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  1. AU=Poole Stephen
  2. AU="Kislova, Maria"
  3. AU="Balducelli, Emma"
  4. AU="Mudrak, Nathan J"
  5. AU="Fagundes, Addller Oliveira"
  6. AU="Qi, Xiaoli" AU="Qi, Xiaoli"
  7. AU="Durymanov, Mikhail"
  8. AU=Yin Wenzhe
  9. AU=Vlachos Ioannis S.
  10. AU=Grundy Scott M
  11. AU="Koumoutsea, Evangelia Vlachodimitropoulou"
  12. AU="Almen, Aimee"
  13. AU="Howard, Dianna S."
  14. AU="Elizete Rizzo"
  15. AU="El Sayegh, Suzanne"
  16. AU="Vaittinen, Tiina"
  17. AU="Khir, Amir S"
  18. AU=Patterson Andrew D
  19. AU="Kim, Joyce Mary"
  20. AU="Saribay, S Adil"
  21. AU="Couderc, M."
  22. AU="Macerlane de Lira Silva"
  23. AU=Neal Michael S
  24. AU="Nakai, Kozo"
  25. AU="Debatin, Jörg F."
  26. AU="Plant, Laura"
  27. AU="Manuel Tisminetzky"
  28. AU="Monaco, Carlo"
  29. AU="Srivastava, Rupesh"
  30. AU="Nathan, Jaimie D"
  31. AU="Schnegelberger, Regina D"
  32. AU=Doshi Paresh
  33. AU="Cecilia Hognon"
  34. AU="Mason, Jeremy K."
  35. AU=Hasumi Hisashi
  36. AU="Swati Sethi"
  37. AU="Martin G. Myers, Jr."
  38. AU="Marcus-Sekura, Carol"
  39. AU="Petagine, Lucy"
  40. AU="Jessa R. Alexander"
  41. AU=Rauner Martina
  42. AU="Richlen, Mindy L"
  43. AU="Merghani, Nada M"
  44. AU=Splitt M P
  45. AU="Zlatanović, Gordana"

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  1. Artikel ; Online: Editorial: Disorderly street users of novel psychoactive substances: What might help?

    Campbell, Stephen / Poole, Rob

    Criminal behaviour and mental health : CBMH

    2020  Band 30, Heft 2-3, Seite(n) 53–58

    Sprache Englisch
    Erscheinungsdatum 2020-05-03
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 2042697-5
    ISSN 1471-2857 ; 0957-9664
    ISSN (online) 1471-2857
    ISSN 0957-9664
    DOI 10.1002/cbm.2146
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  2. Artikel ; Online: Reversible Inactivation of Ferret Auditory Cortex Impairs Spatial and Nonspatial Hearing.

    Town, Stephen M / Poole, Katarina C / Wood, Katherine C / Bizley, Jennifer K

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2023  Band 43, Heft 5, Seite(n) 749–763

    Abstract: A key question in auditory neuroscience is to what extent are brain regions functionally specialized for processing specific sound features, such as location and identity. In auditory cortex, correlations between neural activity and sounds support both ... ...

    Abstract A key question in auditory neuroscience is to what extent are brain regions functionally specialized for processing specific sound features, such as location and identity. In auditory cortex, correlations between neural activity and sounds support both the specialization of distinct cortical subfields, and encoding of multiple sound features within individual cortical areas. However, few studies have tested the contribution of auditory cortex to hearing in multiple contexts. Here we determined the role of ferret primary auditory cortex in both spatial and nonspatial hearing by reversibly inactivating the middle ectosylvian gyrus during behavior using cooling (
    Mesh-Begriff(e) Animals ; Female ; Auditory Cortex/physiology ; Ferrets/physiology ; Channelrhodopsins/genetics ; Acoustic Stimulation ; Sound Localization/physiology ; Auditory Perception/physiology ; Hearing
    Chemische Substanzen Channelrhodopsins
    Sprache Englisch
    Erscheinungsdatum 2023-01-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1426-22.2022
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  3. Artikel ; Online: Repurposing an endogenous degradation domain for antibody-mediated disposal of cell-surface proteins.

    Schmitt, Janika / Poole, Emma / Groves, Ian / Owen, David J / Graham, Stephen C / Sinclair, John / Kelly, Bernard T

    EMBO reports

    2024  Band 25, Heft 3, Seite(n) 951–970

    Abstract: The exquisite specificity of antibodies can be harnessed to effect targeted degradation of membrane proteins. Here, we demonstrate targeted protein removal utilising a protein degradation domain derived from the endogenous human protein Proprotein ... ...

    Abstract The exquisite specificity of antibodies can be harnessed to effect targeted degradation of membrane proteins. Here, we demonstrate targeted protein removal utilising a protein degradation domain derived from the endogenous human protein Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9). Recombinant antibodies genetically fused to this domain drive the degradation of membrane proteins that undergo constitutive internalisation and recycling, including the transferrin receptor and the human cytomegalovirus latency-associated protein US28. We term this approach PACTAC (PCSK9-Antibody Clearance-Targeting Chimeras).
    Mesh-Begriff(e) Humans ; Proprotein Convertase 9/metabolism ; Serine Endopeptidases ; Proprotein Convertases/metabolism ; Membrane Proteins ; Receptors, LDL/metabolism
    Chemische Substanzen PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-) ; Proprotein Convertases (EC 3.4.21.-) ; Membrane Proteins ; Receptors, LDL
    Sprache Englisch
    Erscheinungsdatum 2024-01-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/s44319-024-00063-3
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  4. Artikel ; Online: Current and potential use of animal disease data by stakeholders in the global south and north.

    Grace, Delia / Amenu, Kebede / Daborn, Chris J / Knight-Jones, Theodore / Huntington, Benjamin / Young, Stephen / Poole, Jane / Rushton, Jonathan

    Preventive veterinary medicine

    2024  Band 226, Seite(n) 106189

    Abstract: What cannot be measured will not be managed. The Global Burden of Animal Diseases (GBADs) will generate information on animal disease burdens by species, production system, type and gender of farmer and consumer, geographical region, and time period. To ... ...

    Abstract What cannot be measured will not be managed. The Global Burden of Animal Diseases (GBADs) will generate information on animal disease burdens by species, production system, type and gender of farmer and consumer, geographical region, and time period. To understand the demand for burden of animal disease (BAD) data and how end-users might benefit from this, we reviewed the literature on animal diseases prioritisation processes (ADPP) and conducted a survey of BAD information users. The survey covered their current use of data and prioritizations as well as their needs for different, more, and better information. We identified representative (geography, sector, species) BAD experts from the authors' networks and publicly available documents and e-mailed 1485 experts. Of 791 experts successfully contacted, 271 responded (34% response rate), and 185 complete and valid responses were obtained. Most respondents came from the public sector followed by academia/research, and most were affiliated to institutions in low- and middle-income countries (LMICs). Of the six ADPPs commonly featured in literature, only three were recognised by more than 40% of experts. An additional 23 ADPPs were used. Awareness of ADDPs varied significantly by respondents. Respondents ranked animal disease priorities. We used exploded logit to combine first, second and third disease priorities to better understand prioritzation and their determinants. Expert priorities differed significantly from priorities identified by the ADDPs, and also from the priorities stated veterinary services as reported in a survey for a World Organisation of Animal Health (WOAH) technical item. Respondents identified 15 different uses of BAD data. The most common use was presenting evidence (publications, official reports, followed by disease management, policy development and proposal writing). Few used disease data for prioritzation or resource allocation, fewer routinely used economic data for decision making, and less than half were aware of the use of decision support tools (DSTs). Nearly all respondents considered current BAD metrics inadequate, most considered animal health information insufficiently available and not evidence-based, and most expressed concerns that decision-making processes related to animal health lacked transparency and fairness. Cluster analysis suggested three clusters of BAD users and will inform DSTs to help them better meet their specific objectives. We conclude that there is a lack of satisfaction with current BAD information, and with existing ADDPs, contributing to sub-optimal decision making. Improved BAD data would have multiple uses by different stakeholders leading to better evidenced decisions and policies; moreover, clients will need support (including DSTs) to optimally use BAD information.
    Mesh-Begriff(e) Animals ; Policy Making ; Animal Diseases/epidemiology ; Animal Diseases/prevention & control
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland Netherlands
    Dokumenttyp Review ; Journal Article
    ZDB-ID 43399-8
    ISSN 1873-1716 ; 0167-5877
    ISSN (online) 1873-1716
    ISSN 0167-5877
    DOI 10.1016/j.prevetmed.2024.106189
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  5. Artikel ; Online: Rapid syndromic molecular testing in pneumonia: The current landscape and future potential.

    Poole, Stephen / Clark, Tristan W

    The Journal of infection

    2019  Band 80, Heft 1, Seite(n) 1–7

    Abstract: Community acquired pneumonia (CAP), hospital-acquired pneumonia (HAP) and ventilator associated pneumonia (VAP) are all associated with significant mortality and cause huge expense to health care services around the world. Early, appropriate ... ...

    Abstract Community acquired pneumonia (CAP), hospital-acquired pneumonia (HAP) and ventilator associated pneumonia (VAP) are all associated with significant mortality and cause huge expense to health care services around the world. Early, appropriate antimicrobial therapy is crucial for effective treatment. Syndromic diagnostic testing using novel, rapid multiplexed molecular platforms represents a new opportunity for rapidly targeted antimicrobial therapy to improve patient outcomes and facilitate antibiotic stewardship. In this article we review the currently available testing platforms and discuss the potential benefits and pitfalls of rapid testing in pneumonia.
    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/drug therapy ; Healthcare-Associated Pneumonia/diagnosis ; Healthcare-Associated Pneumonia/drug therapy ; Humans ; Molecular Diagnostic Techniques/methods ; Pneumonia/diagnosis ; Pneumonia/drug therapy ; Pneumonia, Ventilator-Associated/diagnosis ; Pneumonia, Ventilator-Associated/drug therapy ; Treatment Outcome
    Chemische Substanzen Anti-Bacterial Agents
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2019-12-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2019.11.021
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  6. Artikel ; Online: Diagnosis of cystic fibrosis in adulthood and eligibility for novel CFTR modulator therapy.

    Farley, Hannah / Poole, Sarah / Chapman, Stephen / Flight, William

    Postgraduate medical journal

    2021  Band 98, Heft 1159, Seite(n) 341–345

    Abstract: Background: Cystic fibrosis (CF) is an autosomal recessive condition that primarily manifests as a chronic respiratory disease. CF is usually diagnosed in early childhood or through newborn screening although in a small but important group, diagnosis is ...

    Abstract Background: Cystic fibrosis (CF) is an autosomal recessive condition that primarily manifests as a chronic respiratory disease. CF is usually diagnosed in early childhood or through newborn screening although in a small but important group, diagnosis is not made until adulthood. Highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies are now available for most genetic causes of CF highlighting the importance of identifying people with late presentations of CF.
    Aim: We aimed to identify the clinical characteristics of people diagnosed with CF in adulthood and their resulting eligibility for novel CFTR modulator therapies.
    Design: Retrospective single-centre cohort study.
    Methods: Patients diagnosed with CF at age 18 years or older were identified from a patient database. Paper and electronic medical records were reviewed and clinical, microbiological and radiological data at diagnosis were recorded.
    Results: Nineteen patients were identified. Median age at diagnosis was 38 years (range: 19-71) and 9 (47%) were female. All patients had a history of chronic respiratory symptoms and 18/19 (94%) had radiological evidence of bronchiectasis. All patients had two pathogenic CFTR mutations identified with 16/19 (84%) compound heterozygotes for the F508del mutation. The majority of patients had a CFTR genotype considered eligible for CFTR modulator therapy (84% and 89% according to European and US licences, respectively).
    Conclusions: Adult patients with unexplained chronic bronchiectasis should be thoroughly investigated for CF. A low index of suspicion will help to identify adults with undiagnosed CF who are likely to benefit from CFTR modulator therapy.
    Mesh-Begriff(e) Adult ; Bronchiectasis/drug therapy ; Cohort Studies ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Female ; Humans ; Male ; Retrospective Studies
    Chemische Substanzen CFTR protein, human ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Sprache Englisch
    Erscheinungsdatum 2021-01-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2020-139278
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  7. Artikel ; Online: Positive thinking about negative studies.

    Petkova, Eva / Ciarleglio, Adam / Casey, Patricia / Poole, Norman / Kaufman, Kenneth / Lawrie, Stephen M / Malhi, Gin / Siddiqi, Najma / Bhui, Kamaldeep / Lee, William

    The British journal of psychiatry : the journal of mental science

    2024  Band 224, Heft 3, Seite(n) 79–81

    Abstract: The non-reporting of negative studies results in a scientific record that is incomplete, one-sided and misleading. The consequences of this range from inappropriate initiation of further studies that might put participants at unnecessary risk to ... ...

    Abstract The non-reporting of negative studies results in a scientific record that is incomplete, one-sided and misleading. The consequences of this range from inappropriate initiation of further studies that might put participants at unnecessary risk to treatment guidelines that may be in error, thus compromising day-to-day clinical practice.
    Mesh-Begriff(e) Humans ; Anorexia Nervosa/therapy ; Optimism
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.2023.155
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  8. Artikel ; Online: Response to: Metacognition in functional cognitive disorder: contradictory or convergent experimental results?

    Bhome, Rohan / McWilliams, Andrew / Price, Gary / Poole, Norman A / Howard, Robert J / Fleming, Stephen M / Huntley, Jonathan D

    Brain communications

    2022  Band 4, Heft 3, Seite(n) fcac139

    Sprache Englisch
    Erscheinungsdatum 2022-05-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcac139
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  9. Artikel ; Online: Critical role of chemical potential to assure effective encapsulation.

    Yuan, Qingchun / Collins, Stephen / Poole, Joyleen / Jia, Xiaodong / Williams, Richard A

    Journal of colloid and interface science

    2022  Band 623, Seite(n) 86–95

    Abstract: Hypothesis: In emulsification-polymerisation avoiding monomer escape from emulsion droplets is the key to successful encapsulation. So far, it is believed that (1) a hydrophobe needs to be included and (2) free-micelles of surfactant need to be depleted. ...

    Abstract Hypothesis: In emulsification-polymerisation avoiding monomer escape from emulsion droplets is the key to successful encapsulation. So far, it is believed that (1) a hydrophobe needs to be included and (2) free-micelles of surfactant need to be depleted. However, these criteria do not always work. The paper explores the critical role of the chemical potential difference between the inside and outside of the emulsion droplet for successful encapsulation.
    Experiments: Crossflow membrane emulsification was used to produce uniform droplets of 1-2 µm of solutions of 3-iodoprop-2-yn-1-yl butylcarbamate (a biocide), castor oil (hydrophobe) in methyl 2-methylprop-2-enoate (monomer) into aqueous solutions with a large amount of free-micelles of surfactant. The encapsulation was followed by polymerisation. The size distribution of microcapsule from different formula were examined.
    Findings: The biocide encapsulation depends on castor oil content: >12% (full); 6-12% (either full or partial); <6% (minor). Results show a critical molar fraction ratio of the monomer in the droplet to water in the aqueous phase that provides a definitive criterion to assure size retention and full encapsulation. This critical value corresponds to an energy barrier of 116 J/mol to prevent the monomer escaping. This finding is proposed to be used as an advanced rule to guide precision formulation for desired microencapsulation.
    Mesh-Begriff(e) Castor Oil ; Disinfectants ; Emulsions ; Excipients ; Micelles ; Surface-Active Agents ; Water
    Chemische Substanzen Disinfectants ; Emulsions ; Excipients ; Micelles ; Surface-Active Agents ; Water (059QF0KO0R) ; Castor Oil (8001-79-4)
    Sprache Englisch
    Erscheinungsdatum 2022-05-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2022.05.014
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  10. Artikel ; Online: SARS-CoV-2 has displaced other seasonal respiratory viruses: Results from a prospective cohort study.

    Poole, Stephen / Brendish, Nathan J / Clark, Tristan W

    The Journal of infection

    2020  Band 81, Heft 6, Seite(n) 966–972

    Abstract: Objectives: The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying ... ...

    Abstract Objectives: The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying chronic lung diseases. This study aimed to assess the impact of SARS-CoV-2 on the prevalence and clinical characteristics of respiratory virus disease in hospitalised adults.
    Methods: Data for this cohort study were from hospitalised adults who had multiplex PCR testing for respiratory viruses over several seasons in Hampshire, UK. Respiratory virus detection during the first epidemic peak of SARS-CoV-2 was compared to detection during the same time period across previous years.
    Results: 856 patients had multiplex PCR for respiratory viruses between March and May over 5 years. Before 2020, a non-SARS-CoV-2 virus was detected in 54% patients (202/371) compared to 4.1% (20/485) in 2020 (p < 0.0001). SARS-CoV-2 was associated with asthma or COPD exacerbations in a smaller proportion of infected patients compared to other viruses (1.0% vs 37%, p < 0.0001).
    Conclusions: The emergence of SARS-CoV-2 was associated with substantial reductions in the circulation of seasonal respiratory viruses and large differences in the characteristics of viral-associated disease, including illness in a greater proportion of patients without underlying lung disease.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnosis ; COVID-19/epidemiology ; Cohort Studies ; Female ; Hospitalization ; Humans ; Influenza A virus/isolation & purification ; Influenza B virus/isolation & purification ; Male ; Middle Aged ; Multiplex Polymerase Chain Reaction ; Prospective Studies ; Respiratory Syncytial Virus, Human/isolation & purification ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; SARS-CoV-2/isolation & purification ; Seasons ; United Kingdom/epidemiology ; Virus Diseases/epidemiology
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-11-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.11.010
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