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  1. Article ; Online: Inhibition of Starfish Oocyte Maturation by Tumor-Promoting Phorbol Esters*: (starfish oocyte maturation/tumor promoters/phorbol esters/teleocidin/retinoids).

    Kishimoto, Takeo / Yoshikuni, Michiyasu / Ikadai, Hiroyuki / Kanatani, Haruo

    Development, growth & differentiation

    2023  Volume 27, Issue 3, Page(s) 233–242

    Abstract: Effect of tumor promoters including phorbol esters and teleocidin on 1-methyladenine (1-MeAde)-induced oocyte maturation was studied in the starfish. When isolated immature oocytes were treated with 1-MeAde and 12-O-tetradecanoylphorbol-13-acetate (TPA), ...

    Abstract Effect of tumor promoters including phorbol esters and teleocidin on 1-methyladenine (1-MeAde)-induced oocyte maturation was studied in the starfish. When isolated immature oocytes were treated with 1-MeAde and 12-O-tetradecanoylphorbol-13-acetate (TPA), 1-MeAde-induced maturation was completely inhibited at more than 2.5 μg/ml. However, if TPA was added after the hormone-dependent period (the minimum period wherein 1-MeAde is required), such maturation-inhibiting effect was no longer observed. Pretreatment with TPA for 5 min showed that its inhibitory action is irreversible. However, when TPA-injected oocytes were treated with 1-MeAde, all oocytes underwent germinal vesicle breakdown (GVBD). GVBD was induced in TPA-treated oocytes upon injection of the cytoplasm of maturing oocytes containing maturation-promoting factor (MPF). These facts show that TPA acts on the oocyte surface to inhibit the production of MPF. Retinoids including retinal, retinol and retinoic acid reversed the inhibitory effect of TPA on 1-MeAde-induced maturation. Experiments with various phorbol esters showed a good correlation between their maturation-inhibiting activity and their known tumor-promoting activity. Further, telecoidin, which is structurally unrelated to phorbol esters, inhibited 1-MeAde action. Since both tumor-promoting phorbol esters and teleocidin are known to activate Ca
    Language English
    Publishing date 2023-06-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1111/j.1440-169X.1985.00233.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 194: Show issues Location:
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  2. Article ; Online: Anthocyanins act as a sugar-buffer and an alternative electron sink in response to starch depletion during leaf senescence: a case study on a typical anthocyanic tree species, Acer japonicum.

    Kitao, Mitsutoshi / Yazaki, Kenichi / Tobita, Hiroyuki / Agathokleous, Evgenios / Kishimoto, Junko / Takabayashi, Atsushi / Tanaka, Ryouichi

    Journal of experimental botany

    2024  

    Abstract: We hypothesized that anthocyanins act as a sugar-buffer and an alternative electron sink during leaf senescence to prevent sugar-mediated early senescence and photoinhibition. To elucidate the anthocyanin role, we monitored seasonal changes in ... ...

    Abstract We hypothesized that anthocyanins act as a sugar-buffer and an alternative electron sink during leaf senescence to prevent sugar-mediated early senescence and photoinhibition. To elucidate the anthocyanin role, we monitored seasonal changes in photosynthetic traits, sugar, starch and N contents, pigment composition, and gene expression profiles in leaves exposed to substantially different light conditions within a canopy of an adult tree of fullmoon maple (Acer japonicum). Enhancement of starch amylolysis accompanied with cessation of starch synthesis occurred in the same manner independent of light conditions. Leaf sugar contents increased, but reached upper limits in the late stage of leaf senescence, even though leaf anthocyanins further increased after complete depletion of starch. Sun-exposed leaves maintained higher energy consumption via electron flow than shade-grown leaves during leaf N resorption. Thus, anthocyanins accumulated in sun-exposed leaves might have a regulative role as a sugar buffer, retarding leaf senescence, and an indirect photoprotective role as an alternative sink for electron consumption to compensate declines in other metabolic processes such as starch and protein synthesis. In this context, anthocyanins might be key substrates protecting both outer-canopy leaves (against photoinhibition) and inner-canopy leaves (via shading by outer-canopy leaves) from high light stress during N resorption.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erae109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Risk Factors Related to Severity in COVID-19 Patients: A Real-world Retrospective Cohort Study.

    Kawaji, Hiromichi / Kishimoto, Nobuhito / Muguruma, Naoki / Kozai, Hiroyuki / Horiuchi, Noriaki

    Internal medicine (Tokyo, Japan)

    2023  Volume 62, Issue 18, Page(s) 2627–2634

    Abstract: Objective Understanding the clinical factors associated with the severity of coronavirus disease 2019 (COVID-19) is very important for the effective use of limited medical resources, including the appropriate evaluation of the need for hospitalization ... ...

    Abstract Objective Understanding the clinical factors associated with the severity of coronavirus disease 2019 (COVID-19) is very important for the effective use of limited medical resources, including the appropriate evaluation of the need for hospitalization and discharge. Methods Patients hospitalized with a diagnosis of COVID-19 from March 2021 to October 2022 were included in the study. Patients admitted to our facility were classified into four waves: 4th (April to June 2021), 5th (July to October 2021), 6th (January to June 2022), and 7th waves (July to October 2022). We analyzed the severity, patients' background characteristics, presence of pneumonia on chest computed tomography (CT), and blood test results in each wave. Patients were further classified into respiratory failure and nonrespiratory failure groups and statistically compared. Results Of the 565 patients diagnosed with COVID-19, 546 were included in this study. The percentage of patients classified as mild was approximately 10% in the 4th and 5th waves, but the rate increased after the 6th wave, with rates of 55.7% and 54.8% in each wave. Although more than 80% of patients in the 4th and 5th waves showed pneumonia on chest CT, the percentage decreased to approximately 40% after the 6th wave. Further comparisons between the respiratory failure group (n=75) and the nonrespiratory failure group (n=471) revealed significant differences in the age, sex, vaccination history, and biomarker values between the two groups. Conclusion In this study, elderly men were found to be more likely to develop severe disease than others, and biomarkers of COVID-19, such as C-reactive protein and lactate dehydrogenase, were useful for predicting severity. This study also suggested that vaccination may have contributed to a reduced disease severity.
    MeSH term(s) Male ; Humans ; Aged ; COVID-19/epidemiology ; SARS-CoV-2 ; Retrospective Studies ; Respiratory Insufficiency/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-06-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.1934-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article: Dyeing of chitin nanofibers with reactive dyes and preparation of their sheets and nanofiber/resin composites

    Kishimoto, Mizuki / Izawa, Hironori / Saimoto, Hiroyuki / Ifuku, Shinsuke

    Cellulose. 2022 Mar., v. 29, no. 5

    2022  

    Abstract: Blue, red and yellow chitin nanofibers were obtained using reactive dyes. Since the chitin nanofibers and the dye are covalently bonded, they are resistant to hot water and detergents. Since the dyed chitin nanofibers can be mixed at an arbitrary ratio, ... ...

    Abstract Blue, red and yellow chitin nanofibers were obtained using reactive dyes. Since the chitin nanofibers and the dye are covalently bonded, they are resistant to hot water and detergents. Since the dyed chitin nanofibers can be mixed at an arbitrary ratio, purple, orange, and green nanofibers corresponding to the mixed colors could be obtained. The dyed chitin nanofibers were evaluated by the reflection spectrum and the color space (L*a*b*). From the viewpoint of reaction yield and color properties, the appropriate ratio of the reactive dye to chitin was 5% at the maximum. The morphology of chitin nanofibers was maintained even after the introduction of the reactive dye. A resin combined with dyed chitin nanofibers was prepared. By combining with nanofibers, it may be possible to give color and improve mechanical strength to resin while maintaining the transparency of the resin to some extent.
    Keywords cellulose ; chemical bonding ; chitin ; color ; nanofibers ; reflectance spectroscopy ; strength (mechanics)
    Language English
    Dates of publication 2022-03
    Size p. 2829-2837.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 1496831-9
    ISSN 1572-882X ; 0969-0239
    ISSN (online) 1572-882X
    ISSN 0969-0239
    DOI 10.1007/s10570-021-04079-z
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study.

    Okada, Kentaro / Yokota, Jumpei / Yamashita, Tomoki / Inui, Tatsuya / Kishimoto, Wataru / Nakase, Hiroshi / Mizuguchi, Hiroyuki

    Drug metabolism and pharmacokinetics

    2023  Volume 54, Page(s) 100532

    Abstract: Human intestinal organoids (HIOs) have been reported to exert their functions in a way that mimics living organs, and HIOs-derived monolayers are expected to be applied to in vitro intestinal pharmacokinetic studies. However, HIOs are established from ... ...

    Abstract Human intestinal organoids (HIOs) have been reported to exert their functions in a way that mimics living organs, and HIOs-derived monolayers are expected to be applied to in vitro intestinal pharmacokinetic studies. However, HIOs are established from human tissue, which raises issues of availability and ethics. In the present study, to solve these problems, we have established intestinal organoids using commercially available cryopreserved human intestinal epithelial cells (C-IOs), and compared their functions with biopsy-derived human intestinal organoids (B-IOs) from a pharmacokinetic point of view. Both C-IOs and B-IOs reproduced the morphological features of the intestinal tract and were shown to be composed of epithelial cells. Monolayers generated from C-IOs and B-IOs (C-IO-2D, B-IO-2D, respectively) structurally mimic the small intestine. The C-IOs showed gene expression levels comparable to those of the B-IOs, which were close to those of adult human small intestine. Importantly, the C-IOs-2D showed levels of pharmacokinetics-related protein expression and activity-including cytochrome P450 3A4 (CYP3A4) and carboxylesterase 2 (CES2) enzymatic activities and P-glycoprotein (P-gp) transporter activities -similar to those of B-IOs-2D. This study addresses the difficulties associated with B-IOs and provides fundamental characteristics for the application of C-IOs in pharmacokinetic studies.
    MeSH term(s) Adult ; Humans ; Intestines ; Intestinal Mucosa/metabolism ; Intestine, Small/metabolism ; Epithelial Cells/metabolism ; Organoids/metabolism
    Language English
    Publishing date 2023-10-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2095748-8
    ISSN 1880-0920 ; 1347-4367 ; 0916-1139
    ISSN (online) 1880-0920
    ISSN 1347-4367 ; 0916-1139
    DOI 10.1016/j.dmpk.2023.100532
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3734: Show issues Location:
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  6. Article: Exposure to strong irradiance exacerbates photoinhibition and suppresses N resorption during leaf senescence in shade-grown seedlings of fullmoon maple (

    Kitao, Mitsutoshi / Yazaki, Kenichi / Tobita, Hiroyuki / Agathokleous, Evgenios / Kishimoto, Junko / Takabayashi, Atsushi / Tanaka, Ryouichi

    Frontiers in plant science

    2022  Volume 13, Page(s) 1006413

    Abstract: Leaves of fullmoon maple ( ...

    Abstract Leaves of fullmoon maple (
    Language English
    Publishing date 2022-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.1006413
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  7. Article ; Online: Microscopic observation of the effects of elongation on the polymer chain dynamics of crosslinked polybutadiene using quasi-elastic γ-ray scattering.

    Mashita, Ryo / Saito, Makina / Yoda, Yoshitaka / Kishimoto, Hiroyuki / Seto, Makoto / Kanaya, Toshiji

    Journal of synchrotron radiation

    2022  Volume 29, Issue Pt 5, Page(s) 1180–1186

    Abstract: A synchrotron-radiation-based quasi-elastic γ-ray scattering system has been developed that uses time-domain interferometry to observe microscopic polymer dynamics under uniaxial deformation. The stress-producing mechanism of crosslinked polybutadiene ... ...

    Abstract A synchrotron-radiation-based quasi-elastic γ-ray scattering system has been developed that uses time-domain interferometry to observe microscopic polymer dynamics under uniaxial deformation. The stress-producing mechanism of crosslinked polybutadiene has been studied from a microscopic viewpoint. It was found that the mean relaxation time ⟨τ⟩ of the microscopic polymer motion observed over a relatively high temperature (T) range (i.e. T
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2021413-3
    ISSN 1600-5775 ; 0909-0495
    ISSN (online) 1600-5775
    ISSN 0909-0495
    DOI 10.1107/S1600577522007998
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  8. Article ; Online: Tele-monitoring and tele-sedation for systemic management during dental treatment.

    Kishimoto, Naotaka / Saida, Luka / Takino, Hiroyuki / Seo, Kenji

    Journal of dental sciences

    2019  Volume 15, Issue 2, Page(s) 230–231

    Language English
    Publishing date 2019-12-24
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2019.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.

    Metwally, Hozaifa / Elbrashy, Maha M / Ozawa, Tatsuhiko / Okuyama, Kazuki / White, Jason T / Tulyeu, Janyerkye / Søndergaard, Jonas Nørskov / Wing, James Badger / Muratsu, Arisa / Matsumoto, Hisatake / Ikawa, Masahito / Kishi, Hiroyuki / Taniuchi, Ichiro / Kishimoto, Tadamitsu

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 17, Page(s) e2402226121

    Abstract: Since its discovery over three decades ago, signal transducer and activator of transcription 1 (STAT1) has been extensively studied as a central mediator for interferons (IFNs) signaling and antiviral defense. Here, using genetic and biochemical assays, ... ...

    Abstract Since its discovery over three decades ago, signal transducer and activator of transcription 1 (STAT1) has been extensively studied as a central mediator for interferons (IFNs) signaling and antiviral defense. Here, using genetic and biochemical assays, we unveil Thr
    MeSH term(s) Animals ; Mice ; Phosphorylation ; Lipopolysaccharides/pharmacology ; Signal Transduction ; Interferons/metabolism ; Inflammation/metabolism ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism
    Chemical Substances Lipopolysaccharides ; Interferons (9008-11-1) ; STAT1 Transcription Factor
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2402226121
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: High-speed rotating device for X-ray tomography with 10 ms temporal resolution.

    Mashita, Ryo / Yashiro, Wataru / Kaneko, Daisuke / Bito, Yasumasa / Kishimoto, Hiroyuki

    Journal of synchrotron radiation

    2021  Volume 28, Issue Pt 1, Page(s) 322–326

    Abstract: The temporal resolution of X-ray tomography, using a synchrotron radiation X-ray source, has been improved to millisecond order in recent years. However, the sample must be rotated at a speed of more than a few thousand revolutions per minute, which ... ...

    Abstract The temporal resolution of X-ray tomography, using a synchrotron radiation X-ray source, has been improved to millisecond order in recent years. However, the sample must be rotated at a speed of more than a few thousand revolutions per minute, which makes it difficult to control the environment around the sample. In this study, a high-speed rotation device has been developed, comprising two synchronized coaxial motors movable along the direction of the axis, which can stretch or compress the rotating sample. Using this device, tomograms of breaking rubber were successfully obtained at a temporal resolution of 10 ms.
    MeSH term(s) Equipment Design ; Rotation ; Synchrotrons ; Tomography, X-Ray/instrumentation
    Language English
    Publishing date 2021-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2021413-3
    ISSN 1600-5775 ; 0909-0495
    ISSN (online) 1600-5775
    ISSN 0909-0495
    DOI 10.1107/S1600577520014666
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