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  1. Article ; Online: Physiological bases of bone regeneration II. The remodeling process.

    Fernández-Tresguerres-Hernández-Gil, Isabel / Alobera-Gracia, Miguel Angel / del-Canto-Pingarrón, Mariano / Blanco-Jerez, Luis

    Medicina oral, patologia oral y cirugia bucal

    2006  Volume 11, Issue 2, Page(s) E151–7

    Abstract: Bone remodeling is the restructuring process of existing bone, which is in constant resorption and formation. Under normal conditions, this balanced process allows the renewal of 5-10% of bone volume per year. At the microscopic level, bone remodeling is ...

    Abstract Bone remodeling is the restructuring process of existing bone, which is in constant resorption and formation. Under normal conditions, this balanced process allows the renewal of 5-10% of bone volume per year. At the microscopic level, bone remodeling is produced in basic multicellular units, where osteoclasts resorb a certain quantity of bone and osteoblasts form the osteoid matrix and mineralize it to fill the previously created cavity. These units contain osteoclasts, macrophages, preosteoblasts and osteoblasts, and are controlled by a series of factors, both general and local, allowing normal bone function and maintaining the bone mass. When this process becomes unbalanced then bone pathology appears, either in excess (osteopetrosis) or deficit (osteoporosis). The purpose of this study is to undertake a revision of current knowledge on the physiological and biological mechanisms of the bone remodeling process; highlighting the role played by the regulating factors, in particular that of the growth factors.
    MeSH term(s) Biological Factors/physiology ; Bone Regeneration/physiology ; Bone Remodeling/physiology ; Humans
    Chemical Substances Biological Factors
    Language Spanish
    Publishing date 2006-03-01
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 2171573-7
    ISSN 1698-6946 ; 1698-4447
    ISSN (online) 1698-6946
    ISSN 1698-4447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Physiological bases of bone regeneration I. Histology and physiology of bone tissue.

    Fernández-Tresguerres-Hernández-Gil, Isabel / Alobera-Gracia, Miguel Angel / del-Canto-Pingarrón, Mariano / Blanco-Jerez, Luis

    Medicina oral, patologia oral y cirugia bucal

    2006  Volume 11, Issue 1, Page(s) E47–51

    Abstract: Bone is the only body tissue capable of regeneration, allowing the restitutio ad integrum following trauma. In the event of a fracture or bone graft, new bone is formed, which following the remodeling process is identical to the pre-existing. Bone is a ... ...

    Abstract Bone is the only body tissue capable of regeneration, allowing the restitutio ad integrum following trauma. In the event of a fracture or bone graft, new bone is formed, which following the remodeling process is identical to the pre-existing. Bone is a dynamic tissue in constant formation and resorption. This balanced phenomena, known as the remodeling process, allows the renovation of 5-15% of the total bone mass per year under normal conditions. Bone remodeling consists of the resorption of a certain amount of bone by osteoclasts, likewise the formation of osteoid matrix by osteoblasts, and its subsequent mineralization. This phenomenon occurs in small areas of the cortical bone or the trabecular surface, called Basic Multicellular Units (BMU). Treatment in Traumatology, Orthopedics, Implantology, and Maxillofacial and Oral Surgery, is based on the biologic principals of bone regeneration, in which cells, extracellular matrix, and osteoinductive signals are involved. The aim of this paper is to provide an up date on current knowledge on the biochemical and physiological mechanisms of bone regeneration, paying particular attention to the role played by the cells and proteins of the bone matrix.
    MeSH term(s) Bone Matrix/chemistry ; Bone Matrix/physiology ; Bone Regeneration/physiology ; Bone and Bones/chemistry ; Bone and Bones/cytology ; Bone and Bones/physiology ; Extracellular Matrix Proteins/metabolism ; Humans ; Osteoblasts
    Chemical Substances Extracellular Matrix Proteins
    Language Spanish
    Publishing date 2006-01-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2171573-7
    ISSN 1698-6946 ; 1698-4447
    ISSN (online) 1698-6946
    ISSN 1698-4447
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

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