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  1. Book: Severe myoclonic epilepsy - Dravet syndrome

    Guerrini, Renzo

    thirty years later

    (Epilepsia ; 52, Suppl. 2)

    2011  

    Author's details guest ed.: Renzo Guerrini
    Series title Epilepsia ; 52, Suppl. 2
    Collection
    Language English
    Size 104 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Malden, MA
    Publishing country United States
    Document type Book
    HBZ-ID HT016809844
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 517 -52,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  2. Book: The causes of epilepsy

    Shorvon, S. D. / Guerrini, Renzo / Schachter, Steven C. / Trinka, Eugen

    common and uncommon causes in adults and children

    2019  

    Author's details edited by Simon Shorvon, Renzo Guerrini, Steven Schachter, Eugen Trinka
    Keywords Epilepsy/Etiology
    Subject code 616.853
    Language English
    Size xxii, 989 Seiten, Illustrationen, 29 cm
    Edition Second edition
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Previous edition: 2011
    HBZ-ID HT020135161
    ISBN 978-1-108-42075-4 ; 1-108-42075-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 1235 available for loan (reading room) Lesesaal EG

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  3. Book: Epilepsy and movement disorders

    Guerrini, Renzo

    2002  

    Author's details ed. by Renzo Guerrini
    Keywords Epilepsy ; Movement Disorders ; Epilepsie ; Bewegungsstörung
    Subject Motorische Störung ; Bewegungsschwäche ; Fallsucht
    Language English
    Size XXVII, 557 S. : Ill., graph. Darst.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013230628
    ISBN 0-521-77110-2 ; 978-0-521-77110-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 306 order for loan Magazin

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  4. Article ; Online: Epilepsy of infancy with migrating focal seizures or rigidity and multifocal seizure syndrome, lethal neonatal? Different emphases on a severe phenotype.

    Guerrini, Renzo

    Developmental medicine and child neurology

    2019  Volume 62, Issue 9, Page(s) 1012

    MeSH term(s) Brain Diseases ; Epilepsy ; Humans ; Infant ; Infant, Newborn ; Nuclear Proteins ; Phenotype ; Seizures
    Chemical Substances BRAT1 protein, human ; Nuclear Proteins
    Language English
    Publishing date 2019-12-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.14445
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 5: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Book: Dravet syndrome

    Dravet, Charlotte / Guerrini, Renzo

    (Topics in epilepsy ; 3)

    2011  

    Author's details authors Charlotte Dravet ; Renzo Guerrini
    Series title Topics in epilepsy ; 3
    Collection
    Keywords Epilepsies, Myoclonic / therapy ; Epilepsies, Myoclonic / genetics ; Seizures, Febrile ; Infant ; Child
    Language English
    Size VII, 119 S. : Ill., graph. Darst.
    Publisher Libbey Eurotext
    Publishing place Montrouge
    Publishing country France
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT017167117
    ISBN 978-2-7420-0737-0 ; 2-7420-0737-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 2129 order for loan Magazin

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  6. Article ; Online: SLC32A1

    Guerrini, Renzo / Marini, Carla

    Neurology

    2021  Volume 96, Issue 18, Page(s) 831–832

    MeSH term(s) Epilepsy/genetics ; Epilepsy, Generalized/genetics ; Humans ; Seizures, Febrile
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.153: Show issues Location:
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    Zs.MG 18: Show issues
    Zs.MO 374: Show issues

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  7. Article ; Online: Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first-line add-on therapies for seizures in Dravet syndrome: A network meta-analysis.

    Guerrini, Renzo / Chiron, Catherine / Vandame, Delphine / Linley, Warren / Toward, Toby

    Epilepsia open

    2024  Volume 9, Issue 2, Page(s) 689–703

    Abstract: Objectives: Stiripentol, fenfluramine, and cannabidiol are licensed add-on therapies to treat seizures in Dravet Syndrome (DS). There are no direct or indirect comparisons assessing their full licensed dose regimens, across different jurisdictions, as ... ...

    Abstract Objectives: Stiripentol, fenfluramine, and cannabidiol are licensed add-on therapies to treat seizures in Dravet Syndrome (DS). There are no direct or indirect comparisons assessing their full licensed dose regimens, across different jurisdictions, as first-line add-on therapies in DS.
    Methods: We conducted a systematic review and frequentist network meta-analysis (NMA) of randomized controlled trial (RCT) data for licensed add-on DS therapies. We compared the proportions of patients experiencing: reductions from baseline in monthly convulsive seizure frequency (MCSF) of ≥50% (clinically meaningful), ≥75% (profound), and 100% (seizure-free); serious adverse events (SAEs); discontinuations due to AEs.
    Results: We identified relevant data from two placebo-controlled RCTs for each drug. Stiripentol 50 mg/kg/day and fenfluramine 0.7 mg/kg/day had similar efficacy in achieving ≥50% (clinically meaningful) and ≥75% (profound) reductions from baseline in MCSF (absolute risk difference [RD] for stiripentol versus fenfluramine 1% [95% confidence interval: -20% to 22%; p = 0.93] and 6% [-15% to 27%; p = 0.59], respectively), and both were statistically superior (p < 0.05) to licensed dose regimens of cannabidiol (10 or 20 mg/kg/day, with/irrespective of clobazam) for these outcomes. Stiripentol was statistically superior in achieving seizure-free intervals compared to fenfluramine (RD = 26% [CI: 8% to 44%; p < 0.01]) and licensed dose regimens of cannabidiol. There were no significant differences in the proportions of patients experiencing SAEs. The risk of discontinuations due to AEs was lower for stiripentol, although the stiripentol trials were shorter.
    Significance: This NMA of RCT data indicates stiripentol, as a first-line add-on therapy in DS, is at least as effective as fenfluramine and both are more effective than cannabidiol in reducing convulsive seizures. No significant difference in the incidence of SAEs between the three add-on agents was observed, but stiripentol may have a lower risk of discontinuations due to AEs. These results may inform clinical decision-making and the continued development of guidelines for the treatment of people with DS.
    Plain language summary: This study compared three drugs (stiripentol, fenfluramine, and cannabidiol) used alongside other medications for managing seizures in a severe type of epilepsy called DS. The study found that stiripentol and fenfluramine were similarly effective in reducing seizures and both were more effective than cannabidiol. Stiripentol was the best drug for stopping seizures completely based on the available clinical trial data. All three drugs had similar rates of serious side effects, but stiripentol had a lower chance of being stopped due to side effects. This information can help guide treatment choices for people with DS.
    MeSH term(s) Humans ; Cannabidiol/therapeutic use ; Anticonvulsants/therapeutic use ; Fenfluramine/therapeutic use ; Network Meta-Analysis ; Seizures/drug therapy ; Seizures/etiology ; Epilepsies, Myoclonic/drug therapy ; Randomized Controlled Trials as Topic ; Dioxolanes
    Chemical Substances Cannabidiol (19GBJ60SN5) ; stiripentol (R02XOT8V8I) ; Anticonvulsants ; Fenfluramine (2DS058H2CF) ; Dioxolanes
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Focal cortical dysplasia: a practical guide for neurologists.

    Balestrini, Simona / Barba, Carmen / Thom, Maria / Guerrini, Renzo

    Practical neurology

    2023  Volume 23, Issue 4, Page(s) 293–302

    Abstract: Focal cortical dysplasia (FCD) is a malformation of cortical development characterised by disruption of cortical cytoarchitecture. Classification of FCDs subtypes has initially been based on correlation of the histopathology with relevant clinical, ... ...

    Abstract Focal cortical dysplasia (FCD) is a malformation of cortical development characterised by disruption of cortical cytoarchitecture. Classification of FCDs subtypes has initially been based on correlation of the histopathology with relevant clinical, electroencephalographic and neuroimaging features. A recently proposed classification update recommends a multilayered, genotype-phenotype approach, integrating findings from histopathology, genetic analysis of resected tissue and presurgical MRI. FCDs are caused either by single somatic activating mutations in MTOR pathway genes or by double-hit inactivating mutations with a constitutional and a somatic loss-of-function mutation in repressors of the signalling pathway. Mild malformation with oligodendroglial hyperplasia in epilepsy is caused by somatic pathogenic
    MeSH term(s) Humans ; Malformations of Cortical Development/diagnostic imaging ; Malformations of Cortical Development/genetics ; Malformations of Cortical Development/therapy ; Focal Cortical Dysplasia ; Neurologists ; Epilepsy/pathology ; Mutation ; Drug Resistant Epilepsy
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/pn-2022-003404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6001: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Book: Progress in epileptic spasms and West syndrome

    Guzzetta, Franco / Dalla Bernadina, Bernardo / Guerrini, Renzo

    (Progress in epileptic disorders ; 4)

    2007  

    Author's details Franco Guzzetta ; Bernardo Dalla Bernadina ; Renzo Guerrini
    Series title Progress in epileptic disorders ; 4
    Collection
    Keywords Spasms, Infantile / diagnosis ; Spasms, Infantile / therapy
    Language English
    Size 173 S. : Ill., graph. Darst.
    Publisher Libbey Eurotext
    Publishing place Montrouge
    Publishing country France
    Document type Book
    HBZ-ID HT015544036
    ISBN 978-2-74-200655-7 ; 2-74-200655-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 5089 order for loan Magazin

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  10. Article ; Online: Breaking up genetic influences on seizure onset, spread, and termination.

    Guerrini, Renzo / Meador, Kimford J

    Neurology

    2020  Volume 95, Issue 15, Page(s) 667–668

    MeSH term(s) Epilepsies, Partial ; Humans ; Seizures/genetics ; Status Epilepticus
    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000010760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.153: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 374: Show issues

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