LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 16

Search options

  1. Article ; Online: Synthesis, spectroscopic analysis, and computational-based investigations on 'azo-coumarin-Co(II)-galangin' hybrids exhibit multipotential activities.

    Swain, Shasank Sekhar / Sahoo, Alaka / Singh, Satya Ranjan / Sahoo, Jyotirmaya / Paidesetty, Sudhir Kumar

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–12

    Abstract: The present study synthesized a series of cobalt (II) metal ion frame hybrid candidates ( ...

    Abstract The present study synthesized a series of cobalt (II) metal ion frame hybrid candidates (
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2326666
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Editorial: Drug-ability strategies for potential antimycobacterial candidate: opportunities and challenges.

    Swain, Shasank Sekhar / Oyedemi, Sunday / Paidesetty, Sudhir Kumar / Mohanty, Soumitra / Hussain, Tahziba

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1294912

    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1294912
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Nanotheranostics: A Cutting-Edge Technology for Cancer Management.

    Dash, Shwetapadma / Swain, Shasank Sekhar / Khuntia, Auromira / Dutta, Sneha / Sahoo, Sanjeeb Kumar

    Current pharmaceutical biotechnology

    2024  

    Abstract: Cancer is the second-leading cause of death in the 21st century, where early detection and appropriate therapeutic interventions are two components essential for effective cancer management. Despite the availability of several conventional diagnostics ... ...

    Abstract Cancer is the second-leading cause of death in the 21st century, where early detection and appropriate therapeutic interventions are two components essential for effective cancer management. Despite the availability of several conventional diagnostics and therapeutic agents, cancer mortality rates are rising due to an increase in the frequency of recurrence and metastasis in cancer patients. Therefore, tremendous efforts have been expended to address this significant clinical issue and improve therapeutic efficacy. In this regard, nanotheranostic is a multipotential single platform for both cancer diagnosis and treatment through enhanced aqueous solubility and bioavailability of the encapsulated agent, stimulus responsiveness, tumor-specific targeting ability, precise tumor imaging, and real-time drug delivery. Nonetheless, the translational success of nanotheranostic platforms is still in its infancy and requires more extensive research in the context of tumor heterogeneity, safety profile, and regulatory issues, which pose one of the largest technological limitations. The present review summarizes different nanotheranostic platforms and nanotheranostic candidates in clinical trials (AGuIX® , NBTXR3, Ferumoxtran, MM-398, EndoTAG-1, etc.), along with disadvantages and challenges to improving cancer diagnosis and treatment. Overall, the concept, platform, and technical knowledge of nanotheranostics are really helpful to academic and pharmaceutical researchers.
    Language English
    Publishing date 2024-03-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/0113892010285567240222072959
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Andrographolide induces anti-SARS-CoV-2 response through host-directed mechanism: an

    Das, Bhabani Shankar / Das, Nabarun Chandra / Swain, Shasank Sekhar / Mukherjee, Suprabhat / Bhattacharya, Debapriya

    Future virology

    2022  

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2022-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254606-6
    ISSN 1746-0808 ; 1746-0794
    ISSN (online) 1746-0808
    ISSN 1746-0794
    DOI 10.2217/fvl-2021-0171
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Editorial

    Shasank Sekhar Swain / Sunday Oyedemi / Sudhir Kumar Paidesetty / Soumitra Mohanty / Tahziba Hussain

    Frontiers in Pharmacology, Vol

    Drug-ability strategies for potential antimycobacterial candidate: opportunities and challenges

    2023  Volume 14

    Keywords anti-TB drug development ; drug development strategies against tuberculosis ; natural product-based drug discovery ; bioinformatics tools ; medicinal chemistry and drug synthesis ; Therapeutics. Pharmacology ; RM1-950
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Phytochemical-Based Nanomedicine for Targeting Tumor Microenvironment and Inhibiting Cancer Chemoresistance: Recent Advances and Pharmacological Insights.

    Sa, Pratikshya / Mohapatra, Priyanka / Swain, Shasank Sekhar / Khuntia, Auromira / Sahoo, Sanjeeb Kumar

    Molecular pharmaceutics

    2023  Volume 20, Issue 11, Page(s) 5254–5277

    Abstract: Cancer remains the leading cause of death and rapidly evolving disease worldwide. The understanding of disease pathophysiology has improved through advanced research investigation, and several therapeutic strategies are being used for better cancer ... ...

    Abstract Cancer remains the leading cause of death and rapidly evolving disease worldwide. The understanding of disease pathophysiology has improved through advanced research investigation, and several therapeutic strategies are being used for better cancer treatment. However, the increase in cancer relapse and metastatic-related deaths indicate that available therapies and clinically approved chemotherapy drugs are not sufficient to combat cancer. Further, the constant crosstalk between tumor cells and the tumor microenvironment (TME) is crucial for the development, progression, metastasis, and therapeutic response to tumors. In this regard, phytochemicals with multimodal targeting abilities can be used as an alternative to current cancer therapy by inhibiting cancer survival pathways or modulating TME. However, due to their poor pharmacokinetics and low bioavailability, the success of phytochemicals in clinical trials is limited. Therefore, developing phytochemical-based nanomedicine or phytonanomedicine can improve the pharmacokinetic profile of these phytochemicals. Herein, the molecular characteristics and pharmacological insights of the proposed phytonanomedicine in cancer therapy targeting tumor tissue and altering the characteristics of cancer stem cells, chemoresistance, TME, and cancer immunity are well discussed. Further, we have highlighted the clinical perspective and challenges of phytonanomedicine in filling the gap in potential cancer therapeutics using various nanoplatforms. Overall, we have discussed how clinical success and pharmacological insights could make it more beneficial to boost the concept of nanomedicine in the academic and pharmaceutical fields to counter cancer metastases and drug resistance.
    MeSH term(s) Humans ; Nanomedicine ; Drug Resistance, Neoplasm ; Tumor Microenvironment ; Neoplasms/pathology ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use
    Chemical Substances Phytochemicals
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c00286
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Phytochemicals against SARS-CoV as potential drug leads

    Shasank Sekhar Swain / Sujogya Kumar Panda / Walter Luyten

    Biomedical Journal, Vol 44, Iss 1, Pp 74-

    2021  Volume 85

    Abstract: The newly emerged SARS-CoV-2 strains from the coronavirus (CoV) family is causing one of the most disruptive pandemics of the past century. Developing antiviral drugs is a challenge for the scientific community and pharmaceutical industry. Given the ... ...

    Abstract The newly emerged SARS-CoV-2 strains from the coronavirus (CoV) family is causing one of the most disruptive pandemics of the past century. Developing antiviral drugs is a challenge for the scientific community and pharmaceutical industry. Given the health emergency, repurposing of existing antiviral, antiinflammatory or antimalarial drugs is an attractive option for controlling SARS-CoV-2 with drugs. However, phytochemicals selected based on ethnomedicinal information as well as in vitro antiviral studies could be promising as well. Here, we summarise the phytochemicals with reported anti-CoV activity, and further analyzed them computationally to accelerate validation for drug development against SARS-CoV-2. This systematic review started from the most potent phytocompounds (IC50 in μM) against SARS-CoV, followed by a cluster analysis to locate the most suitable lead(s). The advanced molecular docking used the crystallography structure of SARS-CoV-2-cysteine-like protease (SARS-CoV-2-3CLpro) as a target. In total, seventy-eight phytochemicals with anti-CoV activity against different strains in cellular assays, were selected for this computational study, and compared with two existing repurposed FDA-approved drugs: lopinavir and ritonavir. This review brings insights in the potential application of phytochemicals and their derivatives, which could guide researchers to develop safe drugs against SARS-CoV-2.
    Keywords Coronavirus ; Herbal medicine ; MERS ; Molecular docking ; SARS-CoV-2 ; Natural products ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 500
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Bentonite-in hypromellose-poloxamer sol-gel for corneal application of trimetazidine: Study of rheology and ocular anti inflammatory potential.

    Swain, Rakesh / Nandi, Souvik / Swain, Shasank Sekhar / Pattanaik, Krushna Prasad / Mohapatra, Sujata / Panigrahi, Dhananjay / Mallick, Subrata

    International journal of biological macromolecules

    2023  Volume 242, Issue Pt 1, Page(s) 124628

    Abstract: Bentonite is reported to be used for extending ocular drug delivery safely in a controlled manner. Bentonite combined hydroxypropyl methylcellulose (HPMC)-poloxamer based sol-to-gel formulation has been developed for the prophylactic ocular anti- ... ...

    Abstract Bentonite is reported to be used for extending ocular drug delivery safely in a controlled manner. Bentonite combined hydroxypropyl methylcellulose (HPMC)-poloxamer based sol-to-gel formulation has been developed for the prophylactic ocular anti-inflammatory effect of trimetazidine after corneal application. HPMC-poloxamer sol formulation was prepared incorporating trimetazidine to bentonite at 1: 2*10
    MeSH term(s) Animals ; Rabbits ; Poloxamer ; Hypromellose Derivatives ; Trimetazidine/pharmacology ; Bentonite ; Carrageenan ; Gels ; Drug Delivery Systems/methods ; Anti-Inflammatory Agents ; Cornea/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Rheology
    Chemical Substances Poloxamer (106392-12-5) ; Hypromellose Derivatives (3NXW29V3WO) ; Trimetazidine (N9A0A0R9S8) ; Bentonite (1302-78-9) ; Carrageenan (9000-07-1) ; Gels ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-04-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.124628
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: The anticandidal activity of the diterpenediol 8(14),15-sandaracopimaradiene-7alpha,18-diol from Tetradenia riparia against the emerging pathogen Candida auris.

    Panda, Sujogya Kumar / Khan, Ajmal / Swain, Shasank Sekhar / Aissa, Abdallah / Mukazayire, Marie Jeanne / Van Puyvelde, Luc / Luyten, Walter

    Phytotherapy research : PTR

    2022  Volume 37, Issue 1, Page(s) 3–6

    MeSH term(s) Candida auris ; Plant Extracts ; Lamiaceae ; Antifungal Agents/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Plant Extracts ; Antifungal Agents
    Language English
    Publishing date 2022-10-05
    Publishing country England
    Document type Letter
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7638
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 3092: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Phytochemicals against SARS-CoV as potential drug leads.

    Swain, Shasank Sekhar / Panda, Sujogya Kumar / Luyten, Walter

    Biomedical journal

    2020  Volume 44, Issue 1, Page(s) 74–85

    Abstract: The newly emerged SARS-CoV-2 strains from the coronavirus (CoV) family is causing one of the most disruptive pandemics of the past century. Developing antiviral drugs is a challenge for the scientific community and pharmaceutical industry. Given the ... ...

    Abstract The newly emerged SARS-CoV-2 strains from the coronavirus (CoV) family is causing one of the most disruptive pandemics of the past century. Developing antiviral drugs is a challenge for the scientific community and pharmaceutical industry. Given the health emergency, repurposing of existing antiviral, antiinflammatory or antimalarial drugs is an attractive option for controlling SARS-CoV-2 with drugs. However, phytochemicals selected based on ethnomedicinal information as well as in vitro antiviral studies could be promising as well. Here, we summarise the phytochemicals with reported anti-CoV activity, and further analyzed them computationally to accelerate validation for drug development against SARS-CoV-2. This systematic review started from the most potent phytocompounds (IC
    MeSH term(s) COVID-19/drug therapy ; Chymases/antagonists & inhibitors ; Chymases/chemistry ; Drug Repositioning ; Humans ; Molecular Docking Simulation ; Phytochemicals/chemistry ; Phytochemicals/therapeutic use ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology
    Chemical Substances Phytochemicals ; Chymases (EC 3.4.21.39)
    Language English
    Publishing date 2020-12-10
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2020.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top