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Article ; Online: Extended aortic arch repair via simple median sternotomy using a parabronchial approach: A case report.

Kowatari, Ryosuke / Sasaki, Hanae / Yamazaki, Shiho / Daitoku, Kazuyuki / Minakawa, Masahito

2022 Volume 37, Issue 11, Page(s) 3919–3921

Abstract: Background and aims: Surgery for extensive thoracic aortic aneurysms is challenging. We aim to report our novel extended arch repair method, which we termed "parabronchial approach" for such disease.: Materials and methods: The patient case data was ... ...

Abstract	Background and aims: Surgery for extensive thoracic aortic aneurysms is challenging. We aim to report our novel extended arch repair method, which we termed "parabronchial approach" for such disease. Materials and methods: The patient case data was extracted from hospital records. Results: The patient was the case of a 31-year-old woman with Takayasu's arteritis who developed aortic dissection. She underwent extended arch repair via a simple sternotomy approach. The left pulmonary artery compression with a retractor arrowed us to obtain adequate working space. Postoperative computed tomography revealed a distal anastomosis site level was at the sixth thoracic vertebra. Discussion and conclusion: This parabronchial approach could reduce the frequency of choosing a highly invasive approach and can be a potential minimally invasive approach in cases requiring extensive thoracic aortic aneurysm repair.
MeSH term(s)	Adult ; Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/surgery ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis Implantation/methods ; Female ; Humans ; Sternotomy/methods
Language	English
Publishing date	2022-09-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.16905
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Article ; Online: Pairing of white wine made with shade-grown grapes and Japanese cuisine.

Takahashi, Takuji / Nakano, Kumiko / Yamashita, Machiko / Yamazaki, Hanae / Fushiki, Tohru

NPJ science of food

2021 Volume 5, Issue 1, Page(s) 5

Abstract: This study investigated the effect of pairing of wine vinified from shade-grown grapes before onset of ripening on the palatability of sashimi, a typical Japanese cuisine. GC-MS analyses of volatile chemicals revealed that shading reduced phenolic ... ...

Abstract	This study investigated the effect of pairing of wine vinified from shade-grown grapes before onset of ripening on the palatability of sashimi, a typical Japanese cuisine. GC-MS analyses of volatile chemicals revealed that shading reduced phenolic compounds and terpenoids, and added fatty acid ethyl esters which are also known to contribute to the flavor of Japanese sake. When the pairing of sashimi with wine was evaluated by individuals who regularly drink Japanese sake during meals, shade wine was more highly rated than wine made from normally-grown grapes.
Language	English
Publishing date	2021-03-01
Publishing country	England
Document type	Journal Article
ISSN	2396-8370
ISSN (online)	2396-8370
DOI	10.1038/s41538-021-00089-0
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Article ; Online: Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.

Fujita, Ken-Ichi / Ito, Misa / Irie, Midori / Harada, Kotaro / Fujiwara, Naoko / Ikeda, Yuya / Yoshioka, Hanae / Yamazaki, Tomohiro / Kojima, Masaki / Mikami, Bunzo / Mayeda, Akila / Masuda, Seiji

Nature communications

2024 Volume 15, Issue 1, Page(s) 455

Abstract: mRNA export is an essential pathway for the regulation of gene expression. In humans, closely related RNA helicases, UAP56 and URH49, shape selective mRNA export pathways through the formation of distinct complexes, known as apo-TREX and apo-AREX ... ...

Abstract	mRNA export is an essential pathway for the regulation of gene expression. In humans, closely related RNA helicases, UAP56 and URH49, shape selective mRNA export pathways through the formation of distinct complexes, known as apo-TREX and apo-AREX complexes, and their subsequent remodeling into similar ATP-bound complexes. Therefore, defining the unidentified components of the apo-AREX complex and elucidating the molecular mechanisms underlying the formation of distinct apo-complexes is key to understanding their functional divergence. In this study, we identify additional apo-AREX components physically and functionally associated with URH49. Furthermore, by comparing the structures of UAP56 and URH49 and performing an integrated analysis of their chimeric mutants, we exhibit unique structural features that would contribute to the formation of their respective complexes. This study provides insights into the specific structural and functional diversification of these two helicases that diverged from the common ancestral gene Sub2.
MeSH term(s)	Humans ; Active Transport, Cell Nucleus ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; RNA Helicases/metabolism ; RNA Transport ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	DEAD-box RNA Helicases (EC 3.6.4.13) ; RNA Helicases (EC 3.6.4.13) ; RNA, Messenger ; DDX39A protein, human (EC 3.6.1.-) ; DDX39B protein, human (EC 3.6.1.-)
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44217-8
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Article ; Online: Tryptophan metabolism and small fibre neuropathy: a correlation study.

Kushibiki, Hanae / Mizukami, Hiroki / Osonoi, Sho / Takeuchi, Yuki / Sasaki, Takanori / Ogasawara, Saori / Wada, Kanichiro / Midorikawa, Shin / Ryuzaki, Masaki / Wang, Zhenchao / Yamada, Takahiro / Yamazaki, Keisuke / Tarusawa, Takefusa / Tanba, Taiyo / Mikami, Tatsuya / Matsubara, Atsushi / Ishibashi, Yasuyuki / Hakamada, Kenichi / Nakaji, Shigeyuki

Brain communications

2024 Volume 6, Issue 2, Page(s) fcae103

Abstract: Small nerve fibres located in the epidermis sense pain. Dysfunction of these fibres decreases the pain threshold known as small fibre neuropathy. Diabetes mellitus is accompanied by metabolic changes other than glucose, synergistically eliciting small ... ...

Abstract	Small nerve fibres located in the epidermis sense pain. Dysfunction of these fibres decreases the pain threshold known as small fibre neuropathy. Diabetes mellitus is accompanied by metabolic changes other than glucose, synergistically eliciting small fibre neuropathy. These findings suggest that various metabolic changes may be involved in small fibre neuropathy. Herein, we explored the correlation between pain sensation and changes in plasma metabolites in healthy Japanese subjects. The pain threshold evaluated from the intraepidermal electrical stimulation was used to quantify pain sensation in a total of 1021 individuals in the 2017 Iwaki Health Promotion Project. Participants with a pain threshold evaluated from the intraepidermal electrical stimulation index <0.20 mA were categorized into the pain threshold evaluated from the intraepidermal electrical stimulation index-low group (
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcae103
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Article ; Online: The Japan Society for Innovative Cuisine: Exploring New Visions of Japanese Cuisine.

Yamazaki, Hanae / Fushiki, Tohru

Journal of nutritional science and vitaminology

2015 Volume 61 Suppl, Page(s) S162–3

Abstract: Kyoto cuisine has a long history and its traditions have been practiced for hundreds of years. In Kyoto, a group of scientists and renowned chefs strives to better understand traditional Kyoto cuisine in order to foster culinary innovation within ... ...

Abstract	Kyoto cuisine has a long history and its traditions have been practiced for hundreds of years. In Kyoto, a group of scientists and renowned chefs strives to better understand traditional Kyoto cuisine in order to foster culinary innovation within traditional Kyoto cuisine. We launched a research project in April 2009 using a specially equipped "laboratory-kitchen" located in Kyoto University. Chefs chose a variety of topics related to basic concepts and techniques for cooking. We conducted culinary experimentation, thorough analysis, and diligent discussion on each topic for approximately 6 mo. In the symposium, chefs will present the results of their experiments, discussing their techniques and bringing samples of final products.
MeSH term(s)	Cooking/methods ; Diet ; Humans ; Japan ; Restaurants ; Taste
Language	English
Publishing date	2015
Publishing country	Japan
Document type	Journal Article
ZDB-ID	191366-9
ISSN	1881-7742 ; 0301-4800
ISSN (online)	1881-7742
ISSN	0301-4800
DOI	10.3177/jnsv.61.S162
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Article ; Online: Dual epigenetic changes in diabetes mellitus-associated pancreatic ductal adenocarcinoma correlate with downregulation of E-cadherin and worsened prognosis.

Hara, Yutaro / Mizukami, Hiroki / Yamazaki, Keisuke / Yamada, Takahiro / Igawa, Akiko / Takeuchi, Yuki / Sasaki, Takanori / Kushibiki, Hanae / Murakami, Kotaro / Kudoh, Kazuhiro / Ishido, Keinosuke / Hakamada, Kenichi

The journal of pathology. Clinical research

2023 Volume 9, Issue 5, Page(s) 354–366

Abstract: Diabetes mellitus (DM) is a risk factor for pancreatic ductal adenocarcinoma (PDAC) that promotes the promoter methylation of CDH1. It is still unclear whether DM can exert other epigenetic effects, such as altering microRNA (miR) expression, in PDAC. ... ...

Abstract	Diabetes mellitus (DM) is a risk factor for pancreatic ductal adenocarcinoma (PDAC) that promotes the promoter methylation of CDH1. It is still unclear whether DM can exert other epigenetic effects, such as altering microRNA (miR) expression, in PDAC. The expression of miR-100-5p is known to be changed in DM patients and can suppress the expression of E-cadherin. In this study, the correlation between DM status and dual epigenetic changes was evaluated in PDAC specimens from patients who underwent radical surgical resection. A total of 132 consecutive patients with PDAC were clinicopathologically evaluated. E-cadherin and nuclear β-catenin expression was measured using immunohistochemistry. DNA and miRs were extracted from the main tumor site on formalin-fixed paraffin-embedded tissue sections. TaqMan miR assays were applied to assess miR-100-5p expression. Bisulfite modification was conducted on the extracted DNA, which was then subjected to methylation-specific polymerase chain reaction. Immunohistochemistry revealed that decreased E-cadherin expression and increased nuclear β-catenin expression were significantly associated with DM and poor tumor cell differentiation. The presence of long-duration DM (≥3 years) was a significant factor contributing to CDH1 promoter methylation (p < 0.01), while miR-100-5p expression was proportionally correlated with the preoperative HbA1c level (R = 0.34, p < 0.01), but not the duration of DM. The subjects with high miR-100-5p expression and CDH1 promoter methylation showed the highest level of vessel invasion and prevalence of tumor size ≥30 mm. PDAC subjects with dual epigenetic changes showed poorer overall survival (OS) than those with a single epigenetic change. miR-100-5p expression ≥4.13 and CDH1 promoter methylation independently predicted poor OS and disease-free survival (DFS) in the multivariate analysis. OS and DFS worsened in DM subjects with both HbA1c ≥ 6.5% and DM duration ≥3 years. Thus, DM is associated with two modes of epigenetic change by independent mechanisms and worsens prognosis.
MeSH term(s)	Humans ; beta Catenin/genetics ; Down-Regulation ; Glycated Hemoglobin ; DNA Methylation ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Cadherins/genetics ; Epigenesis, Genetic ; Prognosis ; Diabetes Mellitus/genetics ; MicroRNAs/genetics ; Pancreatic Neoplasms
Chemical Substances	beta Catenin ; Glycated Hemoglobin ; Cadherins ; MicroRNAs
Language	English
Publishing date	2023-05-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2814357-7
ISSN	2056-4538 ; 2056-4538
ISSN (online)	2056-4538
ISSN	2056-4538
DOI	10.1002/cjp2.326
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Article ; Online: Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma.

Pan, Xuekai / Mizukami, Hiroki / Hara, Yutaro / Yamada, Takahiro / Yamazaki, Keisuke / Kudoh, Kazuhiro / Takeuchi, Yuki / Sasaki, Takanori / Kushibiki, Hanae / Igawa, Akiko / Hakamada, Kenichi

Journal of diabetes investigation

2022 Volume 14, Issue 1, Page(s) 132–144

Abstract: Aims/introduction: The mismatch repair (MMR) protein recognizes DNA replication errors and plays an important role in tumorigenesis, including pancreatic ductal adenocarcinoma (PDAC). Although PMS2, a MMR protein, is degraded under oxidative stress, the ...

Abstract	Aims/introduction: The mismatch repair (MMR) protein recognizes DNA replication errors and plays an important role in tumorigenesis, including pancreatic ductal adenocarcinoma (PDAC). Although PMS2, a MMR protein, is degraded under oxidative stress, the effects of diabetes are still unclear. Herein, we focused on whether diabetes affected MMR protein expression in PDAC. Materials and methods: Tissues from 61 surgically resected PDAC subjects were clinicopathologically analyzed. Immunohistochemical analysis was performed for MMR protein expression, oxidative stress, and immune cell infiltration. The change of MMR protein expression was assessed in PDAC cell lines under stimulation with 25 mM glucose and 500 μM palmitic acid. Survival curves were analyzed by the Kaplan-Meier method with the log-rank test. Results: Diabetes complicated with dyslipidemia significantly decreased the expression of PMS2 in PDAC tissues with an inverse correlation with the degree of oxidative stress. Palmitic acid combined with high glucose induced degradation of PMS2 protein, enhancing oxidative stress in vitro. CD8 Conclusions: The different phases of diabetes have a major impact on PDAC by altering PMS2 expression and the tumor immune microenvironment, which can be targeted by an immune checkpoint inhibitor.
MeSH term(s)	Humans ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism ; DNA Mismatch Repair ; Tumor Microenvironment ; Diabetes Mellitus, Type 2/complications ; Palmitic Acid ; Pancreatic Neoplasms/genetics ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Prognosis ; Pancreatic Neoplasms
Chemical Substances	Mismatch Repair Endonuclease PMS2 (EC 3.6.1.3) ; Palmitic Acid (2V16EO95H1) ; PMS2 protein, human (EC 3.6.1.-)
Language	English
Publishing date	2022-12-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2625840-7
ISSN	2040-1124 ; 2040-1116
ISSN (online)	2040-1124
ISSN	2040-1116
DOI	10.1111/jdi.13929
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Article ; Online: Clinical utility of comprehensive genomic profiling tests for advanced or metastatic solid tumor in clinical practice.

Ida, Hanae / Koyama, Takafumi / Mizuno, Takaaki / Sunami, Kuniko / Kubo, Takashi / Sudo, Kazuki / Tao, Kayoko / Hirata, Makoto / Yonemori, Kan / Kato, Ken / Okusaka, Takuji / Ohe, Yuichiro / Matsui, Yoshiyuki / Yamazaki, Naoya / Ogawa, Chitose / Kawai, Akira / Narita, Yoshitaka / Esaki, Minoru / Yamamoto, Noboru

Cancer science

2022

Abstract: Previous clinical trials indicate that 10%-25% of patients received genomically matched therapy after comprehensive genomic profiling (CGP) tests. However, the clinical utility of CGP tests has not been assessed in clinical practice. We assessed the ... ...

Abstract	Previous clinical trials indicate that 10%-25% of patients received genomically matched therapy after comprehensive genomic profiling (CGP) tests. However, the clinical utility of CGP tests has not been assessed in clinical practice. We assessed the clinical utility of CGP tests for advanced or metastatic solid tumor and determined the proportion of patients receiving genomically matched therapy among those with common and non-common cancers. From August 2019 to July 2020, a total of 418 patients had undergone CGP tests, and the results were discussed through the molecular tumor board at our site. The median age of patients was 57 (range: 3-86) years. Colorectal cancer was the most common, with 47 (11%) patients. Actionable genomic alterations (median 3, range: 1-17) were identified in 368 (88.0%) of 418 patients. Druggable genomic alterations were determined in 196 (46.9%) of 418 patients through the molecular tumor board. Genomically matched therapy was administered as the subsequent line of therapy in 51 (12.2%) patients, which is comparable to the proportion we previously reported in a clinical trial (13.4%) (p = 0.6919). The proportion of patients receiving genomically matched therapy was significantly higher among those with common cancers (16.2%) than non-common cancers (9.4%) (p = 0.0365). Genomically matched therapy after the CGP tests was administered to 12.2% of patients, which is similar to the proportion reported in the previous clinical trials. The clinical utility of CGP tests in patients with common cancers greatly exceeded that in patients with non-common cancers.
Language	English
Publishing date	2022-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15586
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Article ; Online: The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population.

Takeuchi, Yuki / Mizukami, Hiroki / Kudoh, Kazuhiro / Osonoi, Sho / Sasaki, Takanori / Kushibiki, Hanae / Ogasawara, Saori / Hara, Yutaro / Igawa, Akiko / Pan, Xuekai / Yamada, Takahiro / Yamazaki, Keisuke / Mikami, Tatsuya / Daimon, Makoto / Yagihashi, Soroku / Hakamada, Kenichi / Nakaji, Shigeyuki

Neurobiology of disease

2022 Volume 173, Page(s) 105839

Abstract: Small fibre neuropathy (SFN) is an initial pathology of diabetic polyneuropathy (DPN). Serum lipopolysaccharide binding protein levels are positively correlated with the pain threshold in the foot, suggesting that the abundance of gut Gram-negative ... ...

Abstract	Small fibre neuropathy (SFN) is an initial pathology of diabetic polyneuropathy (DPN). Serum lipopolysaccharide binding protein levels are positively correlated with the pain threshold in the foot, suggesting that the abundance of gut Gram-negative bacilli, which are a source of lipopolysaccharides, may be involved in the development of DPN. Furthermore, the abundance of the gut and oral microbiota is assumed to be involved in the pathogenesis of diabetes. Nevertheless, the association between SFN and the microbiota has not been clarified. A total of 1056 individuals were recruited in the 2018 Iwaki Health Promotion Project. Pain sensation was evaluated based on the pain threshold from intraepidermal electrical stimulation (PINT). Patients with PINT scores <0.15 mA were categorized into the low-PINT group (n = 718); otherwise, they were categorized into the high-PINT group (n = 283). Furthermore, each group was divided into the subjects with or without glucose tolerance based on HbA1c levels, fasting blood glucose levels and diabetic history. Principal coordinate analysis and α- and β-diversity of the microbiota were evaluated. The correlation between clinical and microbiota data was examined. Oral microbiota diversity showed no structural differences according to PINT scores, whereas principal coordinate analysis and α- and β-diversity revealed significant structural differences in gut microbiota (p < 0.01, p < 0.05 and p < 0.05, respectively), even after the participants with glucose intolerance were excluded (p < 0.01, p < 0.05 and p < 0.05, respectively). The relative abundance of the genus Bacteroides was significantly lower in high-PINT participants compared with low-PINT participants (10 ± 6.7% vs. 11.3 ± 7.0%, p < 0.01), even after the exclusion of subjects with diabetes and impaired fasting glucose (10.0 ± 6.5% vs. 11.2 ± 6.9%, p < 0.05). In univariate linear regression analyses, PINT was significantly correlated with metabolic syndrome parameters, eGFR, uric acid level and the abundance of Bacteroides. The correlation between Bacteroides and PINT scores remained significant after adjustment for multiple factors (β = -0.07181, p < 0.05). Changes of bacterial diversity and a low abundance of gut Bacteroides were correlated with elevated PINT scores in the Japanese population. This correlation may represent a new therapeutic option for SFN.
MeSH term(s)	Bacteroides ; Blood Glucose ; Diabetic Neuropathies ; Gastrointestinal Microbiome ; Glycated Hemoglobin A ; Humans ; Japan ; Lipopolysaccharides ; NAD ; Pain Threshold ; Uric Acid
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Lipopolysaccharides ; NAD (0U46U6E8UK) ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2022.105839
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Zs.A 4444: Show issues

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Article: Allyl isothiocyanate increases carbohydrate oxidation through enhancing insulin secretion by TRPV1

Mori, Noriyuki / Kurata, Manami / Yamazaki, Hanae / Matsumura, Shigenobu / Hashimoto, Takashi / Kanazawa, Kazuki / Nadamoto, Tomonori / Inoue, Kazuo / Fushiki, Tohru

Bioscience, biotechnology, and biochemistry. 2018 Apr. 3, v. 82, no. 4

2018

Abstract: The transient receptor potential (TRP) V1 is a cation channel belonging to the TRP channel family and it has been reported to be involved in energy metabolism, especially glucose metabolism. While, we have previously shown that intragastric ... ...

Abstract	The transient receptor potential (TRP) V1 is a cation channel belonging to the TRP channel family and it has been reported to be involved in energy metabolism, especially glucose metabolism. While, we have previously shown that intragastric administration of allyl isothiocyanate (AITC) enhanced glucose metabolism via TRPV1, the underlying mechanism has not been elucidated. In this study, we examined the relationship between insulin secretion and the increase in carbohydrate oxidation due to AITC. Intragastric administration of AITC elevated blood insulin levels in mice and AITC directly enhanced insulin secretion from isolated islets. These observations were not reproduced in TRPV1 knockout mice. Furthermore, AITC did not increase carbohydrate oxidation in streptozotocin-treated mice. These results suggest that intragastric administration of AITC could induce insulin secretion from islets via TRPV1 and that enhancement of insulin secretion was related to the increased carbohydrate oxidation due to AITC.
Keywords	allyl isothiocyanate ; biotechnology ; blood ; energy metabolism ; glucose ; insulin ; insulin secretion ; intragastric administration ; oxidation ; transient receptor potential vanilloid channels
Language	English
Dates of publication	2018-0403
Size	p. 698-708.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1080/09168451.2017.1407234
Database	NAL-Catalogue (AGRICOLA)

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