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  1. Article ; Online: The Term 'Deselect' is Ambiguous as Used in Research Studies to Support Prescription to Nonprescription Switches.

    Brass, Eric P

    Therapeutic innovation & regulatory science

    2023  Volume 58, Issue 1, Page(s) 16–17

    MeSH term(s) Nonprescription Drugs ; Drug Prescriptions
    Chemical Substances Nonprescription Drugs
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2708397-4
    ISSN 2168-4804 ; 2168-4790
    ISSN (online) 2168-4804
    ISSN 2168-4790
    DOI 10.1007/s43441-023-00590-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Food and Drug Administration and the Future of Drug Development for the Treatment of Diabetes.

    Brass, Eric P

    Diabetes spectrum : a publication of the American Diabetes Association

    2014  Volume 27, Issue 2, Page(s) 75–77

    Language English
    Publishing date 2014-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211544-4
    ISSN 1040-9165
    ISSN 1040-9165
    DOI 10.2337/diaspect.27.2.75
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6232: Show issues Location:
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  3. Article ; Online: Response by Brass and Hiatt to Letter Regarding Article, "Aspirin Monotherapy Should Not Be Recommended for Cardioprotection in Patients With Symptomatic Peripheral Artery Disease".

    Brass, Eric P / Hiatt, William R

    Circulation

    2018  Volume 137, Issue 12, Page(s) 1304

    MeSH term(s) Aspirin ; Humans ; Peripheral Arterial Disease ; Platelet Aggregation Inhibitors
    Chemical Substances Platelet Aggregation Inhibitors ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2018-03-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.117.032707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Effectiveness of Nonprescription Drug Labels in the United States: Insights from Recent Research and Opportunities for the Future.

    Catlin, Jesse R / Brass, Eric P

    Pharmacy (Basel, Switzerland)

    2018  Volume 6, Issue 4

    Abstract: Despite providing a consistent and comprehensible format for over-the-counter (OTC) drug communication, research suggests important limitations in the communication effectiveness of the Drug Facts Label required on OTC drugs in the United States. This ... ...

    Abstract Despite providing a consistent and comprehensible format for over-the-counter (OTC) drug communication, research suggests important limitations in the communication effectiveness of the Drug Facts Label required on OTC drugs in the United States. This literature is reviewed and some of these critical limitations of the Drug Facts Label (DFL) highlighted. These include difficulty communicating complex information that requires integration of multiple pieces of label information and limited adaptability to serve the unique needs of individual populations (e.g., low literacy or older consumers). Potential ways to improve the DFL's communication effectiveness are identified along with complementary opportunities to improve OTC drug communication by leveraging the role of pharmacists and use of adjunctive technologies.
    Language English
    Publishing date 2018-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737194-3
    ISSN 2226-4787 ; 2226-4787
    ISSN (online) 2226-4787
    ISSN 2226-4787
    DOI 10.3390/pharmacy6040119
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  5. Article: Cerebrotendinous xanthomatosis-associated diarrhea and response to chenodeoxycholic acid treatment.

    Brass, Eric P / Stelten, Bianca M L / Verrips, Aad

    JIMD reports

    2020  Volume 56, Issue 1, Page(s) 105–111

    Abstract: Background: In patients with cerebrotendinous xanthomatosis (CTX), chronic diarrhea is one of the earliest and main symptoms of the disease. In the current study, we evaluated the characteristics of the diarrhea and its response to chenodeoxycholic acid ...

    Abstract Background: In patients with cerebrotendinous xanthomatosis (CTX), chronic diarrhea is one of the earliest and main symptoms of the disease. In the current study, we evaluated the characteristics of the diarrhea and its response to chenodeoxycholic acid (CDCA) therapy in a cohort of Dutch CTX patients.
    Methods: We performed a retrospective review of medical records for 33 genetically confirmed CTX patients, and abstracted the characteristics of the diarrhea and the response to CDCA therapy (15 mg/kg/day up to 750 mg/day). The Bristol Stool Scale (BSS) was used for qualitative characterization of the stool.
    Results: Twenty-five patients had diarrhea documented at baseline (76%). Of these patients, 10 had diarrhea rated as 6 (fluffy pieces with ragged edges, a mushy stool), and 6 had diarrhea rated as 7 (watery, no solid pieces, entirely liquid) using the BSS. In 10 patients for whom data were recorded, the median stool frequency at baseline was 3 per day (range 2-6 per day). The response rate with CDCA for diarrhea resolution was 100% based on at least one post-baseline visit without diarrhea and 95% as assessed at the first post-baseline visit. In 68% of cases resolution was complete and sustained as no episodes of diarrhea were documented for follow-up periods as long as 25 years.
    Conclusions: Chronic diarrhea persisting for years without spontaneous remission is a common feature of CTX at diagnosis. Chenodeoxycholic acid is an effective treatment for symptomatic relief of diarrhea in patients with CTX.
    Language English
    Publishing date 2020-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2672872-2
    ISSN 2192-8312 ; 2192-8304
    ISSN (online) 2192-8312
    ISSN 2192-8304
    DOI 10.1002/jmd2.12163
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  6. Article ; Online: Assessing the benefit-risk for new drugs: are the FDA's Endocrinologic and Metabolic Drugs Advisory Committee and the Division of Metabolism and Endocrinology Products in sync?

    Brass, Eric P

    Diabetes care

    2013  Volume 36, Issue 7, Page(s) 1823–1826

    MeSH term(s) Advisory Committees ; Drug Approval ; Humans ; Risk Assessment ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2013-05-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc13-0891
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    Zs.A 1434: Show issues Location:
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    Zs.MO 365: Show issues

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  7. Article ; Online: Cardiovascular risks with azithromycin.

    Brass, Eric P

    The New England journal of medicine

    2013  Volume 369, Issue 6, Page(s) 580

    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Azithromycin/adverse effects ; Cardiovascular Diseases/mortality ; Death, Sudden, Cardiac/etiology ; Female ; Humans ; Male ; Penicillin V/adverse effects
    Chemical Substances Anti-Bacterial Agents ; Azithromycin (83905-01-5) ; Penicillin V (Z61I075U2W)
    Language English
    Publishing date 2013-08-08
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1306999#SA2
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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Modeling the potential benefit of an over-the-counter progestin-only pill in preventing unintended pregnancies in the U.S.

    Guillard, Hélène / Laurora, Irene / Sober, Stephanie / Karapet, Artin / Brass, Eric P / Glasier, Anna

    Contraception

    2022  Volume 117, Page(s) 7–12

    Abstract: Objectives: To develop a model to estimate the possible impact of use of an over-the-counter (OTC) progestin-only pill (POP) on the number of unintended pregnancies in the United States.: Study design: Using typical use failure rates (7% for POPs), ... ...

    Abstract Objectives: To develop a model to estimate the possible impact of use of an over-the-counter (OTC) progestin-only pill (POP) on the number of unintended pregnancies in the United States.
    Study design: Using typical use failure rates (7% for POPs), we compared the expected number of unintended pregnancies for two theoretical cohorts of 100,000 women: one which purchased and used an OTC POP exclusively for contraception, the other using contraceptive methods at proportions obtained from an actual-use clinical trial simulating OTC use of norgestrel 0.075 mg (including 35% using no method and only 19% using hormonal contraception or long-acting contraceptives). Sensitivity analyses were conducted using alternative model inputs such as different failure rates for OTC POPs and varied alternative contraceptive method mix.
    Results: An estimated 37,624 unintended pregnancies would occur annually if 100,000 women continued their usual contraceptive method as used at baseline in the actual use trial. This would be reduced by 81% to 7,000 pregnancies with the exclusive use of an OTC POP - a net reduction of 30,624 unintended pregnancies annually. While the number of unintended pregnancies prevented varied as the model parameters were modified (ranging from 1,461 to 34,124), a net benefit of OTC POP use was observed over a wide range of input values.
    Conclusions: Using data from a real-world contraception user profile, our model suggests that use of an OTC POP could reduce the overall number of unintended pregnancies in the United States. This conclusion remains true across a wide range of modeled scenarios.
    Implications: The estimates suggested by this model are supportive of an OTC switch for a POP.
    MeSH term(s) Pregnancy ; United States ; Female ; Humans ; Pregnancy, Unplanned ; Progestins ; Contraception/methods ; Contraceptive Agents ; Norgestrel
    Chemical Substances Progestins ; Contraceptive Agents ; Norgestrel (3J8Q1747Z2)
    Language English
    Publishing date 2022-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2022.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 629: Show issues Location:
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  9. Article ; Online: Resident's morning report: an opportunity to reinforce principles of biomedical science in a clinical context.

    Brass, Eric P

    Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

    2013  Volume 41, Issue 5, Page(s) 315–318

    Abstract: The principles of biochemistry are core to understanding cellular and tissue function, as well as the pathophysiology of disease. However, the clinical utility of biochemical principles is often obscure to clinical trainees. Resident's Morning Report is ... ...

    Abstract The principles of biochemistry are core to understanding cellular and tissue function, as well as the pathophysiology of disease. However, the clinical utility of biochemical principles is often obscure to clinical trainees. Resident's Morning Report is a common teaching conference in which residents present clinical cases of interest to a faculty member for discussion. This venue provides an opportunity to illustrate how basic biomedical principles facilitate an understanding of the clinical presentation, the relevant pathophysiology, and the rationale for diagnostic and therapeutic strategies. A discussion of biochemical principles can easily be incorporated into these case discussions, with the potential to reinforce these concepts and to illustrate their application to clinical decision making. This approach maintains the effort to teach basic biomedical sciences in the context of clinical application across the educational continuum.
    MeSH term(s) Biological Science Disciplines/education ; Biomedical Research/education ; Clinical Trials as Topic ; Humans ; Internship and Residency ; Science/education ; Students
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Journal Article
    ISSN 1539-3429
    ISSN (online) 1539-3429
    DOI 10.1002/bmb.20714
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  10. Article ; Online: Aspirin Monotherapy Should Not Be Recommended for Cardioprotection in Patients With Symptomatic Peripheral Artery Disease.

    Brass, Eric P / Hiatt, William R

    Circulation

    2017  Volume 136, Issue 9, Page(s) 785–786

    MeSH term(s) Aspirin/adverse effects ; Aspirin/therapeutic use ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Clinical Decision-Making ; Clopidogrel/adverse effects ; Clopidogrel/therapeutic use ; Evidence-Based Medicine ; Humans ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/drug therapy ; Peripheral Arterial Disease/epidemiology ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Practice Guidelines as Topic ; Risk Factors ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2017-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.117.028888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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