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  1. Article ; Online: Economic Costs of Severe Osteoporotic Fractures Continue to Increase at Expense of Refracture.

    Clarke, Bart L

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2022  Volume 37, Issue 10, Page(s) 1809–1810

    MeSH term(s) Humans ; Osteoporotic Fractures ; Fractures, Compression ; Spinal Fractures ; Retrospective Studies
    Language English
    Publishing date 2022-10-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4713
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  2. Article ; Online: Hypoparathyroidism: update of guidelines from the 2022 International Task Force.

    Clarke, Bart L

    Archives of endocrinology and metabolism

    2022  Volume 66, Issue 5, Page(s) 604–610

    Abstract: The 2022 International Task Force guidelines for chronic hypoparathyroidism will be published within several months in the Journal of Bone and Mineral Research. These guidelines update the original guidelines published in 2016, and include new ... ...

    Abstract The 2022 International Task Force guidelines for chronic hypoparathyroidism will be published within several months in the Journal of Bone and Mineral Research. These guidelines update the original guidelines published in 2016, and include new information from literature published since then. Chronic postsurgical hypoparathyroidism is now defined as lasting for at least 12 months after surgery, rather than 6 months. Chronic postsurgical hypoparathyroidism may be predicted by serum PTH <10 pg/mL in the first 12-24 hours after surgery. The most common symptoms and complications of chronic hypoparathyroidism based on the literature are summarized in detail. How to monitor and manage patients with hypoparathyroidism is described in detail where recommendations can be given. These guidelines are intended to frame the diagnosis and care of patients with chronic hypoparathyroidism for at least the next five years.
    MeSH term(s) Humans ; Calcium ; Hypoparathyroidism/diagnosis ; Hypoparathyroidism/etiology ; Hypoparathyroidism/therapy ; Bone and Bones ; Parathyroid Hormone ; Hypocalcemia
    Chemical Substances Calcium (SY7Q814VUP) ; Parathyroid Hormone
    Language English
    Publishing date 2022-11-11
    Publishing country Brazil
    Document type Guideline
    ISSN 2359-4292
    ISSN (online) 2359-4292
    DOI 10.20945/2359-3997000000549
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  3. Article ; Online: Is Moderate Hypophosphatemia a New Indication for Surgery in Asymptomatic Primary Hyperparathyroidism?

    Clarke, Bart L

    The Journal of clinical endocrinology and metabolism

    2021  Volume 107, Issue 4, Page(s) e1756–e1757

    MeSH term(s) Calcium ; Humans ; Hyperparathyroidism, Primary/diagnosis ; Hyperparathyroidism, Primary/surgery ; Hyperplasia ; Hypophosphatemia/etiology
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-10-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgab768
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  4. Article ; Online: Hypoparathyroidism

    Bart L. Clarke

    Archives of Endocrinology and Metabolism, Vol 66, Iss 5, Pp 604-

    update of guidelines from the 2022 International Task Force

    2022  Volume 610

    Abstract: ABSTRACT The 2022 International Task Force guidelines for chronic hypoparathyroidism will be published within several months in the Journal of Bone and Mineral Research. These guidelines update the original guidelines published in 2016, and include new ... ...

    Abstract ABSTRACT The 2022 International Task Force guidelines for chronic hypoparathyroidism will be published within several months in the Journal of Bone and Mineral Research. These guidelines update the original guidelines published in 2016, and include new information from literature published since then. Chronic postsurgical hypoparathyroidism is now defined as lasting for at least 12 months after surgery, rather than 6 months. Chronic postsurgical hypoparathyroidism may be predicted by serum PTH <10 pg/mL in the first 12-24 hours after surgery. The most common symptoms and complications of chronic hypoparathyroidism based on the literature are summarized in detail. How to monitor and manage patients with hypoparathyroidism is described in detail where recommendations can be given. These guidelines are intended to frame the diagnosis and care of patients with chronic hypoparathyroidism for at least the next five years.
    Keywords Hypoparathyroidism ; hypocalcemia ; nephrolithiasis ; nephrocalcinosis ; increased bone density ; Medicine ; R ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Brazilian Society of Endocrinology and Metabolism
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Premenopausal osteoporosis: Focus on the female athlete triad.

    Zavatta, Guido / Clarke, Bart L

    Case reports in women's health

    2020  Volume 29, Page(s) e00276

    Language English
    Publishing date 2020-11-27
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2800286-6
    ISSN 2214-9112 ; 2214-9112
    ISSN (online) 2214-9112
    ISSN 2214-9112
    DOI 10.1016/j.crwh.2020.e00276
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  6. Article ; Online: Glucocorticoid- and Transplantation-Induced Osteoporosis.

    Zavatta, Guido / Clarke, Bart L

    Endocrinology and metabolism clinics of North America

    2021  Volume 50, Issue 2, Page(s) 251–273

    Abstract: Glucocorticoid-induced osteoporosis is the most common cause of secondary osteoporosis; nonetheless, it remains an undertreated condition. Transplantation-induced osteoporosis encompasses a broad range of unique pathogenetic features with distinct ... ...

    Abstract Glucocorticoid-induced osteoporosis is the most common cause of secondary osteoporosis; nonetheless, it remains an undertreated condition. Transplantation-induced osteoporosis encompasses a broad range of unique pathogenetic features with distinct characteristics dependent on the transplanted organ. Understanding the pathogenesis of bone loss is key to recommending osteoporosis therapy in these patients. This review summarizes recent advances and addresses current issues in these fields.
    MeSH term(s) Bone Density ; Glucocorticoids/adverse effects ; Humans ; Osteoporosis/chemically induced ; Osteoporosis/drug therapy
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2021-04-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2021.03.002
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  7. Article ; Online: Epidemiology and Complications of Hypoparathyroidism.

    Clarke, Bart L

    Endocrinology and metabolism clinics of North America

    2018  Volume 47, Issue 4, Page(s) 771–782

    Abstract: Until recently, very few studies have described the epidemiology of this rare disorder. Several large population-based studies have recently been published describing the prevalence and incidence of hypoparathyroidism in various countries. Some of these ... ...

    Abstract Until recently, very few studies have described the epidemiology of this rare disorder. Several large population-based studies have recently been published describing the prevalence and incidence of hypoparathyroidism in various countries. Some of these studies have described the epidemiology of both postsurgical and nonsurgical hypoparathyroidism. In addition, a number of studies have now been published describing the prevalence of complications of this disorder. This article summarizes the published medical literature regarding the prevalence and incidence of this disorder, and the risk of known complications of hypoparathyroidism.
    MeSH term(s) Humans ; Hypoparathyroidism/complications ; Hypoparathyroidism/epidemiology ; Hypoparathyroidism/mortality ; Incidence ; Prevalence
    Language English
    Publishing date 2018-10-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2018.07.004
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  8. Article ; Online: Asymptomatic Primary Hyperparathyroidism.

    Clarke, Bart L

    Frontiers of hormone research

    2018  Volume 51, Page(s) 13–22

    Abstract: Asymptomatic primary hyperparathyroidism has become the most common presentation of primary hyperparathyroidism in Europe and North America, and an increasingly common presentation in other parts of the world. As many as 25% of asymptomatic patients may ... ...

    Abstract Asymptomatic primary hyperparathyroidism has become the most common presentation of primary hyperparathyroidism in Europe and North America, and an increasingly common presentation in other parts of the world. As many as 25% of asymptomatic patients may develop indications for parathyroidectomy when followed long-term for up to 15 years. Patients who remain asymptomatic should be monitored for the development of complications that justify surgery. Patients who become symptomatic should be referred for surgery. Surgery may improve quality of life even in patients who remain asymptomatic.
    MeSH term(s) Humans ; Hyperparathyroidism, Primary/diagnosis ; Hyperparathyroidism, Primary/epidemiology ; Hyperparathyroidism, Primary/therapy
    Language English
    Publishing date 2018-11-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-3762 ; 0301-3073
    ISSN (online) 1662-3762
    ISSN 0301-3073
    DOI 10.1159/000491035
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  9. Article ; Online: Normocalcemic Primary Hyperparathyroidism: Need for a Standardized Clinical Approach.

    Zavatta, Guido / Clarke, Bart L

    Endocrinology and metabolism (Seoul, Korea)

    2021  Volume 36, Issue 3, Page(s) 525–535

    Abstract: Since normocalcemic primary hyperparathyroidism (NHPT) was first defined at the Third International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism in 2008, many papers have been published describing its prevalence and possible ... ...

    Abstract Since normocalcemic primary hyperparathyroidism (NHPT) was first defined at the Third International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism in 2008, many papers have been published describing its prevalence and possible complications. Guidelines for the management of this condition are still lacking, and making the diagnosis requires fulfillment of strict criteria. Recent studies have shown that intermittent oscillations of serum calcium just below and slightly above the normal limits are very frequent, therefore challenging the assumption that serum calcium must be consistently normal to make the diagnosis. There is debate if these variations in serum calcium outside the normal range should be included under the rubric of NHPT or, rather, a milder form of classical primary hyperparathyroidism. Innovative approaches to define NHPT have been proposed that still need to be validated in prospective studies. Non-classical complications, especially cardiovascular complications, have been associated with NHPT, indicating that hyperparathyroidism may be a cardiovascular risk factor. New associations between parathyroid hormone (PTH) and several other comorbidities have also been reported from observational studies, suggesting that excessive PTH secretion might cause tissue dysfunction independent of serum calcium. Heterogeneous studies using different definitions of NHPT, however, make it difficult to draw definitive conclusions regarding the role of PTH excess when complications other than osteoporosis or kidney stones are described. This review will focus on clinical aspects and suggest an approach to NHPT.
    MeSH term(s) Calcium ; Humans ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/diagnosis ; Osteoporosis ; Parathyroid Hormone ; Prospective Studies
    Chemical Substances Parathyroid Hormone ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-06-01
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2802452-7
    ISSN 2093-5978 ; 2093-5978
    ISSN (online) 2093-5978
    ISSN 2093-5978
    DOI 10.3803/EnM.2021.1061
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  10. Article ; Online: A bridge too far? Attempting to bridge the treatment gap in osteoporosis.

    Clarke, Bart L / Shoback, Dolores M

    Endocrine

    2020  Volume 69, Issue 2, Page(s) 241–243

    MeSH term(s) Absorptiometry, Photon ; Bone Density ; Humans ; Osteoporosis/drug therapy ; Osteoporotic Fractures/prevention & control ; Risk Assessment
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-020-02346-w
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