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  1. Article: Meniere Disease: Deciphering Vestibular Tests to Aid in Diagnosis.

    Bhandari, Anita

    Neurology. Clinical practice

    2024  Volume 14, Issue 2, Page(s) e200257

    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000200257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Outpatient management of established bronchopulmonary dysplasia: An update.

    Bhandari, Anita / Alexiou, Stamatia

    Seminars in perinatology

    2023  Volume 47, Issue 6, Page(s) 151820

    Abstract: As the incidence of infants with bronchopulmonary dyspasia (BPD) has continued to rise, so has their rate of survival. Their medical management is often complex and requires the use of numerous therapies such as steroids, bronchodilators, diuretics and ... ...

    Abstract As the incidence of infants with bronchopulmonary dyspasia (BPD) has continued to rise, so has their rate of survival. Their medical management is often complex and requires the use of numerous therapies such as steroids, bronchodilators, diuretics and modalities to deliver supplemental oxygen and positive pressure. It also requires multi-disciplinary care to ensure adequate growth and to optimize neurodevelopmental outcomes. This review aims to discuss the most widely used therapies in the treatment of patients with established BPD. The focus will be on ongoing outpatient (post-neonatal intensive care) management of children with BPD. Since many of the mentioned therapies lack solid evidence to support their use, more high quality research, such as randomized controlled trials, is needed to assess their effectiveness using defined outcomes.
    MeSH term(s) Infant, Newborn ; Infant ; Child ; Humans ; Infant, Premature ; Bronchopulmonary Dysplasia/therapy ; Outpatients ; Respiration, Artificial ; Intensive Care, Neonatal
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 752403-1
    ISSN 1558-075X ; 0146-0005
    ISSN (online) 1558-075X
    ISSN 0146-0005
    DOI 10.1016/j.semperi.2023.151820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnostic Delay in Pediatric Vestibular Disorders.

    Bhandari, Anita / Bhandari, Rajneesh / Kumbhat, Payal

    The journal of international advanced otology

    2023  Volume 19, Issue 4, Page(s) 318–322

    Abstract: Background: Vertigo and dizziness in children can be multi-factorial. Vestibular function tests allow an improved differential diagnosis and treatment. Delay in diagnosis of the diverse etiologies causing dizziness can adversely affect the health of ... ...

    Abstract Background: Vertigo and dizziness in children can be multi-factorial. Vestibular function tests allow an improved differential diagnosis and treatment. Delay in diagnosis of the diverse etiologies causing dizziness can adversely affect the health of children and is a matter of concern for their families. This study analyzes the delay in diagnosis and the importance of establishing a diagnosis with detailed history and neuro-otological evaluation.
    Methods: A total of 241 children presenting with vertigo to a tertiary otoneurology clinic between January 2019 and April 2022 were analyzed for the duration between the onset of symptoms and diagnosis, presenting complaints, and characteristic findings.
    Results: Two hundred and forty-one patients with a mean age of 12.5 ± 3.02 years (range, 5-16 years) were evaluated. About 39.4% of patients were diagnosed after over a year (with some over 5 years) of suffering from vertigo and only 18.7% of patients were diagnosed correctly within 1 month of symptom onset. The presenting features were variable with 174 (72.2%) complaining of spinning, unsteadiness, and falls seen in 36+10+37 (34.4%). Vestibular migraine was the most common diagnosis (63.39%), followed by benign paroxysmal positional vertigo (24.48%), of which the posterior canal was most affected (50.85%) followed by horizontal (40.68%) and anterior canal (8.47%). Other etiologies noted were central (14.10%) and peripheral vestibulopathy (17.42%) and variable other causes (6.19%).
    Conclusion: Many pediatric vertigo and dizziness patients do not reach the correct diagnosis for long durations and are treated as "unspecified dizziness." A detailed examination with a multidisciplinary approach including vestibular evaluation is advocated to give definitive treatment to these children.
    MeSH term(s) Humans ; Child ; Adolescent ; Dizziness/diagnosis ; Dizziness/etiology ; Delayed Diagnosis/adverse effects ; Vestibular Diseases/complications ; Vestibular Diseases/diagnosis ; Benign Paroxysmal Positional Vertigo/diagnosis ; Benign Paroxysmal Positional Vertigo/complications ; Migraine Disorders/diagnosis
    Language English
    Publishing date 2023-08-01
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2561231-1
    ISSN 2148-3817 ; 1308-7649 ; 2148-3817
    ISSN (online) 2148-3817
    ISSN 1308-7649 ; 2148-3817
    DOI 10.5152/iao.2023.231052
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  4. Article: Editorial: Benign paroxysmal positional vertigo.

    Bhandari, Anita / Sharma, Shivam / Zuma E Maia, Francisco Carlos / Ramos, Bernardo Faria / Martin-Sanz, Eduardo

    Frontiers in neurology

    2024  Volume 15, Page(s) 1358860

    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1358860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Large Variability of Head Angulation During the Epley Maneuver: Use of a Head-Mounted Guidance System with Visual Feedback to Improve Outcomes.

    Bhandari, Rajneesh / Bhandari, Anita / Kingma, Herman / Berg, Raymond van de

    The journal of international advanced otology

    2023  Volume 19, Issue 3, Page(s) 234–241

    Abstract: Background: The aim of this study was to show the variability in head angulation during the canalolith repositioning maneuvers to treat benign paroxysmal positional vertigo and to describe a head-mounted benign paroxysmal positional vertigo guidance ... ...

    Abstract Background: The aim of this study was to show the variability in head angulation during the canalolith repositioning maneuvers to treat benign paroxysmal positional vertigo and to describe a head-mounted benign paroxysmal positional vertigo guidance system to measure the head orientation.
    Methods: A guidance system for benign paroxysmal positional vertigo was developed by NeuroEquilibrium Diagnostic Systems to measure head orientation and provide visual feedback and instructions to examiners during various maneuvers for benign paroxysmal positional vertigo. Twenty-five experienced examiners and 25 healthy volunteers (aged 21-35 years) were recruited. Each examiner applied the Epley maneuver twice in 1 volunteer: without and with the use visual feedback from a guidance system. Head orientation in both procedures was measured and compared.
    Results: The trained examiners demonstrated a large variability in head orientation during the Epley maneuver, which was reduced by using the benign paroxysmal positional vertigo guidance system. There was a variability of 39-65° in head orientation measured without the guidance system. The use of the guidance system reduced the variation range to a sixfold decrease in variability.
    Conclusion: There is a large variability in head orientation when performing repositioning maneuvers, which could compromise the efficacy of benign paroxysmal positional vertigo treatment. Treatment for benign paroxysmal positional vertigo can be optimized by reducing this variability with a benign paroxysmal positional vertigo guidance system. It might also be a useful tool for teaching.
    MeSH term(s) Humans ; Benign Paroxysmal Positional Vertigo/therapy ; Feedback, Sensory ; Physical Therapy Modalities ; Patient Positioning/methods ; Treatment Outcome
    Language English
    Publishing date 2023-06-05
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2561231-1
    ISSN 2148-3817 ; 1308-7649 ; 2148-3817
    ISSN (online) 2148-3817
    ISSN 1308-7649 ; 2148-3817
    DOI 10.5152/iao.2023.22969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Diagnostic and Therapeutic Maneuvers for Anterior Canal BPPV Canalithiasis: Three-Dimensional Simulations.

    Bhandari, Anita / Bhandari, Rajneesh / Kingma, Herman / Strupp, Michael

    Frontiers in neurology

    2021  Volume 12, Page(s) 740599

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    Language English
    Publishing date 2021-09-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.740599
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  7. Article: Modified Interpretations of the Supine Roll Test in Horizontal Canal BPPV Based on Simulations: How the Initial Position of the Debris in the Canal and the Sequence of Testing Affects the Direction of the Nystagmus and the Diagnosis.

    Bhandari, Anita / Bhandari, Rajneesh / Kingma, Herman / Strupp, Michael

    Frontiers in neurology

    2022  Volume 13, Page(s) 881156

    Abstract: Background and objectives: The aim of this study was to show with three-dimensional simulations how the diagnostic supine roll test (SRT) is affected by the initial position of the debris within the horizontal canal (hc) and study the nystagmus patterns ...

    Abstract Background and objectives: The aim of this study was to show with three-dimensional simulations how the diagnostic supine roll test (SRT) is affected by the initial position of the debris within the horizontal canal (hc) and study the nystagmus patterns on changing the sequence of testing and its impact on the diagnosis of the side of involvement in hc-BPPV.
    Methods: A 3D dynamic simulation model was developed and applied based on reconstructed MRI images and fluid dynamics. Each semicircular canal was linked to the respective extraocular muscles to visualize nystagmus generated on stimulation of the canal.
    Results: The simulations of hc-canalithiasis showed that the nystagmus pattern seen with the SRT is changed by the initial position of the otolith debris within the canal and the sequence of testing. The debris changes position during SRT so that sequential steps do not start at the initial position as previously assumed. The sequence of performing the SRT steps from the right or left side influences the nystagmus pattern generated: bilateral direction-changing, bilateral direction-fixed, and unilateral nystagmus can be seen in different test conditions. The SRT itself may even reposition the debris out of the canal.
    Conclusions and clinical implications: Simulations provide a dynamic tool to study the diagnostic SRT in hc-canalithiasis. Starting the SRT from right or left has a major impact on the test outcome (unlike the Dix-Hallpike maneuver). The findings provide a new interpretation for the results of the SRT. The simulations explain the phenomenon of direction-fixed nystagmus as a logical consequence of starting the SRT with the head turned toward the non-affected side in hc-canalithiasis with debris in the ampullary arm. They also show that unilateral nystagmus seen on SRT indicates canalithiasis of the non-ampullary arm of the side opposite to the side of nystagmus. The generation of bilateral direction-changing, bilateral direction-fixed, and unilateral nystagmus can be the cause of misdiagnoses in terms of the affected side and underlying mechanisms. Finally, a recommendation for a standardized protocol for the sequence of positional tests should be established to ensure uniform interpretation of test results.
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.881156
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  8. Article: Prevalence of Horizontal Canal Variant in 3,975 Patients With Benign Paroxysmal Positional Vertigo: A Cross-sectional Study.

    Bhandari, Rajneesh / Bhandari, Anita / Hsieh, Yu-Hsiang / Edlow, Jonathan / Omron, Rodney

    Neurology. Clinical practice

    2023  Volume 13, Issue 5, Page(s) e200191

    Abstract: Background and objectives: Current understanding based on older studies is that pc-BPPV is far more common than hc-BPPV. Such studies are limited by small sample sizes, and often the supine roll test for hc-BPPV is not performed. To better estimate the ... ...

    Abstract Background and objectives: Current understanding based on older studies is that pc-BPPV is far more common than hc-BPPV. Such studies are limited by small sample sizes, and often the supine roll test for hc-BPPV is not performed. To better estimate the prevalence of hc-BPPV, we studied a large cross-section of patients with VOG-diagnosed BPPV.
    Methods: Using a cross-sectional study of patients with BPPV, we investigated patients referred to NeuroEquilibrium specialty clinics throughout India between January 1, 2021, and December 31, 2021. All patients were evaluated with video oculography (VOG) during positional tests, and all diagnoses were confirmed by a neurotologist and neurologist.
    Results: Of 3,975 patients with VOG-confirmed and specialist-diagnosed BPPV (median age, 51 years; 56
    Discussion: This study found that hc-BPPV is far more common than previously reported. It is important to perform the supine roll test in addition to the Dix-Hallpike in all patients suspected with BPPV. Better training to diagnose patients with BPPV and to accurately recognize the nystagmus pattern of hc-BPPV should be a priority.
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000200191
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  9. Article: BPPV Simulation: A Powerful Tool to Understand and Optimize the Diagnostics and Treatment of all Possible Variants of BPPV.

    Bhandari, Anita / Kingma, Herman / Bhandari, Rajneesh

    Frontiers in neurology

    2021  Volume 12, Page(s) 632286

    Abstract: BPPV is a mechanical disorder caused by the displacement of otolith debris into the semicircular canals. The treatment involves different repositioning maneuvers to bring the debris back into the utricle. This study aims to show how dynamic simulation ... ...

    Abstract BPPV is a mechanical disorder caused by the displacement of otolith debris into the semicircular canals. The treatment involves different repositioning maneuvers to bring the debris back into the utricle. This study aims to show how dynamic simulation models based on fluid dynamics and MRI, can help to visualize and understand the movement of the debris within the canals during head movement in 3D as a function of time. The user can define the rotation angle and plane at each step of the maneuver and then the model visualizes the canal and the otoconial movement in 3D. The simulation developed also allows alteration of various parameters like the rotational head acceleration, the duration of each step of the maneuver, the initial position of the otoconial debris in the canal, the size and the number of the particles and fluid dynamics of endolymph. The clod movement is visualized in such a way that it allows a better understanding of the impact and efficacy of various liberation maneuvers and why certain maneuvers might fail when not applied properly in the clinic. The model allows simulation of multi-canal BPPV. In this paper we demonstrate the power of the model applied on the maneuvers of Semont and Yacovino when executed in different ways. The model aims to provide a visual explanation for the need of specific maneuvers for each type of BPPV. The simulator presented here can be used to test the efficacy of existing maneuvers and help in the development of new maneuvers to treat different BPPV variants.
    Language English
    Publishing date 2021-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.632286
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  10. Article ; Online: Diagnosis and management of bronchopulmonary dysplasia.

    Gilfillan, Margaret / Bhandari, Anita / Bhandari, Vineet

    BMJ (Clinical research ed.)

    2021  Volume 375, Page(s) n1974

    Abstract: Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants and is associated with increased mortality, respiratory morbidity, neurodevelopmental impairment, and increased healthcare costs. In parallel with advances made in the ... ...

    Abstract Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants and is associated with increased mortality, respiratory morbidity, neurodevelopmental impairment, and increased healthcare costs. In parallel with advances made in the field of neonatal intensive care, the phenotype of BPD has evolved from a fibrocystic disease affecting late preterm infants to one of impaired parenchymal development and dysregulated vascular growth predominantly affecting infants born before 29 weeks' gestational age. BPD has been shown to have significant lifelong consequences. Adults with BPD have been found to have abnormal lung function tests, reduced exercise tolerance, and may be at increased risk for developing chronic obstructive pulmonary disease. Evidence shows that BPD occurs secondary to genetic-environmental interactions in an immature lung. In this review, we evaluate the various clinical definitions, imaging modalities, and biomarker data that are helpful in making an early diagnosis of BPD. In addition, we evaluate recent evidence about the prevention and treatment of BPD. We discuss the invasive and non-invasive ventilation strategies and pharmacological agents used in the early, evolving, and established phases of BPD.
    MeSH term(s) Bronchopulmonary Dysplasia/diagnosis ; Bronchopulmonary Dysplasia/etiology ; Bronchopulmonary Dysplasia/therapy ; Combined Modality Therapy ; Gene-Environment Interaction ; Humans ; Infant, Newborn ; Infant, Premature
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n1974
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