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  1. Book: Das große Buch der chinesischen Medizin

    Kaptchuk, Ted J. / Biller, Ingeborg

    Die Medizin von Yin und Yang in Theorie und Praxis

    2022  

    Author's details Ted J. Kaptchuk erhielt seinen Doktortitel 1975 am Macao Institut für Chinesische Medizin. Heute ist er als Associate Director im Center for Alternative Medicine Research and Education in Boston tätig sowie als Assistant Professor an der Harvard Medical School
    Keywords Behandlung Körper ; Geist ; Seele ; China ; Chinesische Philosophie ; Einsteiger ; Energiemedizin ; Gesundheit ; Gesundheitsvorsorge ; Heilung ; Kaptchuk ; Krankheiten verstehen ; Medizinisches Buch ; Prävention ; Ratgeber Gesundheit ; Selbstheilung ; Selbstheilung stärken ; Selbstheilungskräfte aktivieren ; Selbstverantwortung Gesundheit ; Standardwerk ; TCM ; TCM Buch ; TCM Grundlagen ; TCM Medizin ; TCM chinesische Medizin ; TCM einfach erklärt ; TCM für Anfänger ; Ted J. Kaptchuk ; Ted Kaptchuk ; Traditionelle chinesische Medizin ; Vorteile TCM ; Wirksamkeit TCM ; Yin und Yang ; alternative Heilmethoden ; alternative Medizin ; chinesische Heilkunst ; chinesische Medizin ; ganzheiltliche Gesundheit ; gesund bleiben mit TCM ; Östliche Medizin ; Östliche Heilkunde ; östliche Heilmethoden ; holistische Heilverfahren ; gesünder leben ; ganzheitlich gesund ; ganzheitliche Medizin ; wie funktioniert TCM
    Language German
    Size 464 p.
    Edition 1
    Publisher Verlagsgruppe Droemer Knaur
    Document type Book
    Note PDA Manuell_15
    Format 133 x 209 x 35
    ISBN 9783426879283 ; 342687928X
    Database PDA

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  2. Article ; Online: Reply to Arandia and Di Paolo.

    Ongaro, Giulio / Kaptchuk, Ted J

    Pain

    2022  Volume 163, Issue 4, Page(s) e605–e606

    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000002489
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  3. Article: Placebo Effects in Acupuncture.

    Kaptchuk, Ted J

    Medical acupuncture

    2020  Volume 32, Issue 6, Page(s) 352–356

    Abstract: This article is a summary of a talk presented in February 2019 at a conference on acupuncture sponsored by the National Institutes of Cancer (NCI) and the National Center for Complementary and Integrative Health (NCCIH) at the National of Institutes of ... ...

    Abstract This article is a summary of a talk presented in February 2019 at a conference on acupuncture sponsored by the National Institutes of Cancer (NCI) and the National Center for Complementary and Integrative Health (NCCIH) at the National of Institutes of Health (NIH). The article touches on the history of placebos in biomedicine and its absence in traditional East Asian Medicine. It then examines some of the predicaments of evaluating acupuncture's efficacy in relationship to placebo controls. Although acupuncture in randomized controlled trials (RCTs) generally demonstrate equivalence or even superiority to medical interventions or other nonpharmacologic therapies, acupuncture's ability to show superiority to placebo controls has been inconclusive, contradictory and, at best, modest. This article highlights the efforts of the German health insurance funds to evaluate acupuncture. Using a large meta-analysis, the article summaries acupuncture's effectiveness and efficacy. Subsequently, RCTs and meta-analyses testing the hypothesis that sham acupuncture, and other device placebos, have augmented placebo responses are described. It seems that acupuncture, and devices in general, have enhanced placebo responses. These findings may be relevant to designing and evaluating placebo-control acupuncture RCTs. Research into placebo acupuncture may also be helpful for other conditions where detection of intervention-placebo differences can be problematic. Further research is warranted.
    Language English
    Publishing date 2020-12-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2296110-0
    ISSN 1933-6594 ; 1933-6586
    ISSN (online) 1933-6594
    ISSN 1933-6586
    DOI 10.1089/acu.2020.1483
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  4. Article ; Online: Quantifying and controlling the impact of regression to the mean on randomized controlled trials in epilepsy.

    Goldenholz, Daniel M / Goldenholz, Eliana B / Kaptchuk, Ted J

    Epilepsia

    2023  Volume 64, Issue 10, Page(s) 2635–2643

    Abstract: Objective: Randomized controlled trials (RCTs) in epilepsy for drug treatments are plagued by high costs. One potential remedy is to reduce placebo response via better control over regression to the mean (RTM). Here, RTM represents an initial observed ... ...

    Abstract Objective: Randomized controlled trials (RCTs) in epilepsy for drug treatments are plagued by high costs. One potential remedy is to reduce placebo response via better control over regression to the mean (RTM). Here, RTM represents an initial observed seizure rate higher than the long-term average, which gradually settles closer to the average, resulting in apparent response to treatment. This study used simulation to clarify the relationship between eligibility criteria and RTM.
    Methods: Using a statistically realistic seizure diary simulator, the impact of RTM on placebo response and trial efficacy was explored by varying eligibility criteria for a traditional treatment phase II/III RCT for drug-resistant epilepsy.
    Results: When the baseline period was included in the eligibility criteria, increasingly larger fractions of RTM were observed (25%-47% vs. 23%-25%). Higher fractions of RTM corresponded with higher expected placebo responses (50% responder rate [RR50]: 2%-9% vs. 0%-8%) and lower statistical efficacy (RR50: 47%-67% vs. 47%-81%). The exclusion of baseline from eligibility criteria was shown to decrease the number of patients needed by roughly 30%.
    Significance: The manipulation of eligibility criteria for RCTs has a predictable and important impact on RTM, and therefore on placebo response; the difference between drug and placebo was more easily detected. This in turn impacts trial efficacy and therefore cost. This study found dramatic improvements in efficacy and cost when baseline was not included in eligibility.
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17730
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  5. Article ; Online: Open-Label Placebo: Reflections on a Research Agenda.

    Kaptchuk, Ted J

    Perspectives in biology and medicine

    2018  Volume 61, Issue 3, Page(s) 311–334

    Abstract: Open-label placebos (OLP)-placebo pills honestly prescribed-have challenged the notion that placebos require either deception or concealment to evoke salubrious benefits. This essay describes how the author arrived at the counter-intuitive OLP hypothesis, ...

    Abstract Open-label placebos (OLP)-placebo pills honestly prescribed-have challenged the notion that placebos require either deception or concealment to evoke salubrious benefits. This essay describes how the author arrived at the counter-intuitive OLP hypothesis, discusses evidence for OLP effectiveness, and examines mechanistic explanations for OLP. Current dominant theories such as expectation and conditioning are found to be insufficient or inaccurate. The author proposes that emerging concepts of prediction and error processing (PEP), Bayesian brain, and embodied cognition are more appropriate models for understanding OLP. As a neural processing model, PEP argues that sensory predictions are embedded in and inseparable from perceptions; PEP circumvents mind-body dualism. The author discusses how OLP, mostly non-consciously, might perturb aberrant symptom amplifications and central sensitization resulting in perceptions of improvement in symptoms. Placebo effects are neurologically encoded predictions, less what patients think and more what they enact and perform.
    MeSH term(s) Bayes Theorem ; Bioethical Issues ; Cognition ; Double-Blind Method ; Humans ; Models, Neurological ; Models, Psychological ; Models, Theoretical ; Placebo Effect ; Placebos ; Randomized Controlled Trials as Topic/ethics
    Chemical Substances Placebos
    Language English
    Publishing date 2018-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80373-x
    ISSN 1529-8795 ; 0031-5982
    ISSN (online) 1529-8795
    ISSN 0031-5982
    DOI 10.1353/pbm.2018.0045
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  6. Article: The Effect of Singular Nonverbal Behaviours of Experimenters on Pain Reports.

    Daniali, Hojjat / Ruben, Mollie A / Aslaksen, Per M / Fiskum, Charlotte / Kaptchuk, Ted J / Flaten, Magne A

    Journal of pain research

    2024  Volume 17, Page(s) 1345–1360

    Abstract: Introduction: Studies suggest facial expressions of caregivers may be important in placebo effects; however, this has not been systematically tested. This experiment investigated the effects of caregivers' singular positive nonverbal behaviours (NBs) on ...

    Abstract Introduction: Studies suggest facial expressions of caregivers may be important in placebo effects; however, this has not been systematically tested. This experiment investigated the effects of caregivers' singular positive nonverbal behaviours (NBs) on pain reports.
    Methods: Fifty-one males and 53 females (total of 104) participants were randomized to four groups that were displayed positive facial expressions, tone of voice, body movement, or neutral NBs of videotaped experimenters. Subjective reports of pain, stress, arousal, and cardiac activity were obtained in a pre-test, a conditioning phase, and at a post-test. Four minutes of heat pain was induced in each test, and a placebo cream was administered before the conditioning and post-test in all groups.
    Results: There were no differences between the NB groups in the reduced pain. Males had larger reduction in pain in the post-test, and females had lower arousal than the opposite sex. During the conditioning, females had larger reduction in pain ie, unconditioned pain response (UPR). In females, the UPR predicted the reinforced expectation ie, increase in expectations from conditioning to post-test, and fear of minor pain negatively predicted both the UPR and reinforced expectation.
    Discussion: Singular NBs of caregiver were weak to enhance placebo effects. Females had lower pain during conditioning, and the UPR amplitude in females was associated with positive expectations. Moreover, for females, fear of minor pain weakened the UPR and expectations of cream.
    Conclusion: No NB of caregivers is more effective in reducing pain. Caregivers' NBs are less effective when displayed individually. Males and females may be different in underlying mechanisms of placebo effects.
    Language English
    Publishing date 2024-04-03
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S449150
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  7. Article ; Online: "Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial.

    Pan, Yiqi / Frank, Miriam L / Kaptchuk, Ted J / Nestoriuc, Yvonne

    PloS one

    2022  Volume 17, Issue 11, Page(s) e0276499

    Abstract: Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent and benefitted from open-label placebo ... ...

    Abstract Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent and benefitted from open-label placebo treatment in a randomized-controlled trial of hot flushes. Data were analyzed using Interpretative Phenomenological Analysis. We found that the women had low expectations about the placebo treatment yet endorsed what they referred to as "hope" and openness to "see what happens". Recording hot flushes via the symptom diary was viewed as a valuable opportunity for self-examination and appraising outcomes. Receiving relief from the placebo treatment empowered women and enhanced their sense of control and agency. In summary, participants' initial openness towards placebos, their hopes to get better, monitoring symptoms closely, and taking the initiative to address symptoms were components of a positive open-label placebo experience.
    MeSH term(s) Humans ; Female ; Hot Flashes/drug therapy ; Menopause ; Double-Blind Method
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0276499
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  8. Article ; Online: Symptom perception, placebo effects, and the Bayesian brain.

    Ongaro, Giulio / Kaptchuk, Ted J

    Pain

    2018  Volume 160, Issue 1, Page(s) 1–4

    MeSH term(s) Bayes Theorem ; Brain/physiopathology ; Humans ; Perception/physiology ; Placebo Effect
    Language English
    Publishing date 2018-05-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000001367
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  9. Book: Akupunktur in der Praxis

    MacPherson, Hugh / Kaptchuk, Ted J.

    Einblicke in Krankengeschichten aus dem Westen ; [Fallbesprechungen westlicher Experten]

    2001  

    Author's details Hugh MacPherson ; Ted J. Kaptchuk
    Keywords Akupunktur
    Language German
    Size 495 S. : Ill., 27 cm
    Publisher Verl. für Ganzheitliche Medizin, Wühr
    Publishing place Kötzting/Bayer. Wald
    Publishing country Germany
    Document type Book
    Note Aus dem Engl. übers. ; Literaturangaben
    HBZ-ID HT013250056
    ISBN 3-927344-38-9 ; 978-3-927344-38-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 A 874 order for loan Magazin

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  10. Article ; Online: Acupuncture for Japanese Katakori (Chronic Neck Pain): A Randomized Placebo-Controlled Double-Blind Study.

    Takakura, Nobuari / Takayama, Miho / Kawase, Akiko / Kaptchuk, Ted J / Kong, Jian / Vangel, Mark / Yajima, Hiroyoshi

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 12

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Neck Pain/therapy ; Double-Blind Method ; Japan ; Acupuncture Therapy ; Skin
    Language English
    Publishing date 2023-12-09
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59122141
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