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  1. Article ; Online: 'A prospective case control study to evaluate shock index for identifying patients at risk of clinically important malaria in refugee settings'.

    Kuhrt, Katy / Seed, Paul T / Shennan, Andrew H

    Tropical doctor

    2023  Volume 53, Issue 2, Page(s) 233–236

    Abstract: Bidibidi Refugee Settlement's 223,000 refugees are vulnerable to malaria due to crowded conditions and limited healthcare access. Early identification and referral of suspected cases is key to reduce morbidity and mortality. We evaluated the shock index ( ...

    Abstract Bidibidi Refugee Settlement's 223,000 refugees are vulnerable to malaria due to crowded conditions and limited healthcare access. Early identification and referral of suspected cases is key to reduce morbidity and mortality. We evaluated the shock index (heart rate/ systolic blood pressure) for detection of abnormal vital signs, calculated by the CRADLE Vital Signs Alert device, which can be used in routine patient blood pressure and heart rate assessment by non-medically trained Voluntary Health Team workers. The single most frequent diagnosis causing shock was malaria, and thus the device was useful to detect severe cases (as well as discovering other cases), after calculating appropriate shock indices.
    MeSH term(s) Humans ; Refugees ; Case-Control Studies ; Malaria/diagnosis ; Blood Pressure ; Shock/diagnosis
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 193169-6
    ISSN 1758-1133 ; 0049-4755
    ISSN (online) 1758-1133
    ISSN 0049-4755
    DOI 10.1177/00494755221134975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: "A stitch in time saves nine": the impact of video-based training for surgical procedures in low-resource settings.

    Kuhrt, Katy / Martin, Anastasia / Mwaikasu, Lusako Paskali / Shennan, Andrew

    American journal of obstetrics & gynecology MFM

    2023  Volume 5, Issue 6, Page(s) 100967

    Abstract: Access to training and education in novel surgical and medical techniques is challenging in low-and- middle income settings where the burden of maternal morbidity and mortality is highest. Video-based education tools are cost effective and sustainable, ... ...

    Abstract Access to training and education in novel surgical and medical techniques is challenging in low-and- middle income settings where the burden of maternal morbidity and mortality is highest. Video-based education tools are cost effective and sustainable, and enable clinicians, even those based in rural, remote settings, to develop new skills, to improve the quality of care delivered to their patients. This is illustrated by the case of a clinician in Tanzania who successfully performed a transabdominal cerclage on two patients, after studying a video our team developed describing the technique. Both women who underwent the procedure had successful pregnancy outcomes, despite poor obstetric histories. Video is a versatile medium for delivery of training and education to medical students and doctors, and should be further integrated into surgical training curricula globally.
    MeSH term(s) Pregnancy ; Humans ; Female ; Premature Birth ; Cerclage, Cervical/methods ; Pregnancy Outcome ; Gestational Age
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2023.100967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Household air pollution and incidence of eclampsia in eight low- and middle-income countries.

    Robbins, Tanya / Kuhrt, Katy / Vousden, Nicola / Seed, Paul / Shennan, Andrew

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2022  Volume 160, Issue 2, Page(s) 449–450

    MeSH term(s) Pregnancy ; Female ; Humans ; Eclampsia/epidemiology ; Incidence ; Developing Countries ; Air Pollution ; Pre-Eclampsia/epidemiology
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.14484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Placental Alpha Microglobulin-1 Compared With Fetal Fibronectin to Predict Preterm Delivery in Symptomatic Women.

    Kuhrt, Katy / Watson, Helena / Seed, Paul / Shennan, Andrew

    Obstetrics and gynecology

    2018  Volume 131, Issue 4, Page(s) 743

    MeSH term(s) Cervical Length Measurement ; Female ; Fibronectins ; Humans ; Infant, Newborn ; Obstetric Labor, Premature ; Placenta ; Pregnancy ; Premature Birth
    Chemical Substances Fibronectins
    Language English
    Publishing date 2018-03-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000002554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Placental abruption in a twin pregnancy at 32 weeks' gestation complicated by coronavirus disease 2019 without vertical transmission to the babies.

    Kuhrt, Katy / McMicking, Jess / Nanda, Surabhi / Nelson-Piercy, Catherine / Shennan, Andrew

    American journal of obstetrics & gynecology MFM

    2020  Volume 2, Issue 3, Page(s) 100135

    MeSH term(s) Abruptio Placentae/diagnosis ; Abruptio Placentae/physiopathology ; Abruptio Placentae/therapy ; Adult ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/physiopathology ; Cesarean Section/methods ; Emergency Medical Services/methods ; Female ; Fetal Distress/diagnosis ; Fetal Distress/etiology ; Fetal Distress/therapy ; Gestational Age ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Patient Care Management/methods ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/physiopathology ; Pregnancy Complications, Infectious/virology ; Pregnancy Outcome ; Pregnancy, Twin ; SARS-CoV-2/isolation & purification ; Treatment Outcome ; Uterine Hemorrhage/diagnosis ; Uterine Hemorrhage/etiology
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2020.100135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Development of a video to teach clinicians how to perform a transabdominal cerclage.

    Suff, Natalie / Kuhrt, Katy / Chandiramani, Manju / Saridogan, Ertan / David, Anna / Shennan, Andrew H

    American journal of obstetrics & gynecology MFM

    2020  Volume 2, Issue 4, Page(s) 100238

    Abstract: Background: A transabdominal cerclage has been shown in a recent randomized controlled trial to be superior to a low vaginal cerclage in reducing the risk of early preterm birth (8% [3/39] vs 33% [11/33]; relative risk, 0.23; 95% confidence interval, 0 ... ...

    Abstract Background: A transabdominal cerclage has been shown in a recent randomized controlled trial to be superior to a low vaginal cerclage in reducing the risk of early preterm birth (8% [3/39] vs 33% [11/33]; relative risk, 0.23; 95% confidence interval, 0.07-0.76; P=.01570) and fetal loss (3% [1/39] vs 21% [7/33]; relative risk, 0.12; 95% confidence interval, 0.016-0.930) in women with a previous failed vaginal cerclage.
    Study design: Transabdominal cerclage insertion in a non-gravid and gravid uterus (less than 14 weeks' gestation) via laparotomy and laparoscopy was filmed with patients' and clinicians' consent in main theatres at St Thomas' Hospital and University College London Hospital. The film footage was edited, and an audio narration by the surgeon was included to provide a description of the procedures.
    Results: We developed an 8-minute video with an audio narration describing the insertion and management issues of an abdominal cerclage for free dissemination among clinicians who wish to learn how to perform this procedure.
    Conclusion: An abdominal cerclage has been shown to significantly reduce early preterm birth and fetal loss more effectively than a low vaginal cerclage in women with a previous failed cerclage. More obstetricians and gynecologists need to be trained on how to perform the transabdominal cerclage procedure to increase its availability to suitable women. This procedure is technically straightforward and can be taught via video, which can easily be shared among clinicians at a low cost.
    MeSH term(s) Cerclage, Cervical ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Laparoscopy ; London ; Pregnancy ; Premature Birth/prevention & control
    Language English
    Publishing date 2020-09-21
    Publishing country United States
    Document type Video-Audio Media
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2020.100238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluating the use of the QUiPP app and its impact on the management of threatened preterm labour: A cluster randomised trial.

    Watson, Helena A / Carlisle, Naomi / Seed, Paul T / Carter, Jenny / Kuhrt, Katy / Tribe, Rachel M / Shennan, Andrew H

    PLoS medicine

    2021  Volume 18, Issue 7, Page(s) e1003689

    Abstract: Background: Preterm delivery (before 37 weeks of gestation) is the single most important contributor to neonatal death and morbidity, with lifelong repercussions. However, the majority of women who present with preterm labour (PTL) symptoms do not ... ...

    Abstract Background: Preterm delivery (before 37 weeks of gestation) is the single most important contributor to neonatal death and morbidity, with lifelong repercussions. However, the majority of women who present with preterm labour (PTL) symptoms do not deliver imminently. Accurate prediction of PTL is needed in order ensure correct management of those most at risk of preterm birth (PTB) and to prevent the maternal and fetal risks incurred by unnecessary interventions given to the majority. The QUantitative Innovation in Predicting Preterm birth (QUIPP) app aims to support clinical decision-making about women in threatened preterm labour (TPTL) by combining quantitative fetal fibronectin (qfFN) values, cervical length (CL), and significant PTB risk factors to create an individualised percentage risk of delivery.
    Methods and findings: EQUIPTT was a multi-centre cluster randomised controlled trial (RCT) involving 13 maternity units in South and Eastern England (United Kingdom) between March 2018 and February 2019. Pregnant women (n = 1,872) between 23+0 and 34+6 weeks' gestation with symptoms of PTL in the analysis period were assigned to either the intervention (762) or control (1,111). The mean age of the study population was 30.2 (+/- SD 5.93). A total of 56.0% were white, 19.6% were black, 14.2% were Asian, and 10.2% were of other ethnicities. The intervention was the use of the QUiPP app with admission, antenatal corticosteroids (ACSs), and transfer advised for women with a QUiPP risk of delivery >5% within 7 days. Control sites continued with their conventional management of TPTL. Unnecessary management for TPTL was a composite primary outcome defined by the sum of unnecessary admission decisions (admitted and delivery interval >7 days or not admitted and delivery interval ≤7 days) and the number of unnecessary in utero transfer (IUT) decisions/actions (IUT that occurred or were attempted >7 days prior to delivery) and ex utero transfers (EUTs) that should have been in utero (attempted and not attempted). Unnecessary management of TPTL was 11.3% (84/741) at the intervention sites versus 11.5% (126/1094) at control sites (odds ratio [OR] 0.97, 95% confidence interval [CI] 0.66-1.42, p = 0.883). Control sites frequently used qfFN and did not follow UK national guidance, which recommends routine treatment below 30 weeks without testing. Unnecessary management largely consisted of unnecessary admissions which were similar at intervention and control sites (10.7% versus 10.8% of all visits). In terms of adverse outcomes for women in TPTL <36 weeks, 4 women from the intervention sites and 12 from the control sites did not receive recommended management. If the QUiPP percentage risk was used as per protocol, unnecessary management would have been 7.4% (43/578) versus 9.9% (134/1,351) (OR 0.72, 95% CI 0.45-1.16). Our external validation of the QUiPP app confirmed that it was highly predictive of delivery in 7 days; receiver operating curve area was 0.90 (95% CI 0.85-0.95) for symptomatic women. Study limitations included a lack of compliance with national guidance at the control sites and difficulties in implementation of the QUiPP app.
    Conclusions: This cluster randomised trial did not demonstrate that the use of the QUiPP app reduced unnecessary management of TPTL compared to current management but would safely improve the management recommended by the National Institute for Health and Care Excellence (NICE). Interpretation of qfFN, with or without the QUiPP app, is a safe and accurate method for identifying women most likely to benefit from PTL interventions.
    Trial registration: ISRCTN Registry ISRCTN17846337.
    MeSH term(s) Adult ; Female ; Humans ; Mobile Applications ; Obstetric Labor, Premature/diagnosis ; Obstetric Labor, Premature/prevention & control ; Pregnancy
    Language English
    Publishing date 2021-07-06
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2185925-5
    ISSN 1549-1676 ; 1549-1277
    ISSN (online) 1549-1676
    ISSN 1549-1277
    DOI 10.1371/journal.pmed.1003689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Placental abruption in a twin pregnancy at 32 weeks' gestation complicated by COVID-19, without vertical transmission to the babies

    Kuhrt, Katy / McMicking, Jess / Nanda, Surabhi / Nelson-Piercy, Catherine / Shennan, Andrew

    Am J Obstet Gynecol MFM

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32391520
    Database COVID19

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  9. Article: Placental abruption in a twin pregnancy at 32 weeks' gestation complicated by coronavirus disease 2019 without vertical transmission to the babies

    Kuhrt, Katy / McMicking, Jess / Nanda, Surabhi / Nelson-Piercy, Catherine / Shennan, Andrew

    Am J Obstet Gynecol MFM

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #238934
    Database COVID19

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  10. Article ; Online: Quantitative fetal fibronectin for prediction of preterm birth in asymptomatic twin pregnancy.

    Kuhrt, Katy / Hezelgrave-Elliott, Natasha / Stock, Sarah J / Tribe, Rachel / Seed, Paul T / Shennan, Andrew H

    Acta obstetricia et gynecologica Scandinavica

    2020  Volume 99, Issue 9, Page(s) 1191–1197

    Abstract: Introduction: To evaluate cervicovaginal fluid quantitative fetal fibronectin, measured by a bedside analyzer, to predict spontaneous preterm birth in twin pregnancy before 30 weeks of gestation.: Material and methods: In a prospective cohort study, ... ...

    Abstract Introduction: To evaluate cervicovaginal fluid quantitative fetal fibronectin, measured by a bedside analyzer, to predict spontaneous preterm birth in twin pregnancy before 30 weeks of gestation.
    Material and methods: In a prospective cohort study, we studied the accuracy of quantitative fetal fibronectin measured between 18 and 27
    Results: Of 130 eligible women identified with quantitative fetal fibronectin tests undertaken during the standard testing period, 9% delivered before 30 weeks of gestation. Quantitative fetal fibronectin was significantly related to outcome before 30/40 (ROC curves of 0.8 [95% CI 0.7-1]). Early tests were not significantly predictive; ROC area 0.53 (95% CI 0.29-0.81). There was a trend towards better predictive accuracy when one or more additional risk factors for spontaneous preterm birth or cervical length were considered.
    Conclusions: Quantitative fetal fibronectin measured from 22 to 27
    MeSH term(s) Amniotic Fluid/chemistry ; Cervical Length Measurement ; Female ; Fibronectins/analysis ; Humans ; Pregnancy ; Pregnancy, Twin ; Premature Birth/diagnosis
    Chemical Substances Fibronectins
    Language English
    Publishing date 2020-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/aogs.13861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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