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  1. Book ; Thesis: Wirkungen von Leukotrien D 4 und E 4 auf die Nierendurchblutung

    Gulbins, Erich

    (Untersuchungen an der normalen und hydronephrotischen Niere)

    1990  

    Author's details vorgelegt von Erich Gulbins
    Size 120 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 1992
    HBZ-ID HT004024640
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    92 E 1348 order for loan Magazin

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  2. Article ; Online: Tribute to Andrea Huwiler (1966-2023).

    Pfeilschifter, Josef / Gulbins, Erich

    Pflugers Archiv : European journal of physiology

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country Germany
    Document type Editorial
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-024-02958-5
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  3. Article: Sphingolipids in thyroid eye disease.

    Gulbins, Anne / Görtz, Gina-Eva / Gulbins, Erich / Eckstein, Anja

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1170884

    Abstract: Graves' disease (GD) is caused by an autoimmune formation of autoantibodies and autoreactive T-cells against the thyroid stimulating hormone receptor (TSHR). The autoimmune reaction does not only lead to overstimulation of the thyroid gland, but very ... ...

    Abstract Graves' disease (GD) is caused by an autoimmune formation of autoantibodies and autoreactive T-cells against the thyroid stimulating hormone receptor (TSHR). The autoimmune reaction does not only lead to overstimulation of the thyroid gland, but very often also to an immune reaction against antigens within the orbital tissue leading to thyroid eye disease, which is characterized by activation of orbital fibroblasts, orbital generation of adipocytes and myofibroblasts and increased hyaluronan production in the orbit. Thyroid eye disease is the most common extra-thyroidal manifestation of the autoimmune Graves' disease. Several studies indicate an important role of sphingolipids, in particular the acid sphingomyelinase/ceramide system and sphingosine 1-phosphate in thyroid eye disease. Here, we discuss how the biophysical properties of sphingolipids contribute to cell signaling, in particular in the context of thyroid eye disease. We further review the role of the acid sphingomyelinase/ceramide system in autoimmune diseases and its function in T lymphocytes to provide some novel hypotheses for the pathogenesis of thyroid eye disease and potentially allowing the development of novel treatments.
    MeSH term(s) Humans ; Graves Ophthalmopathy ; Sphingomyelin Phosphodiesterase ; Sphingolipids ; Graves Disease ; Autoimmune Diseases ; Ceramides
    Chemical Substances Sphingomyelin Phosphodiesterase (EC 3.1.4.12) ; Sphingolipids ; Ceramides
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1170884
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  4. Article: New Therapeutic Options in Pulmonal Diseases: Sphingolipids and Modulation of Sphingolipid Metabolism.

    Kleuser, Burkhard / Schumacher, Fabian / Gulbins, Erich

    Handbook of experimental pharmacology

    2023  Volume 284, Page(s) 289–312

    Abstract: Sphingolipids are crucial molecules in the respiratory airways. As in most other tissues and organs, in the lung sphingolipids play an essential role as structural constituents as they regulate barrier function and fluidity of cell membranes. A lung- ... ...

    Abstract Sphingolipids are crucial molecules in the respiratory airways. As in most other tissues and organs, in the lung sphingolipids play an essential role as structural constituents as they regulate barrier function and fluidity of cell membranes. A lung-specific feature is the occurrence of sphingolipids as minor structural components in the surfactant. However, sphingolipids are also key signaling molecules involved in airway cell signaling and their dynamical formation and metabolism are important for normal lung physiology. Dysregulation of sphingolipid metabolism and signaling is involved in altering lung tissue and initiates inflammatory processes promoting the pathogenesis of pulmonal diseases including cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and asthma.In the present review, the important role of specific sphingolipid species in pulmonal diseases will be discussed. Only such an understanding opens up the possibility of developing new therapeutic strategies with the aim of correcting the imbalance in sphingolipid metabolism and signaling. Such delivery strategies have already been studied in animal models of these lung diseases, demonstrating that targeting the sphingolipid profile represents new therapeutic opportunities for lung disorders.
    MeSH term(s) Animals ; Sphingolipids ; Lung ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/metabolism ; Cystic Fibrosis/drug therapy ; Signal Transduction ; Ceramides ; Sphingosine
    Chemical Substances Sphingolipids ; Ceramides ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2023-11-02
    Publishing country Germany
    Document type Review ; Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2023_700
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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  5. Article: New Molecular Targets for Antidepressant Drugs.

    Kornhuber, Johannes / Gulbins, Erich

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 9

    Abstract: Major depressive disorder (MDD) is a common and severe mental disorder that is usually recurrent and has a high risk of suicide. This disorder manifests not only with psychological symptoms but also multiple changes throughout the body, including ... ...

    Abstract Major depressive disorder (MDD) is a common and severe mental disorder that is usually recurrent and has a high risk of suicide. This disorder manifests not only with psychological symptoms but also multiple changes throughout the body, including increased risks of obesity, diabetes, and cardiovascular disease. Peripheral markers of oxidative stress and inflammation are elevated. MDD is therefore best described as a multisystem whole-body disease. Pharmacological treatment with antidepressants usually requires several weeks before the desired effects manifest. Previous theories of depression, such as the monoamine or neurogenesis hypotheses, do not explain these characteristics well. In recent years, new mechanisms of action have been discovered for long-standing antidepressants that also shed new light on depression, including the sphingolipid system and the receptor for brain-derived neurotrophic factor (BDNF).
    Language English
    Publishing date 2021-09-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14090894
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  6. Article ; Online: Sphingosine Prevents Rhinoviral Infections.

    Lang, Judith / Soddemann, Matthias / Edwards, Michael J / Wilson, Gregory C / Lang, Karl S / Gulbins, Erich

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Rhinoviral infections cause approximately 50% of upper respiratory tract infections and novel treatment options are urgently required. We tested the effects of 10 μM to 20 μM sphingosine on the infection of cultured and freshly isolated human cells with ... ...

    Abstract Rhinoviral infections cause approximately 50% of upper respiratory tract infections and novel treatment options are urgently required. We tested the effects of 10 μM to 20 μM sphingosine on the infection of cultured and freshly isolated human cells with minor and major group rhinovirus in vitro. We also performed in vivo studies on mice that were treated with an intranasal application of 10 μL of either a 10 μM or a 100 μM sphingosine prior and after infection with rhinovirus strains 1 and 2 and determined the infection of nasal epithelial cells in the presence or absence of sphingosine. Finally, we determined and characterized a direct binding of sphingosine to rhinovirus. Our data show that treating freshly isolated human nasal epithelial cells with sphingosine prevents infections with rhinovirus strains 2 (minor group) and 14 (major group). Nasal infection of mice with rhinovirus 1b and 2 is prevented by the intranasal application of sphingosine before or as long as 8 h after infection with rhinovirus. Nasal application of the same doses of sphingosine exerts no adverse effects on epithelial cells as determined by hemalaun and TUNEL stainings. The solvent, octylglucopyranoside, was without any effect in vitro and in vivo. Mechanistically, we demonstrate that the positively charged lipid sphingosine binds to negatively charged molecules in the virus, which seems to prevent the infection of epithelial cells. These findings indicate that exogenous sphingosine prevents infections with rhinoviruses, a finding that could be therapeutically exploited. In addition, we demonstrated that sphingosine has no obvious adverse effects on the nasal mucosa. Sphingosine prevents rhinoviral infections by a biophysical mode of action, suggesting that sphingosine could serve to prevent many viral infections of airways and epithelial cells in general. Future studies need to determine the molecular mechanisms of how sphingosine prevents rhinoviral infections and whether sphingosine also prevents infections with other viruses inducing respiratory tract infections. Furthermore, our studies do not provide detailed pharmacokinetics that are definitely required before the further development of sphingosine.
    MeSH term(s) Humans ; Animals ; Mice ; Sphingosine ; Nasal Mucosa ; Enterovirus Infections ; Epithelial Cells ; Rhinovirus ; Respiratory Tract Infections
    Chemical Substances Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052486
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  7. Article ; Online: Highlight: molecular medicine of sphingolipids.

    Gulbins, Erich

    Biological chemistry

    2015  Volume 396, Issue 6-7, Page(s) 569–571

    MeSH term(s) Animals ; Humans ; Molecular Medicine ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Signal Transduction/physiology ; Sphingolipids/metabolism
    Chemical Substances Sphingolipids ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; sphingosine kinase (EC 2.7.1.-)
    Language English
    Publishing date 2015-06
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2015-0163
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  8. Article ; Online: Analysis of Lipids in Ceramide-Enriched Membrane Domains.

    Carpinteiro, Alexander / Gulbins, Erich

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2187, Page(s) 207–213

    Abstract: Ceramide can be generated on cell surfaces by the activity of the acid sphingomyelinase. The unique biophysical properties of ceramide result in the self-formation of small ceramide-enriched membrane domains that spontaneously fuse to large ceramide- ... ...

    Abstract Ceramide can be generated on cell surfaces by the activity of the acid sphingomyelinase. The unique biophysical properties of ceramide result in the self-formation of small ceramide-enriched membrane domains that spontaneously fuse to large ceramide-enriched membrane macrodomains. The present chapter describes how these domains can be labeled and thereby visualized in cells. Further, the chapter provides protocols how ceramide and sphingosine can be quantified on the surface of cells and organs.
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Cells, Cultured ; Ceramides/metabolism ; Humans ; Immunochemistry/methods ; Membrane Lipids/metabolism ; Membrane Microdomains/metabolism ; Signal Transduction/physiology ; Sphingosine/metabolism
    Chemical Substances Ceramides ; Membrane Lipids ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0814-2_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sphingolipid control of cognitive functions in health and disease.

    Kalinichenko, Liubov S / Gulbins, Erich / Kornhuber, Johannes / Müller, Christian P

    Progress in lipid research

    2022  Volume 86, Page(s) 101162

    Abstract: Cognitive processes, particularly learning and memory, are crucial brain mechanisms mediating the successful adaptation of individuals to constantly changing environmental conditions. Impairments in memory performance during neurodegenerative disorders ... ...

    Abstract Cognitive processes, particularly learning and memory, are crucial brain mechanisms mediating the successful adaptation of individuals to constantly changing environmental conditions. Impairments in memory performance during neurodegenerative disorders or dementias affect life quality of patients as well as their relatives and careers, and thus have a severe socio-economic impact. The last decades have viewed learning and memory as predominantly protein-mediated process at the synapses of brain neurons. However, recent developments propose a principally new, lipid-based mechanism that regulates cognition. Thereby, crucial members of cell membranes, the sphingolipids, emerged to play an outstanding role in learning and memory. The most abundant brain sphingolipids, ceramides and gangliosides, dynamically shape the composition of protein carrying cellular membranes. This, in turn, regulates protein signaling through the membranes and overall neuronal plasticity. An imbalance in sphingolipid composition and disrupted dynamics significantly affect normal functioning of cells and results in the development of multiple psychiatric and neurological disorders with cognitive impairments. Ceramides and gangliosides interact with a plethora of molecular pathways determining de novo learning and memory, as well as pathogenic pathways of neurodegenerative disorders and dementias of various origins. Considering sphingolipids as a trigger mechanism for learning and memory under physiological and pathological conditions, a principally new class of lipid-based preventive and therapeutic approaches to target cognitive impairments and dementias is emerging.
    MeSH term(s) Ceramides/metabolism ; Cognition ; Dementia ; Gangliosides/metabolism ; Humans ; Neurodegenerative Diseases ; Sphingolipids/metabolism
    Chemical Substances Ceramides ; Gangliosides ; Sphingolipids
    Language English
    Publishing date 2022-03-19
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 282560-0
    ISSN 1873-2194 ; 0079-6832 ; 0163-7827
    ISSN (online) 1873-2194
    ISSN 0079-6832 ; 0163-7827
    DOI 10.1016/j.plipres.2022.101162
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  10. Article ; Online: Caveolin-1 affects early mycobacterial infection and apoptosis in macrophages and mice.

    Wu, Yuqing / Riehle, Andrea / Pollmeier, Barbara / Kadow, Stephanie / Schumacher, Fabian / Drab, Marek / Kleuser, Burkhard / Gulbins, Erich / Grassmé, Heike

    Tuberculosis (Edinburgh, Scotland)

    2024  Volume 147, Page(s) 102493

    Abstract: Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the deadliest infections in humans. Because Mycobacterium bovis Bacillus Calmette-Guérin (BCG) share genetic similarities with Mycobacterium tuberculosis, it is often used as a model to ... ...

    Abstract Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the deadliest infections in humans. Because Mycobacterium bovis Bacillus Calmette-Guérin (BCG) share genetic similarities with Mycobacterium tuberculosis, it is often used as a model to elucidate the molecular mechanisms of more severe tuberculosis infection. Caveolin-1 has been implied in many physiological processes and diseases, but it's role in mycobacterial infections has barely been studied. We isolated macrophages from Wildtype or Caveolin-1 deficient mice and analyzed hallmarks of infection, such as internalization, induction of autophagy and apoptosis. For in vivo assays we intravenously injected mice with BCG and investigated tissues for bacterial load with colony-forming unit assays, bioactive lipids with mass spectrometry and changes of protein expressions by Western blotting. Our results revealed that Caveolin-1 was important for early killing of BCG infection in vivo and in vitro, controlled acid sphingomyelinase (Asm)-dependent ceramide formation, apoptosis and inflammatory cytokines upon infection with BCG. In accordance, Caveolin-1 deficient mice and macrophages showed higher bacterial burdens in the livers. The findings indicate that Caveolin-1 plays a role in infection of mice and murine macrophages with BCG, by controlling cellular apoptosis and inflammatory host response. These clues might be useful in the fight against tuberculosis.
    Language English
    Publishing date 2024-02-12
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2046804-0
    ISSN 1873-281X ; 1472-9792
    ISSN (online) 1873-281X
    ISSN 1472-9792
    DOI 10.1016/j.tube.2024.102493
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