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Article ; Online: HLA-G

Becerra-Loaiza, Denisse Stephania / Roldan Flores, Luisa Fernanda / Ochoa-Ramírez, Luis Antonio / Gutiérrez-Zepeda, Bricia M / Del Toro-Arreola, Alicia / Franco-Topete, Ramón Antonio / Morán-Mendoza, Andrés / Oceguera-Villanueva, Antonio / Topete, Antonio / Javalera, David / Quintero-Ramos, Antonio / Daneri-Navarro, Adrián

Current issues in molecular biology

2023 Volume 45, Issue 8, Page(s) 6842–6850

Abstract: HLA-G is a physiology and pathologic immunomodulator detrimentally related to cancer. Its gene is ...

Abstract	HLA-G is a physiology and pathologic immunomodulator detrimentally related to cancer. Its gene is heavily transcriptionally and post-transcriptionally regulated by variants located in regulator regions like 3'UTR, being the most studied Ins/Del of 14-bp (rs66554220), which is known to influence the effects of endogen cell factors; nevertheless, the reports are discrepant and controversial. Herein, the relationship of the 14-bp Ins/Del variant (rs66554220) with breast cancer (BC) and its clinical characteristics were analyzed in 182 women with non-familial BC and 221 disease-free women as a reference group. Both groups from western Mexico and sex-age-matched (sm-RG). The rs66554220 variant was amplified by SSP-PCR and the fragments were visualized in polyacrylamide gel electrophoresis. The variant rs66554220 was not associated with BC in our population. However, we suggest the Ins allele as a possible risk factor for developing BC at clinical stage IV (OR = 3.05, 95% CI = 1.16-7.96,
Language	English
Publishing date	2023-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb45080432
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Article ; Online: Urgent manifestations of immunoglobulin G

Della-Torre, E / Mancuso, G / Lanzillotta, M / Ramirez, G A / Arcidiacono, P G / Capurso, G / Falconi, M / Dagna, L

Scandinavian journal of rheumatology

2020 Volume 50, Issue 1, Page(s) 48–51

Abstract: ... ...

Abstract	Objective
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Delayed Diagnosis ; Emergency Medical Services/statistics & numerical data ; Emergency Service, Hospital/statistics & numerical data ; Female ; Humans ; Immunoglobulin G4-Related Disease/blood ; Immunoglobulin G4-Related Disease/diagnosis ; Immunoglobulin G4-Related Disease/epidemiology ; Italy/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2020-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	121265-5
ISSN	1502-7732 ; 0300-9742
ISSN (online)	1502-7732
ISSN	0300-9742
DOI	10.1080/03009742.2020.1771763
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Article ; Online: Deletion of the EP402R Gene from the Genome of African Swine Fever Vaccine Strain ASFV-G-∆I177L Provides the Potential Capability of Differentiating between Infected and Vaccinated Animals.

Borca, Manuel V / Ramirez-Medina, Elizabeth / Espinoza, Nallely / Rai, Ayushi / Spinard, Edward / Velazquez-Salinas, Lauro / Valladares, Alyssa / Silva, Ediane / Burton, Leeanna / Meyers, Amanda / Clark, Jason / Wu, Ping / Gay, Cyril G / Gladue, Douglas P

Viruses

2024 Volume 16, Issue 3

Abstract: The African swine fever virus (ASFV) mutant ASFV-G-∆I177L is a safe and efficacious vaccine ... with ASFV-G-∆I177L and those infected with wild-type viruses. In this report, we describe the development ... of the ASFV-G-∆I177L mutant having deleted the ...

Abstract	The African swine fever virus (ASFV) mutant ASFV-G-∆I177L is a safe and efficacious vaccine which induces protection against the challenge of its parental virus, the Georgia 2010 isolate. Although a genetic DIVA (differentiation between infected and vaccinated animals) assay has been developed for this vaccine, still there is not a serological DIVA test for differentiating between animals vaccinated with ASFV-G-∆I177L and those infected with wild-type viruses. In this report, we describe the development of the ASFV-G-∆I177L mutant having deleted the
MeSH term(s)	Swine ; Animals ; African Swine Fever Virus ; African Swine Fever ; Viral Vaccines/genetics ; Sus scrofa ; Virulence ; Vaccines, Synthetic/genetics ; Vaccines, Attenuated/genetics ; Recombinant Proteins/genetics ; Gene Deletion
Chemical Substances	Viral Vaccines ; Vaccines, Synthetic ; Vaccines, Attenuated ; Recombinant Proteins
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16030376
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Article: Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study).

Fountoulakis, Konstantinos N / Karakatsoulis, Grigorios N / Abraham, Seri / Adorjan, Kristina / Ahmed, Helal Uddin / Alarcón, Renato D / Arai, Kiyomi / Auwal, Sani Salihu / Berk, Michael / Bjedov, Sarah / Bobes, Julio / Bobes-Bascaran, Teresa / Bourgin-Duchesnay, Julie / Bredicean, Cristina Ana / Bukelskis, Laurynas / Burkadze, Akaki / Cabrera Abud, Indira Indiana / Castilla-Puentes, Ruby / Cetkovich, Marcelo /

Colon-Rivera, Hector / Corral, Ricardo / Cortez-Vergara, Carla / Crepin, Piirika / De Berardis, Domenico / Zamora Delgado, Sergio / Lucena, David De / Sousa, Avinash De / Stefano, Ramona Di / Dodd, Seetal / Priyanka Elek, Livia / Elissa, Anna / Erdelyi-Hamza, Berta / Erzin, Gamze / Etchevers, Martin J / Falkai, Peter / Farcas, Adriana / Fedotov, Ilya / Filatova, Viktoriia / Fountoulakis, Nikolaos K / Frankova, Iryna / Franza, Francesco / Frias, Pedro / Galako, Tatiana / Garay, Cristian J / Garcia-Álvarez, Leticia / García-Portilla, Maria Paz / Gonda, Xenia / Gondek, Tomasz M / Morera González, Daniela / Gould, Hilary / Grandinetti, Paolo / Grau, Arturo / Groudeva, Violeta / Hagin, Michal / Harada, Takayuki / Hasan, Tasdik M / Azreen Hashim, Nurul / Hilbig, Jan / Hossain, Sahadat / Iakimova, Rossitza / Ibrahim, Mona / Iftene, Felicia / Ignatenko, Yulia / Irarrazaval, Matias / Ismail, Zaliha / Ismayilova, Jamila / Jakobs, Asaf / Jakovljević, Miro / Jakšić, Nenad / Javed, Afzal / Kafali, Helin Yilmaz / Karia, Sagar / Kazakova, Olga / Khalifa, Doaa / Khaustova, Olena / Koh, Steve / Kopishinskaia, Svetlana / Kosenko, Korneliia / Koupidis, Sotirios A / Kovacs, Illes / Kulig, Barbara / Lalljee, Alisha / Liewig, Justine / Majid, Abdul / Malashonkova, Evgeniia / Malik, Khamelia / Malik, Najma Iqbal / Mammadzada, Gulay / Mandalia, Bilvesh / Marazziti, Donatella / Marčinko, Darko / Martinez, Stephanie / Matiekus, Eimantas / Mejia, Gabriela / Memon, Roha Saeed / Meza Martínez, Xarah Elenne / Mickevičiūtė, Dalia / Milev, Roumen / Mohammed, Muftau / Molina-López, Alejandro / Morozov, Petr / Muhammad, Nuru Suleiman / Mustač, Filip / Naor, Mika S / Nassieb, Amira / Navickas, Alvydas / Okasha, Tarek / Pandova, Milena / Panfil, Anca-Livia / Panteleeva, Liliya / Papava, Ion / Patsali, Mikaella E / Pavlichenko, Alexey / Pejuskovic, Bojana / Pinto Da Costa, Mariana / Popkov, Mikhail / Popovic, Dina / Raduan, Nor Jannah Nasution / Vargas Ramírez, Francisca / Rancans, Elmars / Razali, Salmi / Rebok, Federico / Rewekant, Anna / Ninoska Reyes Flores, Elena / Rivera-Encinas, María Teresa / Saiz, Pilar / Sánchez de Carmona, Manuel / Saucedo Martínez, David / Saw, Jo Anne / Saygili, Görkem / Schneidereit, Patricia / Shah, Bhumika / Shirasaka, Tomohiro / Silagadze, Ketevan / Sitanggang, Satti / Skugarevsky, Oleg / Spikina, Anna / Mahalingappa, Sridevi Sira / Stoyanova, Maria / Szczegielniak, Anna / Tamasan, Simona Claudia / Tavormina, Giuseppe / Tavormina, Maurilio Giuseppe Maria / Theodorakis, Pavlos N / Tohen, Mauricio / Tsapakis, Eva Maria / Tukhvatullina, Dina / Ullah, Irfan / Vaidya, Ratnaraj / Vega-Dienstmaier, Johann M / Vrublevska, Jelena / Vukovic, Olivera / Vysotska, Olga / Widiasih, Natalia / Yashikhina, Anna / Prezerakos, Panagiotis E / Smirnova, Daria

CNS spectrums

2024 Volume 29, Issue 2, Page(s) 126–149

Abstract: ... males; 1.11% nonbinary gender) from 40 countries (COMET-G study). The analysis was based ...

Abstract	Background: The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders. Methods: The sample included 54,826 subjects (64.73% females; 34.15% males; 1.11% nonbinary gender) from 40 countries (COMET-G study). The analysis was based on the registration of previous history that could serve as a fair approximation for the lifetime prevalence of various medical conditions. Results: About 24.5% reported a history of somatic and 26.14% of mental disorders. Mental disorders were by far the most prevalent group of medical conditions. Comorbidity of any somatic with any mental disorder was reported by 8.21%. One-third to almost two-thirds of somatic patients were also suffering from a mental disorder depending on the severity and multicomorbidity. Bipolar and psychotic patients and to a lesser extent depressives, manifested an earlier (15-20 years) manifestation of somatic multicomorbidity, severe disability, and probably earlier death. The overwhelming majority of patients with mental disorders were not receiving treatment or were being treated in a way that was not recommended. Antipsychotics and antidepressants were not related to the development of metabolic syndrome. Conclusions: The finding that one-third to almost two-thirds of somatic patients also suffered from a mental disorder strongly suggests that psychiatry is the field with the most trans-specialty and interdisciplinary value and application points to the importance of teaching psychiatry and mental health in medical schools and also to the need for more technocratically oriented training of psychiatric residents.
MeSH term(s)	Male ; Female ; Humans ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/drug therapy ; Mental Disorders/epidemiology ; Mental Disorders/drug therapy ; Antipsychotic Agents/therapeutic use ; Mental Health ; Comorbidity
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2008418-3
ISSN	2165-6509 ; 1092-8529
ISSN (online)	2165-6509
ISSN	1092-8529
DOI	10.1017/S1092852924000026
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Article ; Online: Non-binary gender, vulnerable populations and mental health during the COVID-19 pandemic: Data from the COVID-19 MEntal health inTernational for the general population (COMET-G) study.

Fountoulakis, Konstantinos N / Vrublevska, Jelena / Abraham, Seri / Adorjan, Kristina / Ahmed, Helal Uddin / Alarcón, Renato D / Arai, Kiyomi / Auwal, Sani Salihu / Berk, Michael / Bjedov, Sarah / Bobes, Julio / Bobes-Bascaran, Teresa / Bourgin-Duchesnay, Julie / Bredicean, Cristina Ana / Bukelskis, Laurynas / Burkadze, Akaki / Abud, Indira Indiana Cabrera / Castilla-Puentes, Ruby / Cetkovich, Marcelo /

Colon-Rivera, Hector / Corral, Ricardo / Cortez-Vergara, Carla / Crepin, Piirika / De Berardis, Domenico / Delgado, Sergio Zamora / De Lucena, David / De Sousa, Avinash / Di Stefano, Ramona / Dodd, Seetal / Elek, Livia Priyanka / Elissa, Anna / Erdelyi-Hamza, Berta / Erzin, Gamze / Etchevers, Martin J / Falkai, Peter / Farcas, Adriana / Fedotov, Ilya / Filatova, Viktoriia / Fountoulakis, Nikolaos K / Frankova, Iryna / Franza, Francesco / Frias, Pedro / Galako, Tatiana / Garay, Cristian J / Garcia-Álvarez, Leticia / García-Portilla, Maria Paz / Gonda, Xenia / Gondek, Tomasz M / González, Daniela Morera / Gould, Hilary / Grandinetti, Paolo / Grau, Arturo / Groudeva, Violeta / Hagin, Michal / Harada, Takayuki / Hasan, Tasdik M / Hashim, Nurul Azreen / Hilbig, Jan / Hossain, Sahadat / Iakimova, Rossitza / Ibrahim, Mona / Iftene, Felicia / Ignatenko, Yulia / Irarrazaval, Matias / Ismail, Zaliha / Ismayilova, Jamila / Jacobs, Asaf / Jakovljević, Miro / Jakšić, Nenad / Javed, Afzal / Kafali, Helin Yilmaz / Karia, Sagar / Kazakova, Olga / Khalifa, Doaa / Khaustova, Olena / Koh, Steve / Kosenko, Korneliia / Koupidis, Sotirios A / Lalljee, Alisha / Liewig, Justine / Majid, Abdul / Malashonkova, Evgeniia / Malik, Khamelia / Malik, Najma Iqbal / Mammadzada, Gulay / Mandalia, Bilvesh / Marazziti, Donatella / Marčinko, Darko / Martinez, Stephanie / Matiekus, Eimantas / Mejia, Gabriela / Memon, Roha Saeed / Martínez, Xarah Elenne Meza / Mickevičiūtė, Dalia / Milev, Roumen / Mohammed, Muftau / Molina-López, Alejandro / Morozov, Petr / Muhammad, Nuru Suleiman / Mustač, Filip / Naor, Mika S / Nassieb, Amira / Navickas, Alvydas / Okasha, Tarek / Pandova, Milena / Panfil, Anca-Livia / Panteleeva, Liliya / Papava, Ion / Patsali, Mikaella E / Pavlichenko, Alexey / Pejuskovic, Bojana / Da Costa, Mariana Pinto / Popkov, Mikhail / Popovic, Dina / Raduan, Nor Jannah Nasution / Ramírez, Francisca Vargas / Rancans, Elmars / Razali, Salmi / Rebok, Federico / Rewekant, Anna / Flores, Elena Ninoska Reyes / Rivera-Encinas, María Teresa / Saiz, Pilar / de Carmona, Manuel Sánchez / Martínez, David Saucedo / Saw, Jo Anne / Saygili, Görkem / Schneidereit, Patricia / Shah, Bhumika / Shirasaka, Tomohiro / Silagadze, Ketevan / Sitanggang, Satti / Skugarevsky, Oleg / Spikina, Anna / Mahalingappa, Sridevi Sira / Stoyanova, Maria / Szczegielniak, Anna / Tamasan, Simona Claudia / Tavormina, Giuseppe / Tavormina, Maurilio Giuseppe Maria / Theodorakis, Pavlos N / Tohen, Mauricio / Tsapakis, Eva Maria / Tukhvatullina, Dina / Ullah, Irfan / Vaidya, Ratnaraj / Vega-Dienstmaier, Johann M / Vukovic, Olivera / Vysotska, Olga / Widiasih, Natalia / Yashikhina, Anna / Smirnova, Daria

Journal of affective disorders

2024 Volume 352, Page(s) 536–551

Abstract: Background: The COVID-19 pandemic has brought significant mental health challenges, particularly for vulnerable populations, including non-binary gender individuals. The COMET international study aimed to investigate specific risk factors for clinical ... ...

Abstract	Background: The COVID-19 pandemic has brought significant mental health challenges, particularly for vulnerable populations, including non-binary gender individuals. The COMET international study aimed to investigate specific risk factors for clinical depression or distress during the pandemic, also in these special populations. Methods: Chi-square tests were used for initial screening to select only those variables which would show an initial significance. Risk Ratios (RR) were calculated, and a Multiple Backward Stepwise Linear Regression Analysis (MBSLRA) was followed with those variables given significant results at screening and with the presence of distress or depression or the lack of both of them. Results: The most important risk factors for depression were female (RR = 1.59-5.49) and non-binary gender (RR = 1.56-7.41), unemployment (RR = 1.41-6.57), not working during lockdowns (RR = 1.43-5.79), bad general health (RR = 2.74-9.98), chronic somatic disorder (RR = 1.22-5.57), history of mental disorders (depression RR = 2.31-9.47; suicide attempt RR = 2.33-9.75; psychosis RR = 2.14-10.08; Bipolar disorder RR = 2.75-12.86), smoking status (RR = 1.15-5.31) and substance use (RR = 1.77-8.01). The risk factors for distress or depression that survived MBSLRA were younger age, being widowed, living alone, bad general health, being a carer, chronic somatic disorder, not working during lockdowns, being single, self-reported history of depression, bipolar disorder, self-harm, suicide attempts and of other mental disorders, smoking, alcohol, and substance use. Conclusions: Targeted preventive interventions are crucial to safeguard the mental health of vulnerable groups, emphasizing the importance of diverse samples in future research. Limitations: Online data collection may have resulted in the underrepresentation of certain population groups.
MeSH term(s)	Humans ; Female ; Male ; COVID-19/epidemiology ; Mental Health ; Pandemics ; Population Groups ; Vulnerable Populations ; Communicable Disease Control ; Substance-Related Disorders/epidemiology ; Depression/epidemiology
Language	English
Publishing date	2024-02-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.02.050
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Article: Chitosan-G-Glycidyl Methacrylate/Au Nanocomposites Promote Accelerated Skin Wound Healing.

López-Muñoz, Héctor A / Lopez-Romero, Mauricio / Franco-Molina, Moises A / Manzano-Ramirez, Alejandro / Velasquillo, Cristina / España-Sanchez, Beatriz Liliana / Martinez-Hernandez, Ana Laura / Vergara-Castañeda, Hayde / Giraldo-Betancur, Astrid / Favela, Sarai / Rodriguez-Rodriguez, Rogelio / Mixteco, Juan Carlos / Tapia-Picazo, Juan Carlos / Zarate-Triviño, Diana G / Prokhorov, Evgeny / Luna-Barcenas, Gabriel

Pharmaceutics

2022 Volume 14, Issue 9

Abstract: Herein, we report the synthesis of Au nanoparticles (AuNPs) in chitosan (CTS) solution by chemically reducing ... ...

Abstract	Herein, we report the synthesis of Au nanoparticles (AuNPs) in chitosan (CTS) solution by chemically reducing HAuCl
Language	English
Publishing date	2022-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14091855
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Article: Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged with the Virulent African Swine Fever Virus Field Isolate Georgia 2010.

Ramirez-Medina, Elizabeth / Rai, Ayushi / Espinoza, Nallely / Spinard, Edward / Silva, Ediane / Burton, Leeanna / Clark, Jason / Meyers, Amanda / Valladares, Alyssa / Velazquez-Salinas, Lauro / Gay, Cyril G / Gladue, Douglas P / Borca, Manuel V

Pathogens (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G ... 2010 (ASFV-G). As reported, ASFV-G-Δ9GL/ΔUK induces protection, while intramuscularly (IM ...

Abstract	We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G). As reported, ASFV-G-Δ9GL/ΔUK induces protection, while intramuscularly (IM), administered at doses of 10
Language	English
Publishing date	2024-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens13040319
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Article ; Online: African Swine Fever Vaccine Candidate ASFV-G-ΔI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge.

Borca, Manuel V / Rai, Ayushi / Espinoza, Nallely / Ramirez-Medina, Elizabeth / Spinard, Edward / Velazquez-Salinas, Lauro / Valladares, Alyssa / Silva, Ediane / Burton, Leeanna / Meyers, Amanda / Gay, Cyril G / Gladue, Douglas P

Viruses

2023 Volume 15, Issue 10

Abstract: ASFV vaccine candidate ASFV-G-ΔI177L has been shown to be highly efficacious in inducing protection ... isolated from Vietnam. ASFV-G-ΔI177L has been shown to produce protection even when used at low doses (10 ...

Abstract	ASFV vaccine candidate ASFV-G-ΔI177L has been shown to be highly efficacious in inducing protection against challenges with the parental virus, the Georgia 2010 isolate, as well as against field strains isolated from Vietnam. ASFV-G-ΔI177L has been shown to produce protection even when used at low doses (10
MeSH term(s)	Swine ; Animals ; African Swine Fever ; African Swine Fever Virus ; Viral Vaccines ; Viral Proteins/genetics ; Sus scrofa ; Macrophages ; Cell Line
Chemical Substances	Viral Vaccines ; Viral Proteins
Language	English
Publishing date	2023-10-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15102064
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Article ; Online: Reply to Scarpati, G.; Piazza, O. Comment on "Guerrero-Romero et al. Magnesium-to-Calcium Ratio and Mortality from COVID-19.

Guerrero-Romero, Fernando / Mercado, Moises / Rodríguez-Morán, Martha / Ramírez-Renteria, Claudia / Martínez-Aguilar, Gerardo / Marrero-Rodríguez, Daniel / Ferreira-Hermosillo, Aldo / Simental-Mendía, Luis E / Remba-Shapiro, Ilan / Gamboa-Gómez, Claudia I / Albarrán-Sánchez, Alejandra / Sanchez-García, Miriam L

Nutrients

2022 Volume 14, Issue 16

Abstract: We thank Dr. Scarpati and Dr. Piazza for their interest and comments [ ... ]. ...

Abstract	We thank Dr. Scarpati and Dr. Piazza for their interest and comments [...].
MeSH term(s)	COVID-19 ; Calcium ; Humans ; Magnesium ; Nutrients
Chemical Substances	Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14163443
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Article ; Online: ASFV-G-∆I177L as an Effective Oral Nasal Vaccine against the Eurasia Strain of Africa Swine Fever.

Borca, Manuel V / Ramirez-Medina, Elizabeth / Silva, Ediane / Vuono, Elizabeth / Rai, Ayushi / Pruitt, Sarah / Espinoza, Nallely / Velazquez-Salinas, Lauro / Gay, Cyril G / Gladue, Douglas P

Viruses

2021 Volume 13, Issue 5

Abstract: ... strain Georgia (ASFV-G). ASFV-G-ΔI177L has been proven safe and highly efficacious in challenge studies ... using parental ASFV-G. Here, we present data demonstrating that ASFV-G-ΔI177L can be administered ... receiving ON ASFV-G-ΔI177L were completely protected against virulent ASFV-G challenge. As previously ...

Abstract	The African swine fever virus (ASFV) is currently causing a pandemic affecting wild and domestic swine from Western Europe to Asia. No commercial vaccines are available to prevent African swine fever (ASF), resulting in overwhelming economic losses to the swine industry. We recently developed a recombinant vaccine candidate, ASFVG-ΔI177L, by deleting the I177L gene from the genome of the highly virulent ASFV strain Georgia (ASFV-G). ASFV-G-ΔI177L has been proven safe and highly efficacious in challenge studies using parental ASFV-G. Here, we present data demonstrating that ASFV-G-ΔI177L can be administered by the oronasal (ON) route to achieve a similar efficacy to that of intramuscular (IM) administration. Animals receiving ON ASFV-G-ΔI177L were completely protected against virulent ASFV-G challenge. As previously described, similar results were obtained when ASFV-G-ΔI177L was given intramuscularly. Interestingly, viremias induced in animals inoculated oronasally were lower than those measured in IM-inoculated animals. ASFV-specific antibody responses, mediated by IgG1, IgG2 and IgM, do not differ in animals inoculated by the ON route from that had IM inoculations. Therefore, the ASFV-G-ΔI177L vaccine candidate can be administered oronasally, a critical attribute for potential vaccination of wild swine populations.
MeSH term(s)	Administration, Intranasal ; Administration, Oral ; African Swine Fever/mortality ; African Swine Fever/prevention & control ; African Swine Fever/virology ; African Swine Fever Virus/classification ; African Swine Fever Virus/genetics ; African Swine Fever Virus/immunology ; Animals ; Antibodies, Viral/immunology ; Immunization ; Swine ; Viral Proteins/genetics ; Viral Proteins/immunology ; Viral Vaccines/administration & dosage ; Viral Vaccines/genetics ; Viral Vaccines/immunology ; Virulence ; Virus Replication
Chemical Substances	Antibodies, Viral ; Viral Proteins ; Viral Vaccines
Language	English
Publishing date	2021-04-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13050765
Database	MEDical Literature Analysis and Retrieval System OnLINE

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