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Article ; Online: Renal denervation for resistant hypertension.

Mircheva, Miryana / Neuhofer, Wolfgang / Popa, Ciprian / Krämer, Bernhard K / Heitzmann, Dirk

2015 Volume 386, Issue 10000, Page(s) 1239–1240

MeSH term(s)	Antihypertensive Agents/therapeutic use ; Catheter Ablation/methods ; Denervation/methods ; Female ; Humans ; Hypertension/therapy ; Male
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2015-09-26
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(15)00258-5
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Zs.MG 94: Show issues

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Article: Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.

Heitzmann, Dirk / Warth, Richard

Physiological reviews

2008 Volume 88, Issue 3, Page(s) 1119–1182

Abstract: Epithelial cells of the gastrointestinal tract are an important barrier between the "milieu interne" and the luminal content of the gut. They perform transport of nutrients, salts, and water, which is essential for the maintenance of body homeostasis. In ...

Abstract	Epithelial cells of the gastrointestinal tract are an important barrier between the "milieu interne" and the luminal content of the gut. They perform transport of nutrients, salts, and water, which is essential for the maintenance of body homeostasis. In these epithelia, a variety of K(+) channels are expressed, allowing adaptation to different needs. This review provides an overview of the current literature that has led to a better understanding of the multifaceted function of gastrointestinal K(+) channels, thereby shedding light on pathophysiological implications of impaired channel function. For instance, in gastric mucosa, K(+) channel function is a prerequisite for acid secretion of parietal cells. In epithelial cells of small intestine, K(+) channels provide the driving force for electrogenic transport processes across the plasma membrane, and they are involved in cell volume regulation. Fine tuning of salt and water transport and of K(+) homeostasis occurs in colonic epithelia cells, where K(+) channels are involved in secretory and reabsorptive processes. Furthermore, there is growing evidence for changes in epithelial K(+) channel expression during cell proliferation, differentiation, apoptosis, and, under pathological conditions, carcinogenesis. In the future, integrative approaches using functional and postgenomic/proteomic techniques will help us to gain comprehensive insights into the role of K(+) channels of the gastrointestinal tract.
MeSH term(s)	Animals ; Epithelial Cells/enzymology ; Epithelial Cells/metabolism ; Gastrointestinal Tract/enzymology ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/physiopathology ; H(+)-K(+)-Exchanging ATPase/metabolism ; Humans ; Intestine, Large/metabolism ; Intestine, Small/metabolism ; Pancreas, Exocrine/metabolism ; Pancreas, Exocrine/secretion ; Parietal Cells, Gastric/enzymology ; Potassium Channels/classification ; Potassium Channels/metabolism ; Salivary Glands/metabolism ; Salivary Glands/secretion
Chemical Substances	Potassium Channels ; H(+)-K(+)-Exchanging ATPase (EC 3.6.3.10)
Language	English
Publishing date	2008-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	209902-0
ISSN	1522-1210 ; 0031-9333
ISSN (online)	1522-1210
ISSN	0031-9333
DOI	10.1152/physrev.00020.2007
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Article ; Online: The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse.

Heitzmann, Dirk / Buehler, Philipp / Schweda, Frank / Georgieff, Michael / Warth, Richard / Thomas, Joerg

Respiratory physiology & neurobiology

2016 Volume 222, Page(s) 16–28

Abstract: The nucleoside adenosine has been implicated in the regulation of respiration, especially during hypoxia in the newborn. In this study the role of adenosine A1 receptors for the control of respiration was investigated in vivo. To this end, respiration of ...

Abstract	The nucleoside adenosine has been implicated in the regulation of respiration, especially during hypoxia in the newborn. In this study the role of adenosine A1 receptors for the control of respiration was investigated in vivo. To this end, respiration of unrestrained adult and neonatal adenosine A1 receptor knockout mice (A1R(-/-)) was measured in a plethysmographic device. Under control conditions (21% O2) and mild hypoxia (12-15% O2) no difference of respiratory parameters was observed between adult wildtype (A1R(+/+)) and A1R(-/-) mice. Under more severe hypoxia (6-10% O2) A1R(+/+) mice showed, after a transient increase of respiration, a decrease of respiration frequency (fR) and tidal volume (VT) leading to a decrease of minute volume (MV). This depression of respiration during severe hypoxia was absent in A1R(-/-) mice which displayed a stimulated respiration as indicated by the enhancement of MV by some 50-60%. During hypercapnia-hyperoxia (3-10% CO2/97-90 % O2), no obvious differences in respiration of A1R(-/-) and A1R(+/+) was observed. In neonatal mice, the respiratory response to hypoxia was surprisingly similar in both genotypes. However, neonatal A1R(-/-) mice appeared to have more frequently periods of apnea during hypoxia and in the post-hypoxic control period. In conclusion, these data indicate that the adenosine A1 receptor is an important molecular component mediating hypoxic depression in adult mice and it appears to stabilize respiration of neonatal mice.
MeSH term(s)	Aging/physiology ; Animals ; Animals, Newborn ; Apnea/physiopathology ; Blood Gas Analysis ; Disease Models, Animal ; Female ; Hypercapnia/physiopathology ; Hypoxia/physiopathology ; Male ; Mice, Knockout ; Phenotype ; Plethysmography, Whole Body ; Receptor, Adenosine A1/genetics ; Receptor, Adenosine A1/metabolism ; Respiration ; Tidal Volume/physiology
Chemical Substances	Receptor, Adenosine A1
Language	English
Publishing date	2016-02-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2015.11.005
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Zs.A 519: Show issues

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Article ; Online: Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice.

Buehler, Philipp K / Bleiler, Doris / Tegtmeier, Ines / Heitzmann, Dirk / Both, Christian / Georgieff, Michael / Lesage, Florian / Warth, Richard / Thomas, Jörg

Respiratory physiology & neurobiology

2017 Volume 244, Page(s) 17–25

Abstract: Despite intensive research, the exact function of TASK potassium channels in central and peripheral chemoreception is still under debate. In this study, we investigated the respiration of unrestrained TASK-3 (TASK- ... ...

Abstract	Despite intensive research, the exact function of TASK potassium channels in central and peripheral chemoreception is still under debate. In this study, we investigated the respiration of unrestrained TASK-3 (TASK-3
Language	English
Publishing date	2017-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2017.06.009
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Zs.A 519: Show issues

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Book ; Online ; Thesis: Die Regulation des Na+2Cl-K+-Cotransporters in der basolateralen Membran der Rattenkolonkrypte

Heitzmann, Dirk

2000

Author's details	vorgelegt von Dirk Heitzmann
Language	German
Size	Online-Ressource
Edition	[Elektronische Ressource]
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Univ., Diss--Freiburg (Breisgau), 2001
Database	Former special subject collection: coastal and deep sea fishing

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Article: No potassium, no acid: K+ channels and gastric acid secretion.

Heitzmann, Dirk / Warth, Richard

Physiology (Bethesda, Md.)

2007 Volume 22, Page(s) 335–341

Abstract: The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels ... ...

Abstract	The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.
MeSH term(s)	Animals ; Gastric Acid/secretion ; H(+)-K(+)-Exchanging ATPase/metabolism ; Humans ; KCNQ1 Potassium Channel/metabolism ; Parietal Cells, Gastric/cytology ; Parietal Cells, Gastric/metabolism ; Parietal Cells, Gastric/pathology ; Potassium/metabolism ; Potassium Channels, Inwardly Rectifying/metabolism ; Potassium Channels, Voltage-Gated/antagonists & inhibitors ; Potassium Channels, Voltage-Gated/metabolism ; Signal Transduction/physiology
Chemical Substances	KCNQ1 Potassium Channel ; Potassium Channels, Inwardly Rectifying ; Potassium Channels, Voltage-Gated ; H(+)-K(+)-Exchanging ATPase (EC 3.6.3.10) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2007-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2158667-6
ISSN	1548-9221 ; 1548-9213
ISSN (online)	1548-9221
ISSN	1548-9213
DOI	10.1152/physiol.00016.2007
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Book ; Online ; Thesis: Die Regulation des Na+2Cl-K+-Cotransporters in der basolateralen Membran der Rattenkolonkrypte

Heitzmann, Dirk [Verfasser]

2000

Author's details	vorgelegt von Dirk Heitzmann
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Sex-dependent differences in the in vivo respiratory phenotype of the TASK-1 potassium channel knockout mouse.

Jungbauer, Stefan / Buehler, Philipp Karl / Neubauer, Jacqueline / Haas, Cordula / Heitzmann, Dirk / Tegtmeier, Ines / Sterner, Christina / Barhanin, Jacques / Georgieff, Michael / Warth, Richard / Thomas, Jörg

Respiratory physiology & neurobiology

2017 Volume 245, Page(s) 13–28

Abstract: TASK-1 potassium channels have been implicated in central and peripheral chemoreception; however, the precise contribution of TASK-1 for the control of respiration is still under debate. Here, we investigated the respiration of unrestrained adult and ... ...

Abstract	TASK-1 potassium channels have been implicated in central and peripheral chemoreception; however, the precise contribution of TASK-1 for the control of respiration is still under debate. Here, we investigated the respiration of unrestrained adult and neonatal TASK-1 knockout mice (TASK-1
MeSH term(s)	Aging/metabolism ; Anesthetics, Inhalation/pharmacology ; Animals ; Animals, Newborn ; Cohort Studies ; Female ; Humans ; Hypercapnia/physiopathology ; Infant ; Isoflurane/pharmacology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Tissue Proteins/deficiency ; Nerve Tissue Proteins/genetics ; Plethysmography, Whole Body ; Potassium Channels, Tandem Pore Domain/deficiency ; Potassium Channels, Tandem Pore Domain/genetics ; Respiration/drug effects ; Sex Characteristics ; Sudden Infant Death/genetics ; Tidal Volume/physiology
Chemical Substances	Anesthetics, Inhalation ; Nerve Tissue Proteins ; Potassium Channels, Tandem Pore Domain ; potassium channel subfamily K member 3 ; Isoflurane (CYS9AKD70P)
Language	English
Publishing date	2017
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2016.11.005
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Article ; Online: Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis.

Beckmann, Denise / Römer-Hillmann, Anja / Krause, Annika / Hansen, Uwe / Wehmeyer, Corinna / Intemann, Johanna / de Gorter, David J J / Dankbar, Berno / Hillen, Jan / Heitzmann, Marianne / Begemann, Isabell / Galic, Milos / Weinhage, Toni / Foell, Dirk / Ai, Rizi / Kremerskothen, Joachim / Kiener, Hans P / Müller, Sylvia / Kamradt, Thomas /

Schröder, Christopher / Leitão, Elsa / Horsthemke, Bernhard / Rosenstiel, Philip / Nordström, Karl / Gasparoni, Gilles / Gasparoni, Nina / Walter, Jörn / Li, Na / Yang, Xinyi / Chung, Ho-Ryun / Pavenstädt, Hermann / Lindemann, Nico / Schnittler, Hans J / Wang, Wei / Firestein, Gary S / Pap, Thomas / Korb-Pap, Adelheid

Nature communications

2021 Volume 12, Issue 1, Page(s) 3624

Abstract: The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regulation of Lasp1 and its function in the ... ...

Abstract	The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regulation of Lasp1 and its function in the aggressive transformation of cells is unclear. Here we use integrative epigenomic profiling of invasive fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) and from mouse models of the disease, to identify Lasp1 as an epigenomically co-modified region in chronic inflammatory arthritis and a functionally important binding partner of the Cadherin-11/β-Catenin complex in zipper-like cell-to-cell contacts. In vitro, loss or blocking of Lasp1 alters pathological tissue formation, migratory behaviour and platelet-derived growth factor response of arthritic FLS. In arthritic human TNF transgenic mice, deletion of Lasp1 reduces arthritic joint destruction. Therefore, we show a function of Lasp1 in cellular junction formation and inflammatory tissue remodelling and identify Lasp1 as a potential target for treating inflammatory joint disorders associated with aggressive cellular transformation.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Adherens Junctions/metabolism ; Animals ; Arthritis/metabolism ; Arthritis/pathology ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/pathology ; Cadherins/metabolism ; Cell Transformation, Neoplastic/metabolism ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Female ; Fibroblasts/metabolism ; Homeodomain Proteins ; LIM Domain Proteins/genetics ; LIM Domain Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Osteoblasts ; beta Catenin/metabolism
Chemical Substances	Adaptor Proteins, Signal Transducing ; CTNNB1 protein, human ; Cadherins ; Cytoskeletal Proteins ; Homeodomain Proteins ; LASP1 protein, human ; LIM Domain Proteins ; Lasp1 protein, mouse ; beta Catenin ; osteoblast cadherin (156621-71-5)
Language	English
Publishing date	2021-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-23706-8
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Article ; Online: The TFIIH subunit p89 (XPB) localizes to the centrosome during mitosis.

Weber, Achim / Chung, Hye-Jung / Springer, Erik / Heitzmann, Dirk / Warth, Richard

Cellular oncology : the official journal of the International Society for Cellular Oncology

2010 Volume 32, Issue 1-2, Page(s) 121–130

Abstract: Background: The general transcription factor II H (TFIIH), comprised of a core complex and an associated CAK-complex, functions in transcription, DNA repair and cell cycle control. Mutations of the two largest subunits, p89 (XPB) and p80 (XPD), cause ... ...

Abstract	Background: The general transcription factor II H (TFIIH), comprised of a core complex and an associated CAK-complex, functions in transcription, DNA repair and cell cycle control. Mutations of the two largest subunits, p89 (XPB) and p80 (XPD), cause the hereditary cancer-prone syndrome xeroderma pigmentosum. Methods: The TFIIH subunit p89 was monitored during interphase and cell division by immunofluorescence staining, GFP-fusion constructs including deletions, live cell imaging and immuno-precipitations. Results: Here we demonstrate that during cell division, from prophase until telophase, the TFIIH core subunit p89, but not other subunits of TFIIH, associates with the centrosomes and the adjacent parts of the mitotic spindle. With overall constant levels throughout mitosis, p89 re-localizes to the newly formed nuclei by the end of mitosis. Furthermore, p89 interacts with the centrosomal protein gamma-tubulin. Truncations of p89 result in an abnormal subcellular distribution during interphase and abolished centrosomal association during mitosis. Conclusions: Our observations suggest a so far unappreciated role for p89 in cell cycle regulation, and may be the structural basis for a long known, but hitherto unexplained interaction between p89 and tubulin.
MeSH term(s)	Centrosome/metabolism ; DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; HeLa Cells ; Humans ; Mitosis ; Protein Transport ; Tubulin/metabolism
Chemical Substances	DNA-Binding Proteins ; Tubulin ; XPBC-ERCC-3 protein (146045-44-5) ; DNA Helicases (EC 3.6.4.-)
Language	English
Publishing date	2010
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2157351-7
ISSN	1875-8606 ; 1570-5870
ISSN (online)	1875-8606
ISSN	1570-5870
DOI	10.3233/CLO-2009-0509
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