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  1. Article ; Online: Lack of hemochromatosis in Saint Augustine in his studio by Sandro Botticelli.

    Kluger, N

    Journal of endocrinological investigation

    2024  

    Language English
    Publishing date 2024-04-27
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/s40618-024-02367-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1480: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article: Application of the S-N Curve Mean Stress Correction Model in Terms of Fatigue Life Estimation for Random Torsional Loading for Selected Aluminum Alloys.

    Böhm, Michał / Kluger, Krzysztof / Pochwała, Sławomir / Kupina, Mariusz

    Materials (Basel, Switzerland)

    2020  Volume 13, Issue 13

    Abstract: The paper presents the experimental fatigue test results for cyclic constant amplitude loading conditions for the case of the torsion of the PA4 (AW-6082-T6), PA6 (AW-2017A-T4) and PA7 (AW-2024-T3) aluminum alloy for a drilled diabolo type test specimen. ...

    Abstract The paper presents the experimental fatigue test results for cyclic constant amplitude loading conditions for the case of the torsion of the PA4 (AW-6082-T6), PA6 (AW-2017A-T4) and PA7 (AW-2024-T3) aluminum alloy for a drilled diabolo type test specimen. The tests have been performed for the stress asymmetry ratios
    Language English
    Publishing date 2020-07-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13132985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pityriasis Lichenoides Chronica in Skin of Color.

    Kluger, Nicolas

    Journal of cutaneous medicine and surgery

    2024  , Page(s) 12034754241229349

    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/12034754241229349
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4987: Show issues Location:
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  4. Article ; Online: Hallux patch during anti-TIF-1γ dermatomyositis.

    Kluger, Nicolas

    Clinical and experimental dermatology

    2024  

    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llae142
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    Zs.A 1278: Show issues Location:
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  5. Article: Photodynamic therapy-induced flare of superficial pemphigus.

    Kluger, N

    Annales de dermatologie et de venereologie

    2023  Volume 150, Issue 4, Page(s) 297–298

    Language English
    Publishing date 2023-12-08
    Publishing country France
    Document type Letter
    ZDB-ID 391805-1
    ISSN 2214-5451 ; 0151-9638
    ISSN (online) 2214-5451
    ISSN 0151-9638
    DOI 10.1016/j.annder.2023.06.002
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  6. Article: Rigorous insistence on smoking cessation as a condition for surgery is detrimental for hidradenitis suppurativa patients.

    Kluger, N

    Annales de dermatologie et de venereologie

    2023  Volume 150, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Hidradenitis Suppurativa ; Smoking Cessation
    Language English
    Publishing date 2023-02-20
    Publishing country France
    Document type Editorial
    ZDB-ID 391805-1
    ISSN 2214-5451 ; 0151-9638
    ISSN (online) 2214-5451
    ISSN 0151-9638
    DOI 10.1016/j.annder.2023.01.001
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  7. Article ; Online: MEK targeting in N-RAS mutated metastatic melanoma.

    Thumar, Jaykumar / Shahbazian, David / Aziz, Saadia A / Jilaveanu, Lucia B / Kluger, Harriet M

    Molecular cancer

    2014  Volume 13, Page(s) 45

    Abstract: Background: Gain of function mutations in B-RAF and N-RAS occur frequently in melanoma, leading ... Clinical and pathologic data were collected retrospectively on melanoma patients tested for B-RAF and N-RAS ... cultures.: Results: In a cohort of 144 metastatic melanoma patients we found that patients with N-RAS ...

    Abstract Background: Gain of function mutations in B-RAF and N-RAS occur frequently in melanoma, leading to mitogen activating protein kinase (MAPK) pathway activation, and this pathway is the target of drugs in development. Our purpose was to study clinical characteristics of patients with mutations in this pathway and to determine activity of inhibitors of B-RAF and MEK in short term cultures grown from tumors of some of these patients.
    Methods: Clinical and pathologic data were collected retrospectively on melanoma patients tested for B-RAF and N-RAS mutations at the Yale Cancer Center and associations with survival were determined. We studied in vitro activity of the pan-RAF inhibitor, RAF265, and the MEK inhibitor, MEK162, in 22 melanoma short term cultures. We further characterized the effect of MEK inhibition on apoptosis and growth of melanoma cultures.
    Results: In a cohort of 144 metastatic melanoma patients we found that patients with N-RAS mutant melanoma had a worse prognosis. These patients were more likely to have brain metastases at the time of presentation with metastatic disease than their N-RAS-wild-type counterparts. All N-RAS mutant melanoma cultures tested in our study (n = 7) were sensitive to MEK inhibition 162. Exposure to MEK162 reduced ERK1/2 phosphorylation, and induced apoptosis. Clonogenic survival was significantly reduced in sensitive melanoma cell cultures.
    Conclusions: The prognosis of patients with melanoma expressing constitutively active N-RAS is poor, consistent with studies performed at other institutions. N-RAS mutant melanoma cultures appear to be particularly sensitive to MEK162, supporting ongoing clinical trials with MEK162 in N-RAS mutated melanoma.
    MeSH term(s) Aged ; Benzimidazoles/pharmacology ; Blotting, Western ; Female ; Genes, ras/genetics ; Humans ; Kaplan-Meier Estimate ; MAP Kinase Kinase Kinases/metabolism ; Male ; Melanoma/genetics ; Melanoma/metabolism ; Melanoma/mortality ; Middle Aged ; Mutation ; Neoplasm Metastasis ; Proportional Hazards Models ; Protein Kinase Inhibitors/pharmacology ; Tumor Cells, Cultured
    Chemical Substances Benzimidazoles ; Protein Kinase Inhibitors ; binimetinib (181R97MR71) ; MAP Kinase Kinase Kinases (EC 2.7.11.25)
    Language English
    Publishing date 2014-03-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1476-4598
    ISSN (online) 1476-4598
    DOI 10.1186/1476-4598-13-45
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  8. Article ; Online: Tattoos, tattooists, moles and melanomas.

    Kluger, Nicolas

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 37, Issue 9, Page(s) e1121–e1122

    MeSH term(s) Humans ; Animals ; Moles ; Tattooing/adverse effects ; Nevus ; Nevus, Pigmented ; Melanoma/etiology ; Skin Neoplasms/etiology
    Language English
    Publishing date 2023-05-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19170
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    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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  9. Article ; Online: A case of hidradenitis suppurativa in a 19th-century painting at the Leopold Museum?

    Kluger, Nicolas

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 38, Issue 1, Page(s) 20–21

    MeSH term(s) Humans ; Hidradenitis Suppurativa ; Museums
    Language English
    Publishing date 2023-09-15
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19476
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3492: Show issues Location:
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  10. Article: Thyroid Diseases in a Cohort of Finnish Patients with Hidradenitis Suppurativa.

    Kluger, Nicolas

    Skin appendage disorders

    2023  Volume 9, Issue 3, Page(s) 191–194

    Abstract: Introduction: The association between thyroid disorders (hyperthyroidism or hypothyroidism) and hidradenitis suppurativa is controversial. Our study aimed to determine the phenotype and comorbidities of HS patients with thyroid disorders.: Methods: A ...

    Abstract Introduction: The association between thyroid disorders (hyperthyroidism or hypothyroidism) and hidradenitis suppurativa is controversial. Our study aimed to determine the phenotype and comorbidities of HS patients with thyroid disorders.
    Methods: A retrospective study was conducted in the department of dermatology, Helsinki University Hospital, Finland, and included all the attending patients with HS diagnosis in 2018.
    Results: A total of 167 patients were included (97 women). The prevalence of thyroid disorders was 12% and of hypothyroidism 10.7%. Patients with thyroid disorders were more likely to have a BMI ≥25 (
    Conclusion: Our study is in line with previous ones that showed the association of HS and thyroid disorders in nonsmokers. Asthma may be simply an association with thyroid disorders and unrelated to HS as such.
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806972-9
    ISSN 2296-9160 ; 2296-9195
    ISSN (online) 2296-9160
    ISSN 2296-9195
    DOI 10.1159/000529907
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