Article ; Online: Polymerase chain reaction in the diagnosis of invasive aspergillosis: approaches for appropriate use.
2023 Volume 64, Issue 7, Page(s) 1330–1334
Abstract: Detection of aspergillus by PCR is a helpful tool for early diagnosis. The test has excellent sensitivity and specificity with a high negative predictive value. Well-accepted, standardized method for DNA extraction for PCR testing is to be adopted for ... ...
Abstract | Detection of aspergillus by PCR is a helpful tool for early diagnosis. The test has excellent sensitivity and specificity with a high negative predictive value. Well-accepted, standardized method for DNA extraction for PCR testing is to be adopted for all commercial assays and conclusive validation data are awaited in varied clinical settings. This perspective offers guidance for utilizing PCR testing while awaiting such data. Quantification by PCR, species-specific identification assays and detection of resistance genetic markers are of future promise. Herein, we summarize the available data on aspergillus PCR and describe its potential utility through a clinical case scenario-based approach. |
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MeSH term(s) | Humans ; Aspergillosis/diagnosis ; Polymerase Chain Reaction/methods ; Aspergillus/genetics ; Predictive Value of Tests ; Invasive Fungal Infections ; Sensitivity and Specificity |
Language | English |
Publishing date | 2023-05-21 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 1042374-6 |
ISSN | 1029-2403 ; 1042-8194 |
ISSN (online) | 1029-2403 |
ISSN | 1042-8194 |
DOI | 10.1080/10428194.2023.2209683 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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