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  1. Article ; Online: The Geometry of Y-Stent Configurations Used for Wide-Necked Aneurysm Treatment: Analyzing Double-Barrel Stents In Vitro Using Flat-Panel Computed Tomography.

    Caton, M Travis / Copelan, Alexander Z / Narsinh, Kazim H / Baker, Amanda / Abla, Adib A / Higashida, Randall T / Amans, Matthew R / Hetts, Steven W / Cooke, Daniel L

    World neurosurgery

    2021  Volume 151, Page(s) e363–e371

    Abstract: ... a Y configuration stent. A similar stent configuration, termed kissing/double-barrel (KDB), is used ...

    Abstract Background: Stent-assisted coil embolization of wide-necked bifurcation aneurysms often employs a Y configuration stent. A similar stent configuration, termed kissing/double-barrel (KDB), is used often at the aortoiliac bifurcation. Studies of KDB stents in aortoiliac disease show that rates of thromboembolic complications vary with the cross-sectional geometry of the stent pair, a function of the radial crush resistive force of each stent. We assessed cross-sectional geometry of intracranial stent pairs in an in vitro model of the basilar artery using flat-panel computed tomography.
    Methods: In a silicone model of a wide-necked basilar tip aneurysm, 6 simulated KDB stent deployment trials were performed using combinations of 5 stents (Enterprise 1, Enterprise 2, Neuroform Atlas, LVIS, LVIS Jr.). Flat-panel computed tomography reconstructions were used to assess cross-sectional stent geometry. Relative conformability, defined by ovalization and D-ratio, radial crush resistive force (predicted vs. actual), and radial mismatch fraction were compared by stent type (braided vs. laser-cut).
    Results: Several distinct forms of cross-sectional stent geometry were observed. Braided stents had lower ovalization and D-ratio (P = 0.015) than laser-cut stents. The Neuroform Atlas/LVIS combination yielded the lowest radial mismatch fraction (19.7% vs. mean 44.3% ± 0.7%). Braided stents tended to have a deployed stent radius closer to the expected (nominal) diameter (i.e., higher relative crush resistive force) than laser-cut stents (measured vs. nominal diameter discrepancy +38.6% ± 21.1% vs. -10.7% ±16.1%, P = 0.14).
    Conclusions: In constant anatomy, cross-sectional geometry of the KDB stent configuration will vary depending on the design and structure of the stents employed.
    MeSH term(s) Embolization, Therapeutic/methods ; Endovascular Procedures/methods ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Models, Neurological ; Stents ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2021.04.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
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  2. Article ; Online: Oxytocin transported from the blood across the blood-brain barrier by receptor for advanced glycation end-products (RAGE) affects brain function related to social behavior.

    Higashida, Haruhiro / Oshima, Yu / Yamamoto, Yasuhiko

    Peptides

    2024  , Page(s) 171230

    Abstract: Oxytocin (OT) is a neuropeptide that primarily functions as a hormone controlling female reproductive processes. Since numerous recent studies have shown that single and repetitive administrations of OT increase trust, social interaction, and maternal ... ...

    Abstract Oxytocin (OT) is a neuropeptide that primarily functions as a hormone controlling female reproductive processes. Since numerous recent studies have shown that single and repetitive administrations of OT increase trust, social interaction, and maternal behaviors in humans and animals, OT is considered a key molecule that regulates social memory and behavior. Furthermore, OT binds to receptors for advanced glycation end-products (RAGE), and it has been demonstrated that loss of RAGE in the brain vascular endothelial cells of mice fails to increase brain OT concentrations following peripheral OT administration. This leads to the hypothesis that RAGE is involved in the direct transport of OT, allowing it access to the brain by transporting it across the blood-brain barrier; however, this hypothesis is only based on limited evidence. Herein, we review the recent results related to this hypothesis, such as the mode of transport of OT in the blood circulation to the brain via different forms of RAGE, including membrane-bound full-length RAGE and soluble RAGE. We further review the modulation of brain function and social behavior, which seem to be mediated by RAGE-dependent OT. Overall, this review mostly confirms that RAGE enables the recruitment of circulating OT to the brain, thereby influencing social behavior. The requirement for further studies considering the physiological aspects of RAGE is also discussed.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2024.171230
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  3. Article: Enhanced Conformational Sampling of Nanobody CDR H3 Loop by Generalized Replica-Exchange with Solute Tempering.

    Higashida, Ren / Matsunaga, Yasuhiro

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 12

    Abstract: The variable domains of heavy-chain antibodies, known as nanobodies, are potential substitutes for IgG antibodies. They have similar affinities to antigens as antibodies, but are more heat resistant. Their small size allows us to exploit computational ... ...

    Abstract The variable domains of heavy-chain antibodies, known as nanobodies, are potential substitutes for IgG antibodies. They have similar affinities to antigens as antibodies, but are more heat resistant. Their small size allows us to exploit computational approaches for structural modeling or design. Here, we investigate the applicability of an enhanced sampling method, a generalized replica-exchange with solute tempering (gREST) for sampling CDR-H3 loop structures of nanobodies. In the conventional replica-exchange methods, temperatures of only a whole system or scaling parameters of a solute molecule are selected for temperature or parameter exchange. In gREST, we can flexibly select a part of a solute molecule and a part of the potential energy terms as a parameter exchange region. We selected the CDR-H3 loop and investigated which potential energy term should be selected for the efficient sampling of the loop structures. We found that the gREST with dihedral terms can explore a global conformational space, but the relaxation to the global equilibrium is slow. On the other hand, gREST with all the potential energy terms can sample the equilibrium distribution, but the structural exploration is slower than with dihedral terms. The lessons learned from this study can be applied to future studies of loop modeling.
    Language English
    Publishing date 2021-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11121428
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  4. Article ; Online: Viewing zone enlargement method for holographic displays based on the slanted pixel arrangement on a spatial light modulator.

    Yamaguchi, Yuta / Miura, Masato / Higashida, Ryo / Aoshima, Ken-Ichi / Machida, Kenji

    Applied optics

    2024  Volume 63, Issue 9, Page(s) 2204–2211

    Abstract: This study proposes a method for enlarging the viewing zone of holographic displays using the slanted arrangement of pixels on a spatial light modulator (SLM). The pixel arrangement equivalently reduces the horizontal pixel pitch, which enlarges the ... ...

    Abstract This study proposes a method for enlarging the viewing zone of holographic displays using the slanted arrangement of pixels on a spatial light modulator (SLM). The pixel arrangement equivalently reduces the horizontal pixel pitch, which enlarges the horizontal viewing zone of displays. Computer-generated holograms (CGHs) were calculated using an asymmetric band-limit filter corresponding to the asymmetric bandwidth of the SLM with slanted pixels. The proposed methods were evaluated through an optical reconstruction experiment using static holograms with a pixel size of 1×1µ
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.506449
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  5. Article ; Online: Dimetal-Binding Scaffold 2-(Pyridin-2-yl)imidazo [1,5-b]pyridazine-7-ylidene: Synthesis of Trinuclear Heterobimetallic Complexes Involving Gold-Metal Interactions.

    Kitabayashi, Akito / Ono, Yuriko / Taketsugu, Tetsuya / Sawamura, Masaya / Higashida, Kosuke

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 52, Page(s) e202301673

    Abstract: As a dimetal-binding rigid scaffold, 2-(pyridin-2-yl)imidazo[1,5-b]pyridazine-7-ylidene was introduced. The scaffold was first converted into a meridional Au,N,N-tridentate ligand through binding of a Au(I)Cl moiety at the carbene center. The Au(I) ... ...

    Abstract As a dimetal-binding rigid scaffold, 2-(pyridin-2-yl)imidazo[1,5-b]pyridazine-7-ylidene was introduced. The scaffold was first converted into a meridional Au,N,N-tridentate ligand through binding of a Au(I)Cl moiety at the carbene center. The Au(I) center and the N,N-chelating moiety were expected to function as metallophilic and 4e-σ-donative interaction sites, respectively, in the binding of the second metal center. In this manner, various trinuclear heterobimetallic complexes were synthesized with different 3d-metal sources, such as cationic Cu
    Language English
    Publishing date 2023-08-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301673
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  6. Article ; Online: Receptor for advanced glycation end-products and child neglect in mice: A possible link to postpartum depression.

    Higashida, Haruhiro / Gerasimenko, Maria / Yamamoto, Yasuhiko

    Comprehensive psychoneuroendocrinology

    2022  Volume 11, Page(s) 100146

    Abstract: The receptor for advanced glycation end-products (RAGE), a pattern recognition molecule, has a role in the remodeling of vascular endothelial cells mainly in lungs, kidney and brain under pathological conditions. We recently discovered that RAGE binds ... ...

    Abstract The receptor for advanced glycation end-products (RAGE), a pattern recognition molecule, has a role in the remodeling of vascular endothelial cells mainly in lungs, kidney and brain under pathological conditions. We recently discovered that RAGE binds oxytocin (OT) and transports it to the brain from circulation on neurovascular endothelial cells. We produced knockout mice of the mouse homologue of the human RAGE gene,
    Language English
    Publishing date 2022-06-03
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-4976
    ISSN (online) 2666-4976
    DOI 10.1016/j.cpnec.2022.100146
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  7. Article ; Online: Low-carbohydrate, high-fat diet, and running exercise influence bone parameters in old mice.

    Aikawa, Yuki / Yamashita, Takenori / Nakai, Naoya / Higashida, Kazuhiko

    Journal of applied physiology (Bethesda, Md. : 1985)

    2022  Volume 132, Issue 5, Page(s) 1204–1212

    Abstract: We examined the effects and interactions of a low-carbohydrate, high-fat (LCHF) diet and voluntary running exercise on bone in older mice. Male 19-mo-old mice were divided into four groups by diet (control vs. LCHF) and exercise (sedentary vs. voluntary ... ...

    Abstract We examined the effects and interactions of a low-carbohydrate, high-fat (LCHF) diet and voluntary running exercise on bone in older mice. Male 19-mo-old mice were divided into four groups by diet (control vs. LCHF) and exercise (sedentary vs. voluntary running). The control diet was 55% carbohydrate, 23% protein, and 22% fat, and the LCHF diet was 10% carbohydrate, 33% protein, and 57% fat as percentages of calories. The experiment ended when the mice reached 24 mo old. Statistical analysis was conducted using two-way analysis of variance with diet and exercise. The LCHF diet decreased bone mineral content (BMC), bone mineral density, bone volume fraction, and trabecular number. There was no significant interaction between diet and exercise on many bone parameters. However, there were significant diet and exercise interactions on lumbar BMC and tibial trabecular total tissue volume and average cortical thickness. The LCHF diet attenuated the benefit of running exercise on lumbar BMC and caused running to have a negative effect on tibial trabecular total tissue volume. Our study suggests that the LCHF diet impairs bone mass and some trabecular microstructure and reduces the benefit of exercise on lumbar BMC in old mice.
    MeSH term(s) Animals ; Bone Density ; Carbohydrates ; Diet, Carbohydrate-Restricted ; Diet, High-Fat ; Energy Intake ; Male ; Mice ; Physical Conditioning, Animal ; Running
    Chemical Substances Carbohydrates
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00789.2021
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    Uc I Zs.249: Show issues Location:
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  8. Article ; Online: RAGE regulates oxytocin transport into the brain.

    Yamamoto, Yasuhiko / Higashida, Haruhiro

    Communications biology

    2020  Volume 3, Issue 1, Page(s) 70

    MeSH term(s) Animals ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Female ; Humans ; Oxytocin/blood ; Oxytocin/metabolism ; Pregnancy ; Protein Transport ; Receptor for Advanced Glycation End Products/metabolism
    Chemical Substances Receptor for Advanced Glycation End Products ; Oxytocin (50-56-6)
    Language English
    Publishing date 2020-02-13
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-020-0799-2
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  9. Article: Carotid endarterectomy with stent removal for recurring in-stent restenosis: A case report and literature review.

    Takahashi, Yuichi / Higashida, Tetsuhiro / Uchida, Takanori / Watanabe, Saiko / Kanazawa, Ryuzaburo

    Surgical neurology international

    2022  Volume 13, Page(s) 192

    Abstract: Background: Percutaneous transcatheter angioplasty (PTA) and carotid artery stenting (CAS) are often performed repeatedly for in-stent restenosis (ISR) after CAS. Only a few reports describe the treatment for repeated ISR. Furthermore, only a few ... ...

    Abstract Background: Percutaneous transcatheter angioplasty (PTA) and carotid artery stenting (CAS) are often performed repeatedly for in-stent restenosis (ISR) after CAS. Only a few reports describe the treatment for repeated ISR. Furthermore, only a few reports describe carotid endarterectomy (CEA) after CAS; thus, the evidence for this procedure is insufficient.
    Case description: Herein, we describe a case in which CEA with stent removal was performed in a patient with repeated ISR after CAS. A 78-year-old man presented with dysarthria and slight left limb weakness. CAS was performed for the right internal carotid artery stenosis. ISR occurred again and PTA and stenting were performed. After the second CAS, ISR occurred again. CEA with stent removal was performed. After the CEA with stent removal, the patient experienced no restenosis or other complications.
    Conclusion: CEA with stent removal can be a good option for treating repeated ISR after CAS.
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Case Reports
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_1222_2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Nickel-Catalyzed Defluorophosphonylation of Aryl Fluorides.

    You, Zhensheng / Masuda, Yusuke / Iwai, Tomohiro / Higashida, Kosuke / Sawamura, Masaya

    The Journal of organic chemistry

    2022  Volume 87, Issue 21, Page(s) 14731–14737

    Abstract: A Ni-catalyzed cross-coupling reaction between aryl fluorides and dialkyl phosphonates [HP(O)(OR) ...

    Abstract A Ni-catalyzed cross-coupling reaction between aryl fluorides and dialkyl phosphonates [HP(O)(OR)
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c02048
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    Zs.A 4473: Show issues Location:
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