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  1. Article ; Online: "If I want to be able to keep going, I must be active." Exploring older adults' perspectives of remote physical activity supports: a mixed-methods study.

    Mehrabi, Samira / Drisdelle, Sara / Dutt, Hanna R / Middleton, Laura E

    Frontiers in public health

    2024  Volume 12, Page(s) 1328492

    Abstract: Introduction: Pandemic-related public health restrictions limited older adults' physical activity programs and opportunities. Physical activity supports shifted to remote options, however, information on their adoption and effectiveness is limited. This ...

    Abstract Introduction: Pandemic-related public health restrictions limited older adults' physical activity programs and opportunities. Physical activity supports shifted to remote options, however, information on their adoption and effectiveness is limited. This study aims to describe the remote supports received by older adults and their perceived effectiveness. Additionally, it aims to describe facilitators and barriers to remote supports for physical activity among older adults, particularly those reliant on technology.
    Methods: This study used an explanatory, sequential, mixed-methods design. Community-dwelling older adults (≥ 60 years) were recruited to partake in a web-based survey and an optional semi-structured follow-up interview informed by the COM-B model. Participant characteristics, perceived effectiveness of remote supports, and the presence and severity of barriers were described. Changes in physical activity levels before and during the pandemic were analyzed using the Wilcoxon signed-rank test. Qualitative data underwent inductive thematic analysis.
    Results: Fifty seven older adults (68.3 ± 7.1 years, 43 Female) completed the survey, of which 15 participants (67.4 ± 5.8 years, 12 Female) participated in interviews. The majority were Caucasian, highly educated, and resided in Canada. Total physical activity levels showed no statistically significant change from before to during the pandemic (
    Conclusion: Virtual platforms show promise in supporting older adults' physical activity at home, especially for those with limited in-person access. Our study suggests that both real-time and pre-recorded virtual exercise supports are feasible, depending on technological capacity and support. While interactive real-time virtual programs allow interaction with professionals and peers, pre-recorded programs provide timing flexibility. Further research is needed to establish best practices for safe and effective virtual exercise programming, promoting its long-term adoption for supporting a wider range of older adults.
    MeSH term(s) Humans ; Female ; Aged ; Exercise ; Exercise Therapy/methods ; Motivation ; Canada
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1328492
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  2. Article ; Online: Current challenges ahead in preparation, characterization, and pharmaceutical applications of nanoemulsions.

    Yousefpoor, Yaser / Esnaashari, Seyedeh Sara / Baharifar, Hadi / Mehrabi, Mohsen / Amani, Amir

    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

    2023  Volume 15, Issue 6, Page(s) e1920

    Abstract: Nanoemulsions (NEs) are emulsions with particle size of less than around 100 nm. Reviewing the literature, several reports are available on NEs, including preparation, characterization, and applications of them. This review aims to brief challenges that ... ...

    Abstract Nanoemulsions (NEs) are emulsions with particle size of less than around 100 nm. Reviewing the literature, several reports are available on NEs, including preparation, characterization, and applications of them. This review aims to brief challenges that researchers or formulators may encounter when working with NEs. For instance, when selecting NE components and identifying their concentrations, stability and safety of the preparation should be evaluated. When preparing an NE, issues over scale-up of the preparation as well as possible effects of the preparation process on the active ingredient need to be considered. When characterizing the NEs, the two major concerns are accuracy of the method and accessibility of the characterizing instrument. Also a highly efficient NE for clinical use to deliver the active ingredient to the target tissue with maximum safety profile is commonly sought. Throughout the review we also have tried to suggest approaches to overcome the challenges. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies.
    MeSH term(s) Emulsions ; Particle Size
    Chemical Substances Emulsions
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2502698-7
    ISSN 1939-0041 ; 1939-5116
    ISSN (online) 1939-0041
    ISSN 1939-5116
    DOI 10.1002/wnan.1920
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  3. Article ; Online: Post-dural puncture headache prevention and treatment with aminophylline or theophylline: a systematic review and meta-analysis.

    Barati-Boldaji, Reza / Shojaei-Zarghani, Sara / Mehrabi, Manoosh / Amini, Afshin / Safarpour, Ali Reza

    Anesthesia and pain medicine

    2023  Volume 18, Issue 2, Page(s) 177–189

    Abstract: Background: Post-dural puncture headache (PDPH) is one of the most common complications in patients undergoing spinal anesthesia. The present systematic review and meta-analysis aimed to assess the therapeutic and prophylactic effects of aminophylline ... ...

    Abstract Background: Post-dural puncture headache (PDPH) is one of the most common complications in patients undergoing spinal anesthesia. The present systematic review and meta-analysis aimed to assess the therapeutic and prophylactic effects of aminophylline and theophylline on PDPH.
    Methods: Relevant studies were identified by searching the following electronic databases, without language restriction, until June 2020: Scopus, EMBASE, MEDLINE, Google Scholar, Web of Science, Cochrane Library-CENTRAL, and CINAHL Complete. Random effects models were used to calculate the standardized mean difference (SMD) and risk ratios (RRs) with 95% confidence intervals (95% CI) to assess the therapeutic and prophylactic effects of aminophylline and theophylline on PDPH, respectively. The Cochrane tool was used for the quality assessment of the included studies. The certainty of the evidence was rated using the Grading of Recommendations Assessment, Development, and Evaluation method.
    Results: Of the 1,349 initial records, 15 met our eligibility criteria (6 studies on therapeutic and 9 on prophylactic effects). A significant reduction in the pain score was observed following aminophylline/theophylline treatment (SMD = -1.67; 95% CI, -2.28 to -1.05; P < 0.001, I2 = 84.7%; P < 0.001). Subgroup analysis revealed that the therapeutic effect was significantly higher when these agents were compared to placebo than when conventional therapies were used. The risk of PDPH after aminophylline administration was not significantly reduced (RR = 0.74; 95% CI, 0.42 to 1.31; P = 0.290).
    Conclusions: Theophylline and aminophylline have therapeutic, but not prophylactic, effects on PDPH.
    Language English
    Publishing date 2023-04-28
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2383-7977
    ISSN (online) 2383-7977
    DOI 10.17085/apm.22247
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  4. Article: Outcomes of the Fluoroscopically-Guided vs. Computed-Tomography-Guided Transforaminal Epidural Steroid Injection in Low Back Pain: A Propensity-matched Prospective Cohort.

    Rafati, Ali / Ghanaati, Hossein / Asadi, Bahador / Mehrabi, Farzad / Rahmatian, Aryoobarzan / Hassani, Sara

    Medical journal of the Islamic Republic of Iran

    2023  Volume 37, Page(s) 23

    Abstract: Background: Low back pain (LBP), the most common musculoskeletal condition, imposes a significant burden on healthcare and triggers mental and physical disorders. Before surgery, patients are eligible for minimally-invasive treatments, including ... ...

    Abstract Background: Low back pain (LBP), the most common musculoskeletal condition, imposes a significant burden on healthcare and triggers mental and physical disorders. Before surgery, patients are eligible for minimally-invasive treatments, including transforaminal epidural steroid injection (TFESI). We aimed to compare fluoroscopically- and CT-guided TFESI in patients with subacute (4-12 weeks) and chronic (≥12 weeks) LBP.
    Methods: In this prospective cohort study, 121 adults with subacute or chronic LBP were recruited. Using propensity score matching (PSM), we created two age, sex, and body mass index (BMI) matched groups of fluoroscopically- and CT-guided TFESI, each including 38 patients. The outcomes of interest were the Oswestry disability index (ODI) and numerical rating scale (NRS), which were measured in all patients before the procedure and at the three-month follow-up. Then, the ODI and NRS mean changes were compared between Fluoroscopy and CT groups using repeated measures ANOVA. All analyses were performed with IBM SPSS Statistics for Windows, version 26 (IBM Corp., Armonk, NY, USA).
    Results: Of the total 76 matched patients with a mean (SD) age of 66.22 (13.49), 81 (66.9%) were female. ODI and NRS scores significantly decreased from baseline to the three-month follow-up in both treatment groups. The ODI score mean change from baseline to follow-up compared between the two groups was insignificant (fluoroscopy vs. CT mean difference (95% CI): 1.092 (-0.333-2.518),
    Conclusion: Fluoroscopically- and CT-guided TFESI show similar therapeutic effectiveness in patients with subacute and chronic LBP.
    Language English
    Publishing date 2023-03-15
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 1095990-7
    ISSN 1016-1430
    ISSN 1016-1430
    DOI 10.47176/mjiri.37.23
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  5. Article ; Online: Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial.

    Ahmadi, Sedigheh / Mehrabi, Zeinab / Zare, Morteza / Ghadir, Sara / Masoumi, Seyed Jalil

    International journal of clinical practice

    2023  Volume 2023, Page(s) 5734675

    Abstract: Background: Curcumin is a polyphenol derivative of the : Aim: We explored nanocurcumin's effect on the clinical manifestations of patients hospitalized with mild-to-moderate COVID-19.: Methods: This double-blind, randomized clinical trial involved ...

    Abstract Background: Curcumin is a polyphenol derivative of the
    Aim: We explored nanocurcumin's effect on the clinical manifestations of patients hospitalized with mild-to-moderate COVID-19.
    Methods: This double-blind, randomized clinical trial involved 76 COVID-19 patients admitted to Ali-Asghar Hospital from December 2021 to March 2022. All patients received standard coronavirus treatment as per national guidelines. In addition, four times a day for two weeks, the curcumin group received 40 mg of nanocurcumin, while the control group received a placebo. Clinical manifestations were examined and recorded by the associate doctors working in the department. Statistical analysis was done using SPSS v. 21.
    Results: Thirty-nine people from the control group and 29 from the curcumin group completed the study. At baseline, the groups were comparable in age, gender, body mass index, hospitalization duration, and background diseases. The mean age of patients in the control and treatment groups was 53.9 ± 11.9 and 54.6 ± 13.4, respectively. Compared with the placebo, nanocurcumin minimized coughs (
    Conclusions: This preliminary study suggests that nanocurcumin has a potentiating anti-inflammatory effect when combined with standard COVID-19 treatment, helping the recovery from the acute inflammatory phase of the disease in hospitalized patients with mild-to-moderate disease severity. This trial is registered with Iranian Registry of Clinical Trials: IRCT20211126053183N1 (registered while recruiting on 13/12/2021).
    MeSH term(s) Humans ; COVID-19 ; Curcumin/therapeutic use ; Iran ; COVID-19 Drug Treatment ; Treatment Outcome ; Oxygen ; Anti-Inflammatory Agents/therapeutic use ; Double-Blind Method
    Chemical Substances Curcumin (IT942ZTH98) ; Oxygen (S88TT14065) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-07-28
    Publishing country India
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1155/2023/5734675
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  6. Article ; Online: The Casuarina glauca metallothionein I promoter in nodulated transgenic hairy roots of the actinorhizal plant Datisca glomerata.

    Rashidi, Behnoosh / Mehrabi, Sara / Demchenko, Kirill / Pawlowski, Katharina

    Functional plant biology : FPB

    2020  Volume 38, Issue 9, Page(s) 728–737

    Abstract: The activity of the promoter of a metallothionein gene expressed in actinorhizal nodules of Casuarina glauca Sieber ex Spreng., CgMT1, has previously been analysed in Casaurinaceae and in tobacco (Nicotiana tabacum L.), Arabidopsis and rice. In all these ...

    Abstract The activity of the promoter of a metallothionein gene expressed in actinorhizal nodules of Casuarina glauca Sieber ex Spreng., CgMT1, has previously been analysed in Casaurinaceae and in tobacco (Nicotiana tabacum L.), Arabidopsis and rice. In all these plants, the promoter showed high activity in the root cortex and epidermis, making it a useful tool for the expression of transgenes. Therefore, its activity was now analysed in transgenic root systems of Datisca glomerata (C. Presl) Baill, an actinorhizal plant from a different phylogenetic group than C. glauca, using the same CgMT1::GUS fusion as in previous studies. However, in contrast with all other plant species examined previously, the CgMT1::GUS construct showed no activity at all in D. glomerata hairy roots: the expression pattern in nodules resembled that found in C. glauca nodules. This is probably due to the changed hormone balance in hairy roots since experiments on the CgMT1::GUS construct in transgenic Arabidopsis showed that CgMT1 promoter activity was repressed by auxin or cytokinin, respectively. Yet, in hairy roots of the model legume Lotus japonicus L. induced by the same Agrobacterium rhizogenes strain, the CgMT1 promoter was active in roots and not in nodules. These results indicate that although the expression of pRi T-DNA genes leads to changes in root hormone balance, these changes do not abolish the differences in phytohormone levels or sensitivity between plant species. Therefore, gene expression data obtained using transgenic hairy root systems have to be viewed with care, not only due to the disturbed hormone balance, but also because the effects of the pRI-T-DNA genes can differ between species.
    Language English
    Publishing date 2020-06-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2071582-1
    ISSN 1445-4416 ; 1445-4408
    ISSN (online) 1445-4416
    ISSN 1445-4408
    DOI 10.1071/FP10216
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  7. Article ; Online: Barriers to weight management in pregnant mothers with obesity: a qualitative study on mothers with low socioeconomic background.

    Mehrabi, Fahimeh / Ahmaripour, Najva / Jalali-Farahani, Sara / Amiri, Parisa

    BMC pregnancy and childbirth

    2021  Volume 21, Issue 1, Page(s) 779

    Abstract: Background: Maternal obesity is a public health issue that could affect both women's and children's health. This qualitative study aimed to identify barriers to weight management of pregnant women with obesity and low socioeconomic backgrounds.: ... ...

    Abstract Background: Maternal obesity is a public health issue that could affect both women's and children's health. This qualitative study aimed to identify barriers to weight management of pregnant women with obesity and low socioeconomic backgrounds.
    Methods: The current qualitative study has been conducted using a grounded theory approach by analyzing data collected from in-depth interviews with clients of Tehran's public health care centers for prenatal care. The criteria for selecting participants were excessive weight gain during the first two trimesters of pregnancy, low socioeconomic status, and willingness to share their experiences. A semi-structured guide consisting of open-ended questions was asked in a private room. Open, axial, and selective coding were applied to the data.
    Findings: Four main themes emerged from data, each of which has some subcategories: 1) personal factors (unpleasant emotions and feelings, personal tastes/hobbies, workload and responsibilities, and history of diseases), 2) pregnancy status (unintended and high-risk pregnancy), 3) interpersonal relationships and support (lack of a spouse's support and unhealthy role modeling of relatives), 4) socio-cultural factors/influences (social norms and values, lack of access to health services, and unreliable information channels).
    Conclusions: This study provides an overview of the barriers to the weight management of pregnant women from low socioeconomic backgrounds. The results could help develop appropriate health strategies for low socioeconomic women with obesity. Also, health care providers for this group of women could use these findings as a guide to consider their conditions and background.
    MeSH term(s) Adult ; Body Weight Maintenance ; Emotions ; Female ; Gestational Weight Gain ; Health Services Accessibility ; Humans ; Interpersonal Relations ; Iran ; Obesity, Maternal/psychology ; Pregnancy ; Pregnant Women/psychology ; Qualitative Research ; Social Norms ; Social Support ; Socioeconomic Factors
    Language English
    Publishing date 2021-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-021-04243-0
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  8. Article ; Online: Effective Reduction of Tau Amyloid Aggregates in the Presence of Cyclophilin from

    Mehrabi, Masomeh / Bijari, Nooshin / Akbari, Vali / Ranjbar, Samira / Karima, Saeed / Sankian, Mojtaba / Ojaghi, Sara / Khodarahmi, Reza

    Current protein & peptide science

    2023  Volume 24, Issue 6, Page(s) 518–532

    Abstract: Background: A hallmark pathology of Alzheimer's disease (AD) is the construction of neurofibrillary tangles, which are made of hyperphosphorylated Tau. The cis-proline isomer of the pThr/Ser-Pro sequence has been suggested to act as an aggregation ... ...

    Abstract Background: A hallmark pathology of Alzheimer's disease (AD) is the construction of neurofibrillary tangles, which are made of hyperphosphorylated Tau. The cis-proline isomer of the pThr/Ser-Pro sequence has been suggested to act as an aggregation precursor according to the 'Cistauosis' hypothesis; however, this aggregation scheme is not yet completely approved. Various peptidyl-prolyl isomerases (PPIases) may specifically isomerize cis/trans-proline bonds and restitute Tau's ability to attach microtubules and may control Tau amyloid aggregation in AD.
    Methods: In this study, we provided experimental evidence for indicating the effects of the plant Cyclophilin (P-Cyp) from
    Results: Our findings disclosed that the rate/extent of amyloid formation in the Tau sample which is incubated with P-Cyp decreased and these observations do not seem to be due to the macromolecular crowding effect. Also, as proven that 80% of the prolines in the unfolded protein are in the trans conformation, urea-induced unfolding analyses confirmed this conclusion and showed that the aggregation rate/extent of urea-treated Tau samples decreased compared with those of the native protein. Also, XRD analysis indicated the reduction of scattering intensities and beta structures of amyloid fibrils in the presence of P-Cyp. Therefore, the ability of P-Cyp to suppress Tau aggregation probably depends on cis to trans isomerization of proline peptide bonds (X-Pro) and decreasing cis isomers
    Conclusion: The findings of the current study may inspire possible protective/detrimental effects of various types of cyclophilins on AD onset/progression through direct regulation of intracellular Tau molecules and provides evidence that a protein from a plant source is able to enter the cell cytoplasm and may affect the behavior of cytoplasmic proteins.
    MeSH term(s) Cyclophilins/metabolism ; Amyloid/metabolism ; Allergens ; tau Proteins/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Pollen/metabolism ; Proline/pharmacology ; Proline/chemistry ; Proline/metabolism ; Urea ; Amyloid beta-Peptides
    Chemical Substances Cyclophilins (EC 5.2.1.-) ; Amyloid ; Allergens ; tau Proteins ; Proline (9DLQ4CIU6V) ; Urea (8W8T17847W) ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-06-01
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2045662-1
    ISSN 1875-5550 ; 1389-2037
    ISSN (online) 1875-5550
    ISSN 1389-2037
    DOI 10.2174/1389203724666230530143704
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  9. Article ; Online: Reply to "Biologics Are Effective in the Management of Inflammatory Bowel Disease Following Liver Transplantation in Combination With Antirejection Therapy".

    Safarpour, Ali Reza / Shojaei-Zarghani, Sara / Mehrabi, Manoosh / Keshtkar, Abbas Ali / Oroojan, Ali Akbar / Sivandzadeh, Gholam Reza

    Inflammatory bowel diseases

    2022  Volume 28, Issue 12, Page(s) e153

    MeSH term(s) Humans ; Liver Transplantation ; Biological Products/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/surgery ; Immunosuppression Therapy ; Biological Factors
    Chemical Substances Biological Products ; Biological Factors
    Language English
    Publishing date 2022-09-28
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izac209
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  10. Article ; Online: Nicotine and modafinil combination protects against the neurotoxicity induced by 3,4-Methylenedioxymethamphetamine in hippocampal neurons of male rats.

    Kowsari, Golshad / Mehrabi, Soraya / Soleimani Asl, Sara / Pourhamzeh, Mahsa / Mousavizadeh, Kazem / Mehdizadeh, Mehdi

    Journal of chemical neuroanatomy

    2021  Volume 116, Page(s) 101986

    Abstract: MDMA (3,4-Methylenedioxymethamphetamine) is a common recreational drug of abuse which causes neurodegeneration. Nicotine and modafinil provide antioxidant and neuroprotective properties and may be beneficial in the management of MDMA-induced ... ...

    Abstract MDMA (3,4-Methylenedioxymethamphetamine) is a common recreational drug of abuse which causes neurodegeneration. Nicotine and modafinil provide antioxidant and neuroprotective properties and may be beneficial in the management of MDMA-induced neurotoxicity. The purpose of this study was to characterize how acute and chronic administration of nicotine and/or modafinil exert protective effects against the MDMA-induced impaired cognitive performance, oxidative stress, and neuronal loss. Adult male rats were divided into three groups, namely control, MDMA and treatment (modafinil and/or nicotine). MDMA (10 mg/kg) was administered intraperitoneally during a three-week schedule (two times/day for two consecutive days/week). The treated-groups were classified based on the acute or chronic status of treatment. In the groups which underwent acute treatments, nicotine (0.5 mg/kg) and/or modafinil (100 mg/kg) were injected just prior to the MDMA administration (acute nicotine (NA), acute modafinil (MA), and acute nicotine and modafinil (NMA)). In the rats which received chronic treatments, nicotine (0.5 mg/kg) and/or modafinil (100 mg/kg) were injected every day during the three week-schedule administration of MDMA (chronic nicotine (NC), chronic modafinil (MC), and chronic nicotine and modafinil (NMC)). Learning and memory performance, as well as avoidance response, were assessed by Morris water maze and Shuttle box, respectively. Our findings indicate enhanced learning and memory and avoidance response in the NMC group. By TUNEL test and Cresyl Violet staining we evaluated neuronal loss and apoptosis in the hippocampal CA1 and found increased neuronal viability in the NMC group. On the other hand, chronic administration of modafinil and nicotine significantly down-regulated the caspase 3 and up-regulated both BDNF and TrkB levels in the MDMA-received rats. The serum levels of glutathione peroxidase (GPx) and total antioxidant capacity (TAC) were evaluated and we found that the alterations of serum levels of GPx and TAC were considerably prevented in the NMC group. The overall results indicate that nicotine and modafinil co-administration rescued brain from MDMA-induced neurotoxicity. We suggest that nicotine and modafinil combination therapy could be considered as a possible treatment to reduce the neurological disorders induced by MDMA.
    MeSH term(s) Animals ; Antioxidants/administration & dosage ; Avoidance Learning/drug effects ; Avoidance Learning/physiology ; Drug Therapy, Combination ; Hallucinogens/toxicity ; Hippocampus/drug effects ; Hippocampus/pathology ; Male ; Maze Learning/drug effects ; Maze Learning/physiology ; Modafinil/administration & dosage ; N-Methyl-3,4-methylenedioxyamphetamine/toxicity ; Neurons/drug effects ; Neurons/pathology ; Neuroprotection/drug effects ; Neuroprotection/physiology ; Nicotine/administration & dosage ; Rats
    Chemical Substances Antioxidants ; Hallucinogens ; Nicotine (6M3C89ZY6R) ; N-Methyl-3,4-methylenedioxyamphetamine (KE1SEN21RM) ; Modafinil (R3UK8X3U3D)
    Language English
    Publishing date 2021-06-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639443-7
    ISSN 1873-6300 ; 0891-0618
    ISSN (online) 1873-6300
    ISSN 0891-0618
    DOI 10.1016/j.jchemneu.2021.101986
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