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Article: One new genus and species of the tribe Meconematini (Orthoptera, Tettigoniidae) from Sichuan, China with description of the male sex and transfer of Acosmetura carinata Liu, Zhou & Bi, 2008 to the new genus.

Ming, Shi Fu / Xun, Bian

Zootaxa

2013 Volume 3599, Page(s) 390–394

Abstract: ... nov., Sinocyrtaspiodea longicercus sp. nov. and Sinocyrtaspiodea carinata (Liu, Zhou & Bi, 2008) com ...

Abstract	The paper deals with a new genus, a new species and a new combination, i. e. Sinocyrtaspiodea gen. nov., Sinocyrtaspiodea longicercus sp. nov. and Sinocyrtaspiodea carinata (Liu, Zhou & Bi, 2008) com. nov. All specimens are deposited in the Museum of Hebei University.
MeSH term(s)	Animals ; China ; Female ; Male ; Orthoptera/anatomy & histology ; Orthoptera/classification
Language	English
Publishing date	2013-01-08
Publishing country	New Zealand
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1175-5326
ISSN	1175-5326
DOI	10.11646/zootaxa.3599.4.7
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Article: Antibiotic Culture: A History of Antibiotic Use in the Second Half of the 20th and Early 21st Century in the People's Republic of China.

Zhou, Xun

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Antimicrobial resistance is now widely regarded as a global public health threat. A growing number of studies suggest that antibiotic resistance is higher in China than in most western countries. Despite the current official regulation prohibiting ... ...

Abstract	Antimicrobial resistance is now widely regarded as a global public health threat. A growing number of studies suggest that antibiotic resistance is higher in China than in most western countries. Despite the current official regulation prohibiting pharmacies from the unrestricted selling of antibiotics, there is little sign of declining consumer demand. China now ranks as the second largest consumer of antibiotics in the world, after India. Drawing on published historical data, unpublished archival documents, and recently collected oral interviews, this paper provides a historical overview of antibiotic use and abuse in the People's Republic of China (PRC) from the second half of the 20th century to the present. It demonstrates how the political demand for health improvement, along with the state-sponsored popularization of allopathic medicine, on the one hand, and the lack of access to adequate medical care for the majority of the population, as well as the existing culture of self-medication, on the other hand, are working in tandem to create antibiotic dependency in China. In addition, the privatization and marketization of biomedicine and health care in post-Mao China have helped to build a new and ever-thriving network of production, distribution, and marketing of antibiotics, which has often proven difficult for the authorities to monitor. At the same time, increased purchasing power and easier accessibility created by this new network of production, distribution, and marketing have further contributed to the prevalence of antibiotic overuse in the late 20th and early 21st centuries.
Language	English
Publishing date	2023-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12030510
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Article: Updates of developments in interventional therapy for elderly patients with cardiovascular diseases.

Shen, Hua / Feng, Xun-Xun / Guo, Qian-Yun / Zhou, Yu-Jie

Journal of geriatric cardiology : JGC

2024 Volume 21, Issue 1, Page(s) 1–3

Language	English
Publishing date	2024-02-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2421391-3
ISSN	1671-5411
ISSN	1671-5411
DOI	10.26599/1671-5411.2024.01.010
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Article ; Online: A Survey of the Security Analysis of Embedded Devices.

Zhou, Xu / Wang, Pengfei / Zhou, Lei / Xun, Peng / Lu, Kai

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 22

Abstract: Embedded devices are pervasive nowadays with the rapid development of the Internet of Things (IoT). This brings significant security issues that make the security analysis of embedded devices important. This paper presents a survey on the security ... ...

Abstract	Embedded devices are pervasive nowadays with the rapid development of the Internet of Things (IoT). This brings significant security issues that make the security analysis of embedded devices important. This paper presents a survey on the security analysis research of embedded devices. First, we analyze the embedded device types and their operating systems. Then, we describe a major dynamic security analysis method for an embedded device, i.e., simulating the firmware of the embedded device and performing fuzzing on the web interface provided by the firmware. Third, we discuss some other issues in embedded security analysis, such as analyzing the attack surface, applying static analysis, and performing large-scale analysis. Based on these analyses, we finally conclude three challenges in the current research and present our insights for future research directions.
Language	English
Publishing date	2023-11-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23229221
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Article ; Online: l-arginine and l-lysine supplementation to NaCl tenderizes porcine meat by promoting myosin extraction and actomyosin dissociation.

Fan, Xiaokang / Gao, Xun / Zhou, Cunliu

Food chemistry

2024 Volume 446, Page(s) 138809

Abstract: This study investigated the individual and combined effects of l-arginine, l-lysine, and NaCl on the ultrastructure of porcine myofibrils to uncover the mechanism underlying meat tenderization. Arg or Lys alone shortened A-bands and damaged M-lines, ... ...

Abstract	This study investigated the individual and combined effects of l-arginine, l-lysine, and NaCl on the ultrastructure of porcine myofibrils to uncover the mechanism underlying meat tenderization. Arg or Lys alone shortened A-bands and damaged M-lines, while NaCl alone destroyed M- and Z-lines. Overall, Arg and Lys cooperated with NaCl to destroy the myofibrillar ultrastructure. Moreover, these two amino acids conjoined with NaCl to increase myosin solubility, actin band intensity, and the protein concentration of the actomyosin supernatant. However, they decreased the turbidity and particle size of both myosin and actomyosin solutions, and the remaining activities of Ca
MeSH term(s)	Animals ; Swine ; Actomyosin/chemistry ; Lysine/chemistry ; Sodium Chloride/chemistry ; Myosins/chemistry ; Meat/analysis ; Actins/metabolism ; Arginine/chemistry ; Dietary Supplements
Chemical Substances	Actomyosin (9013-26-7) ; Lysine (K3Z4F929H6) ; Sodium Chloride (451W47IQ8X) ; Myosins (EC 3.6.4.1) ; Actins ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138809
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Article ; Online: BCLAF1 is Expressed as a Potential Anti-oncogene in Bile Duct Cancer.

Zhou, Yutong / Ran, Xun / Han, Min

Biochemical genetics

2024

Abstract: Validating the role of BCLAF1 in the development of Bile Duct Cancer. Differential expression of BCLAF1 in Bile Duct Cancer and normal tissues was analyzed bioinformatically, and immuno-infiltration analysis was performed by R. We also derived the ... ...

Abstract	Validating the role of BCLAF1 in the development of Bile Duct Cancer. Differential expression of BCLAF1 in Bile Duct Cancer and normal tissues was analyzed bioinformatically, and immuno-infiltration analysis was performed by R. We also derived the correlation between the expression of BCLAF1 and HIF-1α by bioinformatics analysis and validated it by Western Blotting, qRT-PCR and scratch assays before and after hypoxia. Through bioinformatics analysis, we found that BCLAF1 mRNA was significantly higher in the tumor tissues of Bile Duct Cancer. The high expression of BCLAF1 implied a more advanced stage but a lower mortality rate. KEGG and GO enrichment analysis showed that BCLAF1 overexpression in Bile Duct Cancer was mainly associated with histone modification, peptidyl lysine modification, and macromolecular methylation. We used the TIMER algorithm to show that BCLAF1 expression in Bile Duct Cancer is associated with immune cell infiltration, which affects tumor progression and patient prognosis. We confirmed by normoxia and hypoxia qRT-PCR, Western Blotting and scratch assays that BCLAF1 and HIF-1α expression are positively correlated and that BCLAF1 may be expressed as anti-oncogene in Bile Duct Cancer. These findings demonstrate that BCLAF1 may act as anti-oncogene in Bile Duct Cancer and may be involved in immune cell infiltration in Bile Duct Cancer, suppressing the expression of HIF-1α.
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2168-4
ISSN	1573-4927 ; 0006-2928
ISSN (online)	1573-4927
ISSN	0006-2928
DOI	10.1007/s10528-023-10616-1
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Article ; Online: Hybrid Density Functional Valence Bond Method with Multistate Treatment.

Wu, Xun / Cao, Chan / Zhou, Chen / Wu, Wei

Journal of chemical theory and computation

2024 Volume 20, Issue 3, Page(s) 1157–1168

Abstract: Recently, a hybrid density functional valence bond (VB) method, λ-DFVB(U), has been proposed and shown to give accuracy that is comparable to that of CASPT2 in calculations of atomization energies, atomic excitation energies, and reaction barriers, while ...

Abstract	Recently, a hybrid density functional valence bond (VB) method, λ-DFVB(U), has been proposed and shown to give accuracy that is comparable to that of CASPT2 in calculations of atomization energies, atomic excitation energies, and reaction barriers, while its computational cost is approximately the same as the valence bond self-consistent-field (VBSCF) method. However, the interaction between electronic states is not included in λ-DFVB(U) since the last step of λ-DFVB(U) is not a diagonalization of the Hamiltonian matrix on the electronic state basis. Therefore, λ-DFVB(U) gives the wrong topology of the potential energy surfaces (PESs) near the conical intersection region. In the present paper, we propose a novel hybrid density functional VB method with multistate treatment, named λ-DFVB(MS), in which an effective Hamiltonian matrix is constructed on the basis of the diabatic states obtained by the valence-bond-based compression approach for the diabatization scheme, and the interaction between electronic states can be included through the diagonalization of the effective Hamiltonian matrix. Test calculations show that λ-DFVB(MS) gives the correct topology of the PESs near the conical intersection region. We also show that the VBSCF wave function with selected VB structures can be applied as a reference in λ-DFVB(MS).
Language	English
Publishing date	2024-01-27
Publishing country	United States
Document type	Journal Article
ISSN	1549-9626
ISSN (online)	1549-9626
DOI	10.1021/acs.jctc.3c01170
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Article ; Online: Exploring Video Denoising in Thermal Infrared Imaging: Physics-inspired Noise Generator, Dataset and Model.

Cai, Lijing / Dong, Xiangyu / Zhou, Kailai / Cao, Xun

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2024 Volume PP

Abstract: We endeavor on a rarely explored task named thermal infrared video denoising. Perception in the thermal infrared significantly enhances the capabilities of machine vision. Nonetheless, noise in imaging systems is one of the factors that hampers the large- ...

Abstract	We endeavor on a rarely explored task named thermal infrared video denoising. Perception in the thermal infrared significantly enhances the capabilities of machine vision. Nonetheless, noise in imaging systems is one of the factors that hampers the large-scale application of equipment. Existing thermal infrared denoising methods, primarily focusing on the image level, inadequately utilize time-domain information and insufficiently conduct investigation of system-level mixed noise, presenting the inferior ability in the video-recorded era; while video denoising methods, commonly applied to RGB cameras, exhibit uncertain effectiveness owing to substantial dissimilarities in the noise models and modalities between RGB and thermal infrared images. In sight of this, we initially revisit the imaging mechanism, while concurrently introducing a physics-inspired noise generator based on the sources and characteristics of system noise. Subsequently, a thermal infrared video denoising dataset consisting of 518 real-world videos is constructed. Lastly, we propose a denoising model called multi-domain infrared video denoising network, capable of concentrating features from the time, space, and frequency domains to restore high-fidelity videos. Extensive experiments demonstrate that the proposed method achieves state-of-the-art denoising quality and can be successfully applied to commercial cameras and downstream vision tasks, providing a new avenue for clear videography in the thermal infrared world. The dataset and code will be available.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2024.3390404
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Article ; Online: Exploration of Ginkgo biloba leaves on non-small cell lung cancer based on network pharmacology and molecular docking.

Wang, Mingxiao / Li, Ruochen / Bai, Moiuqi / Zhou, Xun

Medicine

2024 Volume 103, Issue 9, Page(s) e37218

Abstract: Background: Pharmacological studies have found Ginkgo biloba leaves have the effect of inhibiting neoplasms, it is clinically used in treating various neoplasms. However, the mechanism of Ginkgo biloba leaves in treating non-small cell lung cancer ( ... ...

Abstract	Background: Pharmacological studies have found Ginkgo biloba leaves have the effect of inhibiting neoplasms, it is clinically used in treating various neoplasms. However, the mechanism of Ginkgo biloba leaves in treating non-small cell lung cancer (NSCLC) remains unclear. Methods: The active components and corresponding targets of Ginkgo biloba leaves were obtained from the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) database, and the targets of NSCLC were obtained from the GeneCards, OMIM, TTD, and DrugBank databases. The common targets of NSCLC and Ginkgo biloba leaves were obtained from VENNY 2.1.0. The STRING database was utilized to construct protein-protein intersections, by using the Cytoscape 3.7.1 software, the protein-protein intersection was optimized and the drug-disease network diagram was constructed. The DAVID database was utilized to perform GO and KEGG analysis. Finally, The Autodock Vina software was used to perform molecular docking of core components and targets. Results: The key components of Ginkgo biloba leaves in treating NSCLC include quercetin, luteolin, and kaempferol, which may act on Tp53, AKT1, and TNF. Bioinformatic annotation analysis results suggest that Ginkgo biloba leaves may implicated in PI3K-AKT and MAPK signaling pathways. The molecular docking results show the firm affinity between key ingredients and targets. Conclusion: The potential mechanism of Ginkgo biloba leaves in treating NSCLC has been discussed in this study, which provides a theoretical basis for the clinical treatment of NSCLC and further experimental validation.
MeSH term(s)	Humans ; Ginkgo biloba ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Molecular Docking Simulation ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Lung Neoplasms/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Plant Extracts ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037218
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Article ; Online: First-Principles Study of Structural and Electronic Properties of Monolayer PtX

Ge, Xun / Zhou, Xiaohao / Sun, Deyan / Chen, Xiaoshuang

ACS omega

2023 Volume 8, Issue 6, Page(s) 5715–5721

Abstract: In this work, the structural parameters and electronic properties of ... ...

Abstract	In this work, the structural parameters and electronic properties of PtX
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c07271
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