for two of the six sul2 genes, and that 31.2% of all tested isolates (n = 15) and 37.5% of resistant ones (n = 3) carried virulence genes. Study results also found no significant relationships between metal concentrations and ARG abundance. Additionally, just one genetic linkage was identified between ARGs and a metal resistance gene (MRG), namely merA, a mercury-resistant gene found on the same plasmid as blaTEM, dfrA5, strA, strB, and sul2 in the only isolate of inferred porcine (as opposed to bovine) origin. Overall, findings suggest that ARG (and MRG) acquisition may be occurring prior to groundwater ingress, and are likely a legacy issue arising from agricultural practices.
MeSH term(s)	Animals ; Cattle ; Humans ; Swine ; Escherichia coli/genetics ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Ecosystem ; Ireland ; Anti-Infective Agents/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121970
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Article ; Online: Physical activity: Benefits and challenges during the COVID-19 pandemic.

Dwyer, Michael John / Pasini, Margherita / De Dominicis, Stefano / Righi, Elda

Scandinavian journal of medicine & science in sports

2020 Volume 30, Issue 7, Page(s) 1291–1294

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Exercise ; Fitness Trackers ; Humans ; Mental Health ; Mobile Applications ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-16
Publishing country	Denmark
Document type	Letter
ZDB-ID	1077418-x
ISSN	1600-0838 ; 0905-7188
ISSN (online)	1600-0838
ISSN	0905-7188
DOI	10.1111/sms.13710
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Zs.A 3247: Show issues

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Article ; Online: Symptoms of depression and risk of emergency department visits among people aged 70 years and over.

Dwyer, Rosamond / Jachno, Kim / Tran, Thach / Owen, Alice / Layton, Natasha / Collyer, Taya / Kirkman, Maggie / Lowthian, Judy / Hammarberg, Karin / McNeil, John J / Woods, Robyn L / Berk, Michael / Fisher, Jane

BMC public health

2024 Volume 24, Issue 1, Page(s) 385

Abstract: Background: Older people experiencing depression and anxiety have higher rates of health service utilisation than others, but little is known about whether these influence their seeking of emergency care. The aim was to examine the associations between ... ...

Abstract	Background: Older people experiencing depression and anxiety have higher rates of health service utilisation than others, but little is known about whether these influence their seeking of emergency care. The aim was to examine the associations between symptoms of depression and the use of emergency health care, in an Australian context, among a population of people aged 70 years and over initially free of cardiovascular disease, dementia or major physical disability. Methods: We undertook secondary analyses of data from a large cohort of community-dwelling Australians aged [Formula: see text]70 years. Multivariable logistic regression was used to compare the association of symptoms of depression (measured using the Center for Epidemiological Studies Depression Scale 10 question version, CESD at baseline) with subsequent episodes of emergency care, adjusting for physical and social factors of clinical interest. Marginal adjusted odds ratios were calculated from the logistic regression. Results: Data were available for 10,837 Australian participants aged at least 70 years. In a follow-up assessment three years after the baseline assessment, 17.6% of people self-reported an episode of emergency care (attended an ED of called an emergency ambulance) in the last 12 months. Use of emergency healthcare was similar for men and women (17.8% vs. 17.4% p = 0.61). A score above the cut-off on the CESD at baseline was associated with greater use of emergency health care (OR = 1.35, 95% CI 1.11,1.64). When modelled separately, there was a greater association between a score above the cut-off on the CESD and emergency healthcare for women compared with men. Conclusions: This study is unique in demonstrating how depressive symptoms among healthy older persons are associated with subsequent increased use of emergency healthcare. Improved understanding and monitoring of mental health in primary care is essential to undertake effective healthcare planning including prevention of needing emergency care.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Aged, 80 and over ; Depression/psychology ; Emergency Room Visits ; Australia/epidemiology ; Anxiety ; Emergency Service, Hospital ; Australasian People
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-17794-6
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Article ; Online: Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer.

Daly, John / Carlsten, Mattias / O'Dwyer, Michael

Frontiers in immunology

2019 Volume 10, Page(s) 1047

Abstract: Natural Killer (NK) cells are cytotoxic lymphocytes that play a key role in the immune system, targeting and destroying invading pathogens and malignantly transformed cells. Evading NK cell-mediated immunosurveillance is therefore critical to ... ...

Abstract	Natural Killer (NK) cells are cytotoxic lymphocytes that play a key role in the immune system, targeting and destroying invading pathogens and malignantly transformed cells. Evading NK cell-mediated immunosurveillance is therefore critical to facilitating cancer cell survival and metastasis. Signals from a range of inhibitory and activating receptors located on the NK cell surface regulate NK cell cytotoxicity. Recently, attention has turned to the role of hypersialylated tumor cell surfaces in mediating immune-evasion of NK cells. Two inhibitory sialic acid-binding immunoglobulin-like lectin (Siglec) receptors are expressed by NK cells: Siglec-7 and Siglec-9. The abundance of sialic acids on tumor cell surface is hypothesized to regulate NK cell-mediated cytotoxicity by interacting with Siglec-7 and Siglec-9, causing a dampening of NK cell activation pathways. Targeting Siglec-7 and Siglec-9, or the sialic acid coated tumor cell surface is therefore being investigated as a novel therapeutic approach to enhance the NK cell response against cancer. In this review we report on the currently published documentation of the role for Siglec-7 and Siglec-9 receptors on NK cells and their ligands expressed by tumor cells. We also discuss the strategies currently explored to target Siglec-7, Siglec-9 and the sialylated tumor cell surface as well as the impact abrogation of these interactions have on NK cell cytotoxicity against several cancer types.
MeSH term(s)	Animals ; Antigens, Neoplasm/immunology ; Cytotoxicity, Immunologic ; Humans ; Immunomodulation ; Immunotherapy/methods ; Killer Cells, Natural/immunology ; Molecular Targeted Therapy ; N-Acetylneuraminic Acid/metabolism ; Neoplasms/immunology ; Neoplasms/therapy ; Sialic Acid Binding Immunoglobulin-like Lectins/metabolism ; Sugars/metabolism
Chemical Substances	Antigens, Neoplasm ; Sialic Acid Binding Immunoglobulin-like Lectins ; Sugars ; N-Acetylneuraminic Acid (GZP2782OP0)
Language	English
Publishing date	2019-05-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.01047
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Article ; Online: Assessing antimicrobial and metal resistance genes in Escherichia coli from domestic groundwater supplies in rural Ireland

Andrade, Luisa / P Ryan, Michael / P Burke, Liam / Hynds, Paul / Weatherill, John / O'Dwyer, Jean

Environmental Pollution. 2023 Sept., v. 333 p.121970-

2023

Abstract	Natural ecosystems can become significant reservoirs and/or pathways for antimicrobial resistance (AMR) dissemination, with the potential to affect nearby microbiological, animal, and ultimately human communities. This is further accentuated in environments that provide direct human exposure, such as drinking water. To date, however, few studies have investigated AMR dissemination potential and the presence of co-selective stressors (e.g., metals/metalloids) in groundwater environments of human health significance. Accordingly, the present study analysed samples from rural (drinking) groundwater supplies (i.e., private wells) in the Republic of Ireland, where land use is dominated by livestock grazing activities. In total, 48 Escherichia coli isolates tested phenotypically for antimicrobial susceptibility in an earlier study were further subject to whole genome sequencing (WGS) and corresponding water samples were further analysed for trace metal/metalloid concentrations. Eight isolates (i.e., 16.7%) were genotypically resistant to antimicrobials, confirming prior phenotypic results through the identification of ten antimicrobial resistance genes (ARGs); namely: aph(3″)-lb (strA; n=7), aph(6)-Id (strA; n = 6), blaTEM (n = 6), sul2 (n = 6), tetA (n = 4), floR (n = 2), dfrA5 (n = 1), tetB (n = 1), and tetY (n = 1). Additional bioinformatic analysis revealed that all ARGs were plasmid-borne, except for two of the six sul2 genes, and that 31.2% of all tested isolates (n = 15) and 37.5% of resistant ones (n = 3) carried virulence genes. Study results also found no significant relationships between metal concentrations and ARG abundance. Additionally, just one genetic linkage was identified between ARGs and a metal resistance gene (MRG), namely merA, a mercury-resistant gene found on the same plasmid as blaTEM, dfrA5, strA, strB, and sul2 in the only isolate of inferred porcine (as opposed to bovine) origin. Overall, findings suggest that ARG (and MRG) acquisition may be occurring prior to groundwater ingress, and are likely a legacy issue arising from agricultural practices.
Keywords	Escherichia coli ; anti-infective agents ; antibiotic resistance ; bioinformatics ; cattle ; groundwater ; human health ; humans ; land use ; metal tolerance ; metalloids ; phenotype ; plasmids ; pollution ; resistance genes ; swine ; trace elements ; virulence ; Irish Republic ; Antimicrobial resistant bacteria ; Antimicrobial resistance genes ; Metal resistance genes ; Trace metals ; Private wells
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121970
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Article ; Online: Mental Health Care Providers' Attitudes Toward Telepsychiatry: A Systemwide, Multisite Survey During the COVID-19 Pandemic.

Guinart, Daniel / Marcy, Patricia / Hauser, Marta / Dwyer, Michael / Kane, John M

Psychiatric services (Washington, D.C.)

2021 Volume 72, Issue 6, Page(s) 704–707

Abstract: Objectives: The COVID-19 pandemic has forced a rapid transition to telepsychiatry. This study examined the experience and attitudes of mental health care providers toward telehealth.: Methods: At 18 centers across the United States, 819 mental health ...

Abstract	Objectives: The COVID-19 pandemic has forced a rapid transition to telepsychiatry. This study examined the experience and attitudes of mental health care providers toward telehealth. Methods: At 18 centers across the United States, 819 mental health care providers completed an electronic survey about telepsychiatry use and satisfaction. Results: Overall, 73% of providers using videoconferencing and 66% using the telephone rated their experience as excellent or good. Flexible scheduling or rescheduling (77%) and timely start (69%) were frequently reported advantages for both modalities. Challenges were related to patients' inability to use conferencing devices (52%), lack of sense of closeness or connection (46%), and technical problems (39%). After the pandemic resolves, 64% of respondents would want to continue using telepsychiatry in at least 25% of their caseload. Conclusions: Telepsychiatry was very well perceived among mental health care providers, and many would like to continue using it. Access to technology and training raises concerns.
MeSH term(s)	Adult ; Aged ; Attitude of Health Personnel ; COVID-19 ; Health Care Surveys ; Health Personnel/psychology ; Humans ; Middle Aged ; Pandemics ; Psychiatry ; Surveys and Questionnaires ; Telemedicine ; United States
Language	English
Publishing date	2021-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1220173-x
ISSN	1557-9700 ; 1075-2730
ISSN (online)	1557-9700
ISSN	1075-2730
DOI	10.1176/appi.ps.202000441
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