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  1. Article ; Online: How the flame lily synthesizes a therapeutic natural product.

    Weng, Jing-Ke

    Nature

    2020  Volume 584, Issue 7819, Page(s) 49–50

    MeSH term(s) Biological Products ; Colchicine ; Lilium ; Plant Roots
    Chemical Substances Biological Products ; Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2020-07-19
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-01675-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  2. Article ; Online: Plant Solutions for the COVID-19 Pandemic and Beyond: Historical Reflections and Future Perspectives.

    Weng, Jing-Ke

    Molecular plant

    2020  Volume 13, Issue 6, Page(s) 803–807

    MeSH term(s) Betacoronavirus/drug effects ; COVID-19 ; Climate Change ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Food Supply ; Humans ; Interdisciplinary Research/economics ; Interdisciplinary Research/trends ; Pandemics ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plants, Medicinal/chemistry ; Plants, Medicinal/classification ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Research Support as Topic ; SARS-CoV-2
    Chemical Substances Plant Extracts
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2020.05.014
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  3. Article ; Online: Editorial overview: Advancing basic plant research and crop improvement through cutting-edge biotechnologies.

    Qi, Yiping / Weng, Jing-Ke

    Current opinion in plant biology

    2021  Volume 60, Page(s) 102069

    Language English
    Publishing date 2021-06-05
    Publishing country England
    Document type Editorial
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2021.102069
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    In stock of ZB MED Bonn / Germany

    Z 2005/717: Show issues

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  5. Article ; Online: In Vitro

    Kasprzyk, Philip G / Tremaine, Larry / Fahmi, Odette A / Weng, Jing-Ke

    Nutrients

    2023  Volume 15, Issue 17

    Abstract: Several studies ... ...

    Abstract Several studies utilizing
    MeSH term(s) Animals ; Rabbits ; Rats ; Cytochrome P-450 Enzyme System ; Drug Interactions ; Glucosides ; HEK293 Cells
    Chemical Substances Cytochrome P-450 Enzyme System (9035-51-2) ; Glucosides ; rhodioloside (M983H6N1S9)
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15173723
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  6. Article ; Online: Plant Solutions for the COVID-19 Pandemic and Beyond

    Weng, Jing-Ke

    Molecular Plant

    Historical Reflections and Future Perspectives

    2020  Volume 13, Issue 6, Page(s) 803–807

    Keywords Plant Science ; Molecular Biology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2020.05.014
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  7. Article ; Online: Genome-wide association identifies a BAHD acyltransferase activity that assembles an ester of glucuronosylglycerol and phenylacetic acid.

    Simpson, Jeffrey P / Kim, Colin Y / Kaur, Amanpreet / Weng, Jing-Ke / Dilkes, Brian / Chapple, Clint

    The Plant journal : for cell and molecular biology

    2024  

    Abstract: Genome-wide association studies (GWAS) are an effective approach to identify new specialized metabolites and the genes involved in their biosynthesis and regulation. In this study, GWAS of Arabidopsis thaliana soluble leaf and stem metabolites identified ...

    Abstract Genome-wide association studies (GWAS) are an effective approach to identify new specialized metabolites and the genes involved in their biosynthesis and regulation. In this study, GWAS of Arabidopsis thaliana soluble leaf and stem metabolites identified alleles of an uncharacterized BAHD-family acyltransferase (AT5G57840) associated with natural variation in three structurally related metabolites. These metabolites were esters of glucuronosylglycerol, with one metabolite containing phenylacetic acid as the acyl component of the ester. Knockout and overexpression of AT5G57840 in Arabidopsis and heterologous overexpression in Nicotiana benthamiana and Escherichia coli demonstrated that it is capable of utilizing phenylacetyl-CoA as an acyl donor and glucuronosylglycerol as an acyl acceptor. We, thus, named the protein Glucuronosylglycerol Ester Synthase (GGES). Additionally, phenylacetyl glucuronosylglycerol increased in Arabidopsis CYP79A2 mutants that overproduce phenylacetic acid and was lost in knockout mutants of UDP-sulfoquinovosyl: diacylglycerol sulfoquinovosyl transferase, an enzyme required for glucuronosylglycerol biosynthesis and associated with glycerolipid metabolism under phosphate-starvation stress. GGES is a member of a well-supported clade of BAHD family acyltransferases that arose by duplication and neofunctionalized during the evolution of the Brassicales within a larger clade that includes HCT as well as enzymes that synthesize other plant-specialized metabolites. Together, this work extends our understanding of the catalytic diversity of BAHD acyltransferases and uncovers a pathway that involves contributions from both phenylalanine and lipid metabolism.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1088037-9
    ISSN 1365-313X ; 0960-7412
    ISSN (online) 1365-313X
    ISSN 0960-7412
    DOI 10.1111/tpj.16737
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    In stock of ZB MED Bonn / Germany

    Z 6071: Show issues

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  8. Article ; Online: Exploring Uncharted Territories of Plant Specialized Metabolism in the Postgenomic Era.

    Jacobowitz, Joseph R / Weng, Jing-Ke

    Annual review of plant biology

    2020  Volume 71, Page(s) 631–658

    Abstract: For millennia, humans have used plants for food, raw materials, and medicines, but only within the past two centuries have we begun to connect particular plant metabolites with specific properties and utilities. Since the utility of classical molecular ... ...

    Abstract For millennia, humans have used plants for food, raw materials, and medicines, but only within the past two centuries have we begun to connect particular plant metabolites with specific properties and utilities. Since the utility of classical molecular genetics beyond model species is limited, the vast specialized metabolic systems present in the Earth's flora remain largely unstudied. With an explosion in genomics resources and a rapidly expanding toolbox over the past decade, exploration of plant specialized metabolism in nonmodel species is becoming more feasible than ever before. We review the state-of-the-art tools that have enabled this rapid progress. We present recent examples of de novo biosynthetic pathway discovery that employ various innovative approaches. We also draw attention to the higher-order organization of plant specialized metabolism at subcellular, cellular, tissue, interorgan, and interspecies levels, which will have important implications for the future design of comprehensive metabolic engineering strategies.
    MeSH term(s) Biosynthetic Pathways ; Genomics ; Humans ; Metabolic Engineering ; Plants/genetics
    Language English
    Publishing date 2020-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2098209-4
    ISSN 1545-2123 ; 1543-5008
    ISSN (online) 1545-2123
    ISSN 1543-5008
    DOI 10.1146/annurev-arplant-081519-035634
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  9. Article ; Online: transXpress

    Timothy R. Fallon / Tereza Čalounová / Martin Mokrejš / Jing-Ke Weng / Tomáš Pluskal

    BMC Bioinformatics, Vol 24, Iss 1, Pp 1-

    a Snakemake pipeline for streamlined de novo transcriptome assembly and annotation

    2023  Volume 11

    Abstract: Abstract Background RNA-seq followed by de novo transcriptome assembly has been a transformative technique in biological research of non-model organisms, but the computational processing of RNA-seq data entails many different software tools. The ... ...

    Abstract Abstract Background RNA-seq followed by de novo transcriptome assembly has been a transformative technique in biological research of non-model organisms, but the computational processing of RNA-seq data entails many different software tools. The complexity of these de novo transcriptomics workflows therefore presents a major barrier for researchers to adopt best-practice methods and up-to-date versions of software. Results Here we present a streamlined and universal de novo transcriptome assembly and annotation pipeline, transXpress, implemented in Snakemake. transXpress supports two popular assembly programs, Trinity and rnaSPAdes, and allows parallel execution on heterogeneous cluster computing hardware. Conclusions transXpress simplifies the use of best-practice methods and up-to-date software for de novo transcriptome assembly, and produces standardized output files that can be mined using SequenceServer to facilitate rapid discovery of new genes and proteins in non-model organisms.
    Keywords De novo transcriptome assembly ; RNA-seq ; Non-model organisms ; Transcriptome annotation ; Differential expression analysis ; Reproducible software ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Biology (General) ; QH301-705.5
    Subject code 005
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Unleashing the Synthetic Power of Plant Oxygenases: From Mechanism to Application.

    Mitchell, Andrew J / Weng, Jing-Ke

    Plant physiology

    2019  Volume 179, Issue 3, Page(s) 813–829

    MeSH term(s) Catalysis ; Metabolic Networks and Pathways ; Models, Molecular ; Oxygenases/chemistry ; Oxygenases/genetics ; Oxygenases/physiology ; Plants/enzymology ; Synthetic Biology
    Chemical Substances Oxygenases (EC 1.13.-)
    Language English
    Publishing date 2019-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.18.01223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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