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  1. Article: Editorial: The calcium-sensing receptor: from physiology to pharmacology.

    Ranieri, Marianna / Schepelmann, Martin / Valenti, Giovanna / Kallay, Enikö / Riccardi, Daniela

    Frontiers in physiology

    2023  Volume 14, Page(s) 1225074

    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1225074
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  2. Article ; Online: Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems.

    Riccardi, Claudia / Platella, Chiara / Musumeci, Domenica / Montesarchio, Daniela

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 15

    Abstract: Ru-based chemotherapy is emerging as an effective alternative to the well-established Pt-based one, typically associated with high toxicity. In this context, our recent efforts were devoted to the preparation of nucleolipid-based Ru(III) complexes able ... ...

    Abstract Ru-based chemotherapy is emerging as an effective alternative to the well-established Pt-based one, typically associated with high toxicity. In this context, our recent efforts were devoted to the preparation of nucleolipid-based Ru(III) complexes able to form, under physiological conditions, supramolecular aggregates which can efficiently prevent metal deactivation and convey Ru(III) inside the cells where it exerts its activity. Within an interdisciplinary program for the development of multifunctional nanoparticles for theranostic applications, we here report the design, synthesis, and characterization of a novel functionalized Ru(III) salt, carrying a lipoic acid moiety in the nucleolipid-based scaffold to allow its incorporation onto metal-based nanoparticles.
    MeSH term(s) Thioctic Acid ; Metals ; Metal Nanoparticles
    Chemical Substances Thioctic Acid (73Y7P0K73Y) ; Metals
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28155775
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article ; Online: Medical therapy of cardiogenic shock: Contemporary use of inotropes and vasopressors.

    Riccardi, Mauro / Pagnesi, Matteo / Chioncel, Ovidiu / Mebazaa, Alexandre / Cotter, Gad / Gustafsson, Finn / Tomasoni, Daniela / Latronico, Nicola / Adamo, Marianna / Metra, Marco

    European journal of heart failure

    2024  Volume 26, Issue 2, Page(s) 411–431

    Abstract: Cardiogenic shock is a primary cardiac disorder that results in both clinical and biochemical evidence of tissue hypoperfusion and can lead to multi-organ failure and death depending on its severity. Inadequate cardiac contractility or cardiac power ... ...

    Abstract Cardiogenic shock is a primary cardiac disorder that results in both clinical and biochemical evidence of tissue hypoperfusion and can lead to multi-organ failure and death depending on its severity. Inadequate cardiac contractility or cardiac power secondary to acute myocardial infarction remains the most frequent cause of cardiogenic shock, although its contribution has declined over the past two decades, compared with other causes. Despite some advances in cardiogenic shock management, this clinical syndrome is still burdened by an extremely high mortality. Its management is based on immediate stabilization of haemodynamic parameters so that further treatment, including mechanical circulatory support and transfer to specialized tertiary care centres, can be accomplished. With these aims, medical therapy, consisting mainly of inotropic drugs and vasopressors, still has a major role. The purpose of this article is to review current evidence on the use of these medications in patients with cardiogenic shock and discuss specific clinical settings with indications to their use.
    MeSH term(s) Humans ; Shock, Cardiogenic/drug therapy ; Shock, Cardiogenic/etiology ; Heart Failure/therapy ; Myocardial Infarction/complications ; Myocardial Contraction
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3162
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    Zs.A 5299: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Directing in Vitro Selection towards G-quadruplex-forming Aptamers to Inhibit HMGB1 Pathological Activity.

    Napolitano, Ettore / Criscuolo, Andrea / Riccardi, Claudia / Esposito, Carla L / Catuogno, Silvia / Coppola, Gabriele / Roviello, Giovanni N / Montesarchio, Daniela / Musumeci, Domenica

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 16, Page(s) e202319828

    Abstract: In the search for novel, effective inhibitors of High-Mobility Group Box1 (HMGB1)-a protein involved in various inflammatory and autoimmune diseases as well as in cancer-we herein discovered a set of anti-HMGB1 G-quadruplex(G4)-forming aptamers by using ... ...

    Abstract In the search for novel, effective inhibitors of High-Mobility Group Box1 (HMGB1)-a protein involved in various inflammatory and autoimmune diseases as well as in cancer-we herein discovered a set of anti-HMGB1 G-quadruplex(G4)-forming aptamers by using an in vitro selection procedure applied to a doped library of guanine-rich oligonucleotides. The selected DNA sequences were then studied in a pseudo-physiological buffer mimicking the extracellular medium, where HMGB1 exerts its pathological activity, using spectroscopic, electrophoretic, and chromatographic techniques. All the oligonucleotides proved to fold into monomeric G4s and in some cases also dimeric species, stable at physiological temperature. Remarkably, the protein preferentially recognized the sequences forming dimeric parallel G4 structures, as evidenced by a properly designed chemiluminescent binding assay which also highlighted a good selectivity of these aptamers for HMGB1. Moreover, all aptamers showed anti-HMGB1 activity, inhibiting protein-induced cell migration. The acquired data allowed identifying L12 as the best anti-HMGB1 aptamer, featured by high thermal and enzymatic stability, no toxicity at least up to 5 μM concentration on healthy cells, along with potent anti-HMGB1 activity (IC
    MeSH term(s) HMGB1 Protein ; Aptamers, Nucleotide/pharmacology ; Aptamers, Nucleotide/chemistry ; G-Quadruplexes
    Chemical Substances HMGB1 Protein ; Aptamers, Nucleotide
    Language English
    Publishing date 2024-03-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202319828
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  5. Article ; Online: Device-based percutaneous treatments to decompress the left atrium in heart failure with preserved ejection fraction.

    Riccardi, Mauro / Tomasoni, Daniela / Vizzardi, Enrico / Metra, Marco / Adamo, Marianna

    Heart failure reviews

    2022  Volume 28, Issue 2, Page(s) 315–330

    Abstract: Heart failure with preserved ejection fraction (HFpEF) accounts for more than half of heart failure hospital admissions in the last years and is burdened by high mortality and poor quality of life. Providing effective management for HFpEF patients is a ... ...

    Abstract Heart failure with preserved ejection fraction (HFpEF) accounts for more than half of heart failure hospital admissions in the last years and is burdened by high mortality and poor quality of life. Providing effective management for HFpEF patients is a major unmet clinical need. Increase in left atrial pressure is the key determinant of pulmonary congestion, with consequent dyspnoea and exercise limitation. Evidence on benefits of medical treatment in HFpEF patients is limited. Thus, alternative strategies, including devices able to reduce left atrial pressure, through an interatrial communication determining a left-right shunt, were developed. This review aims to summarize evidence regarding the use of percutaneous interatrial shunting devices. These devices are safe and effective in improving hemodynamic and clinical parameters, including pulmonary capillary wedge pressure, 6-min walking distance, and New York Heart Association functional class. Data on cardiovascular mortality and re-hospitalization for heart failure are still scarce.
    MeSH term(s) Humans ; Heart Failure ; Stroke Volume ; Quality of Life ; Cardiac Catheterization ; Heart Atria ; Ventricular Function, Left
    Language English
    Publishing date 2022-11-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1336499-6
    ISSN 1573-7322 ; 1382-4147
    ISSN (online) 1573-7322
    ISSN 1382-4147
    DOI 10.1007/s10741-022-10280-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Affinity Chromatography-Based Assays for the Screening of Potential Ligands Selective for G-Quadruplex Structures.

    Platella, Chiara / Napolitano, Ettore / Riccardi, Claudia / Musumeci, Domenica / Montesarchio, Daniela

    ChemistryOpen

    2022  Volume 11, Issue 5, Page(s) e202200090

    Abstract: DNA G-quadruplexes (G4s) are key structures for the development of targeted anticancer therapies. In this context, ligands selectively interacting with G4s can represent valuable anticancer drugs. Aiming at speeding up the identification of G4-targeting ... ...

    Abstract DNA G-quadruplexes (G4s) are key structures for the development of targeted anticancer therapies. In this context, ligands selectively interacting with G4s can represent valuable anticancer drugs. Aiming at speeding up the identification of G4-targeting synthetic or natural compounds, we developed an affinity chromatography-based assay, named G-quadruplex on Oligo Affinity Support (G4-OAS), by synthesizing G4-forming sequences on commercially available polystyrene OAS. Then, due to unspecific binding of several hydrophobic ligands on nude OAS, we moved to Controlled Pore Glass (CPG). We thus conceived an ad hoc functionalized, universal support on which both the on-support elongation and deprotection of the G4-forming oligonucleotides can be performed, along with the successive affinity chromatography-based assay, renamed as G-quadruplex on Controlled Pore Glass (G4-CPG) assay. Here we describe these assays and their applications to the screening of several libraries of chemically different putative G4 ligands. Finally, ongoing studies and outlook of our G4-CPG assay are reported.
    MeSH term(s) Antineoplastic Agents ; Chromatography, Affinity ; G-Quadruplexes ; Ligands
    Chemical Substances Antineoplastic Agents ; Ligands
    Language English
    Publishing date 2022-05-23
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2655605-4
    ISSN 2191-1363 ; 2191-1363
    ISSN (online) 2191-1363
    ISSN 2191-1363
    DOI 10.1002/open.202200090
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  7. Article ; Online: Investigating the Interaction of an Anticancer Nucleolipidic Ru(III) Complex with Human Serum Proteins: A Spectroscopic Study.

    Riccardi, Claudia / Campanella, Antonella / Montesarchio, Daniela / Del Vecchio, Pompea / Oliva, Rosario / Paduano, Luigi

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 6

    Abstract: Ruthenium(III) complexes are very promising candidates as metal-based anticancer drugs, and several studies have supported the likely role of human serum proteins in the transport and selective delivery of Ru(III)-based compounds to tumor cells. Herein, ... ...

    Abstract Ruthenium(III) complexes are very promising candidates as metal-based anticancer drugs, and several studies have supported the likely role of human serum proteins in the transport and selective delivery of Ru(III)-based compounds to tumor cells. Herein, the anticancer nanosystem composed of an amphiphilic nucleolipid incorporating a Ru(III) complex, which we named DoHuRu, embedded into the biocompatible cationic lipid DOTAP, was investigated as to its interaction with two human serum proteins thought to be involved in the mechanism of action of Ru(III)-based anticancer drugs, i.e., human serum albumin (HSA) and human transferrin (hTf). This nanosystem was studied in comparison with the simple Ru(III) complex named AziRu, a low molecular weight metal complex previously designed as an analogue of NAMI-A, decorated with the same ruthenium ligands as DoHuRu but devoid of the nucleolipid scaffold and not inserted in liposomal formulations. For this study, different spectroscopic techniques, i.e., Fluorescence Spectroscopy and Circular Dichroism (CD), were exploited, showing that DoHuRu/DOTAP liposomes can interact with both serum proteins without affecting their secondary structures.
    MeSH term(s) Humans ; Ruthenium/chemistry ; Coordination Complexes/chemistry ; Antineoplastic Agents/chemistry ; Blood Proteins ; Liposomes ; Organometallic Compounds/chemistry
    Chemical Substances 1,2-dioleoyloxy-3-(trimethylammonium)propane (MR86K0XRQP) ; Ruthenium (7UI0TKC3U5) ; Coordination Complexes ; Antineoplastic Agents ; Blood Proteins ; Liposomes ; Organometallic Compounds
    Language English
    Publishing date 2023-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28062800
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  8. Article ; Online: Parathyroid hormone-independent role for the calcium-sensing receptor in the control of urinary calcium excretion.

    Riccardi, Daniela

    Journal of the American Society of Nephrology : JASN

    2012  Volume 23, Issue 11, Page(s) 1766–1768

    MeSH term(s) Animals ; Calcium/urine ; Kidney/metabolism ; Receptors, Calcium-Sensing/deficiency
    Chemical Substances Receptors, Calcium-Sensing ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2012-11
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2012090955
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Probing naphthalene diimide and 3-hydroxypropylphosphate as end-conjugating moieties for improved thrombin binding aptamers: Structural and biological effects.

    Riccardi, Claudia / Pérez de Carvasal, Kévan / Platella, Chiara / Meyer, Albert / Smietana, Michael / Morvan, François / Montesarchio, Daniela

    Bioorganic chemistry

    2023  Volume 141, Page(s) 106917

    Abstract: The limitations associated with the in vivo use of the thrombin binding aptamer (TBA or ... ...

    Abstract The limitations associated with the in vivo use of the thrombin binding aptamer (TBA or TBA
    MeSH term(s) Thrombin/metabolism ; Anticoagulants/chemistry ; Imides/pharmacology ; Naphthalenes/pharmacology ; G-Quadruplexes ; Aptamers, Nucleotide/chemistry
    Chemical Substances Thrombin (EC 3.4.21.5) ; naphthalenediimide (22291-04-9) ; Anticoagulants ; Imides ; Naphthalenes ; Aptamers, Nucleotide
    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.106917
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Investigating the Interaction of an Anticancer Nucleolipidic Ru(III) Complex with Human Serum Proteins

    Claudia Riccardi / Antonella Campanella / Daniela Montesarchio / Pompea Del Vecchio / Rosario Oliva / Luigi Paduano

    Molecules, Vol 28, Iss 2800, p

    A Spectroscopic Study

    2023  Volume 2800

    Abstract: Ruthenium(III) complexes are very promising candidates as metal-based anticancer drugs, and several studies have supported the likely role of human serum proteins in the transport and selective delivery of Ru(III)-based compounds to tumor cells. Herein, ... ...

    Abstract Ruthenium(III) complexes are very promising candidates as metal-based anticancer drugs, and several studies have supported the likely role of human serum proteins in the transport and selective delivery of Ru(III)-based compounds to tumor cells. Herein, the anticancer nanosystem composed of an amphiphilic nucleolipid incorporating a Ru(III) complex, which we named DoHuRu, embedded into the biocompatible cationic lipid DOTAP, was investigated as to its interaction with two human serum proteins thought to be involved in the mechanism of action of Ru(III)-based anticancer drugs, i.e., human serum albumin (HSA) and human transferrin (hTf). This nanosystem was studied in comparison with the simple Ru(III) complex named AziRu, a low molecular weight metal complex previously designed as an analogue of NAMI-A, decorated with the same ruthenium ligands as DoHuRu but devoid of the nucleolipid scaffold and not inserted in liposomal formulations. For this study, different spectroscopic techniques, i.e., Fluorescence Spectroscopy and Circular Dichroism (CD), were exploited, showing that DoHuRu/DOTAP liposomes can interact with both serum proteins without affecting their secondary structures.
    Keywords ruthenium(III) complexes ; anticancer drugs ; liposomes ; serum proteins ; interactions ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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