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  1. Article ; Online: Effect of Guo Qing Yi Tang combined with Western medicine cluster therapy on acute pancreatitis.

    Chen, Ying-Jie / Chen, Ming-Zhi / Zhang, Hong-Wei / Wu, Gui-Song / Guo, Sen-Ren

    The American journal of emergency medicine

    2021  Volume 50, Page(s) 66–70

    Abstract: Background: This study evaluated the effect of Guo Qing Yi Tang (GQYT) combined with Western ...

    Abstract Background: This study evaluated the effect of Guo Qing Yi Tang (GQYT) combined with Western medicine cluster therapy on acute pancreatitis (AP).
    Methods: A total of 138 AP patients were recruited and divided into the observation group (68 patients) and control group (70 patients). The control group was treated with cluster therapy alone, while the observation group was treated with trans-jejunum feeding of GQYT combined with cluster therapy. Blood samples were taken before the treatment and 24 h, 72 h, and 1 week after the treatment. The serum concentrations of Di amine oxidase(DAO), Endotoxin(ET), D-lactic acid, Intestinal trefoil factor(ITF), MFG-E8, TNF-α, IL-1β, IL-6, and IL-8 were determined by using spectrophotometry and enzyme-linked immunosorbent assay. The concentrations of urinary lactulose and mannitol (L/M) were determined by high-performance liquid chromatography, and the urinary L/M value was calculated.
    Results: Compared with the control group, the observation group had shorter hospital stay, faster recovery, significantly lower APACHE II score, and higher complete response rate (94.12%) after 1 week of treatment (P < 0.05). Moreover, the indicators related to intestinal mucosal barrier function (DAO, MFG-8, L/M) and inflammatory cytokines (TNF-α, IL-6, IL-8) were significantly reduced in the observation group after 1 week of treatment (P < 0.05).
    Conclusion: GQYT combined with cluster therapy for the treatment of AP has definite curative effect and rapid onset, reduces the level of inflammatory factors, and improves intestinal mucosal barrier function and APACHE II score. Thus, it has obvious clinical therapeutic advantages and can be used as a new therapeutic regimen for AP.
    MeSH term(s) APACHE ; Adult ; Biomarkers/blood ; Biomarkers/urine ; Combined Modality Therapy ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Pancreatitis/drug therapy ; Pancreatitis/therapy
    Chemical Substances Biomarkers ; Drugs, Chinese Herbal
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2021.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2005: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book: "Guo yi" zhi shang

    Zheng, Hong / Lu, Jinguo

    bai nian Zhong yi chen fu lu

    2010  

    Title variant Bai nian Zhong yi chen fu lu
    Author's details Zheng Hong, Lu Jinguo zhu
    MeSH term(s) Medicine, Chinese Traditional ; History, 19th Century ; History, 20th Century
    Keywords China
    Language Chinese
    Size 6, 213 p. :, ill. ;, 24 cm.
    Edition Di 1 ban.
    Publisher Guangdong ke ji chu ban she
    Publishing place Guangzhou
    Document type Book
    ISBN 9787535952837 ; 7535952836
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Book: Zhuan xing shi qi wo guo yi yao shang ye gong ying lian de he zuo yan jiu

    Lü, Hong

    (Jing ji xue xue shu qian yan shu xi)

    2014  

    Author's details Lü Hong zhu
    Series title Jing ji xue xue shu qian yan shu xi
    MeSH term(s) Drug Industry/economics ; Pharmaceutical Preparations/supply & distribution ; Pharmacovigilance
    Keywords China
    Language Chinese
    Size 2, 2, 170 pages :, illustrations ;, 24 cm.
    Edition Di yi ban.
    Document type Book
    ISBN 9787802575974 ; 7802575974
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Book ; Online: Structure-Seabed Interactions in Marine Environments

    Jeng, Dong-Sheng / Guo, Zhen / Hong, Yi

    2021  

    Keywords Technology: general issues ; wave-seabed-structure interactions ; mesh-free model ; local radial basis function collocation method ; oscillatory liquefaction ; irregular wave ; sand ; void ratio ; disturbed state concept ; disturbance function ; constitutive model ; seepage failure ; critical hydraulic gradient ; excess pore pressure ; fluidization degree ; resuspension ; soil ; liquefaction ; fractional order ; cyclic mobility ; spudcan ; stiffness ; reduction ; finite element analysis ; dual-stage Eulerian-Lagrangian technique ; slope stability ; immersed tunnel ; solitary wave ; foundation trench ; numerical modeling ; scour ; marine structures ; numerical modelling ; sediment transport ; Biot's equations ; multiphase theory ; RANS equations ; seabed ; in situ test ; liquefied submarine sediments ; rheological characteristics ; pile jacking ; consolidation effect ; saturated fine-grained soil ; excess pore water pressure ; pile set-up ; side shear resistance ; hybrid Lagrangian-ALE method ; n/a
    Size 1 electronic resource (192 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291324
    ISBN 9783036522067 ; 3036522069
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Integrating single-cell and spatial transcriptomics reveals endoplasmic reticulum stress-related CAF subpopulations associated with chordoma progression.

    Zhang, Tao-Lan / Xia, Chao / Zheng, Bo-Wen / Hu, Hai-Hong / Jiang, Ling-Xiang / Escobar, David / Zheng, Bo-Yv / Chen, Tian-Dong / Li, Jing / Lv, Guo-Hua / Huang, Wei / Yan, Yi-Guo / Zou, Ming-Xiang

    Neuro-oncology

    2024  Volume 26, Issue 2, Page(s) 295–308

    Abstract: Background: With cancer-associated fibroblasts (CAFs) as the main cell type, the rich myxoid stromal components in chordoma tissues may likely contribute to its development and progression.: Methods: Single-cell RNA sequencing (scRNA-seq), spatial ... ...

    Abstract Background: With cancer-associated fibroblasts (CAFs) as the main cell type, the rich myxoid stromal components in chordoma tissues may likely contribute to its development and progression.
    Methods: Single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, bulk RNA-seq, and multiplexed quantitative immunofluorescence (QIF) were used to dissect the heterogeneity, spatial distribution, and clinical implication of CAFs in chordoma.
    Results: We sequenced here 72 097 single cells from 3 primary and 3 recurrent tumor samples, as well as 3 nucleus pulposus samples as controls using scRNA-seq. We identified a unique cluster of CAF in recurrent tumors that highly expressed hypoxic genes and was functionally enriched in endoplasmic reticulum stress (ERS). Pseudotime trajectory and cell communication analyses showed that this ERS-CAF subpopulation originated from normal fibroblasts and widely interacted with tumoral and immune cells. Analyzing the bulk RNA-seq data from 126 patients, we found that the ERS-CAF signature score was associated with the invasion and poor prognosis of chordoma. By integrating the results of scRNA-seq with spatial transcriptomics, we demonstrated the existence of ERS-CAF in chordoma tissues and revealed that this CAF subtype displayed the most proximity to its surrounding tumor cells. In subsequent QIF validation involving 105 additional patients, we confirmed that ERS-CAF was abundant in the chordoma microenvironment and located close to tumor cells. Furthermore, both ERS-CAF density and its distance to tumor cells were correlated with tumor malignant phenotype and adverse patient outcomes.
    Conclusions: These findings depict the CAF landscape for chordoma and may provide insights into the development of novel treatment approaches.
    MeSH term(s) Humans ; Chordoma/genetics ; Cancer-Associated Fibroblasts ; Gene Expression Profiling ; RNA-Seq ; Endoplasmic Reticulum Stress ; Tumor Microenvironment
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noad173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Development and application of haploid embryonic stem cells.

    Wang, Hai-Song / Ma, Xin-Rui / Guo, Yi-Hong

    Stem cell research & therapy

    2024  Volume 15, Issue 1, Page(s) 116

    Abstract: Haploid cells are a kind of cells with only one set of chromosomes. Compared with traditional diploid cells, haploid cells have unique advantages in gene screening and drug-targeted therapy, due to their phenotype being equal to the genotype. Embryonic ... ...

    Abstract Haploid cells are a kind of cells with only one set of chromosomes. Compared with traditional diploid cells, haploid cells have unique advantages in gene screening and drug-targeted therapy, due to their phenotype being equal to the genotype. Embryonic stem cells are a kind of cells with strong differentiation potential that can differentiate into various types of cells under specific conditions in vitro. Therefore, haploid embryonic stem cells have the characteristics of both haploid cells and embryonic stem cells, which makes them have significant advantages in many aspects, such as reproductive developmental mechanism research, genetic screening, and drug-targeted therapy. Consequently, establishing haploid embryonic stem cell lines is of great significance. This paper reviews the progress of haploid embryonic stem cell research and briefly discusses the applications of haploid embryonic stem cells.
    MeSH term(s) Haploidy ; Humans ; Embryonic Stem Cells/metabolism ; Embryonic Stem Cells/cytology ; Animals ; Cell Differentiation
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-024-03727-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nonlocal phonon thermal transport in graphene in hydrodynamic regime.

    Luo, Xiao-Ping / Guo, Yang-Yu / Yi, Hong-Liang

    Journal of physics. Condensed matter : an Institute of Physics journal

    2023  Volume 36, Issue 11

    Abstract: The hydrodynamic behavior of phonons is of particular interest and importance owing to the strong demand for highly thermal conductive materials. Thermal transport in hydrodynamic regime becomes essentially nonlocal, which can give rise to a number of ... ...

    Abstract The hydrodynamic behavior of phonons is of particular interest and importance owing to the strong demand for highly thermal conductive materials. Thermal transport in hydrodynamic regime becomes essentially nonlocal, which can give rise to a number of new and counterintuitive phenomena. In this work, we present a direct numerical study of nonlocal phonon thermal transport in graphene ribbon with vicinity geometry based on the phonon Boltzmann transport equation with first-principles inputs. We demonstrate the viscosity-dominated hydrodynamic transport behaviors with two abnormal thermal transport phenomena: heat current whirlpools and negative nonlocal effect, which originate from phonon viscosity. Phonon viscosity produces the vorticity of shear flows, leading to the backflow of the heat current and the generation of negative nonlocal vicinity response. The system average temperature and the ribbon width as well as the relative positions of the heat sources play a pivotal role in the occurrence of heat current whirlpools and negative nonlocal temperature response. The present work provides solid evidence for phonon hydrodynamic transport in graphene and a potential avenue for experimental detection in the future.
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/1361-648X/ad1362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Recent progress in hair follicle stem cell markers and their regulatory roles.

    Xing, Yi-Zhan / Guo, Hai-Ying / Xiang, Fei / Li, Yu-Hong

    World journal of stem cells

    2024  Volume 16, Issue 2, Page(s) 126–136

    Abstract: Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biomarkers have ... ...

    Abstract Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biomarkers have been used to isolate, label, and trace HFSCs in recent years. Considering more detailed data from single-cell transcriptomics technology, we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2583482-4
    ISSN 1948-0210
    ISSN 1948-0210
    DOI 10.4252/wjsc.v16.i2.126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Distributed Pose-graph Optimization with Multi-level Partitioning for Collaborative SLAM

    Li, Cunhao / Yi, Peng / Guo, Guanghui / Hong, Yiguang

    2024  

    Abstract: The back-end module of Distributed Collaborative Simultaneous Localization and Mapping (DCSLAM) requires solving a nonlinear Pose Graph Optimization (PGO) under a distributed setting, also known as SE(d)-synchronization. Most existing distributed graph ... ...

    Abstract The back-end module of Distributed Collaborative Simultaneous Localization and Mapping (DCSLAM) requires solving a nonlinear Pose Graph Optimization (PGO) under a distributed setting, also known as SE(d)-synchronization. Most existing distributed graph optimization algorithms employ a simple sequential partitioning scheme, which may result in unbalanced subgraph dimensions due to the different geographic locations of each robot, and hence imposes extra communication load. Moreover, the performance of current Riemannian optimization algorithms can be further accelerated. In this letter, we propose a novel distributed pose graph optimization algorithm combining multi-level partitioning with an accelerated Riemannian optimization method. Firstly, we employ the multi-level graph partitioning algorithm to preprocess the naive pose graph to formulate a balanced optimization problem. In addition, inspired by the accelerated coordinate descent method, we devise an Improved Riemannian Block Coordinate Descent (IRBCD) algorithm and the critical point obtained is globally optimal. Finally, we evaluate the effects of four common graph partitioning approaches on the correlation of the inter-subgraphs, and discover that the Highest scheme has the best partitioning performance. Also, we implement simulations to quantitatively demonstrate that our proposed algorithm outperforms the state-of-the-art distributed pose graph optimization protocols.
    Keywords Computer Science - Robotics ; Computer Science - Multiagent Systems
    Publishing date 2024-01-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Self-assembly of peptide nanomaterials at biointerfaces: molecular design and biomedical applications.

    Guo, Xin-Yuan / Yi, Li / Yang, Jia / An, Hong-Wei / Yang, Zi-Xin / Wang, Hao

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 15, Page(s) 2009–2021

    Abstract: Self-assembly is an important strategy for constructing ordered structures and complex functions in nature. Based on this, people can imitate nature and artificially construct functional materials with novel structures through the supermolecular self- ... ...

    Abstract Self-assembly is an important strategy for constructing ordered structures and complex functions in nature. Based on this, people can imitate nature and artificially construct functional materials with novel structures through the supermolecular self-assembly pathway of biological interfaces. Among the many assembly units, peptide molecular self-assembly has received widespread attention in recent years. In this review, we introduce the interactions (hydrophobic interaction, hydrogen bond, and electrostatic interaction) between peptide nanomaterials and biological interfaces, summarizing the latest advancements in multifunctional self-assembling peptide materials. We systematically demonstrate the assembly mechanisms of peptides at biological interfaces, such as proteins and cell membranes, while highlighting their application potential and challenges in fields like drug delivery, antibacterial strategies, and cancer therapy.
    MeSH term(s) Humans ; Peptides/chemistry ; Nanostructures/chemistry ; Drug Delivery Systems
    Chemical Substances Peptides
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc05811e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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