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  1. Article ; Online: Mechanisms of intermittent theta-burst stimulation attenuating nerve injury after ischemic reperfusion in rats through endoplasmic reticulum stress and ferroptosis.

    Shen, Xin-Ya / Zhang, Xing-Yu / Han, Ping-Ping / Zhao, Yi-Ning / Xu, Guo-Hui / Bi, Xia

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 377

    Abstract: Background: Repetitive transcranial magnetic stimulation (rTMS) exerts neuroprotective effects early in cerebral ischemia/reperfusion (I/R) injury. Intermittent theta-brust stimulation (iTBS), a more time-efficient modality of rTMS, improves the ... ...

    Abstract Background: Repetitive transcranial magnetic stimulation (rTMS) exerts neuroprotective effects early in cerebral ischemia/reperfusion (I/R) injury. Intermittent theta-brust stimulation (iTBS), a more time-efficient modality of rTMS, improves the efficiency without at least decreasing the efficacy of the therapy. iTBS elevates cortical excitability, and in recent years it has become increasingly common to apply iTBS to patients in the early post-IS period. However, little is known about the neuroprotective mechanisms of iTBS. Endoplasmic reticulum stress (ERS), and ferroptosis have been shown to be involved in the development of I/R injury. We aimed to investigate the potential regulatory mechanisms by which iTBS attenuates neurological injury after I/R in rats.
    Methods: Rats were randomly divided into three groups: sham-operated group, MCAO/R group, and MCAO/R + iTBS group, and were stimulated with iTBS 36 h after undergoing middle cerebral artery occlusion (MCAO) or sham-operated. The expression of ERS, ferroptosis, and apoptosis-related markers was subsequently detected by western blot assays. We also investigated the mechanism by which iTBS attenuates nerve injury after ischemic reperfusion in rats by using the modified Neurological Severity Score (mNSS) and the balance beam test to measure nerve function.
    Results: iTBS performed early in I/R injury attenuated the levels of ERS, ferroptosis, and apoptosis, and improved neurological function, including mNSS and balance beam experiments. It is suggested that this mode of stimulation reduces the cost per treatment by several times without compromising the efficacy of the treatment and could be a practical and less costly intervention.
    MeSH term(s) Humans ; Rats ; Animals ; Transcranial Magnetic Stimulation ; Ferroptosis ; Reperfusion Injury/therapy ; Reperfusion ; Endoplasmic Reticulum Stress
    Language English
    Publishing date 2024-03-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09241-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus

    Lu, Chun-Ju / Liang, Li-Fen / Zhang, Geng-Si / Li, Hai-Yan / Fu, Chun-Qing / Yu, Qin / Zhou, Dong-Mei / Su, Zhi-Wei / Liu, Kai / Gao, Cheng-Hai / Xu, Xin-Ya / Liu, Yong-Hong

    Marine drugs

    2024  Volume 22, Issue 2

    Abstract: Six benzophenone derivatives, carneusones A-F ( ...

    Abstract Six benzophenone derivatives, carneusones A-F (
    MeSH term(s) Animals ; Mice ; Molecular Structure ; Aspergillus/chemistry ; Anti-Inflammatory Agents/pharmacology ; RAW 264.7 Cells
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md22020063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Enhanced Activity of Enzyme Immobilized on Hydrophobic ZIF-8 Modified by Ni

    Yang, Xiao-Gang / Zhang, Ji-Rui / Tian, Xu-Ke / Qin, Jian-Hua / Zhang, Xin-Ya / Ma, Lu-Fang

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 7, Page(s) e202216699

    Abstract: The development of efficient enzyme immobilization to promote their recyclability and activity is highly desirable. Zeolitic imidazolate framework-8 (ZIF-8) has been proved to be an effective platform for enzyme immobilization due to its easy preparation ...

    Abstract The development of efficient enzyme immobilization to promote their recyclability and activity is highly desirable. Zeolitic imidazolate framework-8 (ZIF-8) has been proved to be an effective platform for enzyme immobilization due to its easy preparation and biocompatibility. However, the intrinsic hydrophobic characteristic hinders its further development in this filed. Herein, a facile synthesis approach was developed to immobilize pepsin (PEP) on the ZIF-8 carrier by using Ni
    MeSH term(s) Metal-Organic Frameworks/chemistry ; Zeolites/chemistry ; Enzymes, Immobilized/chemistry ; Pepsin A ; Ions
    Chemical Substances Metal-Organic Frameworks ; Zeolites (1318-02-1) ; Enzymes, Immobilized ; Pepsin A (EC 3.4.23.1) ; Ions
    Language English
    Publishing date 2023-01-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202216699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent advances of medical polyhydroxyalkanoates in musculoskeletal system.

    Mi, Chen-Hui / Qi, Xin-Ya / Ding, Yan-Wen / Zhou, Jing / Dao, Jin-Wei / Wei, Dai-Xu

    Biomaterials translational

    2023  Volume 4, Issue 4, Page(s) 234–247

    Abstract: Infection and rejection in musculoskeletal trauma often pose challenges for natural healing, prompting the exploration of biomimetic organ and tissue transplantation as a common alternative solution. Polyhydroxyalkanoates (PHAs) are a large family of ... ...

    Abstract Infection and rejection in musculoskeletal trauma often pose challenges for natural healing, prompting the exploration of biomimetic organ and tissue transplantation as a common alternative solution. Polyhydroxyalkanoates (PHAs) are a large family of biopolyesters synthesised in microorganism, demonstrating excellent biocompatibility and controllable biodegradability for tissue remodelling and drug delivery. With different monomer-combination and polymer-types, multi-mechanical properties of PHAs making them have great application prospects in medical devices with stretching, compression, twist in long time, especially in musculoskeletal tissue engineering. This review systematically summarises the applications of PHAs in multiple tissues repair and drug release, encompassing areas such as bone, cartilage, joint, skin, tendons, ligament, cardiovascular tissue, and nervous tissue. It also discusses challenges encountered in their application, including high production costs, potential cytotoxicity, and uncontrollable particle size distribution. In conclusion, PHAs offer a compelling avenue for musculoskeletal system applications, striking a balance between biocompatibility and mechanical performance. However, addressing challenges in their production and application requires further research to unleash their full potential in tackling the complexities of musculoskeletal regeneration.
    Language English
    Publishing date 2023-12-28
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2096-112X
    ISSN (online) 2096-112X
    DOI 10.12336/biomatertransl.2023.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Plant-derived lignans as potential antiviral agents: a systematic review

    Xu, Xin-Ya / Wang, Dong-Ying / Li, Yi-Ping / Deyrup, Stephen T. / Zhang, Hong-Jie

    Phytochemistry reviews. 2022 Feb., v. 21, no. 1

    2022  

    Abstract: Medicinal plants are one of the most important sources of antiviral agents and lead compounds. Lignans are a large class of natural compounds comprising two phenyl propane units. Many of them have demonstrated biological activities, and some of them have ...

    Abstract Medicinal plants are one of the most important sources of antiviral agents and lead compounds. Lignans are a large class of natural compounds comprising two phenyl propane units. Many of them have demonstrated biological activities, and some of them have even been developed as therapeutic drugs. In this review, 630 lignans, including those obtained from medicinal plants and their chemical derivatives, were systematically reviewed for their antiviral activity and mechanism of action. The compounds discussed herein were published in articles between 1998 and 2020. The articles were identified using both database searches (e.g., Web of Science, Pub Med and Scifinder) using key words such as: antiviral activity, antiviral effects, lignans, HBV, HCV, HIV, HPV, HSV, JEV, SARS-CoV, RSV and influenza A virus, and directed searches of scholarly publisher’s websites including ACS, Elsevier, Springer, Thieme, and Wiley. The compounds were classified on their structural characteristics as 1) arylnaphthalene lignans, 2) aryltetralin lignans, 3) dibenzylbutyrolactone lignans, 4) dibenzylbutane lignans, 5) tetrahydrofuranoid and tetrahydrofurofuranoid lignans, 6) benzofuran lignans, 7) neolignans, 8) dibenzocyclooctadiene lignans and homolignans, and 9) norlignans and other lignoids. Details on isolation and antiviral activities of the most active compounds within each class of lignan are discussed in detail, as are studies of synthetic lignans that provide structure–activity relationship information.
    Keywords Influenza A virus ; Internet ; antiviral properties ; databases ; lignans ; mechanism of action ; norlignans ; plant biochemistry ; propane ; structure-activity relationships ; systematic review ; therapeutics
    Language English
    Dates of publication 2022-02
    Size p. 239-289.
    Publishing place Springer Netherlands
    Document type Article
    Note Review
    ZDB-ID 2065661-0
    ISSN 1572-980X ; 1568-7767
    ISSN (online) 1572-980X
    ISSN 1568-7767
    DOI 10.1007/s11101-021-09758-0
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Virtual reconstruction of midfacial bone defect based on generative adversarial network

    Yu-Tao Xiong / Wei Zeng / Lei Xu / Ji-Xiang Guo / Chang Liu / Jun-Tian Chen / Xin-Ya Du / Wei Tang

    Head & Face Medicine, Vol 18, Iss 1, Pp 1-

    2022  Volume 9

    Abstract: Abstract Background The study aims to evaluate the accuracy of the generative adversarial networks (GAN) for reconstructing bony midfacial defects. Methods According to anatomy, the bony midface was divided into five subunit structural regions and ... ...

    Abstract Abstract Background The study aims to evaluate the accuracy of the generative adversarial networks (GAN) for reconstructing bony midfacial defects. Methods According to anatomy, the bony midface was divided into five subunit structural regions and artificial defects are manually created on the corresponding CT images. GAN is trained to reconstruct artificial defects to their previous normal shape and tested. The clinical defects are reconstructed by the trained GAN, where the midspan defects were used for qualitative evaluation and the unilateral defects were used for quantitative evaluation. The cosine similarity and the mean error are used to evaluate the accuracy of reconstruction. The Mann–Whitney U test is used to detect whether reconstruction errors were consistent in artificial and unilateral clinical defects. Results This study included 518 normal CT data, with 415 in training set and 103 in testing set, and 17 real patient data, with 2 midspan defects and 15 unilateral defects. Reconstruction of midspan clinical defects assessed by experts is acceptable. The cosine similarity in the reconstruction of artificial defects and unilateral clinical defects is 0.97 ± 0.01 and 0.96 ± 0.01, P = 0.695. The mean error in the reconstruction of artificial defects and unilateral clinical defects is 0.59 ± 0.31 mm and 0.48 ± 0.08 mm, P = 0.09. Conclusion GAN-based virtual reconstruction technology has reached a high accuracy in testing set, and statistical tests suggest that it can achieve similar results in real patient data. This study has preliminarily solved the problem of bony midfacial defect without reference.
    Keywords Virtual Surgical Planning ; Midface Reconstruction ; Generative Adversarial Networks ; Specialties of internal medicine ; RC581-951
    Subject code 571
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Plant-derived lignans as potential antiviral agents: a systematic review.

    Xu, Xin-Ya / Wang, Dong-Ying / Li, Yi-Ping / Deyrup, Stephen T / Zhang, Hong-Jie

    Phytochemistry reviews : proceedings of the Phytochemical Society of Europe

    2021  Volume 21, Issue 1, Page(s) 239–289

    Abstract: Medicinal plants are one of the most important sources of antiviral agents and lead compounds. Lignans are a large class of natural compounds comprising two phenyl propane units. Many of them have demonstrated biological activities, and some of them have ...

    Abstract Medicinal plants are one of the most important sources of antiviral agents and lead compounds. Lignans are a large class of natural compounds comprising two phenyl propane units. Many of them have demonstrated biological activities, and some of them have even been developed as therapeutic drugs. In this review, 630 lignans, including those obtained from medicinal plants and their chemical derivatives, were systematically reviewed for their antiviral activity and mechanism of action. The compounds discussed herein were published in articles between 1998 and 2020. The articles were identified using both database searches (e.g., Web of Science, Pub Med and Scifinder) using key words such as: antiviral activity, antiviral effects, lignans, HBV, HCV, HIV, HPV, HSV, JEV, SARS-CoV, RSV and influenza A virus, and directed searches of scholarly publisher's websites including ACS, Elsevier, Springer, Thieme, and Wiley. The compounds were classified on their structural characteristics as 1) arylnaphthalene lignans, 2) aryltetralin lignans, 3) dibenzylbutyrolactone lignans, 4) dibenzylbutane lignans, 5) tetrahydrofuranoid and tetrahydrofurofuranoid lignans, 6) benzofuran lignans, 7) neolignans, 8) dibenzocyclooctadiene lignans and homolignans, and 9) norlignans and other lignoids. Details on isolation and antiviral activities of the most active compounds within each class of lignan are discussed in detail, as are studies of synthetic lignans that provide structure-activity relationship information.
    Language English
    Publishing date 2021-05-31
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2065661-0
    ISSN 1572-980X ; 1568-7767
    ISSN (online) 1572-980X
    ISSN 1568-7767
    DOI 10.1007/s11101-021-09758-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke.

    Liu, Pin-Yi / Li, Hui-Qin / Dong, Meng-Qi / Gu, Xin-Ya / Xu, Si-Yi / Xia, Sheng-Nan / Bao, Xin-Yu / Xu, Yun / Cao, Xiang

    Journal of neuroinflammation

    2023  Volume 20, Issue 1, Page(s) 260

    Abstract: Background: Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia. Properdin, which is typically secreted by immune cells such as ... ...

    Abstract Background: Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia. Properdin, which is typically secreted by immune cells such as neutrophils, monocytes, and T cells, has been found to possess damage-associated molecular patterns (DAMPs) properties and can perform functions unrelated to the complement pathway. However, the role of properdin in modulating microglia-mediated post-stroke neuroinflammation remains unclear.
    Methods: Global and conditional (myeloid-specific) properdin-knockout mice were subjected to transient middle cerebral artery occlusion (tMCAO). Histopathological and behavioral tests were performed to assess ischemic brain injury in mice. Single-cell RNA sequencing and immunofluorescence staining were applied to explore the source and the expression level of properdin. The transcriptomic profile of properdin-activated primary microglia was depicted by transcriptome sequencing. Lentivirus was used for macrophage-inducible C-type lectin (Mincle) silencing in microglia. Conditioned medium from primary microglia was administered to primary cortex neurons to determine the neurotoxicity of microglia. A series of cellular and molecular biological techniques were used to evaluate the proinflammatory response, neuronal death, protein-protein interactions, and related signaling pathways, etc. RESULTS: The level of properdin was significantly increased, and brain-infiltrating neutrophils and macrophages were the main sources of properdin in the ischemic brain. Global and conditional myeloid knockout of properdin attenuated microglial overactivation and inflammatory responses at the acute stage of tMCAO in mice. Accordingly, treatment with recombinant properdin enhanced the production of proinflammatory cytokines and augmented microglia-potentiated neuronal death in primary culture. Mechanistically, recombinant properdin served as a novel ligand that activated Mincle receptors on microglia and downstream pathways to drive primary microglia-induced inflammatory responses. Intriguingly, properdin can directly bind to the microglial Mincle receptor to exert the above effects, while Mincle knockdown limits properdin-mediated microglial inflammation.
    Conclusion: Properdin is a new medium by which infiltrating peripheral myeloid cells communicate with microglia, further activate microglia, and exacerbate brain injury in the ischemic brain, suggesting that targeted disruption of the interaction between properdin and Mincle on microglia or inhibition of their downstream signaling may improve the prognosis of ischemic stroke.
    MeSH term(s) Mice ; Animals ; Microglia/metabolism ; Ischemic Stroke/metabolism ; Properdin/metabolism ; Properdin/pharmacology ; Neuroinflammatory Diseases ; Macrophages/metabolism ; Infarction, Middle Cerebral Artery/pathology ; Brain Injuries/metabolism ; Brain Ischemia/metabolism ; Mice, Inbred C57BL
    Chemical Substances Properdin (11016-39-0)
    Language English
    Publishing date 2023-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-023-02946-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Triterpene esters of

    Xu, Qing-Jiang / Liu, Jia-Chen / Huang, Cheng-Jin / Wang, Xin / Shang, Xiao-Ya

    Journal of Asian natural products research

    2024  , Page(s) 1–8

    Abstract: Two new triterpene fatty acid esters, ... ...

    Abstract Two new triterpene fatty acid esters, 3
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2024.2340074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A TrkB cleavage fragment in hippocampus promotes Depressive-Like behavior in mice.

    Wang, Jianhao / Yu, Hang / Li, Xiang / Li, Fang / Chen, Hongyu / Zhang, Xi / Wang, Yamei / Xu, Ruifeng / Gao, Feng / Wang, Jiabei / Liu, Pai / Shi, Yuke / Qin, Dongdong / Li, Yiyi / Liu, Songyan / Ding, Shuai / Gao, Xin-Ya / Wang, Zhi-Hao

    Brain, behavior, and immunity

    2024  Volume 119, Page(s) 56–83

    Abstract: Decreased hippocampal tropomyosin receptor kinase B (TrkB) level is implicated in the pathophysiology of stress-induced mood disorder and cognitive decline. However, how TrkB is modified and mediates behavioral responses to chronic stress remains largely ...

    Abstract Decreased hippocampal tropomyosin receptor kinase B (TrkB) level is implicated in the pathophysiology of stress-induced mood disorder and cognitive decline. However, how TrkB is modified and mediates behavioral responses to chronic stress remains largely unknown. Here the effects and mechanisms of TrkB cleavage by asparagine endopeptidase (AEP) were examined on a preclinical murine model of chronic restraint stress (CRS)-induced depression. CRS activated IL-1β-C/EBPβ-AEP pathway in mice hippocampus, accompanied by elevated TrkB 1-486 fragment generated by AEP. Specifi.c overexpression or suppression of AEP-TrkB axis in hippocampal CaMKIIα-positive cells aggravated or relieved depressive-like behaviors, respectively. Mechanistically, in addition to facilitating AMPARs internalization, TrkB 1-486 interacted with peroxisome proliferator-activated receptor-δ (PPAR-δ) and sequestered it in cytoplasm, repressing PPAR-δ-mediated transactivation and mitochondrial function. Moreover, co-administration of 7,8-dihydroxyflavone and a peptide disrupting the binding of TrkB 1-486 with PPAR-δ attenuated depression-like symptoms not only in CRS animals, but also in Alzheimer's disease and aged mice. These findings reveal a novel role for TrkB cleavage in promoting depressive-like phenotype.
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2024.03.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 327: Show issues

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