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  1. Article ; Online: Letter by Borst Regarding Article, "Rivaroxaban Reduces Arterial Thrombosis by Inhibition of FXa Driven Platelet Activation via Protease Activated Receptor-1".

    Borst, Oliver

    Circulation research

    2020  Volume 126, Issue 8, Page(s) e53

    MeSH term(s) Humans ; Peptide Hydrolases ; Platelet Activation ; Receptor, PAR-1 ; Rivaroxaban ; Thrombosis/drug therapy ; Thrombosis/prevention & control
    Chemical Substances Receptor, PAR-1 ; Rivaroxaban (9NDF7JZ4M3) ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.120.316777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: CRACking the Molecular Regulatory Mechanism of SOCE during Platelet Activation in Thrombo-Occlusive Diseases.

    Münzer, Patrick / Borst, Oliver

    Cells

    2022  Volume 11, Issue 4

    Abstract: Thrombo-occlusive diseases such as myocardial infarction, ischemic stroke and deep vein thrombosis with subsequent pulmonary embolism still represent a major health burden worldwide. Besides the cells of the vasculature or other hematopoietic cells, ... ...

    Abstract Thrombo-occlusive diseases such as myocardial infarction, ischemic stroke and deep vein thrombosis with subsequent pulmonary embolism still represent a major health burden worldwide. Besides the cells of the vasculature or other hematopoietic cells, platelets are primarily responsible for the development and progression of an occluding thrombus. The activation and function of platelets crucially depend on free cytosolic calcium (Ca
    MeSH term(s) Calcium Signaling/physiology ; Humans ; ORAI1 Protein/metabolism ; Platelet Activation ; Stromal Interaction Molecule 1/metabolism ; Thrombosis/metabolism
    Chemical Substances ORAI1 Protein ; Stromal Interaction Molecule 1
    Language English
    Publishing date 2022-02-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11040619
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  3. Book ; Online ; Thesis: Der Einfluss thrombozytärer microRNAs auf die myokardiale Inflammation und das ventrikuläre Remodeling nach Ischämie und Reperfusion am Herzen

    Schütte, Jan Philipp [Verfasser] / Borst, Oliver Alexander [Akademischer Betreuer]

    2024  

    Author's details Jan Philipp Schütte ; Betreuer: Oliver Alexander Borst
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
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  4. Article: NET-(works) in arterial and venous thrombo-occlusive diseases.

    Zdanyte, Monika / Borst, Oliver / Münzer, Patrick

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1155512

    Abstract: Formation of Neutrophil Extracellular Traps (NETosis), accompanied by the release of extracellular decondensed chromatin and pro-inflammatory as well as pro-thrombotic factors, is a pivotal element in the development and progression of thrombo-occlusive ... ...

    Abstract Formation of Neutrophil Extracellular Traps (NETosis), accompanied by the release of extracellular decondensed chromatin and pro-inflammatory as well as pro-thrombotic factors, is a pivotal element in the development and progression of thrombo-occlusive diseases. While the process of NETosis is based on complex intracellular signalling mechanisms, it impacts a wide variety of cells including platelets, leukocytes and endothelial cells. Consequently, although initially mainly associated with venous thromboembolism, NETs also affect and mediate atherothrombosis and its acute complications in the coronary, cerebral and peripheral arterial vasculature. In this context, besides deep vein thrombosis and pulmonary embolism, NETs in atherosclerosis and especially its acute complications such as myocardial infarction and ischemic stroke gained a lot of attention in the cardiovascular research field in the last decade. Thus, since the effect of NETosis on platelets and thrombosis in general is extensively discussed in other review articles, this review focusses on the translational and clinical relevance of NETosis research in cardiovascular thrombo-occlusive diseases. Consequently, after a brief summary of the neutrophil physiology and the cellular and molecular mechanisms underlying NETosis are presented, the role of NETosis in atherosclerotic and venous thrombo-occlusive diseases in chronic and acute settings are discussed. Finally, potential prevention and treatment strategies of NET-associated thrombo-occlusive diseases are considered.
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1155512
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  5. Article ; Online: Current concepts and novel targets for antiplatelet therapy.

    Gawaz, Meinrad / Geisler, Tobias / Borst, Oliver

    Nature reviews. Cardiology

    2023  Volume 20, Issue 9, Page(s) 583–599

    Abstract: Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo-ischaemic complications in atherosclerotic diseases. Current antiplatelet ... ...

    Abstract Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo-ischaemic complications in atherosclerotic diseases. Current antiplatelet therapies substantially improve clinical outcomes in patients with coronary artery disease, but at the cost of increased risk of bleeding. Beyond their role in thrombosis, platelets are known to regulate inflammatory (thrombo-inflammatory) and microcirculatory pathways. Therefore, controlling platelet hyper-reactivity might have implications for both tissue inflammation (myocardial ischaemia) and vascular inflammation (vulnerable plaque formation) to prevent atherosclerosis. In this Review, we summarize the pathophysiological role of platelets in acute myocardial ischaemia, vascular inflammation and atherosclerotic progression. Furthermore, we highlight current clinical concepts of antiplatelet therapy that have contributed to improving patient care and have facilitated more individualized therapy. Finally, we discuss novel therapeutic targets and compounds for antiplatelet therapy that are currently in preclinical development, some of which have a more favourable safety profile than currently approved drugs with regard to bleeding risk. These novel antiplatelet targets might offer new strategies to treat cardiovascular disease.
    MeSH term(s) Humans ; Platelet Aggregation Inhibitors/adverse effects ; Microcirculation ; Blood Platelets ; Atherosclerosis/metabolism ; Coronary Artery Disease/drug therapy ; Coronary Artery Disease/metabolism ; Inflammation/drug therapy
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-023-00854-6
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  6. Article ; Online: CRACking the Molecular Regulatory Mechanism of SOCE during Platelet Activation in Thrombo-Occlusive Diseases

    Patrick Münzer / Oliver Borst

    Cells, Vol 11, Iss 619, p

    2022  Volume 619

    Abstract: Thrombo-occlusive diseases such as myocardial infarction, ischemic stroke and deep vein thrombosis with subsequent pulmonary embolism still represent a major health burden worldwide. Besides the cells of the vasculature or other hematopoietic cells, ... ...

    Abstract Thrombo-occlusive diseases such as myocardial infarction, ischemic stroke and deep vein thrombosis with subsequent pulmonary embolism still represent a major health burden worldwide. Besides the cells of the vasculature or other hematopoietic cells, platelets are primarily responsible for the development and progression of an occluding thrombus. The activation and function of platelets crucially depend on free cytosolic calcium (Ca 2+ ) as second messenger, which modulates platelet secretion, aggregation and thrombus formation. Ca 2+ is elevated upon platelet activation by release of Ca 2+ from intracellular stores thus triggering of the subsequent store-operated Ca 2+ entry (SOCE), which is facilitated by Ca 2+ release-activated channels (CRACs). In general, CRACs are assembled by the pore-forming unit Orai in the plasma membrane and the Ca 2+ -sensing stromal interaction molecule (STIM) in the endoplasmic reticulum after the depletion of internal Ca 2+ stores. In the last few years, there is a growing body of the literature demonstrating the importance of STIM and Orai-mediated mechanism in thrombo-occlusive disorders. Thus, this review provides an overview of the recent understanding of STIM and Orai signaling in platelet function and its implication in the development and progression of ischemic thrombo-occlusive disorders. Moreover, potential pharmacological implications of STIM and Orai signaling in platelets are anticipated and discussed in the end.
    Keywords platelets ; STIM1 ; Orai1 ; SOCE ; CRAC ; thrombosis ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: COVID-19 and the Incidence of Acute Myocardial Injury.

    Mizera, Lars / Borst, Oliver

    Hamostaseologie

    2021  Volume 41, Issue 5, Page(s) 356–364

    Abstract: Cardiovascular manifestations are frequent in COVID-19 infection and are predictive of adverse outcomes. Elevated cardiac biomarkers are common findings in patients with cardiovascular comorbidities and severe COVID-19 infection. Troponin, inflammatory ... ...

    Abstract Cardiovascular manifestations are frequent in COVID-19 infection and are predictive of adverse outcomes. Elevated cardiac biomarkers are common findings in patients with cardiovascular comorbidities and severe COVID-19 infection. Troponin, inflammatory and thrombotic markers may also improve risk prediction in COVID-19. In our comprehensive review, we provide an overview of the incidence, potential mechanisms and outcome of acute cardiac injury in COVID-19. Thereby, we discuss coagulation abnormalities in sepsis and altered immune response as contributing factors favoring myocardial injury. We further highlight the role of endothelial damage in the pathophysiological concepts. Finally, observational studies addressing the incidence of myocardial infarction during COVID-19 pandemic are discussed.
    MeSH term(s) Biomarkers/blood ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/mortality ; Comorbidity ; Heart Injuries/blood ; Heart Injuries/epidemiology ; Heart Injuries/mortality ; Humans ; Incidence ; Models, Cardiovascular ; Myocardial Infarction/blood ; Myocardial Infarction/epidemiology ; Myocardial Infarction/mortality ; Pandemics ; SARS-CoV-2/pathogenicity ; Troponin/blood
    Chemical Substances Biomarkers ; Troponin
    Language English
    Publishing date 2021-10-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1554-6416
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    Zs.A 1631: Show issues Location:
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  8. Article ; Online: Platelet lipid metabolism in vascular thrombo-inflammation.

    Manke, Mailin-Christin / Ahrends, Robert / Borst, Oliver

    Pharmacology & therapeutics

    2022  Volume 237, Page(s) 108258

    Abstract: The function of platelets - and thereby the balance between thrombosis and hemostasis - critically depends on their lipid composition. At the same time, platelets are capable of interacting with inflammatory cells by releasing lipids in a paracrine ... ...

    Abstract The function of platelets - and thereby the balance between thrombosis and hemostasis - critically depends on their lipid composition. At the same time, platelets are capable of interacting with inflammatory cells by releasing lipids in a paracrine manner. Over the years, many studies have emphasized the importance of both, membrane and signaling lipids, in the signaling pathways underlying arterial thrombosis and chronic inflammation. In line with this, an imbalance of platelet lipid homeostasis is associated with thrombo-inflammatory diseases such as acute coronary syndrome. By establishing quantitative platelet lipidomic analysis, an opportunity has arisen to deepen our knowledge about platelet lipids regulating thrombo-inflammation and vice versa. Past and future investigations in this upcoming field are of great clinical importance since they will presumably pave the way for the identification of novel biomarkers. In addition, targeting specific regulators of the platelet lipid metabolism is a promising strategy to receive both anti-thrombotic and anti-inflammatory therapeutics and could be beneficial to a wide variety of patients with vascular thrombo-inflammatory diseases. This review summarizes the latest scientific findings in the field of platelet lipidomics research and does so by focusing on the metabolism of sphingolipids, oxylipins and phosphoinositides, which are affected by dynamic modifications in a pathophysiological manner. Further, this review elucidates the impact of these platelet lipids on thrombo-inflammatory cardiovascular diseases and highlights potential diagnostic and therapeutic targets.
    MeSH term(s) Blood Platelets/metabolism ; Humans ; Inflammation/metabolism ; Lipid Metabolism ; Lipids ; Thrombosis ; Vascular Diseases/metabolism
    Chemical Substances Lipids
    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2022.108258
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  9. Article ; Online: Somatic Integration of Incoherent Dendritic Inputs in the Gerbil Medial Superior Olive.

    Mackenbach, Yarmo / Borst, J Gerard G

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2023  Volume 43, Issue 22, Page(s) 4093–4109

    Abstract: The medial superior olive (MSO) is a binaural nucleus that is specialized in detecting the relative ...

    Abstract The medial superior olive (MSO) is a binaural nucleus that is specialized in detecting the relative arrival times of sounds at both ears. Excitatory inputs to its neurons originating from either ear are segregated to different dendrites. To study the integration of synaptic inputs both within and between dendrites, we made juxtacellular and whole-cell recordings from the MSO in anesthetized female gerbils, while presenting a "double zwuis" stimulus, in which each ear received its own set of tones, which were chosen in a way that all second-order distortion products (DP2s) could be uniquely identified. MSO neurons phase-locked to multiple tones within the multitone stimulus, and vector strength, a measure for spike phase-locking, generally depended linearly on the size of the average subthreshold response to a tone. Subthreshold responses to tones in one ear depended little on the presence of sound in the other ear, suggesting that inputs from different ears sum linearly without a substantial role for somatic inhibition. The "double zwuis" stimulus also evoked response components in the MSO neuron that were phase-locked to DP2s. Bidendritic subthreshold DP2s were quite rare compared with bidendritic suprathreshold DP2s. We observed that in a small subset of cells, the ability to trigger spikes differed substantially between both ears, which might be explained by a dendritic axonal origin. Some neurons that were driven monaurally by only one of the two ears nevertheless showed decent binaural tuning. We conclude that MSO neurons are remarkably good in finding binaural coincidences even among uncorrelated inputs.
    MeSH term(s) Animals ; Female ; Superior Olivary Complex/physiology ; Gerbillinae ; Neurons/physiology ; Acoustic Stimulation ; Sound Localization/physiology ; Olivary Nucleus/physiology ; Auditory Pathways/physiology
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2215-22.2023
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    Zs.A 1668: Show issues Location:
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  10. Article ; Online: Continuous low-dose thrombolysis in patients with intermediate-high risk pulmonary embolism: A retrospective analysis.

    Droppa, Michal / Zdanyte, Monika / Henes, Jessica Kristin / Gawaz, Meinrad / Borst, Oliver / Rath, Dominik

    Thrombosis research

    2023  Volume 226, Page(s) 33–35

    MeSH term(s) Humans ; Retrospective Studies ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/etiology ; Fibrinolytic Agents/therapeutic use ; Fibrinolysis ; Thrombolytic Therapy ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2023.04.006
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