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  1. Article: [4. Magnetic Resonance Imaging of Gynecological Emergency Disease 4-2. MRI Examination of Gynecological Emergent Conditions: A Spectrum of Diseases & Their Clinical Significance].

    Umeoka, Shigeaki

    Nihon Hoshasen Gijutsu Gakkai zasshi

    2018  Volume 74, Issue 8, Page(s) 825–833

    MeSH term(s) Female ; Genital Neoplasms, Female/diagnostic imaging ; Humans ; Magnetic Resonance Imaging
    Language Japanese
    Publishing date 2018-08-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2269092-X
    ISSN 1881-4883 ; 0369-4305
    ISSN (online) 1881-4883
    ISSN 0369-4305
    DOI 10.6009/jjrt.2018_JSRT_74.8.825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 18F-FDG PET/CT Findings of G-CSF-Producing Gallbladder Cancer.

    Sasaki, Fumi / Nakamoto, Ryusuke / Tokunaga, Koji / Ishida, Ayami / Umeoka, Shigeaki

    Clinical nuclear medicine

    2022  Volume 47, Issue 4, Page(s) e368–e369

    Abstract: Abstract: We report a case of granulocyte colony-stimulating factor (G-CSF)-producing gallbladder cancer in a 64-year-old man. Contrast-enhanced CT showed an exophytic hypoattenuation mass with peripheral enhancement in the gallbladder. 18F-FDG PET/CT ... ...

    Abstract Abstract: We report a case of granulocyte colony-stimulating factor (G-CSF)-producing gallbladder cancer in a 64-year-old man. Contrast-enhanced CT showed an exophytic hypoattenuation mass with peripheral enhancement in the gallbladder. 18F-FDG PET/CT showed avid FDG uptake in the gallbladder mass and diffuse FDG uptake in the bone marrow. The patient was diagnosed with G-CSF-producing gallbladder cancer based on an elevated serum level of G-CSF and histological findings. G-CSF-producing tumors are associated with a poor prognosis because of rapid progression. Early and accurate diagnosis of G-CSF-producing tumors based on characteristic PET/CT findings is important to determine treatment strategies and improve prognosis of patients.
    MeSH term(s) Fluorodeoxyglucose F18 ; Gallbladder Neoplasms/diagnostic imaging ; Gallbladder Neoplasms/pathology ; Granulocyte Colony-Stimulating Factor ; Humans ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Invasive solid papillary carcinoma with neuroendocrine differentiation of the breast: a case report and literature review.

    Lin, Xue / Matsumoto, Yoshiaki / Nakakimura, Tomomi / Ono, Kazuo / Umeoka, Shigeaki / Torii, Masae / Yoshibayashi, Hiroshi / Toi, Masakazu

    Surgical case reports

    2020  Volume 6, Issue 1, Page(s) 143

    Abstract: Background: Solid papillary carcinoma (SPC) of the breast is a rare breast cancer that accounts for less than 1% of all breast cancers. The optimal clinical management of SPC remains controversial. Here, we report a case of invasive SPC with ... ...

    Abstract Background: Solid papillary carcinoma (SPC) of the breast is a rare breast cancer that accounts for less than 1% of all breast cancers. The optimal clinical management of SPC remains controversial. Here, we report a case of invasive SPC with neuroendocrine differentiation in addition to review of the current literature.
    Case presentation: A premenopausal 46-year-old female presented with a mass in her left breast that tended to increase in size over a 10-month period. Mammography and ultrasonography revealed a mass in the left upper-inner quadrant. The resulting images suggested a category 3 breast tumor according to the Breast Imaging Reporting and Data System (BI-RADS). A core needle biopsy (CNB) was performed, and the pathological findings showed a solid papillary pattern and atypical cells suggestive of noninvasive SPC. After a left partial mastectomy and sentinel lymph node biopsy (SLNB), the specimens were sent for histopathological analysis for further investigation. Postoperative pathological findings suggested invasive SPC. Whole-breast radiation therapy and adjuvant hormonal therapy were performed as postoperative treatments. Three years after surgery, multiple lung metastases were detected, and the patient was treated with a gonadotropin-releasing hormone agonist and an aromatase inhibitor. Five months later, multiple liver metastases and bone metastases appeared, and oral 5-fluorouracil was chosen for the subsequent treatment. The patient has been treated for 5 years to date, and she is continuing to take oral 5-fluorouracil and is alive without any further disease progression.
    Conclusions: We report a rare case of premenopausal invasive SPC with multiple metastases. Further study is needed to clarify the molecular characteristics and clinical behaviors of SPC and to explore the optimal treatment strategy.
    Language English
    Publishing date 2020-06-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2809613-7
    ISSN 2198-7793
    ISSN 2198-7793
    DOI 10.1186/s40792-020-00905-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Differentiation of uterine low-grade endometrial stromal sarcoma from rare leiomyoma variants by magnetic resonance imaging.

    Himoto, Yuki / Kido, Aki / Sakata, Akihiko / Moribata, Yusaku / Kurata, Yasuhisa / Suzuki, Ayako / Matsumura, Noriomi / Shitano, Fuki / Kawahara, Seiya / Kubo, Shigeto / Umeoka, Shigeaki / Minamiguchi, Sachiko / Mandai, Masaki

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 19124

    Abstract: The purpose of this study is to evaluate utility of MRI in differentiation of uterine low-grade endometrial stromal sarcoma (LGESS) from rare leiomyoma variants. This multi-center retrospective study included consecutive 25 patients with uterine LGESS ... ...

    Abstract The purpose of this study is to evaluate utility of MRI in differentiation of uterine low-grade endometrial stromal sarcoma (LGESS) from rare leiomyoma variants. This multi-center retrospective study included consecutive 25 patients with uterine LGESS and 42 patients with rare leiomyoma variants who had pretreatment MRI. Two radiologists (R1/R2) independently evaluated MRI features, which were analyzed statistically using Fisher's exact test or Student's t-test. Subsequently, using a five-point Likert scale, the two radiologists evaluated the diagnostic performance of a pre-defined MRI system using features reported as characteristics of LGESS in previous case series: uterine tumor with high signal intensity (SI) on diffusion-weighted images and with either worm-like nodular extension, intra-tumoral low SI bands, or low SI rim on T2-weighted images. Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of the two readers' Likert scales were analyzed. Intra-tumoral low SI bands (p < 0.001), cystic/necrotic change (p ≤ 0.02), absence of speckled appearance (p < 0.001) on T2-weighted images, and a low apparent diffusion coefficient value (p ≤ 0.02) were significantly associated with LGESS. The pre-defined MRI system showed very good diagnostic performance: AUC 0.86/0.89, sensitivity 0.95/0.95, and specificity 0.67/0.69 for R1/R2. MRI can be useful to differentiate uterine LGESS from rare leiomyoma variants.
    MeSH term(s) Adult ; Aged ; Diagnosis, Differential ; Diffusion Magnetic Resonance Imaging ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/pathology ; Endometrium/diagnostic imaging ; Endometrium/pathology ; Feasibility Studies ; Female ; Humans ; Leiomyoma/diagnosis ; Leiomyoma/pathology ; Middle Aged ; ROC Curve ; Retrospective Studies ; Sarcoma, Endometrial Stromal/diagnosis ; Sarcoma, Endometrial Stromal/pathology ; Young Adult
    Language English
    Publishing date 2021-09-27
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-98473-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Differentiation of uterine low-grade endometrial stromal sarcoma from rare leiomyoma variants by magnetic resonance imaging

    Yuki Himoto / Aki Kido / Akihiko Sakata / Yusaku Moribata / Yasuhisa Kurata / Ayako Suzuki / Noriomi Matsumura / Fuki Shitano / Seiya Kawahara / Shigeto Kubo / Shigeaki Umeoka / Sachiko Minamiguchi / Masaki Mandai

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 9

    Abstract: Abstract The purpose of this study is to evaluate utility of MRI in differentiation of uterine low-grade endometrial stromal sarcoma (LGESS) from rare leiomyoma variants. This multi-center retrospective study included consecutive 25 patients with uterine ...

    Abstract Abstract The purpose of this study is to evaluate utility of MRI in differentiation of uterine low-grade endometrial stromal sarcoma (LGESS) from rare leiomyoma variants. This multi-center retrospective study included consecutive 25 patients with uterine LGESS and 42 patients with rare leiomyoma variants who had pretreatment MRI. Two radiologists (R1/R2) independently evaluated MRI features, which were analyzed statistically using Fisher’s exact test or Student's t-test. Subsequently, using a five-point Likert scale, the two radiologists evaluated the diagnostic performance of a pre-defined MRI system using features reported as characteristics of LGESS in previous case series: uterine tumor with high signal intensity (SI) on diffusion-weighted images and with either worm-like nodular extension, intra-tumoral low SI bands, or low SI rim on T2-weighted images. Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of the two readers’ Likert scales were analyzed. Intra-tumoral low SI bands (p < 0.001), cystic/necrotic change (p ≤ 0.02), absence of speckled appearance (p < 0.001) on T2-weighted images, and a low apparent diffusion coefficient value (p ≤ 0.02) were significantly associated with LGESS. The pre-defined MRI system showed very good diagnostic performance: AUC 0.86/0.89, sensitivity 0.95/0.95, and specificity 0.67/0.69 for R1/R2. MRI can be useful to differentiate uterine LGESS from rare leiomyoma variants.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Diagnostic performance of chest CT to differentiate COVID-19 pneumonia in non-high-epidemic area in Japan.

    Himoto, Yuki / Sakata, Akihiko / Kirita, Mitsuhiro / Hiroi, Takashi / Kobayashi, Ken-Ichiro / Kubo, Kenji / Kim, Hyunjin / Nishimoto, Azusa / Maeda, Chikara / Kawamura, Akira / Komiya, Nobuhiro / Umeoka, Shigeaki

    Japanese journal of radiology

    2020  Volume 38, Issue 5, Page(s) 400–406

    Abstract: Purpose: To evaluate the diagnostic performance of chest CT to differentiate coronavirus disease 2019 (COVID-19) pneumonia in non-high-epidemic area in Japan.: Materials and methods: This retrospective study included 21 patients clinically suspected ... ...

    Abstract Purpose: To evaluate the diagnostic performance of chest CT to differentiate coronavirus disease 2019 (COVID-19) pneumonia in non-high-epidemic area in Japan.
    Materials and methods: This retrospective study included 21 patients clinically suspected COVID-19 pneumonia and underwent chest CT more than 3 days after the symptom onset: six patients confirmed COVID-19 pneumonia by real-time reverse-transcription polymerase chain reaction (RT-PCR) and 15 patients proved uninfected. Using a Likert scale and its receiver operating characteristic curve analysis, two radiologists (R1/R2) evaluated the diagnostic performance of the five CT criteria: (1) ground glass opacity (GGO)-predominant lesions, (2) GGO- and peripheral-predominant lesions, (3) bilateral GGO-predominant lesions; (4) bilateral GGO- and peripheral-predominant lesions, and (5) bilateral GGO- and peripheral-predominant lesions without nodules, airway abnormalities, pleural effusion, and mediastinal lymphadenopathy.
    Results: All patients confirmed COVID-19 pneumonia had bilateral GGO- and peripheral-predominant lesions without airway abnormalities, mediastinal lymphadenopathy, and pleural effusion. The five CT criteria showed moderate to excellent diagnostic performance with area under the curves (AUCs) ranging 0.77-0.88 for R1 and 0.78-0.92 for R2. The criterion (e) showed the highest AUC.
    Conclusion: Chest CT would play a supplemental role to differentiate COVID-19 pneumonia from other respiratory diseases presenting with similar symptoms in a clinical setting.
    MeSH term(s) Adult ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Diagnosis, Differential ; Female ; Humans ; Japan/epidemiology ; Lymphadenopathy/diagnostic imaging ; Lymphadenopathy/virology ; Male ; Middle Aged ; Pandemics ; Pleural Effusion/diagnostic imaging ; Pleural Effusion/virology ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction/methods ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods
    Keywords covid19
    Language English
    Publishing date 2020-03-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-020-00958-w
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  7. Article ; Online: Placental blood flow disappears coincident with a fall in human chorionic gonadotropin to undetectable levels in conservative management of placenta accreta.

    Imai, Saeko / Kondoh, Eiji / Kawasaki, Kaoru / Mogami, Haruta / Ueda, Akihiko / Umeoka, Shigeaki / Konishi, Ikuo

    European journal of obstetrics, gynecology, and reproductive biology

    2014  Volume 180, Page(s) 199–201

    MeSH term(s) Adult ; Cesarean Section ; Chorionic Gonadotropin/blood ; Cohort Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Placenta/blood supply ; Placenta/diagnostic imaging ; Placenta Accreta/blood ; Placenta Accreta/diagnostic imaging ; Placenta Accreta/pathology ; Postpartum Period ; Pregnancy ; Remission, Spontaneous ; Ultrasonography, Doppler, Color ; Watchful Waiting
    Chemical Substances Chorionic Gonadotropin
    Language English
    Publishing date 2014-09
    Publishing country Ireland
    Document type Letter ; Observational Study
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2014.05.020
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  8. Article ; Online: Assessment of treatment response after lung stereotactic body radiotherapy using diffusion weighted magnetic resonance imaging and positron emission tomography: A pilot study.

    Shintani, Takashi / Matsuo, Yukinori / Iizuka, Yusuke / Mitsuyoshi, Takamasa / Umeoka, Shigeaki / Nakamoto, Yuji / Mizowaki, Takashi / Togashi, Kaori / Hiraoka, Masahiro

    European journal of radiology

    2017  Volume 92, Page(s) 58–63

    Abstract: Background and purpose: There is no early predictor of treatment response after lung stereotactic body radiotherapy (SBRT). We conducted this pilot study to evaluate whether serial diffusion weighted magnetic resonance imaging (DW-MRI) or positron ... ...

    Abstract Background and purpose: There is no early predictor of treatment response after lung stereotactic body radiotherapy (SBRT). We conducted this pilot study to evaluate whether serial diffusion weighted magnetic resonance imaging (DW-MRI) or positron emission tomography (PET) could predict response after SBRT.
    Material and methods: Early stage non-small cell lung cancer patients who received SBRT were eligible. DW-MRI and PET were undertaken pretreatment and every 3 months after SBRT in the first year. Patients with <1year of follow-up were excluded from the analysis. The apparent diffusion coefficient (ADC) value and maximum standardized uptake value (SUV
    Results: Fifteen patients were enrolled and the data of 14 patients were analyzed. The median ADC value was significantly lower in patients with LR (n=3) than in those without LR (n=11) at 3 and 6 months (1.11 vs. 1.54 and 0.98 vs. 1.69 [×10
    Conclusions: DW-MRI could be an early predictor of treatment response after lung SBRT.
    Language English
    Publishing date 2017-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2017.04.022
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  9. Article ; Online: Diagnostic performance of chest CT to differentiate COVID-19 pneumonia in non-high-epidemic area in Japan

    Himoto, Yuki / Sakata, Akihiko / Kirita, Mitsuhiro / Hiroi, Takashi / Kobayashi, Ken-ichiro / Kubo, Kenji / Kim, Hyunjin / Nishimoto, Azusa / Maeda, Chikara / Kawamura, Akira / Komiya, Nobuhiro / Umeoka, Shigeaki

    Japanese Journal of Radiology

    2020  Volume 38, Issue 5, Page(s) 400–406

    Keywords Radiology Nuclear Medicine and imaging ; covid19
    Language English
    Publisher Island Press
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2488907-6
    ISSN 1867-1071
    ISSN 1867-1071
    DOI 10.1007/s11604-020-00958-w
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Predictive value of radiological response rate for pathological response to neoadjuvant chemotherapy and post-cystectomy survival of bladder urothelial cancer.

    Fukui, Tomohiro / Matsui, Yoshiyuki / Umeoka, Shigeaki / Inoue, Takahiro / Kamba, Tomomi / Togashi, Kaori / Ogawa, Osamu / Kobayashi, Takashi

    Japanese journal of clinical oncology

    2016  Volume 46, Issue 6, Page(s) 560–567

    Abstract: Objective: To determine the predictive value of the radiological response rate assessed by serial pelvic computed tomography scans for pathological response to neoadjuvant chemotherapy and clinical outcomes after radical cystectomy in bladder urothelial ...

    Abstract Objective: To determine the predictive value of the radiological response rate assessed by serial pelvic computed tomography scans for pathological response to neoadjuvant chemotherapy and clinical outcomes after radical cystectomy in bladder urothelial cancer patients.
    Methods: We retrospectively reviewed 59 patients with muscle-invasive bladder cancer who underwent radical cystectomy following neoadjuvant chemotherapy. Pretreatment and post-neoadjuvant chemotherapy computed tomography scans were evaluated by a single radiologist to determine the radiological response rate based on the largest diameter of the primary tumor. Association of the radiological response rate with pathological findings of the radical cystectomy specimen and post-radical cystectomy clinical outcomes were assessed.
    Results: The pathological complete response rate was 25% (n = 15) and the median (range) radiological response rate was 0.58 (0.00-1.00). The radiological response rate was significantly associated with ≤pT1. Patients with pathological downstaging to ≤pTa/is or pT1, compared with those with pT2≤ tumor, had significantly better post-radical cystectomy recurrence-free survival (2-year survival 92.0, 88.9, 36.8%, respectively, P < 0.0001), disease-specific survival (2-year survival 95.8, 88.9, 47.3%, respectively, P < 0.0001) and overall survival (2-year survival 91.7, 88.9, 40.1%, respectively, P < 0.0001). Patients with a higher radiological response rate (≥0.57) had significantly better post-radical cystectomy recurrence-free survival (2-year survival 89.7 vs. 48.1%, P = 0.0011), disease-specific survival (2-year survival 93.2 vs. 48.2%, P < 0.0001) and overall survival (2-year survival 90.0 vs. 39.0%, P < 0.0001). Multivariate analyses using the Cox proportional hazard model revealed that the radiological response rate was an independent predictor for favorable pT stage and recurrence-free survival.
    Conclusion: The radiological response rate determined by pretreatment and post-chemotherapy computed tomography scans predicts the pathological outcome and post-radical cystectomy prognosis, which is clinically relevant and useful for patient counselling and decision-making.
    Language English
    Publishing date 2016-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hyw025
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