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  1. Book ; Conference proceedings: Brain and biodefence

    Oomura, Yutaka

    [held at Kyoto in Japan from January 19 to 22, 1998]

    (Taniguchi Symposia on Brain Sciences ; 21)

    1998  

    Institution Symposium on Brain Sciences
    Author's details [Twenty-first International Taniguchi Symposium on Brain Sciences]. Ed. by Yutaka Oomura
    Series title Taniguchi Symposia on Brain Sciences ; 21
    Collection
    Keywords Zentralnervensystem ; Immunmodulation ; Immunsystem ; Neuroendokrinologie ; Neuroimmunologie
    Subject Immunoneurologie ; Körpereigene Abwehr ; Körpereigene Abwehrkräfte ; Körpereigenes Abwehrsystem ; Abwehrkräfte ; Immunsystem ; Immunomodulation ; Zentrales Nervensystem ; ZNS ; Systema nervosum centrale ; Central nervous system ; CNS
    Language English
    Size X, 248 S. : Ill., graph. Darst.
    Publisher Japan Scientific Soc. Press u.a.
    Publishing place Tokyo u.a.
    Publishing country Japan
    Document type Book ; Conference proceedings
    HBZ-ID HT009516054
    ISBN 3-8055-6764-2 ; 978-3-8055-6764-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 8 order for loan Magazin

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  2. Book ; Conference proceedings: Proceedings of the 6th International Congress on Obesity

    Oomura, Yutaka

    [held in Kobe, Japan, 21 - 26 October 1990]

    (Progress in obesity research ; [6.]1990)

    1991  

    Event/congress International Congress on Obesity (6, 1990, Kōbe)
    Author's details ed. by Y. Oomura
    Series title Progress in obesity research ; [6.]1990
    Collection
    Keywords Obesity / congresses ; Fettsucht
    Subject Adipositas ; Fettleibigkeit ; Korpulenz ; Obesität ; Obesity
    Language English
    Size XIII, 688 S. : Ill., graph. Darst.
    Publisher Libbey
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT003863058
    ISBN 0-86196-274-5 ; 978-0-86196-274-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 372 -[6]- verfügbar in Königswinter Königswinter

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  3. Book ; Conference proceedings: Regulation of food intake, metabolism and energy balance

    Oomura, Yutaka

    Yashiro, Japan, October 26 - 29, 1990 ; [proceedings presented at the Symposium on the Regulation of Food Intake, Metabolism, and Energy Balance, a satellite of the Sixth International Congress on Obesity ... held in Kobe, Japan, October 23 to 25, 1991]

    (Brain research bulletin ; 27,3/4 = Special issue)

    1991  

    Institution Symposium on the Regulation of Food Intake, Metabolism, and Energy Balance
    Event/congress International Congress on Obesity (6, 1990, Kōbe)
    Author's details ed. by: Yutaka Oomura
    Series title Brain research bulletin ; 27,3/4 = Special issue
    Keywords Appetite Regulation / physiology / congresses ; Energy Metabolism / physiology / congresses ; Neurotransmitters / congresses
    Size S. [293] - 543 : Ill., graph. Darst.
    Publisher Pergamon Pr
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT004009583
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1243 -27- verfügbar in Königswinter Königswinter

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  4. Book: Emotions

    Oomura, Yutaka

    neuronal and chem. control

    1986  

    Author's details ed. by Yutaka Oomura
    Keywords Emotions ; Gefühl ; Psychobiologie ; Physiologische Chemie ; Neuropsychologie ; Psychologie
    Subject Mensch ; Affektleben ; Emotion ; Emotionalität ; Fühlen ; Gemütsbewegung ; Gefühlsleben ; Gefühle ; Biologische Psychologie ; Chemische Physiologie ; Biochemische Medizin ; Medizinische Biochemie
    Size XV, 446 S. : graph. Darst.
    Publisher Japan Scientific Soc. Pr. u.a.
    Publishing place Tokyo
    Publishing country Japan
    Document type Book
    HBZ-ID HT002824400
    ISBN 3-8055-4405-7 ; 4-7622-9484-5 ; 978-3-8055-4405-4 ; 978-4-7622-9484-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1986 A 3116 order for loan Magazin

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  5. Book ; Conference proceedings: Physiologically active sybstances

    Oomura, Yutaka

    endocrine peptide and neurotransmitter ; proceed. of the Eighth SEIRIKEN Conference on Physiologically Active Substances, ... Okazaki, Japan, Febr. 23 - 25, 1983

    (Biomedical research ; 5, Supplement ; Proceedings of the ... SEIRIKEN conference ; 8)

    1984  

    Event/congress Conference on Physiologically Active Substances (1983, Okazaki)
    Author's details eds.: Y. Oomura
    Series title Biomedical research ; 5, Supplement
    Proceedings of the ... SEIRIKEN conference ; 8
    The proceedings of the ... SEIRIKEN conference
    Collection The proceedings of the ... SEIRIKEN conference
    Keywords NEUROTRANSMITTERS / CONGRESSES ; PEPTIDES / CONGRESSES
    Size 190 S. : Ill., graph. Darst.
    Publisher Biomed. Research Found
    Publishing place Tokyo
    Publishing country Japan
    Document type Book ; Conference proceedings
    HBZ-ID HT002495258
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1654 -5,Suppl.- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Glucose signaling in the brain and periphery to memory.

    Hossain, Md Shamim / Oomura, Yutaka / Fujino, Takehiko / Akashi, Koichi

    Neuroscience and biobehavioral reviews

    2020  Volume 110, Page(s) 100–113

    Abstract: Glucose has many diverse physiological roles such as energy metabolism, appetite control and memory consolidation. We recently reported that memory-related gene expression is epigenetically controlled in murine brain cells and that glucose can regulate ... ...

    Abstract Glucose has many diverse physiological roles such as energy metabolism, appetite control and memory consolidation. We recently reported that memory-related gene expression is epigenetically controlled in murine brain cells and that glucose can regulate gene expression in a cell-specific manner. However, the literature reviews have indicated that glucose can also regulate gut cells to release incretins which might play a role in memory processes directly or indirectly by vagus nerve stimulation. In this review, we discussed the effects of glucose on the gut and brain, aiming to understand more in-depth the role of glucose in memory function. In addition, we also discussed the alteration of glucose-signaling in type-2 diabetes mellitus (T2DM) and a possible link to Alzheimer's disease (AD) pathologies.
    MeSH term(s) Alzheimer Disease/metabolism ; Alzheimer Disease/physiopathology ; Animals ; Brain/physiology ; Brain/physiopathology ; Diabetes Mellitus, Type 2/metabolism ; Glucose/metabolism ; Humans ; Memory/physiology ; Signal Transduction/physiology
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2019.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells.

    Hossain, Md Shamim / Oomura, Yutaka / Katafuchi, Toshihiko

    Molecular neurobiology

    2017  Volume 55, Issue 4, Page(s) 3408–3425

    Abstract: Glucose is believed to improve the memory in both human and mice, but the detailed insights were mostly elusive. In this study, we focused on two major neurotrophic factors, brain-derived neurotrophic factor (BDNF) and fibroblast growth factor 1 (FGF1), ... ...

    Abstract Glucose is believed to improve the memory in both human and mice, but the detailed insights were mostly elusive. In this study, we focused on two major neurotrophic factors, brain-derived neurotrophic factor (BDNF) and fibroblast growth factor 1 (FGF1), which are believed to be associated with the memory enhancement and assessed their expressional regulation among the murine neuronal and glial cells. Our findings showed that the glucose administration increased phosphorylated Akt, phosphorylated CREB, exon 1- and exon 4-specific BDNF transcripts, and FGF1 transcripts that are associated with the epigenetic changes expected to open the chromatin and a reduction in histone deacetylase 2 (HDAC2) in neurons and astrocytes of the murine hippocampus. The glucose administration enhanced the long-term potentiation and the number of dendritic spines in the CA1 and CA3 subfields of hippocampus. The intrahippocampal injection of short hairpin RNA against TrkB canceled the glucose-mediated memory enhancement. Like the glucose, we also report that the HDAC inhibitor can enhance the memory through the BDNF-TrkB pathway but it targeted different brain cell populations to enhance the BDNF and FGF1 transcripts. In addition, the soluble FGF1 treatments significantly increased the BDNF expression in astrocytes and neurons, suggesting that the glucose-mediated induction of the neurotrophic factors could contribute to the memory. Our study provides the valuable insights, explaining the distinctive neuronal and glial cell regulation of the neurotrophic factors by glucose and HDAC inhibitor, which could likely explain how our brain cells can control the release of neurotrophic factors.
    MeSH term(s) Acetylation ; Animals ; Brain/cytology ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Dendritic Spines/drug effects ; Dendritic Spines/metabolism ; Epigenesis, Genetic/drug effects ; Feedback, Physiological ; Fibroblast Growth Factor 1/genetics ; Fibroblast Growth Factor 1/metabolism ; Glucose/pharmacology ; Hippocampus/cytology ; Histone Deacetylase Inhibitors/pharmacology ; Histones/metabolism ; Long-Term Potentiation/drug effects ; Memory/drug effects ; Mice, Inbred C57BL ; Phosphorylation/drug effects ; Promoter Regions, Genetic/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, trkB/metabolism ; Vorinostat/pharmacology
    Chemical Substances Brain-Derived Neurotrophic Factor ; Cyclic AMP Response Element-Binding Protein ; Histone Deacetylase Inhibitors ; Histones ; Fibroblast Growth Factor 1 (104781-85-3) ; Vorinostat (58IFB293JI) ; Receptor, trkB (EC 2.7.10.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2017-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-017-0578-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Book: Central neural Control of eating and obesity

    Wayner, Matthew John / Oomura, Yutaka

    proc. of a United States and Japan Cooperative Science Seminar, held in Honolulu, Hawaii, 1975

    (Pharmacology, biochemistry & behavior ; 3, Suppl. 1)

    1975  

    Author's details ed. by Matthew J[ohn] Wayner and Yutaka Oomura
    Series title Pharmacology, biochemistry & behavior ; 3, Suppl. 1
    Pharmacology, biochemistry and behavior
    Collection Pharmacology, biochemistry and behavior
    Language English
    Size V, 177 S. ; 4-o
    Publisher Ankho
    Publishing place Phoenix, N.Y.
    Publishing country United States
    Document type Book
    HBZ-ID HT008223165
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1060 -3,Suppl.1- verfügbar in Königswinter Königswinter

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  9. Article: Prandial increase of leptin in the brain activates spatial learning and memory.

    Oomura, Yutaka / Aou, Shuji / Fukunaga, Kouji

    Pathophysiology : the official journal of the International Society for Pathophysiology

    2009  Volume 17, Issue 2, Page(s) 119–127

    Abstract: Leptin is well known to be involved in the control of feeding, thermogenesis, reproduction and neuroendocrine functions through its actions on the rodents hypothalamic receptors. Leptin facilitated the presynaptic transmitter release and postsynaptic ... ...

    Abstract Leptin is well known to be involved in the control of feeding, thermogenesis, reproduction and neuroendocrine functions through its actions on the rodents hypothalamic receptors. Leptin facilitated the presynaptic transmitter release and postsynaptic sensitivity to the transmitters in the hippocampal CA1 neurons. Thus long-term potentiation (LTP) and the phosphorylation of Ca(2+)/calmodulin protein kinase II (CaMKII) were facilitated in the CA1 neurons. Therefore behavioral performance related to spatial learning and memory was improved by leptin in vivo applications. We also investigated LTP and spatial learning and memory function in two leptin receptor-deficient rodents, Zucker fatty rats and db/db mice. The CA1 region of both strains showed impairments of LTP and leptin application did not improve these impairments. These strains showed lower basal levels of CaMKII activity in the CA1 region than the respective controls, and the levels did not respond to a brief tetanic stimulation. These strains also showed impaired spatial learning and memory. The present studies suggest that leptin signaling in the brain may have important implications for cognitive function.
    Language English
    Publishing date 2009-07-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1212740-1
    ISSN 0928-4680
    ISSN 0928-4680
    DOI 10.1016/j.pathophys.2009.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Prandial increases of leptin and orexin in the brain modulate spatial learning and memory.

    Oomura, Yutaka / Aou, Shuji / Fukunaga, Kouji / Moriguchi, Sigeki / Sasaki, Kazuo

    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova

    2009  Volume 95, Issue 12, Page(s) 1373–1385

    Abstract: Leptin is well known to be involved in the inhibition of feeding, hermogenesis, reproduction and neuroendocrine functions through its actions on the rodents hypothalamic receptors. Leptin facilitated the presynaptic transmitter release and postsynaptic ... ...

    Abstract Leptin is well known to be involved in the inhibition of feeding, hermogenesis, reproduction and neuroendocrine functions through its actions on the rodents hypothalamic receptors. Leptin facilitated the presynaptic transmitter release and postsynaptic sensitivity to the transmitters in the hippocampal CA1 neurons. Thus long-term potentiation (LTP) and the phosphorylation of Ca2+/calmodulin protein kinase II (CaMK II) were facilitated in the CA1 neurons. Therefore behavioral performance related to spatial learning and memory was improved by leptin in vivo applications. Orexin-A produced by glucose-sensitive neurons in the lateral hypothalamic area (LHA) and released during food intake facilitates feeding. Orexin-A suppressed LTP and CaMK II phosphorylation without affecting the presynaptic transmitter release. Therefore behavioral performance on learning and memory was impaired. The present studies suggest that leptin and orexin signalings in the brain may have important implications for cognitive function.
    MeSH term(s) Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Eating/physiology ; Hypothalamus/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Leptin/metabolism ; Long-Term Potentiation/physiology ; Maze Learning/physiology ; Memory/physiology ; Mice ; Neurons/metabolism ; Neuropeptides/metabolism ; Orexins ; Rats ; Signal Transduction/physiology
    Chemical Substances Intracellular Signaling Peptides and Proteins ; Leptin ; Neuropeptides ; Orexins ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17)
    Language English
    Publishing date 2009-12
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 1401201-7
    ISSN 0869-8139
    ISSN 0869-8139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 83: Show issues Location:
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