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Article ; Online: Management einer persistierenden Kolitis nach erfolgreicher Immuntherapie eines nicht-kleinzelligen Karzinoms der Lunge.

Zellweger, Matthias / Rogler, Gerhard / Komminoth, Paul / Werth, Lucas / Breidert, Matthias

2022 Volume 60, Issue 7, Page(s) 1124–1130

Abstract: Immune checkpoint inhibitors have shown remarkable efficacy as new-generation drugs in anti-tumor therapy. However, the nonspecific activation of the immune system leads to a number of adverse side effects, so-called immune-related adverse events (irAEs), ...

Title translation	Management of persistent colitis after successful immunotherapy for non-small cell carcinoma of the lung.
Abstract	Immune checkpoint inhibitors have shown remarkable efficacy as new-generation drugs in anti-tumor therapy. However, the nonspecific activation of the immune system leads to a number of adverse side effects, so-called immune-related adverse events (irAEs), including the occurrence of diarrhea and colitis in about one third of treated patients.Endoscopically and histologically, there is significant overlap of immune-mediated colitis with classic IBD, making differentiation difficult.Therapeutically, high-dose glucocorticoids are used in grade 3 (severe) to grade 4 (life-threatening) colitis, in addition to discontinuation of ICI therapy. Steroid-refractory cases (up to 42%) benefit from the TNF inhibitor infliximab. Vedolizumab, analogous to inflammatory bowel disease, represents second-line therapy for infliximab-refractory cases. Little data exist to date on the efficacy of tofacitinib in refractory cases.We describe the case and therapeutic management of severe and persistent immune-mediated colitis after successful immunochemotherapy with pembrolizumab in an 80-year-old man with metastatic non-small cell carcinoma of the lung and pre-existing colitis unclassified and other comorbidities.
MeSH term(s)	Aged, 80 and over ; Carcinoma/drug therapy ; Colitis/chemically induced ; Colitis/diagnosis ; Colitis/therapy ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Immunologic Factors ; Immunotherapy/adverse effects ; Infliximab/therapeutic use ; Lung ; Male
Chemical Substances	Immunologic Factors ; Infliximab (B72HH48FLU)
Language	German
Publishing date	2022-01-18
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0172-8504 ; 0044-2771
ISSN (online)	1439-7803
ISSN	0172-8504 ; 0044-2771
DOI	10.1055/a-1652-2638
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Book ; Thesis: Untersuchungen zur serotonininduzierten Thrombozytenaggregation und Serotoninaufnahme in Thrombozyten

Breidert, Matthias

1991

Author's details	vorgelegt von Matthias Breidert
Size	65 S. : Ill., graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Frankfurt am Main, Univ., Diss., 1992
HBZ-ID	HT004363218
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
92 D 4600	order for loan	Magazin

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Article ; Online: Energy Metabolism in Residents in the Low- and Moderate Altitude Regions of Central Asia with MAFLD and Type 2 Diabetes Mellitus.

Toktogulova, Nurgul / Breidert, Matthias / Eschbach, Judith / Kudaibergenova, Indira / Omurzakova, Uulkan / Uvaidillaeva, Feruzakhan / Tagaeva, Bermet / Sultanalieva, Roza / Eftekhari, Pierre

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

2024 Volume 56, Issue 4, Page(s) 294–299

Abstract: The knowledge about the features of energy metabolism in MAFLD in the population living at different climatic and geographic heights is lacking. The goal of this study is to explore the biochemical parameters of blood and erythrocyte energy consumption ... ...

Abstract	The knowledge about the features of energy metabolism in MAFLD in the population living at different climatic and geographic heights is lacking. The goal of this study is to explore the biochemical parameters of blood and erythrocyte energy consumption in patients with MAFLD with and without DM2 living in the low- and moderate-altitude regions of Central Asia. Our study was carried out on patients living in low-altitude mountains: Bishkek, altitude=750-800 m; n=67 (MAFLD with DM 2: n=24; MAFLD without DM2: n=25; control: n=18), and At-Bashy District, Naryn Region, altitude=2046-2300 m; n=58 (MAFLD with DM2: n=28; MAFLD without DM2: n=18; control: n=12). Non-alcoholic fatty liver disease was diagnosed according to history, laboratory tests, liver ultrasound, and exclusion of other liver diseases. The level of liver fibrosis was determined using the FIB-4 score. Blood adenosine 5'-triphosphate (ATP) was determined using the CellTiter-Glo method. Healthy residents living in moderate altitudes have significantly higher levels of cytosolic ATP in their blood (p+≤+0.05) than residents living in low mountains. MAFLD is characterized by an increase in the level of ATP concentration in their blood. ATP concentration decreased significantly in patients with MAFLD with DM2 living in moderate-altitude in comparison to those living in low-altitude mountains. The results suggest that chronic altitude hypoxia leads to a breakdown in adaptive mechanisms of energy metabolism of ATP in patients with MAFLD with type 2 DM.
MeSH term(s)	Humans ; Altitude ; Diabetes Mellitus, Type 2 ; Energy Metabolism ; Adenosine Triphosphate ; Non-alcoholic Fatty Liver Disease ; Asia
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2024-02-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80125-2
ISSN	1439-4286 ; 0018-5043
ISSN (online)	1439-4286
ISSN	0018-5043
DOI	10.1055/a-2256-6358
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Article ; Online: Unusual Aspect of a Choledocholithiasis.

Breidert, Matthias / Weber, Markus / Wildi, Stefan

Gastroenterology

2020 Volume 159, Issue 5, Page(s) 1660–1661

MeSH term(s)	Adult ; Bariatric Surgery/adverse effects ; Cholangiopancreatography, Endoscopic Retrograde ; Choledocholithiasis/diagnostic imaging ; Choledocholithiasis/etiology ; Choledocholithiasis/surgery ; Female ; Humans ; Laparoscopy/adverse effects ; Liver/abnormalities ; Liver/diagnostic imaging ; Obesity/surgery
Language	English
Publishing date	2020-06-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2020.05.072
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Article: Management einer persistierenden Kolitis nach erfolgreicher Immuntherapie eines nicht-kleinzelligen Karzinoms der Lunge

Zellweger, Matthias / Rogler, Gerhard / Komminoth, Paul / Werth, Lucas / Breidert, Matthias

Zeitschrift für Gastroenterologie

2022 Volume 60, Issue 07, Page(s) 1124–1130

Abstract: Immuncheckpoint-Inhibitoren haben als neue Generation von Medikamenten in der Anti-Tumortherapie bemerkenswerte Wirksamkeit gezeigt. Die unspezifische Aktivierung des Immunsystems führt jedoch zu einer Reihe von unerwünschten Nebenwirkungen, sog. immune- ... ...

Abstract	Immuncheckpoint-Inhibitoren haben als neue Generation von Medikamenten in der Anti-Tumortherapie bemerkenswerte Wirksamkeit gezeigt. Die unspezifische Aktivierung des Immunsystems führt jedoch zu einer Reihe von unerwünschten Nebenwirkungen, sog. immune-related adverse events (irAEs), inklusive des Auftretens von Diarrhoe und Kolitis bei etwa einem Drittel der behandelten Patienten. Endoskopisch und histologisch gibt es weitreichende Überlappungen der immunvermittelten Kolitis mit der klassischen CED, was eine Unterscheidung erschwert. Therapeutisch kommen bei Grad-3- (schwere) bis Grad-4-Kolitiden (lebensbedrohlich) neben dem Abbruch der ICI-Therapie hochdosiert Glukokortikoide zum Einsatz. Steroidrefraktäre Fälle (bis 42%) profitieren vom TNF-Hemmer Infliximab. Vedolizumab stellt, analog bei chronisch entzündlichen Darmerkrankungen, die Zweitlinientherapie bei Infliximab-refraktären Fällen dar. Zur Wirksamkeit von Tofacitinib bei therapierefraktären Fällen existieren bislang nur wenige Daten. Wir beschreiben den Fall und das Therapiemanagement einer schweren und andauernden immunvermittelten Kolitis nach erfolgreicher Immunochemotherapie mit Pembrolizumab bei einem 80-jährigen Mann mit einem metastasierten, nicht kleinzelligen Karzinom der Lunge und vorbestehender Colitis indeterminata (colitis unclassified) sowie weiteren Komorbiditäten.
Keywords	Immuncheckpoint Inhibitor ; Immune related colitis ; Pembrolizumab ; Infliximab ; Vedolizumab ; Tofacitinib ; Herpes zoster ; Immuncheckpoint Inhibitor ; Immune related colitis ; Pembrolizumab ; Infliximab ; Vedolizumab ; Tofacitinib ; Herpes zoster
Language	German
Publishing date	2022-01-18
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0044-2771 ; 0172-8504
ISSN (online)	1439-7803
ISSN	0044-2771 ; 0172-8504
DOI	10.1055/a-1652-2638
Database	Thieme publisher's database

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Zs.A 111: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Carpal tunnel syndrome as an occupational disease by Dr. med. Klaus Giersiepen und Dr. med. Michael Spallek in volume 14/2011. Recognize acromegaly.

Breidert, Matthias

Deutsches Arzteblatt international

2011 Volume 108, Issue 24, Page(s) 424; author reply 424

MeSH term(s)	Carpal Tunnel Syndrome/epidemiology ; Humans ; Occupational Diseases/epidemiology ; Occupations/statistics & numerical data ; Word Processing/statistics & numerical data
Language	English
Publishing date	2011-06-17
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	2406159-1
ISSN	1866-0452 ; 1866-0452
ISSN (online)	1866-0452
ISSN	1866-0452
DOI	10.3238/arztebl.2011.0424a
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Article ; Online: Nutrition-related care needs of older patients in hospital: A qualitative multimethod study.

Brunner, Silvia / Mayer, Hanna / Blum, Karin / Breidert, Matthias / Dietrich, Michael / Dahl, Enrico / Müller, Maria

International journal of nursing knowledge

2022 Volume 34, Issue 2, Page(s) 148–160

Abstract: Purpose: To investigate the nutrition-related care needs of older patients in hospitals.: Methods: A qualitative multimethod study was performed. By purposive sampling, older patients were included for observations of the nutrition process and ... ...

Abstract	Purpose: To investigate the nutrition-related care needs of older patients in hospitals. Methods: A qualitative multimethod study was performed. By purposive sampling, older patients were included for observations of the nutrition process and interviews from a perioperative unit, an internal Medicine unit, and one acute geriatric care ward of an acute care hospital. Preliminary findings were discussed, validated, and further explored in two focus group discussions with interprofessional nutritional healthcare experts. Findings: Seventeen women and five men with a mean age of 86 years participated in patient observations and interviews. Eight experts with at least 10 years of professional experience who were employed in this setting for 3 years or more participated in interviews. Three themes of nutrition-related care needs were elaborated: The need to assess and address older patients' attitudes toward life, the need for nutrition-related education, and the need for food intake support. These care needs added to the development and validation of a new nursing diagnosis "risk for inadequate protein energy nutrition" and in consequence to develop a complex nursing intervention to optimize the nutrition of older patients. Conclusions: It is crucial to assess and understand the patients' attitudes toward life, which affect purposes of treatment, diet, and menu choices. Implications for nursing practice: Implementation of assessing nutrition-related care needs of older inpatients is needed. Addressing these care needs within the Advanced Nursing Process can lead to appropriate nursing diagnoses, nursing outcomes, and interventions, which enhance person-centered care, patients' self-care abilities, and consequently patients' nutritional status.
MeSH term(s)	Aged, 80 and over ; Female ; Humans ; Male ; Focus Groups ; Hospitals ; Malnutrition/nursing ; Nutritional Status ; Qualitative Research ; Observation ; Nutrition Therapy/nursing ; Needs Assessment
Language	English
Publishing date	2022-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2640197-6
ISSN	2047-3095 ; 2047-3087
ISSN (online)	2047-3095
ISSN	2047-3087
DOI	10.1111/2047-3095.12389
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [No title information]

Toktogulova, Nurgul / Breidert, Matthias / Eschbach, Judith / Kudaibergenova, Indira / Omurzakova, Uulkan / Uvaidillaeva, Feruzakhan / Tagaeva, Bermet / Sultanalieva, Roza / Eftekhari, Pierre

Hormone and Metabolic Research

(Advances in Endocrinology)

2024 Volume 56, Issue 04, Page(s) 294–299

Series title	Advances in Endocrinology
Abstract	The knowledge about the features of energy metabolism in MAFLD in the population living at different climatic and geographic heights is lacking. The goal of this study is to explore the biochemical parameters of blood and erythrocyte energy consumption in patients with MAFLD with and without DM2 living in the low- and moderate-altitude regions of Central Asia. Our study was carried out on patients living in low-altitude mountains: Bishkek, altitude=750–800 m; n=67 (MAFLD with DM 2: n=24; MAFLD without DM2: n=25; control: n=18), and At-Bashy District, Naryn Region, altitude=2046–2300 m; n=58 (MAFLD with DM2: n=28; MAFLD without DM2: n=18; control: n=12). Non-alcoholic fatty liver disease was diagnosed according to history, laboratory tests, liver ultrasound, and exclusion of other liver diseases. The level of liver fibrosis was determined using the FIB-4 score. Blood adenosine 5′-triphosphate (ATP) was determined using the CellTiter-Glo method. Healthy residents living in moderate altitudes have significantly higher levels of cytosolic ATP in their blood (p+≤+0.05) than residents living in low mountains. MAFLD is characterized by an increase in the level of ATP concentration in their blood. ATP concentration decreased significantly in patients with MAFLD with DM2 living in moderate-altitude in comparison to those living in low-altitude mountains. The results suggest that chronic altitude hypoxia leads to a breakdown in adaptive mechanisms of energy metabolism of ATP in patients with MAFLD with type 2 DM.
Keywords	fatty liver disease ; ATP ; diabetes mellitus
Language	English
Publishing date	2024-02-19
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80125-2
ISSN	1439-4286 ; 0018-5043
ISSN (online)	1439-4286
ISSN	0018-5043
DOI	10.1055/a-2256-6358
Database	Thieme publisher's database

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Article ; Online: Vollwandresektion eines Pylorusdrüsenadenoms im proximalen Duodenum bei einem 67-jährigen Patienten mit attenuierter Polyposis coli.

Anliker, Oliver / Sieweke, Wolfram / Töpfer, Antonia / Wülker, Ines / Breidert, Matthias

Zeitschrift fur Gastroenterologie

2020 Volume 58, Issue 8, Page(s) 767–772

Abstract: Background: Pyloric gland adenomas (PGAs) are very rare and underdiagnosed, mostly be founded in the stomach. Similar to colorectal adenomas they have a high risk of malignant transformation to adenocarcinoma up to 12-47 %. Endoscopic resections in the ...

Title translation	Full thickness resection of a pyloric adenoma in the proximal duodenum in a 67-year-old patient with attenuated polyposis coli.
Abstract	Background: Pyloric gland adenomas (PGAs) are very rare and underdiagnosed, mostly be founded in the stomach. Similar to colorectal adenomas they have a high risk of malignant transformation to adenocarcinoma up to 12-47 %. Endoscopic resections in the duodenum harbor a significant risk of complications. EMR is the current standard technique for treatment of duodenal non-ampullary adenomas. Complete resection rates are considerably high at about 90 %. Adverse events as bleeding was reported up to 25 %. ESD is not recommended for resection of duodenal lesions since the perforation rate may be as high as 35 %. Use of EFTR in the duodenum are limited to a single case study of 20 patients. Case: A 67 year old patient with attenuated polyposis coli presented for screening. Gastroscopy showed a 20 mm large, non-ampullary lesions in the proximal duodenum (pars I). The margins of the duodenal lesions were marked with a high-frequency (HF) probe. An integrated balloon dilatation (20 mm) of the upper esophageal sphincter and the pylorus was performed to facilitate advancing of the gastroduodenal FTRD Conclusion: Herein we present the first case of duodenal EFTR in a patient with attenuated FAP and a PGA. There are currently no specific guidelines for the removal and surveillance. ASGE recommends resection and surveillance endoscopy at 3-5 years interval.
MeSH term(s)	Adenoma/pathology ; Adenoma/surgery ; Adenomatous Polyposis Coli/pathology ; Adenomatous Polyposis Coli/surgery ; Aged ; Duodenal Neoplasms/pathology ; Duodenal Neoplasms/surgery ; Duodenoscopy/instrumentation ; Duodenoscopy/methods ; Duodenum ; Humans ; Male ; Pylorus ; Treatment Outcome
Language	German
Publishing date	2020-05-07
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0172-8504 ; 0044-2771
ISSN (online)	1439-7803
ISSN	0172-8504 ; 0044-2771
DOI	10.1055/a-1143-6640
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Article ; Online: Developing a nursing diagnosis for the risk for malnutrition: a mixed-method study.

Brunner, Silvia / Mayer, Hanna / Breidert, Matthias / Dietrich, Michael / Müller-Staub, Maria

Nursing open

2021 Volume 8, Issue 3, Page(s) 1463–1478

Abstract: Aim: As the risk for malnutrition in older people in hospitals is often underreported, we aimed to develop a risk nursing diagnosis, including label, definition and risk factors.: Design: A convergent parallel mixed-methods design was employed.: ... ...

Abstract	Aim: As the risk for malnutrition in older people in hospitals is often underreported, we aimed to develop a risk nursing diagnosis, including label, definition and risk factors. Design: A convergent parallel mixed-methods design was employed. Methods: A literature review led to risk factors, validated by 22 hospitalized older people's perspectives and observations, including their nursing records. Per participant, one interview (qualitative), one non-participatory observation of three meals (198 hr; qualitative) and one nursing record evaluation (quantitative) were conducted. Findings: According to the classification system of NANDA International, the risk for protein-energy malnutrition is defined with 18 risk factors, including associated conditions. Content validated risk factors are presented from three participants with the most, medium and least coherent nursing record, measured with the Quality of Diagnosis, Intervention and Outcomes tool. Conclusion: This new nursing diagnosis supports nurses to manage the risk for malnutrition and optimize older people's nutrition.
MeSH term(s)	Aged ; Humans ; Malnutrition/diagnosis ; Nursing Diagnosis ; Nursing Process ; Nursing Records ; Nutritional Status
Language	English
Publishing date	2021-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2809556-X
ISSN	2054-1058 ; 2054-1058
ISSN (online)	2054-1058
ISSN	2054-1058
DOI	10.1002/nop2.765
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