LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 179

Search options

  1. Article ; Online: Diurnal and circadian regulation of opsin-like transcripts in the eyeless cnidarian

    Santillo, Silvia / De Petrocellis, Luciano / Musio, Carlo

    Biomolecular concepts

    2024  Volume 15, Issue 1

    Abstract: Opsins play a key role in the ability to sense light both in image-forming vision and in non-visual photoreception (NVP). These modalities, in most animal phyla, share the photoreceptor protein: an opsin-based protein binding a light-sensitive ... ...

    Abstract Opsins play a key role in the ability to sense light both in image-forming vision and in non-visual photoreception (NVP). These modalities, in most animal phyla, share the photoreceptor protein: an opsin-based protein binding a light-sensitive chromophore by a lysine (Lys) residue. So far, visual and non-visual opsins have been discovered throughout the Metazoa phyla, including the photoresponsive
    MeSH term(s) Animals ; Opsins/genetics ; Opsins/chemistry ; Opsins/metabolism ; Cnidaria/genetics ; Cnidaria/metabolism ; Hydra/genetics ; Hydra/metabolism ; Phylogeny ; Circadian Rhythm/genetics
    Chemical Substances Opsins
    Language English
    Publishing date 2024-03-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2557908-3
    ISSN 1868-503X ; 1868-5021
    ISSN (online) 1868-503X
    ISSN 1868-5021
    DOI 10.1515/bmc-2022-0044
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Fluorescence-Based Assay for TRPV1 Channels.

    Moriello, Aniello Schiano / De Petrocellis, Luciano / Vitale, Rosa Maria

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2576, Page(s) 119–131

    Abstract: The transient receptor potential vanilloid 1 ion channel (TRPV1) is a ligand-gated nonselective calcium-permeant cation channel involved in the detection of a wide variety of chemical and physical noxious stimuli, ranging from exogenous and endogenous ... ...

    Abstract The transient receptor potential vanilloid 1 ion channel (TRPV1) is a ligand-gated nonselective calcium-permeant cation channel involved in the detection of a wide variety of chemical and physical noxious stimuli, ranging from exogenous and endogenous ligands to noxious heat (>42 °C) and low pH (pH < 5.2). Due to its central role in pain and hyperalgesia, TRPV1 is considered a relevant therapeutic target for the development of analgesic and anti-inflammatory drugs potentially useful to relieve chronic, neuropathic, and inflammatory pain and to treat disorders such as inflammatory bowel disease. In this view, the availability of in vitro assays for the screening of novel TRPV1 modulators is highly desirable. Since TRPV1 activation leads to an increase in the intracellular calcium (Ca
    MeSH term(s) Analgesics ; Calcium/metabolism ; Capsaicin ; Cations ; Fluorescence ; Fura-2 ; HEK293 Cells ; Humans ; Ligands ; Pain/drug therapy ; TRPV Cation Channels/physiology ; Transient Receptor Potential Channels
    Chemical Substances Analgesics ; Cations ; Ligands ; TRPV Cation Channels ; TRPV1 protein, human ; Transient Receptor Potential Channels ; Capsaicin (S07O44R1ZM) ; Calcium (SY7Q814VUP) ; Fura-2 (TSN3DL106G)
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2728-0_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Conference proceedings: Short Lecture "Phytochemical profiling of a cannabigerol-rich Cannabis sativa strain expands chemical and biological space of underexplored phytocannabinoids"

    Gargiulo, Ernesto / Vitale, Rosa M. / Scafati, Orazio Taglialatela / De Petrocellis, Luciano / Chianese, Giuseppina

    Planta Medica

    2023  Volume 89, Issue 14

    Event/congress 71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Trinity College Dublin Ireland, 2023-07-02
    Language English
    Publishing date 2023-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/s-0043-1773850
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.157: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Phytochemical Characterization and TRPA1/TRPM8 Modulation Profile of the Cannabigerol-Rich

    Gargiulo, Ernesto / Moriello, Aniello Schiano / Benetti, Emanuele / Pagni, Luca / Arnoldi, Lolita / De Petrocellis, Luciano / Chianese, Giuseppina / Vitale, Rosa Maria / Taglialatela-Scafati, Orazio

    Journal of natural products

    2024  Volume 87, Issue 4, Page(s) 722–732

    Abstract: The first detailed phytochemical analysis of the cannabigerol (CBG)-rich chemotype IV ... ...

    Abstract The first detailed phytochemical analysis of the cannabigerol (CBG)-rich chemotype IV of
    MeSH term(s) Cannabis/chemistry ; TRPA1 Cation Channel/antagonists & inhibitors ; Cannabinoids/pharmacology ; Cannabinoids/chemistry ; Cannabinoids/isolation & purification ; TRPM Cation Channels/antagonists & inhibitors ; Molecular Structure ; Transient Receptor Potential Channels/antagonists & inhibitors ; Transient Receptor Potential Channels/drug effects ; Phytochemicals/pharmacology ; Phytochemicals/isolation & purification ; Phytochemicals/chemistry ; Humans ; Cannabidiol/pharmacology ; Cannabidiol/chemistry ; Calcium Channels/metabolism
    Chemical Substances cannabigerol (J1K406072N) ; TRPA1 Cation Channel ; Cannabinoids ; TRPM Cation Channels ; Transient Receptor Potential Channels ; Phytochemicals ; Cannabidiol (19GBJ60SN5) ; cannabidiolic acid (FJX8O3OJCD) ; Calcium Channels
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c00831
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs.

    Mattoteia, Daiana / Schiano Moriello, Aniello / Taglialatela-Scafati, Orazio / Amodeo, Pietro / De Petrocellis, Luciano / Appendino, Giovanni / Vitale, Rosa Maria / Caprioglio, Diego

    Biomedicines

    2021  Volume 9, Issue 8

    Abstract: The affinity of cannabinoids for their ... ...

    Abstract The affinity of cannabinoids for their CB
    Language English
    Publishing date 2021-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9081070
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides.

    Vitale, Rosa Maria / Avonto, Cristina / Del Prete, Danilo / Moriello, Aniello Schiano / Amodeo, Pietro / Appendino, Giovanni / De Petrocellis, Luciano

    Journal of natural products

    2020  Volume 83, Issue 11, Page(s) 3476–3481

    Abstract: As part of a study on triterpenoid conjugates, the dietary pentacyclic triterpenoids oleanolic ( ...

    Abstract As part of a study on triterpenoid conjugates, the dietary pentacyclic triterpenoids oleanolic (
    MeSH term(s) Amides/chemistry ; Drug Discovery ; HEK293 Cells ; Humans ; Molecular Docking Simulation ; TRPV Cation Channels/drug effects ; Triterpenes/chemistry ; Triterpenes/pharmacology
    Chemical Substances Amides ; TRPV Cation Channels ; TRPV1 receptor ; Triterpenes
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c00639
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: In Silico

    Romeo, Isabella / Brizzi, Antonella / Pessina, Federica / Ambrosio, Francesca Alessandra / Aiello, Francesca / Belardo, Carmela / Carullo, Gabriele / Costa, Giosuè / De Petrocellis, Luciano / Frosini, Maria / Luongo, Livio / Maramai, Samuele / Paolino, Marco / Moriello, Aniello Schiano / Mugnaini, Claudia / Scorzelli, Francesco / Maione, Sabatino / Corelli, Federico / Di Marzo, Vincenzo /
    Alcaro, Stefano / Artese, Anna

    Journal of medicinal chemistry

    2023  Volume 66, Issue 10, Page(s) 6994–7015

    Abstract: We describe ... ...

    Abstract We describe an
    MeSH term(s) Rats ; Animals ; Humans ; Thiophenes/pharmacology ; Thiophenes/chemistry ; Molecular Dynamics Simulation ; Oxidative Stress ; Amides ; Drug Design ; Molecular Docking Simulation ; TRPV Cation Channels/agonists
    Chemical Substances Thiophenes ; Amides ; TRPV1 protein, human ; TRPV Cation Channels ; Trpv1 protein, rat
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c00447
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Reprint of: Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

    Pollastro, Federica / De Petrocellis, Luciano / Schiano-Moriello, Aniello / Chianese, Giuseppina / Heyman, Heino / Appendino, Giovanni / Taglialatela-Scafati, Orazio

    Fitoterapia

    2018  Volume 126, Page(s) 35–39

    Language English
    Publishing date 2018-04-11
    Publishing country Netherlands
    Document type Journal Article ; Corrected and Republished Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2018.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1873: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Moringin, A Stable Isothiocyanate from

    Borgonovo, Gigliola / De Petrocellis, Luciano / Schiano Moriello, Aniello / Bertoli, Simona / Leone, Alessandro / Battezzati, Alberto / Mazzini, Stefania / Bassoli, Angela

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 4

    Abstract: ... Moringa ... ...

    Abstract Moringa oleifera
    MeSH term(s) HEK293 Cells ; Humans ; Isothiocyanates/chemistry ; Isothiocyanates/pharmacology ; Moringa oleifera/chemistry ; Nociceptive Pain/drug therapy ; Nociceptive Pain/pathology ; Nociceptors/drug effects ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Somatosensory Cortex ; TRPA1 Cation Channel/antagonists & inhibitors ; TRPA1 Cation Channel/genetics ; TRPM Cation Channels/genetics ; Transfection
    Chemical Substances Isothiocyanates ; Plant Extracts ; TRPA1 Cation Channel ; TRPM Cation Channels ; TRPM8 protein, human ; moringin
    Language English
    Publishing date 2020-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25040976
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress.

    Brizzi, Antonella / Maramai, Samuele / Aiello, Francesca / Baratto, Maria Camilla / Corelli, Federico / Mugnaini, Claudia / Paolino, Marco / Scorzelli, Francesco / Aldinucci, Carlo / De Petrocellis, Luciano / Signorini, Cinzia / Pessina, Federica

    International journal of molecular sciences

    2022  Volume 23, Issue 21

    Abstract: α-Lipoic acid is a sulfur-containing nutrient endowed with pleiotropic actions and a safe biological profile selected to replace the unsaturated alkyl acid of capsaicin with the aim of obtaining lipoic amides potentially active as a TRPV1 ligand and with ...

    Abstract α-Lipoic acid is a sulfur-containing nutrient endowed with pleiotropic actions and a safe biological profile selected to replace the unsaturated alkyl acid of capsaicin with the aim of obtaining lipoic amides potentially active as a TRPV1 ligand and with significant antioxidant properties. Thus, nine compounds were obtained in good yields following a simple synthetic procedure and tested for their functional TRPV1 activity and radical-scavenger activity. The safe biological profile together with the protective effect against hypoxia damage as well as the in vitro antioxidant properties were also evaluated. Although less potent than capsaicin, almost all lipoic amides were found to be TRPV1 agonists and, specifically, compound
    MeSH term(s) Humans ; Capsaicin ; TRPV Cation Channels/metabolism ; Antioxidants/pharmacology ; Amides/pharmacology ; Ligands ; Oxidative Stress ; Hypoxia
    Chemical Substances Capsaicin (S07O44R1ZM) ; TRPV Cation Channels ; Antioxidants ; Amides ; Ligands ; TRPV1 protein, human
    Language English
    Publishing date 2022-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232113580
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top