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Article ; Online: Glucagon-secretion inhibition using somatostatin: An old hormone for the treatment of diabetes-associated pancreatectomy.

Riveline, J-P / Boudou, P / Blondeau, B / Gautier, J-F

2017 Volume 43, Issue 3, Page(s) 269–271

Language	English
Publishing date	2017-06
Publishing country	France
Document type	Letter
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2016.08.002
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Zs.A 1267: Show issues

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Article ; Online: Interest of a hospital-based geriatric living lab among inpatients with neurocognitive disorders: the ALLEGRIA cross-sectional study.

Noublanche, Frédéric / Ben-Sadoun, Grégory / Carcreff, Lena / Gautier, Jennifer / Allain, Philippe / Annweiler, Cédric

Dementia and geriatric cognitive disorders

2024

Abstract: Introduction: The objectives of this study were to determine the participation rates, levels of engagement and abilities to answer User eXperience (UX) questionnaires according to the presence and severity of major neurocognitive disorders (MNCD) among ... ...

Abstract	Introduction: The objectives of this study were to determine the participation rates, levels of engagement and abilities to answer User eXperience (UX) questionnaires according to the presence and severity of major neurocognitive disorders (MNCD) among participants involved in gerontechnological experimentations within a hospital-based geriatric clinical living lab. Methods: Cross-sectional analysis examining all consecutive geriatric patients involved in the Allegro living lab experimentations, separated according to the presence and severity of MNCD. Participation rates were assessed using the "Task-Based Experiment"-type User eXperience (TBE-UX). Participation was considered successful if patients fully completed the TBE-UX experimental procedure. Engagement level was characterized using a five-point scale: Interactive, Constructive, Active, Passive and Disengaged. The abilities to answer UX questionnaires were characterized using a five-point scale from "no completion" to "completion in autonomy". Results: 313 patients were included. All patients without MNCD and with mild MNCD fully completed the TBE-UX procedures. Their engagement behaviors were rather active and constructive. All patients without MNCD and 88% of those with mild MNCD were able to fully complete the UX questionnaires. 96.2% of the patients with moderate MNCD fully followed the TBE-UX procedures. Their engagement behaviors were mainly active or passive. 64.2% were able to fully complete the UX questionnaires. 76.5% of the patients with severe MNCD fully followed the TBE-UX procedures. Their engagement behaviors were mainly passive or disengaged. 35.3% were able to fully complete the UX questionnaires. Discussion/conclusion: Living lab experimentations appear feasible with older adults, even with those with MNCD. Task support can be offered to those with severe MNCD.
Language	English
Publishing date	2024-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1026007-9
ISSN	1421-9824 ; 1013-7424
ISSN (online)	1421-9824
ISSN	1013-7424
DOI	10.1159/000538144
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Zs.A 2866: Show issues

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Article ; Online: Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance.

Gautier-Stein, Amandine / Vily-Petit, Justine / Rajas, Fabienne / Mithieux, Gilles

Biochimie

2023

Abstract: At the interface between the outside world and the self, the intestine is the first organ receiving nutritional information. One intestinal function, gluconeogenesis, is activated by various nutrients, particularly diets enriched in fiber or protein, and ...

Abstract	At the interface between the outside world and the self, the intestine is the first organ receiving nutritional information. One intestinal function, gluconeogenesis, is activated by various nutrients, particularly diets enriched in fiber or protein, and thus results in glucose production in the portal vein in the post-absorptive period. The detection of portal glucose induces a nervous signal controlling the activity of the central nuclei involved in the regulation of metabolism and emotional behavior. Induction of intestinal gluconeogenesis is necessary for the beneficial effects of fiber or protein-enriched diets on metabolism and emotional behavior. Through its ability to translate nutritional information from the diet to the brain's regulatory centers, intestinal gluconeogenesis plays an essential role in maintaining physiological balance.
Language	English
Publishing date	2023-11-30
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2023.11.012
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Uc I Zs.135: Show issues

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Article ; Online: Towards individualised and optimalised positioning of non-ventilated COVID-19 patients: Putting the affected parts of the lung(s) on top?

Froelich, S / Mandonnet, E / Julla, J-B / Touchard, C / Laloi-Michelin, M / Kevorkian, J-P / Gautier, J-F

Diabetes & metabolism

2020 Volume 47, Issue 2, Page(s) 101167

Abstract: The outbreak of COVID-19 led to an unprecedented inflow of hospitalised patients with severe acute respiratory syndrome (SARS), requiring high-flow non-invasive oxygenation, if not invasive mechanical ventilation. While the best option in terms of non- ... ...

Abstract	The outbreak of COVID-19 led to an unprecedented inflow of hospitalised patients with severe acute respiratory syndrome (SARS), requiring high-flow non-invasive oxygenation, if not invasive mechanical ventilation. While the best option in terms of non-invasive systems of oxygen delivery is still a matter of debate, it also remains unclear as to whether or not the optimal in-bed positioning of patients might also help to improve their oxygen saturation levels. On the basis of three representative cases, it is possible to propose the following hypotheses: (i) how patients are positioned has a strong influence on their oxygen saturation levels; (ii) saturation-optimalised positions are patient-specific; (iii) prone positions require ergonomic devices; and (iv) saturation-optimalised positions should aim to place the most affected part(s) of the lung(s) on top. Considered together, these hypotheses have led us to recommend that COVID-19 patients should undergo a specific assessment at admission to determine their saturation-optimalised in-bed position. However, further studies are still needed to assess the benefits of such a strategy on clinical outcomes.
MeSH term(s)	Aged ; COVID-19/diagnostic imaging ; COVID-19/therapy ; Female ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Postural Balance ; Prone Position ; Respiration, Artificial ; SARS-CoV-2 ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-05-28
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2020.05.009
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Article ; Online: Immunomodulatory and/or immunosuppressive drugs should not be stopped prior to skin tests for the assessment of drug allergy.

Dezoteux, F / El Mesbahi, S / Tedbirt, B / Grosjean, J / Gautier, S / Lannoy, D / Nassar, C / Tétart, F / Staumont-Sallé, D

The British journal of dermatology

2022 Volume 186, Issue 4, Page(s) 742–744

MeSH term(s)	Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/etiology ; Humans ; Immunosuppressive Agents/adverse effects ; Skin Tests
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2022-01-23
Publishing country	England
Document type	Letter
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.20901
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Article ; Online: Efficacy of saxagliptin as an add-on to oral monotherapy in the phase 3 clinical development program: predictive factors of the treatment response in type 2 diabetes.

Gautier, J-F / Sauvanet, J-P

Annales d'endocrinologie

2011 Volume 72, Issue 4, Page(s) 287–295

Abstract: Saxagliptin, a dipeptidyl peptidase-4 inhibitor, has been the focus of a large clinical development programme, including Phase 3 randomized vs placebo-controlled clinical trials as add-on therapy in patients with type 2 diabetes (T2D) with inadequate ... ...

Abstract	Saxagliptin, a dipeptidyl peptidase-4 inhibitor, has been the focus of a large clinical development programme, including Phase 3 randomized vs placebo-controlled clinical trials as add-on therapy in patients with type 2 diabetes (T2D) with inadequate glycemic control using initial monotherapy (metformin, glibenclamide, thiazolidinedione). This clinical programme has shown saxagliptin to be effective in the control of fasting and postprandial glycemic parameters, in addition to a good overall safety profile. The present paper aims at reviewing the overall short-term and long-term efficacy of saxagliptin in its Phase 3 development program and tries to pinpoint some factors that may be more predictive of treatment response in clinical practice. In individual and pooled analyses of the three pivotal add-on to monotherapy trials, saxagliptin (5mg once daily) led to significant reductions in HbA(1c) from baseline to 24 weeks. Additional analyses showed that reductions in HbA(1c) were maintained in the long-term, notably for 102 weeks, in combination with metformin. Data have also shown that the absolute reduction in HbA(1c) seen with saxagliptine from baseline to Week 24 was numerically greater with an elevated baseline HbA(1c). In these recently published pooled analyses, clinically pertinent reductions in HbA(1c) were also obtained with saxagliptin across a wide range of subgroups of T2D patients when examined either by specific baseline demographic characteristics or by β-cell function indices such as the HOMA-β.
MeSH term(s)	Adamantane/administration & dosage ; Adamantane/analogs & derivatives ; Adamantane/therapeutic use ; Blood Glucose/analysis ; Clinical Trials, Phase III as Topic ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptides/administration & dosage ; Dipeptides/therapeutic use ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Drug Therapy, Combination ; Fasting ; Food ; Glycated Hemoglobin A/analysis ; Humans ; Hypoglycemic Agents/administration & dosage ; Randomized Controlled Trials as Topic
Chemical Substances	Blood Glucose ; Dipeptides ; Dipeptidyl-Peptidase IV Inhibitors ; Glycated Hemoglobin A ; Hypoglycemic Agents ; saxagliptin (9GB927LAJW) ; Adamantane (PJY633525U)
Language	English
Publishing date	2011-09
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	299-9
ISSN	2213-3941 ; 0003-4266
ISSN (online)	2213-3941
ISSN	0003-4266
DOI	10.1016/j.ando.2011.05.005
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Uh III Zs.132: Show issues

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Article ; Online: Bursting with Potential: How Sensorimotor Beta Bursts Develop from Infancy to Adulthood.

Rayson, Holly / Szul, Maciej J / El-Khoueiry, Perla / Debnath, Ranjan / Gautier-Martins, Marine / Ferrari, Pier F / Fox, Nathan / Bonaiuto, James J

The Journal of neuroscience : the official journal of the Society for Neuroscience

2023 Volume 43, Issue 49, Page(s) 8487–8503

Abstract: Beta activity is thought to play a critical role in sensorimotor processes. However, little is known about how activity in this frequency band develops. Here, we investigated the developmental trajectory of sensorimotor beta activity from infancy to ... ...

Abstract	Beta activity is thought to play a critical role in sensorimotor processes. However, little is known about how activity in this frequency band develops. Here, we investigated the developmental trajectory of sensorimotor beta activity from infancy to adulthood. We recorded EEG from 9-month-old, 12-month-old, and adult humans (male and female) while they observed and executed grasping movements. We analyzed "beta burst" activity using a novel method that combines time-frequency decomposition and principal component analysis. We then examined the changes in burst rate and waveform motifs along the selected principal components. Our results reveal systematic changes in beta activity during action execution across development. We found a decrease in beta burst rate during movement execution in all age groups, with the greatest decrease observed in adults. Additionally, we identified three principal components that defined waveform motifs that systematically changed throughout the trial. We found that bursts with waveform shapes closer to the median waveform were not rate-modulated, whereas those with waveform shapes further from the median were differentially rate-modulated. Interestingly, the decrease in the rate of certain burst motifs occurred earlier during movement and was more lateralized in adults than in infants, suggesting that the rate modulation of specific types of beta bursts becomes increasingly refined with age.
MeSH term(s)	Adult ; Infant ; Humans ; Male ; Female ; Movement ; Brain Injuries ; Sensation ; Beta Rhythm
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.0886-23.2023
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Article ; Online: COVID-19 symptoms masking inaugural ketoacidosis of type 1 diabetes.

Potier, L / Julla, J B / Roussel, R / Boudou, P / Gauthier, D C / Ketfi, C / Gautier, J F

Diabetes & metabolism

2020 Volume 47, Issue 1, Page(s) 101162

MeSH term(s)	Adult ; COVID-19/complications ; COVID-19/diagnosis ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetic Ketoacidosis/complications ; Diabetic Ketoacidosis/diagnosis ; Humans ; Male
Keywords	covid19
Language	English
Publishing date	2020-05-21
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2020.05.004
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Article ; Online: Oxidative and energetic stresses mediate beta-cell dysfunction induced by PGC-1α.

Besseiche, A / Riveline, J-P / Delavallée, L / Foufelle, F / Gautier, J-F / Blondeau, B

Diabetes & metabolism

2017 Volume 44, Issue 1, Page(s) 45–54

Abstract: Aim: Alteration of functional beta-cell mass in adults can be programmed by adverse events during fetal life. Previously, it was demonstrated that high glucocorticoid (GC) levels during fetal life participate in this programming by inhibition of beta- ... ...

Abstract	Aim: Alteration of functional beta-cell mass in adults can be programmed by adverse events during fetal life. Previously, it was demonstrated that high glucocorticoid (GC) levels during fetal life participate in this programming by inhibition of beta-cell development. More specifically, GC levels stimulate expression of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α), a transcriptional co-regulator of the GC receptor (GR), which per se impairs beta-cell mass and function when overexpressed. As PGC-1α is also a potent inducer of mitochondrial biogenesis, our study aimed to determine how PGC-1α modifies mitochondrial function in beta cells and how it might regulate insulin secretion. Methods: Beta-cell function was studied in mice overexpressing PGC-1α specifically in beta cells and in MIN6 cells overexpressing PGC-1α in vitro. Results: PGC-1α overexpression in beta cells in vivo leads to a reduced beta-cell mass early in fetal life, whereas PGC-1α overexpression in vitro stimulates mitochondrial biogenesis and respiratory activity without improving ATP production, while increasing oxidative stress and impairing insulin secretion in response to glucose. While oxidative stress with PGC-1α overexpression in beta cells activates AMPK, it has also been revealed that blocking such oxidative stress or AMPK activation restores insulin secretion. Conclusion: PGC-1α induces oxidative stress, which disrupts insulin secretion by AMPK activation. Thus, control of oxidative or energetic stress in beta cells may help to restore insulin secretion.
MeSH term(s)	Animals ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Mice ; Mice, Transgenic ; Oxidative Stress/genetics ; Oxygen Consumption/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
Chemical Substances	Insulin ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Ppargc1a protein, mouse
Language	English
Publishing date	2017-03-01
Publishing country	France
Document type	Journal Article
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2017.01.007
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Article ; Online: Tailoring coordination environments of single-atom electrocatalysts for hydrogen evolution by topological heteroatom transfer.

Qian, Sheng / Xu, Feng / Fan, Yu / Cheng, Ningyan / Xue, Huaiguo / Yuan, Ye / Gautier, Romain / Jiang, Tengfei / Tian, Jingqi

Nature communications

2024 Volume 15, Issue 1, Page(s) 2774

Abstract: The rational design of carbon-supported transition-metal single-atom catalysts requires the precise arrangement of heteroatoms within the single-atom catalysts. However, achieving this design is challenging due to the collapse of the structure during the ...

Abstract	The rational design of carbon-supported transition-metal single-atom catalysts requires the precise arrangement of heteroatoms within the single-atom catalysts. However, achieving this design is challenging due to the collapse of the structure during the pyrolysis. Here, we introduce a topological heteroatom-transfer strategy to prevent the collapse and accurately control the P coordination in carbon-supported single-atom catalysts. As an illustration, we have prepared self-assembled helical fibers with encapsulated cavities. Within these cavities, adjustable functional groups can chelate metal ions (N
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47061-6
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