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  1. Article ; Online: Asperidines A-C, pyrrolidine and piperidine derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178.

    Phainuphong, Patima / Rukachaisirikul, Vatcharin / Saithong, Saowanit / Phongpaichit, Souwalak / Sakayaroj, Jariya / Srimaroeng, Chutima / Ontawong, Atcharaporn / Duangjai, Acharaporn / Muangnil, Paradorn / Muanprasat, Chatchai

    Bioorganic & medicinal chemistry

    2018  Volume 26, Issue 15, Page(s) 4502–4508

    Abstract: ... 2) and C (3), were isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178 ...

    Abstract One new pyrrolidine derivative, asperidine A (1), and two new piperidine derivatives, asperidines B (2) and C (3), were isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178 together with two known alkaloids. Compound 3 possessed an unprecedented 7-oxa-1-azabicyclo[3.2.1]octane skeleton with four chiral centers. Their structures were determined by spectroscopic evidence. The absolute configurations of compounds 2 and 3 were established using Mosher's method and further confirmed for compound 3 by X-ray crystallographic data. Compound 2 dose-dependently inhibited the CFTR-mediated chloride secretion in T84 cells with an IC
    MeSH term(s) Animals ; Aspergillus/chemistry ; Aspergillus/isolation & purification ; Aspergillus/metabolism ; Caco-2 Cells ; Cell Survival/drug effects ; Cercopithecus aethiops ; Crystallography, X-Ray ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Humans ; Hydrogen Peroxide/toxicity ; Molecular Conformation ; Piperidines/chemistry ; Piperidines/isolation & purification ; Piperidines/pharmacology ; Pyrrolidines/chemistry ; Pyrrolidines/isolation & purification ; Pyrrolidines/pharmacology ; Reactive Oxygen Species/metabolism ; Soil Microbiology ; Vero Cells
    Chemical Substances Piperidines ; Pyrrolidines ; Reactive Oxygen Species ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2018-07-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2018.07.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Coffea arabica

    Ontawong, Atcharaporn / Duangjai, Acharaporn / Srimaroeng, Chutima

    Biomedical reports

    2021  Volume 15, Issue 3, Page(s) 73

    Abstract: The major constituents ... ...

    Abstract The major constituents of
    Language English
    Publishing date 2021-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2021.1449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antispasmodic Effect of Asperidine B, a Pyrrolidine Derivative, through Inhibition of L-Type Ca

    Duangjai, Acharaporn / Rukachaisirikul, Vatcharin / Sukpondma, Yaowapa / Srimaroeng, Chutima / Muanprasat, Chatchai

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 18

    Abstract: Antispasmodic agents are used for modulating gastrointestinal motility. Several compounds isolated from terrestrial plants have antispasmodic properties. This study aimed to explore the inhibitory effect of the pyrrolidine derivative, asperidine B, ... ...

    Abstract Antispasmodic agents are used for modulating gastrointestinal motility. Several compounds isolated from terrestrial plants have antispasmodic properties. This study aimed to explore the inhibitory effect of the pyrrolidine derivative, asperidine B, isolated from the soil-derived fungus
    MeSH term(s) Acetylcholine/metabolism ; Acetylcholine/pharmacology ; Animals ; Calcium/metabolism ; Calcium Channel Blockers/pharmacology ; Calcium Channels, L-Type/metabolism ; Cyclic GMP/metabolism ; Ileum/drug effects ; Ileum/metabolism ; Male ; Methylene Blue/pharmacology ; Muscle Contraction/drug effects ; Muscle, Smooth/drug effects ; Muscle, Smooth/metabolism ; NG-Nitroarginine Methyl Ester/pharmacology ; Parasympatholytics/chemistry ; Parasympatholytics/pharmacology ; Potassium Chloride/pharmacology ; Pyrrolidines/chemistry ; Pyrrolidines/pharmacology ; Rats, Wistar ; Tetraethylammonium/pharmacology ; Rats
    Chemical Substances Calcium Channel Blockers ; Calcium Channels, L-Type ; Parasympatholytics ; Pyrrolidines ; asperidine b ; Tetraethylammonium (66-40-0) ; Potassium Chloride (660YQ98I10) ; Cyclic GMP (H2D2X058MU) ; Acetylcholine (N9YNS0M02X) ; Calcium (SY7Q814VUP) ; Methylene Blue (T42P99266K) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
    Language English
    Publishing date 2021-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26185492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  4. Article: Siamese neem flower extract suppresses cholesterol absorption by interfering NPC1L1 and micellar property

    Duangjai, Acharaporn / Ontawong, Atcharaporn / Srimaroeng, Chutima

    Research in pharmaceutical sciences

    2019  Volume 14, Issue 3, Page(s) 190–200

    Abstract: Siamese neem (Azadirachta indica A. ... ...

    Abstract Siamese neem (Azadirachta indica A. Juss
    Language English
    Publishing date 2019-05-30
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2400156-9
    ISSN 1735-9414 ; 1735-5362
    ISSN (online) 1735-9414
    ISSN 1735-5362
    DOI 10.4103/1735-5362.258485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: High-Efficacy α,β-Dehydromonacolin S Improves Hepatic Steatosis and Suppresses Gluconeogenesis Pathway in High-Fat Diet-Induced Obese Rats.

    Kaewmalee, Jutatip / Ontawong, Atcharaporn / Duangjai, Acharaporn / Tansakul, Chittreeya / Rukachaisirikul, Vatcharin / Muanprasat, Chatchai / Srimaroeng, Chutima

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 4

    Abstract: Isolated α,β-dehydromonacolin S ( ...

    Abstract Isolated α,β-dehydromonacolin S (
    Language English
    Publishing date 2021-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14040375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: High affinity of 4-(4-(dimethylamino)styryl)-N-methylpyridinium transport for assessing organic cation drugs in hepatocellular carcinoma cells.

    Jinakote, Metee / Ontawong, Atcharaporn / Soodvilai, Sunhapas / Pimta, Jeerawat / Pasachan, Tipthida / Chatsudthipong, Varanuj / Srimaroeng, Chutima

    Fundamental & clinical pharmacology

    2020  Volume 34, Issue 3, Page(s) 365–379

    Abstract: Human organic cation transporter 1 (hOCT1) and human organic cation transporter 3 (hOCT3) are highly expressed in hepatocytes and play important roles in cationic drug absorption, distribution, and elimination. A previous study demonstrated that ... ...

    Abstract Human organic cation transporter 1 (hOCT1) and human organic cation transporter 3 (hOCT3) are highly expressed in hepatocytes and play important roles in cationic drug absorption, distribution, and elimination. A previous study demonstrated that downregulation of hOCT1 and hOCT3 mRNA was related to hepatocellular carcinoma (HepG2) prognosis and severity. Whether these transporters expressed in HepG2 cells serve for cationic drug delivery has not been investigated. Besides radioactive transport, options for assessing hOCTs in hepatocytes are limited. This study clarified the significant roles of hOCTs in HepG2 by comparing cationic fluorescent 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP
    MeSH term(s) Biological Transport/physiology ; Carcinoma, Hepatocellular/metabolism ; Cations/metabolism ; Cell Line, Tumor ; Hep G2 Cells ; Hepatocytes/metabolism ; Humans ; Liver Neoplasms/metabolism ; Metformin/metabolism ; Organic Cation Transporter 1/metabolism ; Organic Cation Transporter 2/metabolism ; Paclitaxel/metabolism ; Pyridinium Compounds/metabolism
    Chemical Substances Cations ; Organic Cation Transporter 1 ; Organic Cation Transporter 2 ; Pyridinium Compounds ; 1-methylpyridinium (694-56-4) ; Metformin (9100L32L2N) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 639134-5
    ISSN 1472-8206 ; 0767-3981
    ISSN (online) 1472-8206
    ISSN 0767-3981
    DOI 10.1111/fcp.12531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Tiliacora triandra

    Pasachan, Tipthida / Duangjai, Acharaporn / Ontawong, Atcharaporn / Amornlerdpison, Doungporn / Jinakote, Metee / Phatsara, Manussabhorn / Soodvilai, Sunhapas / Srimaroeng, Chutima

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 5

    Abstract: This study investigated the effects ... ...

    Abstract This study investigated the effects of
    MeSH term(s) Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Drug Screening Assays, Antitumor ; Glucose/antagonists & inhibitors ; Glucose/biosynthesis ; Hep G2 Cells ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Injections, Intraperitoneal ; Male ; Menispermaceae/chemistry ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Rats ; Rats, Wistar ; Reactive Oxygen Species/analysis ; Reactive Oxygen Species/metabolism ; Streptozocin/administration & dosage ; Tumor Cells, Cultured ; Water/chemistry
    Chemical Substances Antineoplastic Agents, Phytogenic ; Hypoglycemic Agents ; Plant Extracts ; Reactive Oxygen Species ; Water (059QF0KO0R) ; Streptozocin (5W494URQ81) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26051239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  8. Article ; Online: Antidiabetic and Renoprotective Effects of

    Boonphang, Oranit / Ontawong, Atcharaporn / Pasachan, Tipthida / Phatsara, Manussabhorn / Duangjai, Acharaporn / Amornlerdpison, Doungporn / Jinakote, Metee / Srimaroeng, Chutima

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 7

    Abstract: ... Coffea ... ...

    Abstract Coffea arabica
    MeSH term(s) Animals ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Carrier Proteins/agonists ; Carrier Proteins/metabolism ; Coffea/chemistry ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/etiology ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Diet, High-Fat/adverse effects ; Drug Combinations ; Drug Synergism ; Hyperglycemia/drug therapy ; Hyperglycemia/etiology ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Insulin Resistance ; Ion Transport/drug effects ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Lipid Peroxidation/drug effects ; Male ; Metformin/pharmacology ; Oxidative Stress/drug effects ; Plant Extracts/chemistry ; Polyphenols/isolation & purification ; Polyphenols/pharmacology ; Rats ; Rats, Wistar ; Streptozocin/administration & dosage
    Chemical Substances Antioxidants ; Carrier Proteins ; Drug Combinations ; Hypoglycemic Agents ; Plant Extracts ; Polyphenols ; Streptozocin (5W494URQ81) ; Metformin (9100L32L2N)
    Language English
    Publishing date 2021-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26071907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Spirogyra neglecta Aqueous Extract Attenuates LPS-Induced Renal Inflammation.

    Ontawong, Atcharaporn / Srimaroeng, Chutima / Boonphang, Oranit / Phatsara, Manussabhorn / Amornlerdpison, Doungporn / Duangjai, Acharaporn

    Biological & pharmaceutical bulletin

    2019  Volume 42, Issue 11, Page(s) 1814–1822

    Abstract: Spirogyra neglecta (SN), commonly named "Tao" in Thai, is a genus of filamentous green macroalgae. SN contains polyphenols such as isoquercetin, catechin, hydroquinone and kaempferol. These constituents exhibit beneficial effects including anti-oxidant, ... ...

    Abstract Spirogyra neglecta (SN), commonly named "Tao" in Thai, is a genus of filamentous green macroalgae. SN contains polyphenols such as isoquercetin, catechin, hydroquinone and kaempferol. These constituents exhibit beneficial effects including anti-oxidant, anti-gastric ulcer, anti-hyperglycaemia and anti-hyperlipidaemia in both in vitro and in vivo models. Whether SN extract (SNE) has an anti-inflammatory effect in vivo remains unclear. This study examined the effect of SNE on renal function and renal organic transport in lipopolysaccharide (LPS)-induced renal inflammation in rats. Rats were randomised and divided into normal saline (NS), NS supplemented with 1000 mg/kg body weight (BW) of SNE (NS + SNE), intraperitoneally injected with 12 mg/kg BW of LPS and LPS treated with 1000 mg/kg BW of SNE (LPS + SNE). Biochemical parameters in serum and urine, lipid peroxidation concentration, kidney function and renal organic anion and cation transports were determined. LPS-injected rats developed renal injury and inflammation by increasing urine microalbumin, total malondialdehyde (MDA) and inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-1β protein expression, respectively. In addition, uptake of renal organic anion, [
    MeSH term(s) Animals ; Cytokines/drug effects ; Inflammation/chemically induced ; Inflammation/drug therapy ; Kidney/drug effects ; Lipopolysaccharides/pharmacology ; Male ; Malondialdehyde ; Organic Anion Transporters, Sodium-Independent/metabolism ; Plant Extracts/pharmacology ; Rats ; Rats, Wistar ; Spirogyra/chemistry
    Chemical Substances Cytokines ; Lipopolysaccharides ; Organic Anion Transporters, Sodium-Independent ; Plant Extracts ; organic anion transport protein 3 ; Malondialdehyde (4Y8F71G49Q)
    Language English
    Publishing date 2019-11-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b19-00199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1474: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes.

    Ospondpant, Dusadee / Phuagkhaopong, Suttinee / Suknuntha, Kran / Sangpairoj, Kant / Kasemsuk, Thitima / Srimaroeng, Chutima / Vivithanaporn, Pornpun

    Environmental toxicology and pharmacology

    2018  Volume 65, Page(s) 53–59

    Abstract: Cadmium is a highly neurotoxic heavy metal impairing neurogenesis and induces neurodegenerative disorders. Toxic concentrations of cadmium induce astrocytic apoptosis by depleting intracellular glutathione levels, elevating intracellular calcium levels, ... ...

    Abstract Cadmium is a highly neurotoxic heavy metal impairing neurogenesis and induces neurodegenerative disorders. Toxic concentrations of cadmium induce astrocytic apoptosis by depleting intracellular glutathione levels, elevating intracellular calcium levels, altering mitochondria membrane potentials, and activating JNK and PI3K/Akt signaling pathways. Cadmium suppresses cell proliferation in kidney epithelial cells, lung fibroblasts, and primary myelocytes; however, cadmium's effects on proteins regulating oxidative stress, apoptosis, and cell proliferation in astrocytes are less known. The present study hypothesized that cadmium alters levels of antioxidant enzymes, apoptotic regulator proteins, and cell cycle inhibitor proteins, resulting in apoptosis and cell cycle arrest. Concentrations ≥20 μM cadmium induced apoptosis and led to intracellular changes including DNA fragmentation, reduced mRNA expression of antioxidant enzymes (i.e., catalase and glutathione S transferase-A4), downregulation of B-cell lymphoma 2 (Bcl-2), and upregulation of Bcl-2-associated X protein (Bax). Moreover, cadmium suppressed astrocytic proliferation by inducing S and G2/M phase cell cycle arrest and promoting p53, p21, and p27 expression. In conclusion, this study provides mechanistic insight into cadmium-induced cytotoxicity of astrocytes and highlights potential targets for prevention of cadmium-induced apoptosis and cell cycle arrest.
    MeSH term(s) Apoptosis/drug effects ; Astrocytes/drug effects ; Astrocytes/physiology ; Cadmium/toxicity ; Cell Cycle/drug effects ; Cell Line, Tumor ; Humans ; MAP Kinase Kinase 4/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Tumor Suppressor Proteins/metabolism
    Chemical Substances Tumor Suppressor Proteins ; Cadmium (00BH33GNGH) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; MAP Kinase Kinase 4 (EC 2.7.12.2)
    Language English
    Publishing date 2018-12-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2018.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4490: Show issues Location:
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