LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 182

Search options

  1. Article ; Online: Phytotherapeutics and SARS-CoV-2 infection: Potential role of bioflavonoids.

    Coppola, Maurizio / Mondola, Raffaella

    Medical hypotheses

    2020  Volume 140, Page(s) 109766

    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109766
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Potential Unconventional Medicines for the Treatment of SARS-CoV-2.

    Coppola, Maurizio / Mondola, Raffaella

    Drug research

    2020  Volume 70, Issue 6, Page(s) 286

    MeSH term(s) Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Drug Repositioning/methods ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country Germany
    Document type Letter
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-1170-4624
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Potential pharmacological perspectives for the treatment/prevention of the SARS-COV-2 infection in opioid dependent patients.

    Coppola, Maurizio / Mondola, Raffaella

    Journal of opioid management

    2020  Volume 16, Issue 3, Page(s) 165–166

    MeSH term(s) Analgesics, Opioid ; Betacoronavirus ; Coronavirus Infections/drug therapy ; Coronavirus Infections/prevention & control ; Humans ; Opioid-Related Disorders ; Pandemics/prevention & control ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/prevention & control
    Chemical Substances Analgesics, Opioid
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Letter
    ZDB-ID 2397614-7
    ISSN 1551-7489
    ISSN 1551-7489
    DOI 10.5055/jom.2020.0564
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Opioid receptor antagonists and major depressive disorder: Current knowledge and future perspectives.

    Coppola, Maurizio / Mondola, Raffaella

    Medical hypotheses

    2020  Volume 144, Page(s) 110215

    MeSH term(s) Analgesics, Opioid/therapeutic use ; Depressive Disorder, Major/drug therapy ; Humans ; Narcotic Antagonists/therapeutic use ; Receptors, Opioid, kappa ; Receptors, Opioid, mu/therapeutic use
    Chemical Substances Analgesics, Opioid ; Narcotic Antagonists ; Receptors, Opioid, kappa ; Receptors, Opioid, mu
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110215
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective?

    Coppola, Maurizio / Bevione, Francesco / Mondola, Raffaella

    Journal of xenobiotics

    2022  Volume 12, Issue 1, Page(s) 41–52

    Abstract: Psychedelics extracted from plants have been used in religious, spiritual, and mystic practices for millennia. In 1957, Dr. Hofmann identified and synthesized the prodrug psilocybin, a substance present in more than 200 species of psychedelic mushrooms. ... ...

    Abstract Psychedelics extracted from plants have been used in religious, spiritual, and mystic practices for millennia. In 1957, Dr. Hofmann identified and synthesized the prodrug psilocybin, a substance present in more than 200 species of psychedelic mushrooms. Although there were limitations related to the scientific design of many studies, clinical observations performed during the 1950s and 1960s showed a potential therapeutic effect of psilocybin for patients affected by depressive symptoms, anxiety, and conversion disorder. Psilocybin was classed as a schedule I substance in 1970, but the fascination with psychedelics has remained almost unchanged over time, promoting a new scientific interest starting in the 1990s. Recent studies have provided further evidence supporting the suggestive hypothesis of the therapeutic use of psilocybin for treating various psychiatric disorders, including pathological anxiety, mood depressive disorder, and addiction.
    Language English
    Publishing date 2022-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649720-7
    ISSN 2039-4713 ; 2039-4713
    ISSN (online) 2039-4713
    ISSN 2039-4713
    DOI 10.3390/jox12010004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Cannabidiol exerts multitarget immunomodulatory effects on PBMCs from individuals with psoriasis vulgaris.

    Pagano, Cristina / Ciaglia, Elena / Coppola, Laura / Lopardo, Valentina / Raimondo, Annunziata / Giuseppe, Monfrecola / Lembo, Serena / Laezza, Chiara / Bifulco, Maurizio

    Frontiers in immunology

    2024  Volume 15, Page(s) 1373435

    Abstract: Introduction: The involvement of endocannabinoid system (ECS) in the inflammatory cascade, and the ability of phytocannabinoids, endocannabinoids and their synthetic analogues to modulate it has become an interesting research area for new therapeutic ... ...

    Abstract Introduction: The involvement of endocannabinoid system (ECS) in the inflammatory cascade, and the ability of phytocannabinoids, endocannabinoids and their synthetic analogues to modulate it has become an interesting research area for new therapeutic approaches in inflammatory skin diseases. Cannabidiol (CBD) appears to be the most promising among phytocannabinoids, due to the lack of psychotropic effects and low toxicity profile. Its anti-inflammatory action has been highlighted in different preclinical models, ranging from experimental colitis to arthritis and neuroinflammation. Our aim was to evaluate CBD immune-modulatory effects in peripheral blood mononuclear cells (PBMC) of psoriasis individuals with particular attention to both innate and adaptative immune arms.
    Methods: We performed
    Results: The results showed that CBD produced a shift from Th1 to Th2 response, while boosting cytotoxic activity of Natural Killer (NK) cells. Furthermore, it also exerted a potent action on monocyte differentiation as, after CBD treatment, monocytes from psoriatic individuals were unable to migrate in response to inflammatory stimuli and to fully differentiate into mature dendritic cells. Finally, a M2 skewing of monocyte-derived macrophages by CBD also contributed to the fine tuning of the magnitude of immune responses.
    Conclusions: These data uncover new potential immunomodulatory properties of this cannabinoid suggesting a possible therapeutic action in the treatment of multiple inflammatory skin diseases.
    MeSH term(s) Humans ; Cannabidiol/pharmacology ; Cannabidiol/therapeutic use ; Leukocytes, Mononuclear ; Cannabinoids ; Psoriasis/drug therapy ; Endocannabinoids
    Chemical Substances Cannabidiol (19GBJ60SN5) ; Cannabinoids ; Endocannabinoids
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1373435
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: [No title information]

    Coppola, Maurizio / Mondola, Raffaella

    Drug Research

    2020  Volume 70, Issue 06, Page(s) 286–286

    Keywords antiviral drugs ; pharmacology ; drug research
    Language English
    Publishing date 2020-05-19
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-1170-4624
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Cannabinoids in the Modulation of Oxidative Signaling.

    Pagano, Cristina / Savarese, Beatrice / Coppola, Laura / Navarra, Giovanna / Avilia, Giorgio / Laezza, Chiara / Bifulco, Maurizio

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Cannabis sativa-derived compounds, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), and components of the endocannabinoids system, such as N-arachidonoylethanolamide (anandamide, AEA) and 2-arachidonoylglycerol (2-AG), are extensively ... ...

    Abstract Cannabis sativa-derived compounds, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), and components of the endocannabinoids system, such as N-arachidonoylethanolamide (anandamide, AEA) and 2-arachidonoylglycerol (2-AG), are extensively studied to investigate their numerous biological effects, including powerful antioxidant effects. Indeed, a series of recent studies have indicated that many disorders are characterized by alterations in the intracellular antioxidant system, which lead to biological macromolecule damage. These pathological conditions are characterized by an unbalanced, and most often increased, reactive oxygen species (ROS) production. For this study, it was of interest to investigate and recapitulate the antioxidant properties of these natural compounds, for the most part CBD and THC, on the production of ROS and the modulation of the intracellular redox state, with an emphasis on their use in various pathological conditions in which the reduction of ROS can be clinically useful, such as neurodegenerative disorders, inflammatory conditions, autoimmunity, and cancers. The further development of ROS-based fundamental research focused on cannabis sativa-derived compounds could be beneficial for future clinical applications.
    MeSH term(s) Cannabinoids/pharmacology ; Antioxidants ; Reactive Oxygen Species ; Cannabidiol/pharmacology ; Cannabis ; Oxidation-Reduction ; Oxidative Stress ; Dronabinol
    Chemical Substances Cannabinoids ; Antioxidants ; Reactive Oxygen Species ; Cannabidiol (19GBJ60SN5) ; anandamide (UR5G69TJKH) ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032513
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top