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  1. Article ; Online: Nuclear Abnormalities in

    Wilke, Matheus V M B / Wick, Myra / Schwab, Tanya L / Starosta, Rodrigo Tzovenos / Clark, Karl J / Connolly, Heidi M / Klee, Eric W

    Genes

    2024  Volume 15, Issue 1

    Abstract: ... ...

    Abstract The
    MeSH term(s) Female ; Humans ; Adult ; Progeria/genetics ; Lamin Type A/genetics ; Cardiomyopathies ; Cardiomyopathy, Dilated/genetics ; Cell Line ; Intermediate Filament Proteins
    Chemical Substances Lamin Type A ; Intermediate Filament Proteins ; LMNA protein, human
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15010112
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  2. Article ; Online: Correction: E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer.

    Russo, Gabriella C / Crawford, Ashleigh J / Clark, David / Cui, Julie / Carney, Ryan / Karl, Michelle N / Su, Boyang / Starich, Bartholomew / Lih, Tung-Shing / Kamat, Pratik / Zhang, Qiming / Nair, Praful R / Wu, Pei-Hsun / Lee, Meng-Horng / Leong, Hon S / Zhang, Hui / Rebecca, Vito W / Wirtz, Denis

    Oncogene

    2024  

    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-024-03023-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2218: Show issues Location:
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  3. Article ; Online: Ovarian stimulation with excessive FSH doses causes cumulus cell and oocyte dysfunction in small ovarian reserve heifers.

    Karl, Kaitlin R / Schall, Peter Z / Clark, Zaramasina L / Ruebel, Meghan L / Cibelli, Jose / Tempelman, Robert J / Latham, Keith E / Ireland, James J

    Molecular human reproduction

    2023  Volume 29, Issue 10

    Abstract: Excessive FSH doses during ovarian stimulation in the small ovarian reserve heifer (SORH) cause premature cumulus expansion and follicular hyperstimulation dysgenesis (FHD) in nearly all ovulatory-size follicles with predicted disruptions in cell- ... ...

    Abstract Excessive FSH doses during ovarian stimulation in the small ovarian reserve heifer (SORH) cause premature cumulus expansion and follicular hyperstimulation dysgenesis (FHD) in nearly all ovulatory-size follicles with predicted disruptions in cell-signaling pathways in cumulus cells and oocytes (before ovulatory hCG stimulation). These observations support the hypothesis that excessive FSH dysregulates cumulus cell function and oocyte maturation. To test this hypothesis, we determined whether excessive FSH-induced differentially expressed genes (DEGs) in cumulus cells identified in our previously published transcriptome analysis were altered independent of extreme phenotypic differences observed amongst ovulatory-size follicles, and assessed predicted roles of these DEGs in cumulus and oocyte biology. We also determined if excessive FSH alters cumulus cell morphology, and oocyte nuclear maturation before (premature) or after an ovulatory hCG stimulus or during IVM. Excessive FSH doses increased expression of 17 cumulus DEGs with known roles in cumulus cell and oocyte functions (responsiveness to gonadotrophins, survival, expansion, and oocyte maturation). Excessive FSH also induced premature cumulus expansion and oocyte maturation but inhibited cumulus expansion and oocyte maturation post-hCG and diminished the ability of oocytes with prematurely expanded cumulus cells to undergo IVF or nuclear maturation during IVM. Ovarian stimulation with excessive FSH is concluded to disrupt cumulus cell and oocyte functions by inducing premature cumulus expansion and dysregulating oocyte maturation without an ovulatory hCG stimulus yielding poor-quality cumulus-oocyte complexes that may be incorrectly judged morphologically as suitable for IVF during ART.
    MeSH term(s) Female ; Cattle ; Animals ; Cumulus Cells/metabolism ; Ovarian Reserve ; Meiosis ; Oocytes/metabolism ; Follicle Stimulating Hormone/pharmacology ; Follicle Stimulating Hormone/metabolism ; Ovulation Induction
    Chemical Substances Follicle Stimulating Hormone (9002-68-0)
    Language English
    Publishing date 2023-09-15
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1324348-2
    ISSN 1460-2407 ; 1360-9947
    ISSN (online) 1460-2407
    ISSN 1360-9947
    DOI 10.1093/molehr/gaad033
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4482: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Mitochondrial Base Editing: Recent Advances towards Therapeutic Opportunities.

    Kar, Bibekananda / Castillo, Santiago R / Sabharwal, Ankit / Clark, Karl J / Ekker, Stephen C

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Mitochondria are critical organelles that form networks within our cells, generate energy dynamically, contribute to diverse cell and organ function, and produce a variety of critical signaling molecules, such as cortisol. This intracellular microbiome ... ...

    Abstract Mitochondria are critical organelles that form networks within our cells, generate energy dynamically, contribute to diverse cell and organ function, and produce a variety of critical signaling molecules, such as cortisol. This intracellular microbiome can differ between cells, tissues, and organs. Mitochondria can change with disease, age, and in response to the environment. Single nucleotide variants in the circular genomes of human mitochondrial DNA are associated with many different life-threatening diseases. Mitochondrial DNA base editing tools have established novel disease models and represent a new possibility toward personalized gene therapies for the treatment of mtDNA-based disorders.
    MeSH term(s) Humans ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/therapy ; Gene Editing ; Mitochondria/genetics ; DNA, Mitochondrial/genetics ; Genetic Therapy
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065798
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  5. Article: Representation Wars: Enacting an Armistice Through Active Inference.

    Constant, Axel / Clark, Andy / Friston, Karl J

    Frontiers in psychology

    2021  Volume 11, Page(s) 598733

    Abstract: Over the last 30 years, representationalist and dynamicist positions in the philosophy of cognitive science have argued over whether neurocognitive processes should be viewed as representational or not. Major scientific and technological developments ... ...

    Abstract Over the last 30 years, representationalist and dynamicist positions in the philosophy of cognitive science have argued over whether neurocognitive processes should be viewed as representational or not. Major scientific and technological developments over the years have furnished both parties with ever more sophisticated conceptual weaponry. In recent years, an enactive generalization of predictive processing - known as active inference - has been proposed as a unifying theory of brain functions. Since then, active inference has fueled both representationalist and dynamicist campaigns. However, we believe that when diving into the formal details of active inference, one should be able to find a solution to the war; if not a peace treaty, surely an armistice of a sort. Based on an analysis of these formal details, this paper shows how both representationalist and dynamicist sensibilities can peacefully coexist within the new territory of active inference.
    Language English
    Publishing date 2021-01-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2020.598733
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  6. Article ; Online: Excessive follicle-stimulating hormone during ovarian stimulation of cattle may induce premature luteinization of most ovulatory-size follicles†.

    Clark, Zaramasina L / Karl, Kaitlin R / Ruebel, Meghan L / Latham, Keith E / Ireland, James J

    Biology of reproduction

    2022  Volume 106, Issue 5, Page(s) 968–978

    Abstract: High follicle-stimulating hormone (FSH) doses during ovarian stimulation are detrimental to ovulatory follicle function and decrease live birth rate in cattle and women. However, the mechanism whereby excessive FSH causes ovarian dysfunction is unknown. ... ...

    Abstract High follicle-stimulating hormone (FSH) doses during ovarian stimulation are detrimental to ovulatory follicle function and decrease live birth rate in cattle and women. However, the mechanism whereby excessive FSH causes ovarian dysfunction is unknown. This study tested the hypothesis that excessive FSH during ovarian stimulation induces premature luteinization of ovulatory-size follicles. Small ovarian reserve heifers were injected twice daily for 4 days with 70 IU (N = 7 heifers) or 210 IU (N = 6 heifers) Folltropin-V [commercial FSH-enriched preparation of porcine pituitary glands with minor (<1%) luteinizing hormone (LH) contamination, cpFSH]. Ovulatory-size (≥10 mm) follicles were excised from ovaries after the last cpFSH injection and hormone concentrations in follicular fluid (FF) were determined using ELISA. Luteinization was monitored by assessing cumulus cell-oocyte complex (COC) morphology and measuring concentrations of estradiol (E), progesterone (P), and oxytocin (O) in FF. COCs were classified as having compact (cCOC) or expanded (eCOC) cumulus cell layers, and as estrogen-active (E:P in FF ≥1), estrogen-inactive (EI, E:P in FF ≤1 > 0.1), or extreme-estrogen-inactive (EEI, E:P in FF ≤0.1). A high proportion (72%) of ovulatory-size follicles in 210 IU, but not 70 IU, dose heifers displayed eCOCs. The high doses also produced higher proportions of EI or EEI follicles which had lower E:P ratio and/or E but higher P and/or O concentrations compared with the 70 IU dose heifers. In conclusion, excessive cpFSH doses during ovarian stimulation may induce premature luteinization of most ovulatory-size follicles in heifers with small ovarian reserves.
    MeSH term(s) Animals ; Cattle ; Estradiol ; Estrogens ; Female ; Follicle Stimulating Hormone/pharmacology ; Luteinization ; Luteinizing Hormone/pharmacology ; Ovulation Induction/veterinary ; Progesterone
    Chemical Substances Estrogens ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1118-6
    ISSN 1529-7268 ; 0006-3363
    ISSN (online) 1529-7268
    ISSN 0006-3363
    DOI 10.1093/biolre/ioac021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 551: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Identification of Graphene Dispersion Agents through Molecular Fingerprints.

    Goldie, Stuart J / Degiacomi, Matteo T / Jiang, Shan / Clark, Stewart J / Erastova, Valentina / Coleman, Karl S

    ACS nano

    2022  Volume 16, Issue 10, Page(s) 16109–16117

    Abstract: The scalable production and dispersion of 2D materials, like graphene, is critical to enable their use in commercial applications. While liquid exfoliation is commonly used, solvents such ... ...

    Abstract The scalable production and dispersion of 2D materials, like graphene, is critical to enable their use in commercial applications. While liquid exfoliation is commonly used, solvents such as
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.2c04406
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  8. Article ; Online: Mitochondrial Base Editing

    Bibekananda Kar / Santiago R. Castillo / Ankit Sabharwal / Karl J. Clark / Stephen C. Ekker

    International Journal of Molecular Sciences, Vol 24, Iss 5798, p

    Recent Advances towards Therapeutic Opportunities

    2023  Volume 5798

    Abstract: Mitochondria are critical organelles that form networks within our cells, generate energy dynamically, contribute to diverse cell and organ function, and produce a variety of critical signaling molecules, such as cortisol. This intracellular microbiome ... ...

    Abstract Mitochondria are critical organelles that form networks within our cells, generate energy dynamically, contribute to diverse cell and organ function, and produce a variety of critical signaling molecules, such as cortisol. This intracellular microbiome can differ between cells, tissues, and organs. Mitochondria can change with disease, age, and in response to the environment. Single nucleotide variants in the circular genomes of human mitochondrial DNA are associated with many different life-threatening diseases. Mitochondrial DNA base editing tools have established novel disease models and represent a new possibility toward personalized gene therapies for the treatment of mtDNA-based disorders.
    Keywords mitochondria ; mitochondrial DNA ; heteroplasmy ; base editing ; DdCBE ; TALED ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Representation Wars

    Axel Constant / Andy Clark / Karl J. Friston

    Frontiers in Psychology, Vol

    Enacting an Armistice Through Active Inference

    2021  Volume 11

    Abstract: Over the last 30 years, representationalist and dynamicist positions in the philosophy of cognitive science have argued over whether neurocognitive processes should be viewed as representational or not. Major scientific and technological developments ... ...

    Abstract Over the last 30 years, representationalist and dynamicist positions in the philosophy of cognitive science have argued over whether neurocognitive processes should be viewed as representational or not. Major scientific and technological developments over the years have furnished both parties with ever more sophisticated conceptual weaponry. In recent years, an enactive generalization of predictive processing – known as active inference – has been proposed as a unifying theory of brain functions. Since then, active inference has fueled both representationalist and dynamicist campaigns. However, we believe that when diving into the formal details of active inference, one should be able to find a solution to the war; if not a peace treaty, surely an armistice of a sort. Based on an analysis of these formal details, this paper shows how both representationalist and dynamicist sensibilities can peacefully coexist within the new territory of active inference.
    Keywords philosophy of cognitive science ; free energy principle ; active inference ; embodiment ; representationalism ; Psychology ; BF1-990
    Subject code 120
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  10. Article ; Online: Controlled Optimism: Reply to Sun and Firestone on the Dark Room Problem.

    Van de Cruys, Sander / Friston, Karl J / Clark, Andy

    Trends in cognitive sciences

    2020  Volume 24, Issue 9, Page(s) 680–681

    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2010989-1
    ISSN 1879-307X ; 1364-6613
    ISSN (online) 1879-307X
    ISSN 1364-6613
    DOI 10.1016/j.tics.2020.05.012
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