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  1. Article ; Online: Rebuttal from Kenton M. Sanders, Sean M. Ward and Andreas Friebe.

    Sanders, Kenton M / Ward, Sean M / Friebe, Andreas

    The Journal of physiology

    2016  Volume 594, Issue 6, Page(s) 1515

    Language English
    Publishing date 2016-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP271971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply from Kenton M. Sanders, Bhupal P. Bhetwal and Brian A. Perrino.

    Sanders, Kenton M / Bhetwal, Bhupal P / Perrino, Brian A

    The Journal of physiology

    2013  Volume 591, Issue 21, Page(s) 5415–5416

    MeSH term(s) Animals ; Calcium/metabolism ; Gastric Fundus/physiology ; Male ; Synaptic Transmission
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2013-11-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2013.264812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interstitial cells of Cajal - pacemakers of the gastrointestinal tract.

    Sanders, Kenton M / Santana, L Fernando / Baker, Salah A

    The Journal of physiology

    2023  

    Abstract: Gastrointestinal (GI) organs display spontaneous, non-neurogenic electrical, and mechanical rhythmicity that underlies fundamental motility patterns, such as peristalsis and segmentation. Electrical rhythmicity (aka slow waves) results from pacemaker ... ...

    Abstract Gastrointestinal (GI) organs display spontaneous, non-neurogenic electrical, and mechanical rhythmicity that underlies fundamental motility patterns, such as peristalsis and segmentation. Electrical rhythmicity (aka slow waves) results from pacemaker activity generated by interstitial cells of Cajal (ICC). ICC express a unique set of ionic conductances and Ca
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Overview of the Enteric Nervous System.

    Mawe, Gary M / Sanders, Kenton M / Camilleri, Michael

    Seminars in neurology

    2023  Volume 43, Issue 4, Page(s) 495–505

    Abstract: Propulsion of contents in the gastrointestinal tract requires coordinated functions of the extrinsic nerves to the gut from the brain and spinal cord, as well as the neuromuscular apparatus within the gut. The latter includes excitatory and inhibitory ... ...

    Abstract Propulsion of contents in the gastrointestinal tract requires coordinated functions of the extrinsic nerves to the gut from the brain and spinal cord, as well as the neuromuscular apparatus within the gut. The latter includes excitatory and inhibitory neurons, pacemaker cells such as the interstitial cells of Cajal and fibroblast-like cells, and smooth muscle cells. Coordination between these extrinsic and enteric neurons results in propulsive functions which include peristaltic reflexes, migrating motor complexes in the small intestine which serve as the housekeeper propelling to the colon the residual content after digestion, and mass movements in the colon which lead to defecation.
    MeSH term(s) Humans ; Enteric Nervous System/physiology ; Colon/innervation ; Colon/physiology ; Neurons
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0043-1771466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles.

    Sanders, Kenton M

    Advances in experimental medicine and biology

    2019  Volume 1124, Page(s) 3–46

    Abstract: The gastrointestinal (GI) tract has multifold tasks of ingesting, processing, and assimilating nutrients and disposing of wastes at appropriate times. These tasks are facilitated by several stereotypical motor patterns that build upon the intrinsic ... ...

    Abstract The gastrointestinal (GI) tract has multifold tasks of ingesting, processing, and assimilating nutrients and disposing of wastes at appropriate times. These tasks are facilitated by several stereotypical motor patterns that build upon the intrinsic rhythmicity of the smooth muscles that generate phasic contractions in many regions of the gut. Phasic contractions result from a cyclical depolarization/repolarization cycle, known as electrical slow waves, which result from intrinsic pacemaker activity. Interstitial cells of Cajal (ICC) are electrically coupled to smooth muscle cells (SMCs) and generate and propagate pacemaker activity and slow waves. The mechanism of slow waves is dependent upon specialized conductances expressed by pacemaker ICC. The primary conductances responsible for slow waves in mice are Ano1, Ca
    MeSH term(s) Animals ; Anoctamin-1/physiology ; Gastrointestinal Motility ; Gastrointestinal Tract/physiology ; Interstitial Cells of Cajal/physiology ; Mice ; Muscle, Smooth/physiology
    Chemical Substances ANO1 protein, mouse ; Anoctamin-1
    Language English
    Publishing date 2019-06-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-981-13-5895-1_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ca

    Sanders, Kenton M / Drumm, Bernard T / Cobine, Caroline A / Baker, Salah A

    Physiological reviews

    2023  Volume 104, Issue 1, Page(s) 329–398

    Abstract: The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI motility, but interstitial cells, electrically coupled to SMCs, tune SMC ... ...

    Abstract The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI motility, but interstitial cells, electrically coupled to SMCs, tune SMC excitability, transduce inputs from enteric motor neurons, and generate pacemaker activity that underlies major motor patterns, such as peristalsis and segmentation. The interstitial cells regulating SMCs are interstitial cells of Cajal (ICC) and PDGF receptor (PDGFR)α
    MeSH term(s) Humans ; Interstitial Cells of Cajal/physiology ; Receptor, Platelet-Derived Growth Factor alpha ; Muscle, Smooth/physiology ; Gastrointestinal Tract ; Intestine, Small/physiology
    Chemical Substances Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1)
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00036.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Gastroparesis.

    Camilleri, Michael / Sanders, Kenton M

    Gastroenterology

    2021  Volume 162, Issue 1, Page(s) 68–87.e1

    Abstract: Gastroparesis is characterized by symptoms suggestive of, and objective evidence of, delayed gastric emptying in the absence of mechanical obstruction. This review addresses the normal emptying of solids and liquids from the stomach and details the ... ...

    Abstract Gastroparesis is characterized by symptoms suggestive of, and objective evidence of, delayed gastric emptying in the absence of mechanical obstruction. This review addresses the normal emptying of solids and liquids from the stomach and details the myogenic and neuromuscular control mechanisms, including the specialized function of the pyloric sphincter, that result in normal emptying, based predominantly on animal research. A clear understanding of fundamental mechanisms is necessary to comprehend derangements leading to gastroparesis, and additional research on human gastric muscles is needed. The section on pathophysiology of gastroparesis considers neuromuscular diseases that affect nonsphincteric gastric muscle, disorders of the extrinsic neural control, and pyloric dysfunction that lead to gastroparesis. The potential cellular basis for gastroparesis is attributed to the effects of oxidative stress and inflammation, with increased pro-inflammatory and decreased resident macrophages, as observed in full-thickness biopsies from patients with gastroparesis. Predominant diagnostic tests involving measurements of gastric emptying, the use of a functional luminal imaging probe, and high-resolution antral duodenal manometry in characterizing the abnormal motor functions at the gastroduodenal junction are discussed. Management is based on supporting nutrition; dietary interventions, including the physical reduction in particle size of solid foods; pharmacological agents, including prokinetics and anti-emetics; and interventions such as gastric electrical stimulation and pyloromyotomy. These are discussed briefly, and comment is added on the potential for individualized treatments in the future, based on optimal gastric emptying measurement and objective documentation of the underlying pathophysiology causing the gastroparesis.
    MeSH term(s) Animals ; Enteric Nervous System/physiopathology ; Gastric Emptying ; Gastroparesis/diagnosis ; Gastroparesis/physiopathology ; Gastroparesis/therapy ; Humans ; Predictive Value of Tests ; Pylorus/innervation ; Treatment Outcome
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.10.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Opiates, the Pylorus, and Gastroparesis.

    Camilleri, Michael / Sanders, Kenton M

    Gastroenterology

    2020  Volume 159, Issue 2, Page(s) 414–421

    MeSH term(s) Analgesics, Opioid/pharmacology ; Analgesics, Opioid/therapeutic use ; Botulinum Toxins/administration & dosage ; Gastric Emptying/drug effects ; Gastric Emptying/physiology ; Gastroparesis/physiopathology ; Gastroparesis/therapy ; Humans ; Natural Orifice Endoscopic Surgery ; Pyloromyotomy/methods ; Pylorus/drug effects ; Pylorus/innervation ; Pylorus/physiopathology ; Pylorus/surgery
    Chemical Substances Analgesics, Opioid ; Botulinum Toxins (EC 3.4.24.69)
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.04.072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Overview of the Enteric Nervous System

    Mawe, Gary M. / Sanders, Kenton M. / Camilleri, Michael

    Seminars in Neurology

    (Neuro-gastroenterology)

    2023  Volume 43, Issue 04, Page(s) 495–505

    Abstract: Propulsion of contents in the gastrointestinal tract requires coordinated functions of the extrinsic nerves to the gut from the brain and spinal cord, as well as the neuromuscular apparatus within the gut. The latter includes excitatory and inhibitory ... ...

    Series title Neuro-gastroenterology
    Abstract Propulsion of contents in the gastrointestinal tract requires coordinated functions of the extrinsic nerves to the gut from the brain and spinal cord, as well as the neuromuscular apparatus within the gut. The latter includes excitatory and inhibitory neurons, pacemaker cells such as the interstitial cells of Cajal and fibroblast-like cells, and smooth muscle cells. Coordination between these extrinsic and enteric neurons results in propulsive functions which include peristaltic reflexes, migrating motor complexes in the small intestine which serve as the housekeeper propelling to the colon the residual content after digestion, and mass movements in the colon which lead to defecation.
    Keywords muscle neuron ; pacemaker ; propulsion ; extrinsic
    Language English
    Publishing date 2023-08-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0043-1771466
    Database Thieme publisher's database

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  10. Article ; Online: Cardiac PDGFRα

    Zheng, Haifeng / Peri, Lauren / Ward, Grace K / Sanders, Kenton M / Ward, Sean M

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2023  Volume 37, Issue 5, Page(s) e22929

    Abstract: The cell types and conductance that contribute to normal cardiac functions remain under investigation. We used mice that express an enhanced green fluorescent protein (eGFP)-histone 2B fusion protein driven off the cell-specific endogenous promoter for ... ...

    Abstract The cell types and conductance that contribute to normal cardiac functions remain under investigation. We used mice that express an enhanced green fluorescent protein (eGFP)-histone 2B fusion protein driven off the cell-specific endogenous promoter for Pdgfra to investigate the distribution and functional role of PDGFRα
    MeSH term(s) Animals ; Mice ; Cations/metabolism ; Heart/physiology ; Macaca fascicularis/metabolism ; Membrane Potentials/physiology ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; TRPM Cation Channels ; Myocardium/metabolism
    Chemical Substances Cations ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1) ; TRPM Cation Channels ; Trpm7 protein, mouse (EC 2.7.1.-)
    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202201712R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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