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Article: A comparison of the Marcus Gunn and alternating light tests for afferent pupillary defects.

Enyedi, L B / Dev, S / Cox, T A

1998 Volume 105, Issue 5, Page(s) 871–873

Abstract: Objective: The authors compared two methods, the Marcus Gunn test and the alternating light test ... Participants: Fourteen patients with unilateral optic neuropathy.: Intervention: The Marcus Gunn and ... alternating light tests were performed on each patient.: Main outcome measures: The results of the Marcus ...

Abstract	Objective: The authors compared two methods, the Marcus Gunn test and the alternating light test, for detecting a relative afferent pupillary defect. Design: A randomized, prospective clinical trial. Participants: Fourteen patients with unilateral optic neuropathy. Intervention: The Marcus Gunn and alternating light tests were performed on each patient. Main outcome measures: The results of the Marcus Gunn and altemating light tests for detecting a relative afferent pupillary defect on the affected side. Results: The Marcus Gunn test was able to identify the affected eye in only 8 of 14 patients, whereas the alternating light test correctly identified the affected eye in 13 of 14 patients. Results of the Marcus Gunn test were indeterminate in 4 of 14 patients and were incorrect in 2 of 14 patients. Results of the alternating light test were indeterminate in one patient and never incorrectly identified the affected eye. Conclusion: The alternating light test is superior to the Marcus Gunn test for detecting relative afferent pupillary defects.
MeSH term(s)	Diagnostic Techniques, Ophthalmological ; Humans ; Light ; Optic Nerve Diseases/complications ; Prospective Studies ; Pupil Disorders/diagnosis ; Reproducibility of Results
Language	English
Publishing date	1998-05
Publishing country	United States
Document type	Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/S0161-6420(98)95029-1
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Ul II Zs.83: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 533: Show issues

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Article ; Online: Safety and Duration of Effect of 40U PrabotulinumtoxinA-xvfs for the Treatment of Moderate to Severe Glabellar Lines in Adult Patients: A Phase II, Multi-Center, Randomized, Double Blind, Active-Controlled Trial.

Fagien, Steven / Avelar, Rui L / Cox, Sue Ellen / Joseph, John H / Kaufman-Janette, Joely / Marcus, Keith A

Aesthetic surgery journal

2024

Abstract: Background: Extending the duration of effect of botulinum toxins - by administering doses beyond those of the approved labels - has been an area of increasing interest in the field of aesthetics.: Objectives: To investigate the safety and duration of ...

Abstract	Background: Extending the duration of effect of botulinum toxins - by administering doses beyond those of the approved labels - has been an area of increasing interest in the field of aesthetics. Objectives: To investigate the safety and duration of effect of 40U prabotulinumtoxinA-xvfs (twice the approved dose and concentration) for the treatment of moderate-to-severe glabellar lines. Methods: 154 adult patients were randomized 1:1:1 to a single treatment of either 40U prabotulinumtoxinA-xvfs (PRA 40, 5 injections of 8U/0.05 mL), or 20U of either prabotulinumtoxinA-xvfs (PRA 20) or onabotulinumtoxinA (ONA 20). Both 20U controls were administered as 5 injections of 4U/0.1 mL. Efficacy and safety were assessed on Days 2, 7 (by phone), 30 and every 30 days thereafter up to 365 days or until the patient had returned to Baseline. The primary effectiveness endpoint was the duration of effect (estimated by Kaplan-Meier analysis), defined as the number of days from Treatment Day (Baseline) to the day that glabellar line severity at maximum frown by investigator assessment returned to the baseline value. Results: Patients had a mean age of 47 years (20-72 years); 69.5% had severe glabellar lines at Baseline. Of the 36 adverse events, 32 (88.9%) were mild and 4 (11.1%) were moderate in severity; none were serious. The median durations of effect were estimated to be 183, 149 and 148 days for PRA 40-, PRA 20- and ONA 20-treated patients, respectively. Conclusions: In this Phase II pilot study, 40U prabotulinumtoxinA-xvfs was observed to be safe and had a duration of 6 months.
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjae051
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Zs.A 5721: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Expression of the microtubule-associated protein 2 (MAP2) as a potential independent prognostic marker in prostate cancer.

Stein, Johannes / Krappe, Eliana / Kremer, Anika / Cronauer, Marcus V / Essler, Markus / Cox, Alexander / Klümper, Niklas / Krausewitz, Philipp / Ellinger, Jörg / Ritter, Manuel / Kristiansen, Glen / Majores, Michael

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 2, Page(s) 76

Abstract: ... prostatectomy (p < 0.001). Multivariate Cox regression analysis confirmed MAP2 as an independent predictor ...

Abstract	Purpose: Investigation of Microtubuli-associated Protein 2 (MAP2) expression and its clinical relevance in prostate cancer. Material and methods: MAP2 expression was immunohistochemically analysed on radical prostatectomy specimens using whole block sections (n = 107) and tissue microarrays (TMA; n = 310). The staining intensity was evaluated for carcinoma, benign tissue and prostatic intraepithelial neoplasia. Expression data were correlated with clinicopathological parameters and biochemical recurrence-free survival. Additionally, MAP2 protein expression was quantitatively analysed in the serum of histologically confirmed prostate carcinoma patients and the control group using a commercial enzyme-linked immunosorbent assay. Results: MAP2 staining was significantly stronger in neoplastic tissue than in non-neoplastic prostatic glands, both in whole block sections (p < 0.01) and in TMA sections (p < 0.05). TMA data revealed significantly stronger MAP2 staining in high-grade tumors. Survival analysis showed a significant correlation between strong MAP2 staining in carcinoma and shortened biochemical recurrence-free survival after prostatectomy (p < 0.001). Multivariate Cox regression analysis confirmed MAP2 as an independent predictor for an unfavourable course. Mean MAP2 serum levels for non-PCA vs. PCA patients differed significantly (non-PCA = 164.7 pg/ml vs. PCA = 242.5 pg/ml, p < 0.001). Conclusion: The present data support MAP2 as a novel biomarker in PCA specimens. MAP2 is correlated with tumor grade and MAP2 high-expressing PCA is associated with an increased risk of biochemical recurrence after radical prostatectomy. Future studies are necessary to evaluate MAP2 as a valuable immunohistochemical biomarker in preoperative PCA diagnostic procedures, in particular with regard to treatment modalities.
MeSH term(s)	Male ; Humans ; Prognosis ; Prostatic Neoplasms/pathology ; Prostatectomy/methods ; Carcinoma/surgery ; Biomarkers ; Microtubule-Associated Proteins ; Biomarkers, Tumor/metabolism
Chemical Substances	Biomarkers ; Microtubule-Associated Proteins ; Biomarkers, Tumor ; MAP2 protein, human
Language	English
Publishing date	2024-02-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-023-05579-0
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Article ; Online: Metal-Free Cortico-Pedicular Device for Supplemental Fixation in Lumbar Interbody Fusion.

Nunley, Pierce D / Eastlack, Robert K / Miller, Larry E / Poelstra, Kornelis A / Cox, J Bridger / Shedden, Peter M / Stone, Marcus

World neurosurgery

2023 Volume 174, Page(s) 4–10

Abstract: Objective: Pedicle screw fixation is a commonly utilized adjunct for lumbar interbody fusion, yet risks include screw malposition, pullout, loosening, neurovascular injury, and stress transfers leading to adjacent segment degeneration. This report ... ...

Abstract	Objective: Pedicle screw fixation is a commonly utilized adjunct for lumbar interbody fusion, yet risks include screw malposition, pullout, loosening, neurovascular injury, and stress transfers leading to adjacent segment degeneration. This report describes the preclinical and initial clinical results of a minimally invasive, metal-free cortico-pedicular fixation device used for supplemental posterior fixation in lumbar interbody fusion. Methods: Safety of arcuate tunnel creation was evaluated in cadaveric lumbar (L1-S1) specimens. A finite element analysis study evaluated clinical stability of the device to pedicular screw-rod fixation at L4-L5. Preliminary clinical results were assessed by analysis of Manufacturer and User Facility Device Experience database complications, and 6-month outcomes in 13 patients treated with the device. Results: Among 35 curved drill holes in 5 lumbar specimens, no breaches of the anterior cortex were identified. The mean minimum distance from the anterior surface of the hole to the spinal canal ranged from 5.1 mm at L1-L2 to 9.8 mm at L5-S1. In the finite element analysis study, the polyetheretherketone strap provided comparable clinical stability and reduced anterior stress shielding compared to the conventional screw-rod construct. The Manufacturer and User Facility Device Experience database identified 1 device fracture with no clinical sequelae among 227 procedures. Initial clinical experience showed a 53% decrease in pain severity (P = 0.009), a 50% decrease in Oswestry Disability Index (P < 0.001), and no device-related complications. Conclusions: Cortico-pedicular fixation is a safe and reproducible procedure that may address limitations of pedicle screw fixation. Longer term clinical data in large clinical studies are recommended to confirm these promising early results.
MeSH term(s)	Animals ; Humans ; Phthiraptera ; Spinal Fusion/methods ; Lumbar Vertebrae/surgery ; Biomechanical Phenomena ; Pedicle Screws
Language	English
Publishing date	2023-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.02.119
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Zs.A 1159: Show issues

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Article: Using Frailty Measures to Predict Functional Outcomes and Mortality After Type II Odontoid Fracture in Elderly Patients: A Retrospective Cohort Study.

Hamrick, Forrest A / Sherrod, Brandon A / Cole, Kyril / Cox, Parker / Croci, Davide M / Bowers, Christian A / Mazur, Marcus D / Dailey, Andrew T / Bisson, Erica F

Global spine journal

2023 , Page(s) 21925682221149394

Abstract: Study design: Single-center retrospective cohort study.: Objectives: Type II odontoid fractures occur disproportionately among elderly populations and cause significant morbidity and mortality. It is a matter of debate whether these injuries are best ...

Abstract	Study design: Single-center retrospective cohort study. Objectives: Type II odontoid fractures occur disproportionately among elderly populations and cause significant morbidity and mortality. It is a matter of debate whether these injuries are best managed surgically or conservatively. Our goal was to identify how treatment modalities and patient characteristics correlated with functional outcome and mortality. Methods: We identified adult patients (>60 years) with traumatic type II odontoid fractures. We used multivariate regression controlling for patient demographics, Glasgow Coma Scale (GCS) score, Charlson Comorbidity Index (CCI), modified Rankin Scale (mRS) score, modified Frailty Index (mFI-5 and mFI-11), fracture displacement, and conservative vs operative treatment. Results: Of the 59 patients (mean age 77.9 years), 24 underwent surgical intervention and 35 underwent conservative management. Operatively managed patients were younger (73.4 vs 80.6 years, P < .001) and had higher degree of fracture displacement (3.5 vs 1.0 mm, P Conclusions: Mortality after type II odontoid fractures in elderly patients is common. mRS score at presentation may help predict mortality more accurately than other patient factors.
Language	English
Publishing date	2023-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2648287-3
ISSN	2192-5690 ; 2192-5682
ISSN (online)	2192-5690
ISSN	2192-5682
DOI	10.1177/21925682221149394
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Book ; Online ; E-Book: The lung microbiome

Cox, Michael J. / Ege, Markus J. / Mutius, Erika von

(ERS monograph)

2019

Author's details	edited by Michael J. Cox, Markus J. Ege and Erika von Mutius
Series title	ERS monograph
Language	English
Size	1 Online-Ressource (xi, 244 Seiten), Diagramme
Publisher	European Respiratory Society
Publishing place	Sheffield
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020051151
ISBN	978-1-84984-102-3 ; 9781849841016 ; 1-84984-102-0 ; 1849841012
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Coronary artery disease grading by cardiac CT for predicting outcome in patients with stable angina.

Oeing, Christian U / Matheson, Matthew B / Ostovaneh, Mohammad R / Rochitte, Carlos E / Chen, Marcus Y / Pieske, Burkert / Kofoed, Klaus F / Schuijf, Joanne D / Niinuma, Hiroyuki / Dewey, Marc / di Carli, Marcelo F / Cox, Christopher / Lima, João A C / Arbab-Zadeh, Armin

Journal of cardiovascular computed tomography

2023 Volume 17, Issue 5, Page(s) 310–317

Abstract: ... RADS, and two simplified CAD staging systems. We applied Cox proportional hazard models and ...

Abstract	Background: The coronary atheroma burden drives major adverse cardiovascular events (MACE) in patients with suspected coronary heart disease (CHD). However, a consensus on how to grade disease burden for effective risk stratification is lacking. The purpose of this study was to compare the effectiveness of common CHD grading tools to risk stratify symptomatic patients. Methods: We analyzed the 5-year outcome of 381 prospectively enrolled patients in the CORE320 international, multicenter study using baseline clinical and cardiac computer-tomography (CT) imaging characteristics, including coronary artery calcium score (CACS), percent atheroma volume, "high-risk" plaque, disease severity grading using the CAD-RADS, and two simplified CAD staging systems. We applied Cox proportional hazard models and area under the curve (AUC) analysis to predict MACE or hard MACE, defined as death, myocardial infarction, or stroke. Analyses were stratified by a history of CHD. Additional forward selection analysis was performed to evaluate incremental value of metrics. Results: Clinical characteristics were the strongest predictors of MACE in the overall cohort. In patients without history of CHD, CACS remained the only independent predictor of MACE yielding an AUC of 73 (CI 67-79) vs. 64 (CI 57-70) for clinical characteristics. Noncalcified plaque volume did not add prognostic value. Simple CHD grading schemes yielded similar risk stratification as the CAD-RADS classification. Forward selection analysis confirmed prominent role of CACS and revealed usefulness of functional testing in subgroup with known CHD. Conclusion: In patients referred for invasive angiography, a history of CHD was the strongest predictor of MACE. In patients without history of CHD, a coronary calcium score yielded at least equal risk stratification vs. more complex CHD grading.
MeSH term(s)	Humans ; Angina, Stable/diagnostic imaging ; Angina, Stable/therapy ; Calcium ; Computed Tomography Angiography/methods ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Multidetector Computed Tomography ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Risk Factors
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2023.07.004
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Article ; Online: Combined Computed Tomography Angiography-Computed Tomography Perfusion in the Identification and Prognostic Assessment of Myocardial Bridging from the CORE320 Study: 5-Year Follow-Up.

Gannon, Michael P / Cerci, Rodrigo J / Valdiviezo, Carolina / Ostovaneh, Mohammad R / Vavere, Andrea L / de Vasconcellos, Henrique Doria / Matheson, Matthew B / Cox, Christopher / Miller, Julie M / di Carli, Marcelo / Arbab-Zadeh, Armin / George, Richard T / Lima, João A C / Chen, Marcus Y

The American journal of cardiology

2023 Volume 207, Page(s) 314–321

Abstract: Our objective is to use computed tomography angiography (CTA) and computed tomography perfusion (CTP) to identify the ischemic significance of myocardial bridging (MB). We also seek to determine the long-term prognostication of MB in the presence or ... ...

Abstract	Our objective is to use computed tomography angiography (CTA) and computed tomography perfusion (CTP) to identify the ischemic significance of myocardial bridging (MB). We also seek to determine the long-term prognostication of MB in the presence or absence of obstructive coronary artery disease (CAD). The CORE320, a prospective, multicenter study including 381 patients with known or suspected CAD clinically referred for invasive coronary angiography who underwent combined (CTA-CTP) and single-photon emission computed tomography before conventional coronary angiography. The incidence of MB was identified in 135 patients (35.4%) with 93.9% identified in the left anterior descending artery. MB were divided as partially encased versus fully encased. There was no difference in ischemia identified between partially encased MB and fully encased MB (37 [40%] vs 25 [35%], p = 0.54]. Ischemia was identified at similar rates in partially versus fully encased MB by single-photon emission computed tomography at (8 [9%] vs 8 [11%], p = 0.57] and CTP (34 [37%] vs 21 [30%], p = 0.33]. There was no difference in the primary outcome of 5-year outcome of combined incidence of myocardial infarction or death. The restricted mean survival time in patients with CTA with <50% stenosis with or without a MB was 4.906 years (95% confidence interval 4.759 to 5.000) and 4.891 years (95% confidence interval 4.718 to 5.000), respectively (p = 0.824). Cardiac computed tomography perfusion imaging can assess both anatomic and functional significance of myocardial bridging with diagnostic accuracy similar to current standard imaging. Furthermore, 5-year cardiovascular events were not different with the presence of MB in both obstructive and non-obstructive CAD.
MeSH term(s)	Humans ; Computed Tomography Angiography ; Prospective Studies ; Prognosis ; Myocardial Bridging ; Follow-Up Studies ; Coronary Artery Disease/diagnostic imaging ; Coronary Angiography/methods ; Myocardial Infarction ; Myocardial Perfusion Imaging/methods ; Perfusion ; Predictive Value of Tests ; Coronary Stenosis
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.08.040
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Book ; Online: Super-Resolution of PROBA-V Images Using Convolutional Neural Networks

Märtens, Marcus / Izzo, Dario / Krzic, Andrej / Cox, Daniël

2019

Abstract: ESA's PROBA-V Earth observation satellite enables us to monitor our planet at a large scale, studying the interaction between vegetation and climate and provides guidance for important decisions on our common global future. However, the interval at which ...

Abstract	ESA's PROBA-V Earth observation satellite enables us to monitor our planet at a large scale, studying the interaction between vegetation and climate and provides guidance for important decisions on our common global future. However, the interval at which high resolution images are recorded spans over several days, in contrast to the availability of lower resolution images which is often daily. We collect an extensive dataset of both, high and low resolution images taken by PROBA-V instruments during monthly periods to investigate Multi Image Super-resolution, a technique to merge several low resolution images to one image of higher quality. We propose a convolutional neural network that is able to cope with changes in illumination, cloud coverage and landscape features which are challenges introduced by the fact that the different images are taken over successive satellite passages over the same region. Given a bicubic upscaling of low resolution images taken under optimal conditions, we find the Peak Signal to Noise Ratio of the reconstructed image of the network to be higher for a large majority of different scenes. This shows that applied machine learning has the potential to enhance large amounts of previously collected earth observation data during multiple satellite passes. Comment: To appear in Special Issue on Applications of Artificial Intelligence in Aerospace Engineering in the Journal "Astrodynamics"
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Electrical Engineering and Systems Science - Image and Video Processing
Subject code	006
Publishing date	2019-07-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Perivascular fat attenuation for predicting adverse cardiac events in stable patients undergoing invasive coronary angiography.

Chatterjee, Devina / Shou, Benjamin L / Matheson, Matthew B / Ostovaneh, Mohammad R / Rochitte, Carlos / Chen, Marcus Y / Dewey, Marc / Ortman, Jason / Cox, Christopher / Lima, Joao A C / Arbab-Zadeh, Armin

Journal of cardiovascular computed tomography

2022 Volume 16, Issue 6, Page(s) 483–490

Abstract: ... follow up was assessed using Cox regression models.: Results: Thirty-seven patients were excluded due ...

Abstract	Background: Inflammation surrounding the coronary arteries can be non-invasively assessed using pericoronary adipose tissue attenuation (PCAT). While PCAT holds promise for further risk stratification of patients with low coronary artery disease (CAD) prevalence, its value in higher risk populations remains unknown. Methods: CORE320 enrolled patients referred for invasive coronary angiography with known or suspected CAD. Coronary computed tomography angiography (CCTA) images were collected for 381 patients for whom clinical outcomes were assessed 5 years after enrollment. Using semi-automated image analysis software, PCAT was obtained and normalized for the right coronary (RCA), left anterior descending (LAD), and left circumflex arteries (LCx). The association between PCAT and major adverse cardiovascular events (MACE) during follow up was assessed using Cox regression models. Results: Thirty-seven patients were excluded due to technical failure. For the remaining 344 patients, median age was 62 (interquartile range, 55-68) with 59% having ≥1 coronary artery stenosis of ≥50% by quantitative coronary angiography. Mean attenuation values for PCAT in RCA, LAD, and LCx were -74.9, -74.2, and -71.2, respectively. Hazard ratios and 95% confidence intervals (CI) for normalized PCAT in the RCA, LAD, and LCx for MACE were 0.96 (CI: 0.75-1.22, p = 0.71), 1.31 (95% CI: 0.96-1.78, p = 0.09), and 0.98 (95% CI: 0.78-1.22, p = 0.84), respectively. For death, stroke, or myocardial infarction only, hazard ratios were 0.68 (0.44-1.07), 0.85 (0.56-1.29), and 0.57 (0.41-0.80), respectively. Conclusions: In patients referred for invasive coronary angiography with suspected CAD, PCAT did not predict MACE during long term follow up. Further studies are needed to understand the relationship of PCAT with CAD risk.
MeSH term(s)	Humans ; Middle Aged ; Coronary Angiography/methods ; Predictive Value of Tests ; Computed Tomography Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Vessels/diagnostic imaging ; Adipose Tissue/diagnostic imaging
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2022.05.004
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