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  1. Book: C. elegans

    Strange, Kevin

    methods and applications

    (Methods in molecular biology ; 351)

    2006  

    Author's details ed. by Kevin Strange
    Series title Methods in molecular biology ; 351
    Collection
    Keywords Caenorhabditis elegans / physiology ; Caenorhabditis elegans / ultrastructure ; Caenorhabditis elegans ; Caenorhabditis elegans/Genetics ; Molecular biology
    Subject code 572.81257
    Language English
    Size XII, 292 S. : Ill., graph. Darst., 24cm
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015232522
    ISBN 1-58829-597-4 ; 978-1-58829-597-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 3161 order for loan Magazin

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  2. Article ; Online: Drug Discovery in Fish, Flies, and Worms.

    Strange, Kevin

    ILAR journal

    2016  Volume 57, Issue 2, Page(s) 133–143

    Abstract: Nonmammalian model organisms such as the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the zebrafish Danio rerio provide numerous experimental advantages for drug discovery including genetic and molecular tractability, ... ...

    Abstract Nonmammalian model organisms such as the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the zebrafish Danio rerio provide numerous experimental advantages for drug discovery including genetic and molecular tractability, amenability to high-throughput screening methods and reduced experimental costs and increased experimental throughput compared to traditional mammalian models. An interdisciplinary approach that strategically combines the study of nonmammalian and mammalian animal models with diverse experimental tools has and will continue to provide deep molecular and genetic understanding of human disease and will significantly enhance the discovery and application of new therapies to treat those diseases. This review will provide an overview of C. elegans, Drosophila, and zebrafish biology and husbandry and will discuss how these models are being used for phenotype-based drug screening and for identification of drug targets and mechanisms of action. The review will also describe how these and other nonmammalian model organisms are uniquely suited for the discovery of drug-based regenerative medicine therapies.
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2192062-X
    ISSN 1930-6180 ; 1084-2020
    ISSN (online) 1930-6180
    ISSN 1084-2020
    DOI 10.1093/ilar/ilw034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Cellular and molecular physiology of cell volume regulation

    Strange, Kevin

    1994  

    Author's details ed. by Kevin Strange
    Keywords Cells / physiology ; Cell Size / physiology ; Water-Electrolyte Balance ; Zellvolumen ; Osmoregulation
    Language English
    Size 400 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006338632
    ISBN 0-8493-4448-4 ; 978-0-8493-4448-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 3091 order for loan Magazin

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  4. Article ; Online: Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly.

    Takahashi, Hirohide / Yamada, Toshiki / Denton, Jerod S / Strange, Kevin / Karakas, Erkan

    eLife

    2023  Volume 12

    Abstract: Volume-regulated anion channels (VRACs) mediate volume regulatory ... ...

    Abstract Volume-regulated anion channels (VRACs) mediate volume regulatory Cl
    MeSH term(s) Membrane Proteins/metabolism ; Cryoelectron Microscopy ; Biological Transport ; Anions/metabolism
    Chemical Substances Membrane Proteins ; Anions
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.82431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: PHARMAZIE. MOLEKULARER JUNGBRUNNEN. Ein antibiotischer Wirkstoff scheint die Regeneration verletzten Körpergewebes stark anzukurbeln

    Strange, Kevin / Yin, Viravuth

    Spektrum der Wissenschaft : Spezial

    2021  Volume -, Issue 1,'Kampf gegen Krankheiten', Page(s) 60

    Language German
    Document type Article
    ZDB-ID 2938618-4
    ISSN 2625-7947 ; 2193-4452
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2122 -Spezial-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Remote and automated high-throughput powder diffraction measurements enabled by a robotic sample changer at SSRL beamline 2-1.

    Stone, Kevin H / Cosby, Monty R / Strange, Nicholas A / Thampy, Vivek / Walroth, Richard C / Troxel, Charles

    Journal of applied crystallography

    2023  Volume 56, Issue Pt 5, Page(s) 1480–1484

    Abstract: The general-purpose powder diffractometer beamline (BL2-1) at the Stanford Synchrotron Radiation Lightsource (SSRL) is described. The evolution of design and performance of BL2-1 are presented, in addition to current operating specifications, ... ...

    Abstract The general-purpose powder diffractometer beamline (BL2-1) at the Stanford Synchrotron Radiation Lightsource (SSRL) is described. The evolution of design and performance of BL2-1 are presented, in addition to current operating specifications, applications and measurement capabilities. Recent developments involve a robotic sample changer enabling high-throughput X-ray diffraction measurements, applicable to mail-in and remote operations.
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2020879-0
    ISSN 1600-5767 ; 0021-8898
    ISSN (online) 1600-5767
    ISSN 0021-8898
    DOI 10.1107/S1600576723007148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Drug Discovery in Fish, Flies, and Worms

    Strange, Kevin

    ILAR journal. 2017 Jan. 04, v. 57, no. 2

    2017  

    Abstract: Nonmammalian model organisms such as the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the zebrafish Danio rerio provide numerous experimental advantages for drug discovery including genetic and molecular tractability, ... ...

    Abstract Nonmammalian model organisms such as the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the zebrafish Danio rerio provide numerous experimental advantages for drug discovery including genetic and molecular tractability, amenability to high-throughput screening methods and reduced experimental costs and increased experimental throughput compared to traditional mammalian models. An interdisciplinary approach that strategically combines the study of nonmammalian and mammalian animal models with diverse experimental tools has and will continue to provide deep molecular and genetic understanding of human disease and will significantly enhance the discovery and application of new therapies to treat those diseases. This review will provide an overview of C. elegans, Drosophila, and zebrafish biology and husbandry and will discuss how these models are being used for phenotype-based drug screening and for identification of drug targets and mechanisms of action. The review will also describe how these and other nonmammalian model organisms are uniquely suited for the discovery of drug-based regenerative medicine therapies.
    Keywords Caenorhabditis elegans ; Danio rerio ; Drosophila melanogaster ; drugs ; fish ; fruit flies ; human diseases ; mammals ; medicine
    Language English
    Dates of publication 2017-0104
    Size p. 133-143.
    Publishing place Oxford University Press
    Document type Article
    ZDB-ID 2192062-X
    ISSN 1930-6180 ; 1084-2020
    ISSN (online) 1930-6180
    ISSN 1084-2020
    DOI 10.1093/ilar/ilw034
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function.

    Yamada, Toshiki / Strange, Kevin

    The Journal of general physiology

    2018  Volume 150, Issue 7, Page(s) 1003–1015

    Abstract: The volume-regulated anion channel (VRAC) is expressed ubiquitously in vertebrate cells and mediates swelling-induced release of ... ...

    Abstract The volume-regulated anion channel (VRAC) is expressed ubiquitously in vertebrate cells and mediates swelling-induced release of Cl
    MeSH term(s) Anions/metabolism ; Cell Size ; HCT116 Cells ; Humans ; Membrane Potentials ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Protein Domains ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism
    Chemical Substances Anions ; LRRC8A protein, human ; Membrane Proteins ; Recombinant Fusion Proteins
    Language English
    Publishing date 2018-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3118-5
    ISSN 1540-7748 ; 0022-1295
    ISSN (online) 1540-7748
    ISSN 0022-1295
    DOI 10.1085/jgp.201812016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Formation of Ba

    Strange, Nicholas A / Bell, Robert T / Park, James Eujin / Stone, Kevin H / Coker, Eric N / Ginley, David S

    Acta crystallographica. Section E, Crystallographic communications

    2023  Volume 79, Issue Pt 5, Page(s) 469–473

    Abstract: The resurgence of inter-est in hydrogen-related technologies has stimulated new studies aimed at advancing lesser-developed water-splitting processes, such as solar thermochemical hydrogen production (STCH). Progress in STCH has been largely hindered by ... ...

    Abstract The resurgence of inter-est in hydrogen-related technologies has stimulated new studies aimed at advancing lesser-developed water-splitting processes, such as solar thermochemical hydrogen production (STCH). Progress in STCH has been largely hindered by a lack of new materials able to efficiently split water at a rate comparable to ceria under identical experimental conditions. BaCe
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 2056-9890 ; 1600-5368
    ISSN 2056-9890 ; 1600-5368
    DOI 10.1107/S2056989023003213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly

    Hirohide Takahashi / Toshiki Yamada / Jerod S Denton / Kevin Strange / Erkan Karakas

    eLife, Vol

    2023  Volume 12

    Abstract: Volume-regulated anion channels (VRACs) mediate volume regulatory Cl- and organic solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins with unknown stoichiometries. Homomeric LRRC8A and LRRC8D channels have a small ... ...

    Abstract Volume-regulated anion channels (VRACs) mediate volume regulatory Cl- and organic solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins with unknown stoichiometries. Homomeric LRRC8A and LRRC8D channels have a small pore, hexameric structure. However, these channels are either non-functional or exhibit abnormal regulation and pharmacology, limiting their utility for structure-function analyses. We circumvented these limitations by developing novel homomeric LRRC8 chimeric channels with functional properties consistent with those of native VRAC/LRRC8 channels. We demonstrate here that the LRRC8C-LRRC8A(IL125) chimera comprising LRRC8C and 25 amino acids unique to the first intracellular loop (IL1) of LRRC8A has a heptameric structure like that of homologous pannexin channels. Unlike homomeric LRRC8A and LRRC8D channels, heptameric LRRC8C-LRRC8A(IL125) channels have a large-diameter pore similar to that estimated for native VRACs, exhibit normal DCPIB pharmacology, and have higher permeability to large organic anions. Lipid-like densities are located between LRRC8C-LRRC8A(IL125) subunits and occlude the channel pore. Our findings provide new insights into VRAC/LRRC8 channel structure and suggest that lipids may play important roles in channel gating and regulation.
    Keywords cryo-EM ; VRAC ; LRRC8C ; LRRC8A ; chimera ; ion channel ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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