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  1. Article ; Online: Authors' reply to the letter to the editor on "Managing geriatric syndromes: necessity of pharmacists' involvements" by Kojima.

    Mizokami, Fumihiro / Hasegawa, Sho / Mizuno, Tomohiro / Yabu, Takeshi / Kameya, Yoshitaka / Hayakawa, Yuji / Arai, Hidenori

    Geriatrics & gerontology international

    2024  Volume 24, Issue 4, Page(s) 448–450

    MeSH term(s) Humans ; Aged ; Pharmacists ; Syndrome
    Language English
    Publishing date 2024-03-11
    Publishing country Japan
    Document type Letter
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14859
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  2. Article ; Online: Path Integral Policy Improvement With Population Adaptation.

    Yamamoto, Kosuke / Ariizumi, Ryo / Hayakawa, Tomohiro / Matsuno, Fumitoshi

    IEEE transactions on cybernetics

    2022  Volume 52, Issue 1, Page(s) 312–322

    Abstract: Path integral policy improvement ( ... ...

    Abstract Path integral policy improvement (PI
    MeSH term(s) Algorithms ; Motion ; Policy ; Reinforcement, Psychology ; Robotics
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 2168-2275
    ISSN (online) 2168-2275
    DOI 10.1109/TCYB.2020.2983923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [A Case of Small Intestinal Metastasis from Lung Cancer].

    Hasegawa, Kumi / Hayakawa, Tomohiro / Takatsuno, Yasushi / Maejima, Kentaro / Kaneko, Jun / Isogai, Jun / Tagawa, Kohei

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 50, Issue 13, Page(s) 1540–1542

    Abstract: An 88-year-old man underwent thoracoscopic lower lobectomy for left lung cancer at the age of 87. Ten months later, he was examined closely for abdominal distention, frequent constipation, and anemia with a decreased Hb of 6.1 g/dL. The CT scan revealed ... ...

    Abstract An 88-year-old man underwent thoracoscopic lower lobectomy for left lung cancer at the age of 87. Ten months later, he was examined closely for abdominal distention, frequent constipation, and anemia with a decreased Hb of 6.1 g/dL. The CT scan revealed an irregular tumor with contrast effect. The patient was diagnosed with malignant tumor of small intestine. At laparotomy, a tumor of 5 cm in diameter was found in the jejunum, and small bowel resection was done. Pathological examination revealed that the tumor was a metastasis of lung cancer. Seven months later, the patient is currently an outpatient, with no evidence of cancer recurrence.
    MeSH term(s) Male ; Humans ; Aged, 80 and over ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology ; Neoplasm Recurrence, Local ; Intestine, Small/surgery ; Intestine, Small/pathology ; Jejunum
    Language Japanese
    Publishing date 2024-02-01
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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  4. Article ; Online: Synthesis and biological evaluation of coprinoferrin, an acylated tripeptide hydroxamate siderophore.

    Hayakawa, Ichiro / Isogai, Tomoki / Takanishi, Jun / Asai, Shihori / Ando, Chika / Tsutsumi, Tomohiro / Watanabe, Kenji / Sakakura, Akira / Tsunematsu, Yuta

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 4, Page(s) 831–837

    Abstract: Coprinoferrin (CPF), originally isolated from a genetically engineered strain ( ... ...

    Abstract Coprinoferrin (CPF), originally isolated from a genetically engineered strain (Δ
    MeSH term(s) Siderophores/chemistry ; Ferric Compounds ; Iron ; Hydroxamic Acids/pharmacology
    Chemical Substances Siderophores ; Ferric Compounds ; Iron (E1UOL152H7) ; Hydroxamic Acids
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob01850d
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  5. Article ; Online: Drug-induced altered self-presentation increases tumor immunogenicity.

    Susukida, Takeshi / Sasaki, So-Ichiro / Shirayanagi, Tomohiro / Aoki, Shigeki / Ito, Kousei / Hayakawa, Yoshihiro

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 165, Page(s) 115241

    Abstract: Anti-human immunodeficiency virus (HIV) drug abacavir (ABC) binds to the specific allele of human leukocyte antigen (HLA-B*57:01) and activates ... ...

    Abstract Anti-human immunodeficiency virus (HIV) drug abacavir (ABC) binds to the specific allele of human leukocyte antigen (HLA-B*57:01) and activates CD8
    MeSH term(s) Mice ; Animals ; CD8-Positive T-Lymphocytes ; Antigens, Neoplasm ; Cell Line, Tumor ; Immunotherapy
    Chemical Substances Antigens, Neoplasm
    Language English
    Publishing date 2023-07-29
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115241
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  6. Article: [The Short-Term and Long-Term Outcomes of Laparoscopic and Open Distal Gastrectomy].

    Maejima, Kentaro / Taniai, Nobuhiko / Yoshida, Hiroshi / Hayakawa, Tomohiro / Takatsuno, Yasushi / Hasegawa, Kumi / Kaneko, Jun

    Gan to kagaku ryoho. Cancer & chemotherapy

    2023  Volume 49, Issue 13, Page(s) 1426–1428

    Abstract: We compared laparoscopic gastrectomy and open gastrectomy for the early gastric cancer. Laparoscopic surgery was comparable to laparotomy in terms of operation time and number of lymph node dissections, significantly less bleeding volume, postoperative ... ...

    Abstract We compared laparoscopic gastrectomy and open gastrectomy for the early gastric cancer. Laparoscopic surgery was comparable to laparotomy in terms of operation time and number of lymph node dissections, significantly less bleeding volume, postoperative hospital stay, and lower postoperative complication rate. As a result of E-PASS, surgical invasion was significantly low and the overall risk score was also significantly low. There was no difference in cancer-specific survival, and overall survival was significantly better with laparoscopic distal gastrectomy. Based on the above, laparoscopic gastrectomy is considered to be superior to open gastrectomy as a surgical technique for the early gastric cancer.
    MeSH term(s) Humans ; Treatment Outcome ; Retrospective Studies ; Stomach Neoplasms/surgery ; Stomach Neoplasms/pathology ; Lymph Node Excision/methods ; Laparoscopy/methods ; Gastrectomy/methods ; Postoperative Complications
    Language Japanese
    Publishing date 2023-01-24
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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  7. Article: [A Case of Rectal GIST under Long-Term Follow-Up with Oral Imatinib].

    Hasegawa, Kumi / Okamoto, Shota / Hayakawa, Tomohiro / Takatsuno, Yasushi / Maejima, Kentaro / Kaneko, Jun / Isogai, Jun

    Gan to kagaku ryoho. Cancer & chemotherapy

    2023  Volume 49, Issue 13, Page(s) 1470–1472

    Abstract: The patient was a 79-year-old man with complaints of defecation difficulties and constipation. CT scan showed a 7.5 cm diameter mass in the lower rectum, and biopsy revealed GIST. MRI findings suggested prostate invasion, and the patient was started ... ...

    Abstract The patient was a 79-year-old man with complaints of defecation difficulties and constipation. CT scan showed a 7.5 cm diameter mass in the lower rectum, and biopsy revealed GIST. MRI findings suggested prostate invasion, and the patient was started treatment with imatinib. Six months later, the tumor shrank to 4.5 cm in diameter. However, the patient refused surgery and continued taking Imatinib. The tumor continued to shrink gradually. Currently, 7 years later at the age of 86, it is only 2 cm in diameter and its inside has almost completely been replaced with calcifications.
    MeSH term(s) Male ; Humans ; Aged ; Imatinib Mesylate/therapeutic use ; Antineoplastic Agents/therapeutic use ; Rectum/pathology ; Gastrointestinal Stromal Tumors/drug therapy ; Gastrointestinal Stromal Tumors/surgery ; Gastrointestinal Stromal Tumors/pathology ; Follow-Up Studies ; Piperazines/therapeutic use ; Pyrimidines/therapeutic use ; Benzamides/therapeutic use ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology
    Chemical Substances Imatinib Mesylate (8A1O1M485B) ; Antineoplastic Agents ; Piperazines ; Pyrimidines ; Benzamides
    Language Japanese
    Publishing date 2023-01-24
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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  8. Article: [A Case of Complete Remission in a Patient with Synchronous Double Cancers of the Breast and Lung].

    Hayakawa, Tomohiro / Hasegawa, Kumi / Maejima, Kentaro / Takatsuno, Yasushi / Kaneko, Jun / Higashi, Yasuhiro / Isogai, Jun / Tagawa, Kohei / Yoshida, Hiroshi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 50, Issue 13, Page(s) 1459–1461

    Abstract: The patient is a 74-year-old woman. She had breast cancer(invasive ductal carcinoma, ER[+], PgR[+], HER2[-], Ki-67: 30-40%)and primary right lung cancer with lumbar metastasis, which led to the diagnosis synchronous double cancers of the breast and the ... ...

    Abstract The patient is a 74-year-old woman. She had breast cancer(invasive ductal carcinoma, ER[+], PgR[+], HER2[-], Ki-67: 30-40%)and primary right lung cancer with lumbar metastasis, which led to the diagnosis synchronous double cancers of the breast and the lung. We decided to precede surgery for lung cancer because breast cancer was indicated hormonal receptor positive. Breast cancer is treated with anastrozole, thoracoscopic right upper lobectomy was performed for the lung cancer. Radiation therapy was performed for metastatic bone tumors. 13 months later, partial mastectomy sentinel lymph node biopsy performed. The histopathological diagnosis of breast cancer was pT2, pN0, cM0, pStage ⅡA, and histological response was Grade 2a. The remaining breast was treated radiation therapy. The breast cancer has not recurred and is doing well 6 months after surgery. As for primary lung cancer, 19 months have passed since surgery, and the patient is in complete remission without recurrence.
    MeSH term(s) Female ; Humans ; Aged ; Breast Neoplasms/surgery ; Breast Neoplasms/diagnosis ; Mastectomy ; Sentinel Lymph Node Biopsy ; Lung/pathology ; Lung Neoplasms/surgery
    Language Japanese
    Publishing date 2024-02-01
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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  9. Article ; Online: Preparation of Ni micropillar arrays with high aspect ratios using anodic porous alumina template and their application to molds for imprinting.

    Yanagishita, Takashi / Hayakawa, Tomohiro / Kondo, Toshiaki / Masuda, Hideki

    RSC advances

    2021  Volume 11, Issue 4, Page(s) 2096–2102

    Abstract: Anodic porous alumina templates with controlled microscale geometrical structures were prepared by a process combining mask formation and subsequent selective etching of the alumina layer. In this process, the anisotropic etching of anodic porous alumina ...

    Abstract Anodic porous alumina templates with controlled microscale geometrical structures were prepared by a process combining mask formation and subsequent selective etching of the alumina layer. In this process, the anisotropic etching of anodic porous alumina allows the preparation of anodic porous alumina with microhole array patterns having high aspect ratios. The electrodeposition of Ni using the obtained alumina templates generated an array of Ni micropillars with high aspect ratios. The height of Ni micropillars could also be controlled by adjusting the thickness of the anodic porous alumina. The obtained Ni micropillar array with a high aspect ratio was applied as a mold for imprinting. The ordered microstructures of TiO
    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d0ra09729b
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  10. Article ; Online: Investigation of geriatric syndromes associated with medication in Japan using insurance claims data.

    Hasegawa, Sho / Mizokami, Fumihiro / Mizuno, Tomohiro / Yabu, Takeshi / Kameya, Yoshitaka / Hayakawa, Yuji / Arai, Hidenori

    Geriatrics & gerontology international

    2023  Volume 24, Issue 1, Page(s) 61–67

    Abstract: Aim: Multiple risk factors are involved in geriatric syndrome (GS) occurring in older adults. Although drug therapy often contributes to GS, the specific causes among older adults in Japan remain unclear. In this study, we examined the possible ... ...

    Abstract Aim: Multiple risk factors are involved in geriatric syndrome (GS) occurring in older adults. Although drug therapy often contributes to GS, the specific causes among older adults in Japan remain unclear. In this study, we examined the possible prescribing cascade rate among older outpatients eligible for Late-stage Elderly Health Insurance and elucidated the differences between GS and GS associated with medication (GSAM) trends.
    Methods: This retrospective study enrolled patients from health insurance claims data in Japan between October 2018 and March 2019; hospitalized patients were excluded. Two groups were identified among the participants with GS: GS (no use of GS-causing medications) and possible-GSAM (p-GSAM; use of GS-causing medications). The collected data were analyzed using the Bell Curve for Excel, and statistical significance was set at P < 0.05.
    Results: In total, 137 781 outpatients were enrolled. Of the 32 259 outpatients who did not use GS-causing medications, 7342 were classified into the GS group. Among 105 522 outpatients who used GS-causing medications, 8347 were classified as having p-GSAM. The mean number of prescriptions was significantly higher in the p-GSAM group than in the GS group (P < 0.01). Furthermore, all GS symptoms showed significant differences, with impaired appetite being the most prevalent in the p-GSAM group than in the GS group (P < 0.01). A possible prescribing cascade was suspected in 2826 (33.9%) of 8347 outpatients in the p-GSAM group.
    Conclusion: Impaired appetite in patients taking GS-causing medications might lead to prescribing cascades. Further studies are needed to prevent such prescribing cascades. Geriatr Gerontol Int 2024; 24: 61-67.
    MeSH term(s) Humans ; Aged ; Retrospective Studies ; Japan/epidemiology ; Risk Factors ; Outpatients ; Insurance
    Language English
    Publishing date 2023-12-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14755
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