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  1. Article ; Online: Immunomodulatory and Mechanistic Considerations of

    Umeoguaju, Francis U / Ephraim-Emmanuel, Benson C / Uba, Joy O / Bekibele, Grace E / Chigozie, Nwondah / Orisakwe, Orish Ebere

    Frontiers in immunology

    2021  Volume 12, Page(s) 550670

    Abstract: ... Hibiscus ... ...

    Abstract Hibiscus sabdariffa
    MeSH term(s) Animals ; C-Reactive Protein/metabolism ; Cytokines/metabolism ; Hibiscus/chemistry ; Humans ; Immune System Diseases/immunology ; Immune System Diseases/metabolism ; Immune System Diseases/prevention & control ; Immunity/drug effects ; Immunity/immunology ; Immunologic Factors/administration & dosage ; Immunologic Factors/pharmacology ; Nitric Oxide Synthase Type II/metabolism ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology
    Chemical Substances Cytokines ; Immunologic Factors ; Plant Extracts ; C-Reactive Protein (9007-41-4) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
    Language English
    Publishing date 2021-05-10
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.550670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Plant-Derived Food Grade Substances (PDFGS) Active Against Respiratory Viruses: A Systematic Review of Non-clinical Studies.

    Umeoguaju, Francis U / Ephraim-Emmanuel, Benson C / Patrick-Iwuanyanwu, Kingsley C / Zelikoff, Judith T / Orisakwe, Orish Ebere

    Frontiers in nutrition

    2021  Volume 8, Page(s) 606782

    Abstract: Human diet comprises several classes of phytochemicals some of which are potentially active against human pathogenic viruses. This study examined available evidence that identifies existing food plants or constituents of edible foods that have been ... ...

    Abstract Human diet comprises several classes of phytochemicals some of which are potentially active against human pathogenic viruses. This study examined available evidence that identifies existing food plants or constituents of edible foods that have been reported to inhibit viral pathogenesis of the human respiratory tract. SCOPUS and PUBMED databases were searched with keywords designed to retrieve articles that investigated the effect of plant-derived food grade substances (PDFGS) on the activities of human pathogenic viruses. Eligible studies for this review were those done on viruses that infect the human respiratory tract. Forty six (46) studies met the specified inclusion criteria from the initial 5,734 hits. The selected studies investigated the effects of different PDFGS on the infectivity, proliferation and cytotoxicity of different respiratory viruses including influenza A virus (IAV), influenza B virus (IBV), Respiratory syncytial virus (RSV), human parainfluenza virus (hPIV), Human coronavirus NL63 (HCoV-NL63), and rhinovirus (RV) in cell lines and mouse models. This review reveals that PDFGS inhibits different stages of the pathological pathways of respiratory viruses including cell entry, replication, viral release and viral-induced dysregulation of cellular homeostasis and functions. These alterations eventually lead to the reduction of virus titer, viral-induced cellular damages and improved survival of host cells. Major food constituents active against respiratory viruses include flavonoids, phenolic acids, tannins, lectins, vitamin D, curcumin, and plant glycosides such as glycyrrhizin, acteoside, geniposide, and iridoid glycosides. Herbal teas such as guava tea, green and black tea, adlay tea, cistanche tea, kuding tea, licorice extracts, and edible bird nest extracts were also effective against respiratory viruses
    Language English
    Publishing date 2021-02-09
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2021.606782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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