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Article ; Online: Fat and Dachsous cadherins in mammalian development.

Kasiah, Jennysue / McNeill, Helen

2023 Volume 154, Page(s) 223–244

Abstract: Cell growth and patterning are critical for tissue development. Here we discuss the evolutionarily conserved cadherins, Fat and Dachsous, and the roles they play during mammalian tissue development and disease. In Drosophila, Fat and Dachsous regulate ... ...

Abstract	Cell growth and patterning are critical for tissue development. Here we discuss the evolutionarily conserved cadherins, Fat and Dachsous, and the roles they play during mammalian tissue development and disease. In Drosophila, Fat and Dachsous regulate tissue growth via the Hippo pathway and planar cell polarity (PCP). The Drosophila wing has been an ideal tissue to observe how mutations in these cadherins affect tissue development. In mammals, there are multiple Fat and Dachsous cadherins, which are expressed in many tissues, but mutations in these cadherins that affect growth and tissue organization are context dependent. Here we examine how mutations in the Fat and Dachsous mammalian genes affect development in mammals and contribute to human disease.
MeSH term(s)	Animals ; Humans ; Cadherins/genetics ; Cadherins/metabolism ; Drosophila/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Growth and Development ; Cell Proliferation ; Cell Polarity/genetics ; Drosophila melanogaster ; Mammals/genetics ; Mammals/metabolism
Chemical Substances	Cadherins ; Drosophila Proteins
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article
ISSN	1557-8933 ; 0070-2153
ISSN (online)	1557-8933
ISSN	0070-2153
DOI	10.1016/bs.ctdb.2023.02.008
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Article ; Online: Cochlear implant referral patterns in the UK suggest a postcode lottery with inequitable access for older adults; results of a pilot audit in five Audiology sites.

Cullington, Helen / Dickinson, Ann-Marie / Martinez de Estibariz, Unai / Blackaby, Joseph / Kennedy, Lisa / McNeill, Katie / O'Neill, Sara

International journal of audiology

2024 , Page(s) 1–6

Abstract: Objective: To use a standardised reporting tool to identify potential eligible candidates for cochlear implant (CI) referral and quantify the proportion of adults who had a CI referral discussion after presenting with an audiogram within United Kingdom ( ...

Abstract	Objective: To use a standardised reporting tool to identify potential eligible candidates for cochlear implant (CI) referral and quantify the proportion of adults who had a CI referral discussion after presenting with an audiogram within United Kingdom (UK) audiometric criteria. Design: Retrospective multicentre 6-month audit of Audiology clinic databases. Study sample: A total of 810 adults from five geographically diverse UK Audiology sites. Results: Data were collected in late 2019 after UK CI audiometric candidacy criteria changed; one site collected only 3 months of data. The proportion of potential eligible adults (based only on audiometry) considered for CI referral was 64% (521 out of 810) and varied by site (from 50% to 83%). About 24% of patients (123 out of 521) declined CI referral; this also varied across sites (12-45%). The median age of patients where CI referral was not considered was 80 years - significantly higher than the group where CI referral was considered (73 years). Conclusions: CI referral is dependent on where adults live, and how old they are. Older adults are significantly less likely to be considered for CI referral by Audiologists. Audiology clinics need more support to empower staff to talk to patients about CI referral.
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2073098-6
ISSN	1708-8186 ; 1499-2027
ISSN (online)	1708-8186
ISSN	1499-2027
DOI	10.1080/14992027.2023.2298751
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Article ; Online: Editorial overview: Cell dynamics: Dynamic cell decision making.

Piddini, Eugenia / McNeill, Helen

Current opinion in cell biology

2017 Volume 48, Page(s) iv–vi

Language	English
Publishing date	2017-08-10
Publishing country	England
Document type	Editorial
ZDB-ID	1026381-0
ISSN	1879-0410 ; 0955-0674
ISSN (online)	1879-0410
ISSN	0955-0674
DOI	10.1016/j.ceb.2017.07.003
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Article ; Online: General Practitioner (GP) trainees' experience of a '1-h protected supervision model' given during psychiatry placements in the United Kingdom.

Thomas, Gareth / McNeill, Helen

Education for primary care : an official publication of the Association of Course Organisers, National Association of GP Tutors, World Organisation of Family Doctors

2018 Volume 29, Issue 3, Page(s) 174–177

Abstract: Background A '1-hour protected supervision model' is well established for Psychiatry trainees. This model is also extended to GP trainees who are on placement in psychiatry.: Aim: To explore the experiences of the '1-hour protected supervision model' ... ...

Abstract	Background A '1-hour protected supervision model' is well established for Psychiatry trainees. This model is also extended to GP trainees who are on placement in psychiatry. Aim: To explore the experiences of the '1-hour protected supervision model' for GP trainees in psychiatry placements in the UK. Methods Using a mixed methods approach, an anonymous online questionnaire was sent to GP trainees in the North West of England who had completed a placement in Psychiatry between February and August 2015. Results Discussing clinical cases whilst using the e-portfolio was the most useful learning event in this model. Patient care can potentially improve if a positive relationship develops between trainee/supervisor, which is impacted by the knowledge of this model at the start of the placement. Trainees found that clinical pressures were impacting on the occurrence of supervision. Conclusion The model works best when both GP trainees and their supervisors understand the model. The most frequently used and educationally beneficial aspect for GP trainees in psychiatry is the exploration of clinical cases using the learning portfolio as an educational tool. For effective delivery of this model of supervision, organisations must reflect on the balance between service delivery and allowing the supervisor and trainee adequate time for it to occur.
MeSH term(s)	Clinical Competence ; General Practitioners/education ; Humans ; Internship and Residency/methods ; Psychiatry/education ; Surveys and Questionnaires ; United Kingdom
Language	English
Publishing date	2018-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2074818-8
ISSN	1475-990X ; 1473-9879
ISSN (online)	1475-990X
ISSN	1473-9879
DOI	10.1080/14739879.2017.1416959
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Article ; Online: MnFe

Dee, Garret / Shayoub, Hend / McNeill, Helen / Lozano, Itziar Sánchez / Rafferty, Aran / Gun'ko, Yurii K

RSC advances

2023 Volume 13, Issue 16, Page(s) 10513–10522

Abstract: Removal of dye pollutants from wastewater is among the most important emerging needs in environmental science and engineering. The main objective of our work is to develop new magnetic core-shell nanostructures and explore their use for potential removal ...

Abstract	Removal of dye pollutants from wastewater is among the most important emerging needs in environmental science and engineering. The main objective of our work is to develop new magnetic core-shell nanostructures and explore their use for potential removal of pollutants from water using an external magnetic field. Herein, we have prepared magnetic core-shell nanoparticles that demonstrated excellent dye pollutant adsorbent properties. These nanoparticles are composed of a manganese ferrite magnetic core coated with silica, to protect the core and enable further functionalisation, then finally coated with ceria, which is shown to be an effective adsorbent. The magnetic core-shell nanostructures have been synthesized by a modification of solvothermal synthesis. The nanoparticles were fully characterised at each stage of the synthesis by powder X-ray diffraction (pXRD), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy (FTIR). These particles were found to be effective in removing methylene blue (MB) dye from water, which was validated by UV-visible (UV-vis) spectroscopy. These particles can be quickly removed from solution using a permanent magnet and then can be recycled after being placed in the furnace at 400 °C to burn off any organic residues. The particles were found to retain their ability to adsorb the pollutant after several cycles and TEM images of the particles after several cycles showed no change in the morphology. This research demonstrated the capacity of magnetic core-shell nanostructures to be used for water remediation.
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra01112g
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Article ; Online: Big roles for Fat cadherins.

Blair, Seth / McNeill, Helen

Current opinion in cell biology

2017 Volume 51, Page(s) 73–80

Abstract: To create an intricately patterned and reproducibly sized and shaped organ, many cellular processes must be tightly regulated. Cell elongation, migration, metabolism, proliferation rates, cell-cell adhesion, planar polarization and junctional ... ...

Abstract	To create an intricately patterned and reproducibly sized and shaped organ, many cellular processes must be tightly regulated. Cell elongation, migration, metabolism, proliferation rates, cell-cell adhesion, planar polarization and junctional contractions all must be coordinated in time and space. Remarkably, a pair of extremely large cell adhesion molecules called Fat (Ft) and Dachsous (Ds), acting largely as a ligand-receptor system, regulate, and likely coordinate, these many diverse processes. Here we describe recent exciting progress on how the Ds-Ft pathway controls these diverse processes, and highlight a few of the many questions remaining as to how these enormous cell adhesion molecules regulate development.
MeSH term(s)	Animals ; Cadherins/metabolism ; Cell Polarity/physiology ; Cell Proliferation ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism
Chemical Substances	Cadherins ; Drosophila Proteins
Language	English
Publishing date	2017-12-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1026381-0
ISSN	1879-0410 ; 0955-0674
ISSN (online)	1879-0410
ISSN	0955-0674
DOI	10.1016/j.ceb.2017.11.006
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Article ; Online: Fat/Dachsous family cadherins in cell and tissue organisation.

Fulford, Alexander D / McNeill, Helen

Current opinion in cell biology

2019 Volume 62, Page(s) 96–103

Abstract: Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell ... ...

Abstract	Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell polarity. Here we describe the recent advances in understanding how these large cadherins coordinate these processes, and discuss additional progress extending their function in regulation of microtubules, migration and disease.
MeSH term(s)	Animals ; Cadherins/metabolism ; Cadherins/physiology ; Cell Polarity/physiology ; Drosophila Proteins/physiology
Chemical Substances	Cadherins ; Drosophila Proteins ; ds protein, Drosophila ; kug protein, Drosophila
Language	English
Publishing date	2019-11-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1026381-0
ISSN	1879-0410 ; 0955-0674
ISSN (online)	1879-0410
ISSN	0955-0674
DOI	10.1016/j.ceb.2019.10.006
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Article ; Online: The Hippo pathway regulates axis formation and morphogenesis in

Brooun, Maria / Salvenmoser, Willi / Dana, Catherine / Sudol, Marius / Steele, Robert / Hobmayer, Bert / McNeill, Helen

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 29, Page(s) e2203257119

Abstract: How did cells of early metazoan organisms first organize themselves to form a body axis? The canonical Wnt pathway has been shown to be sufficient for induction of axis in Cnidaria, a sister group to Bilateria, and is important in bilaterian axis ... ...

Abstract	How did cells of early metazoan organisms first organize themselves to form a body axis? The canonical Wnt pathway has been shown to be sufficient for induction of axis in Cnidaria, a sister group to Bilateria, and is important in bilaterian axis formation. Here, we provide experimental evidence that in cnidarian
MeSH term(s)	Animals ; Body Patterning ; Hippo Signaling Pathway ; Hydra/genetics ; Hydra/growth & development ; Hydra/metabolism ; Morphogenesis/genetics ; Transcription, Genetic ; YAP-Signaling Proteins/metabolism
Chemical Substances	YAP-Signaling Proteins
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2203257119
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Zs.A 1148: Show issues

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Article ; Online: Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation.

McNeill, Helen / Reginensi, Antoine

Journal of the American Society of Nephrology : JASN

2016 Volume 28, Issue 3, Page(s) 852–861

Abstract: In the kidney, formation of the functional filtration units, the nephrons, is essential for postnatal life. During development, mesenchymal progenitors tightly regulate the balance between self-renewal and differentiation to give rise to all nephron ... ...

Abstract	In the kidney, formation of the functional filtration units, the nephrons, is essential for postnatal life. During development, mesenchymal progenitors tightly regulate the balance between self-renewal and differentiation to give rise to all nephron epithelia. Here, we investigated the functions of the Hippo pathway serine/threonine-protein kinases Lats1 and Lats2, which phosphorylate and inhibit the transcriptional coactivators Yap and Taz, in nephron progenitor cells. Genetic deletion of
MeSH term(s)	Adaptor Proteins, Signal Transducing/physiology ; Animals ; Cell Cycle Proteins ; Cell Differentiation ; Epithelium ; Mice ; Myofibroblasts/physiology ; Nephrons/cytology ; Phosphoproteins/physiology ; Phosphorylation ; Protein-Serine-Threonine Kinases/physiology ; Stem Cells/physiology ; Transcription Factors/physiology ; Tumor Suppressor Proteins/physiology
Chemical Substances	Adaptor Proteins, Signal Transducing ; Cell Cycle Proteins ; Phosphoproteins ; Transcription Factors ; Tumor Suppressor Proteins ; Yap1 protein, mouse ; tafazzin protein, mouse (EC 2.3.-) ; Lats1 protein, mouse (EC 2.7.1.-) ; LATS2 protein, mouse (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2016-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2016060611
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Article ; Online: Transgenic force sensors and software to measure force transmission across the mammalian nuclear envelope in vivo.

Fenelon, Kelli D / Thomas, Evan / Samani, Mohammad / Zhu, Min / Tao, Hirotaka / Sun, Yu / McNeill, Helen / Hopyan, Sevan

Biology open

2022 Volume 11, Issue 11

Abstract: Nuclear mechanotransduction is a growing field with exciting implications for the regulation of gene expression and cellular function. Mechanical signals may be transduced to the nuclear interior biochemically or physically through connections between ... ...

Abstract	Nuclear mechanotransduction is a growing field with exciting implications for the regulation of gene expression and cellular function. Mechanical signals may be transduced to the nuclear interior biochemically or physically through connections between the cell surface and chromatin. To define mechanical stresses upon the nucleus in physiological settings, we generated transgenic mouse strains that harbour FRET-based tension sensors or control constructs in the outer and inner aspects of the nuclear envelope. We knocked-in a published esprin-2G sensor to measure tensions across the LINC complex and generated a new sensor that links the inner nuclear membrane to chromatin. To mitigate challenges inherent to fluorescence lifetime analysis in vivo, we developed software (FLIMvivo) that markedly improves the fitting of fluorescence decay curves. In the mouse embryo, the sensors responded to cytoskeletal relaxation and stretch applied by micro-aspiration. They reported organ-specific differences and a spatiotemporal tension gradient along the proximodistal axis of the limb bud, raising the possibility that mechanical mechanisms coregulate pattern formation. These mouse strains and software are potentially valuable tools for testing and refining mechanotransduction hypotheses in vivo.
MeSH term(s)	Mice ; Animals ; Nuclear Envelope/metabolism ; Mechanotransduction, Cellular/physiology ; Nuclear Proteins/genetics ; Chromatin/genetics ; Chromatin/metabolism ; Mice, Transgenic ; Software ; Mammals/genetics ; Mammals/metabolism
Chemical Substances	Nuclear Proteins ; Chromatin
Language	English
Publishing date	2022-11-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2632264-X
ISSN	2046-6390 ; 2046-6390
ISSN (online)	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.059656
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