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  1. Book ; Online ; E-Book: Plant bioactives as natural panacea against age-induced diseases

    Pandey, Kanti Bhooshan / Maitrī Sutthačhit

    nutraceuticals and functional lead compounds for drug development

    (Drug Discovery Update)

    2023  

    Author's details edited by Kanti Bhooshan Pandey, Maitree Suttajit
    Series title Drug Discovery Update
    Keywords Diet therapy for older people
    Subject code 381
    Language English
    Size 1 online resource (500 pages)
    Publisher Elsevier
    Publishing place Amsterdam, Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-91329-6 ; 9780323905817 ; 978-0-323-91329-4 ; 0323905811
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Natural Products and Their Bioactives in Antidiabetic Drug Discovery

    Pandey, Kanti Bhooshan / Suttajit, Maitree / Atukeren, Pinar

    2023  

    Abstract: Diabetes mellitus DM which is commonly known as sugar disease has now become bitter for health and this metabolic disease is increasing worldwide at an alarming rate. The combination of chronic pathological disorders in pancreatic leading to persistent ... ...

    Abstract "Diabetes mellitus DM which is commonly known as sugar disease has now become bitter for health and this metabolic disease is increasing worldwide at an alarming rate. The combination of chronic pathological disorders in pancreatic leading to persistent hyperglycemia is connected to serious organ damage followed by failure including kidneys eyes feet nerves brain gastrointestinal tract and cardiovascular system in DM."--
    Keywords Hypoglycemic agents/Development ; Bioactive compounds ; Diabetes/Research
    Subject code 616.4/6206
    Language English
    Size 1 online resource (352 pages)
    Publisher John Wiley & Sons, Incorporated
    Publishing place Newark
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-119-98334-7 ; 1-119-98332-0 ; 9781119983316 ; 978-1-119-98334-7 ; 978-1-119-98332-3 ; 1119983312
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Piperine protects oxidative modifications in human erythrocytes.

    Singh, Prabhakar / Pandey, Kanti Bhooshan / Rizvi, Syed Ibrahim

    Journal of basic and clinical physiology and pharmacology

    2021  Volume 33, Issue 2, Page(s) 163–167

    Abstract: Objectives: Piperine (1-piperoyl piperidine), a major alkaloid constituent of : Methods: Healthy human erythrocytes and erythrocytes membrane was stressed with free radical inducer chemical; : Results: The results demonstrate that treatment of ... ...

    Abstract Objectives: Piperine (1-piperoyl piperidine), a major alkaloid constituent of
    Methods: Healthy human erythrocytes and erythrocytes membrane was stressed with free radical inducer chemical;
    Results: The results demonstrate that treatment of erythrocytes with piperine (10
    Conclusions: The study concludes that piperine possesses potent anti-oxidant potential which may explain many of its observed biological effects.
    MeSH term(s) Alkaloids/pharmacology ; Benzodioxoles ; Erythrocytes ; Humans ; Oxidative Stress ; Piperidines/pharmacology ; Polyunsaturated Alkamides
    Chemical Substances Alkaloids ; Benzodioxoles ; Piperidines ; Polyunsaturated Alkamides ; piperine (U71XL721QK)
    Language English
    Publishing date 2021-02-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1071737-7
    ISSN 2191-0286 ; 0792-6855 ; 0334-1534
    ISSN (online) 2191-0286
    ISSN 0792-6855 ; 0334-1534
    DOI 10.1515/jbcpp-2020-0100
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    Zs.A 3207: Show issues Location:
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  4. Article ; Online: Compromised Renal and Hepatic Functions and Unsteady Cellular Redox State during Preeclampsia and Gestational Diabetes Mellitus.

    Mishra, Jigeesha / Srivastava, Shailendra Kumar / Pandey, Kanti Bhooshan

    Archives of medical research

    2021  Volume 52, Issue 6, Page(s) 635–640

    Abstract: Introduction: To assess renal and hepatic functions along with the redox state in preeclampsia (PE) and gestational diabetes mellitus (GDM) pregnancies.: Design and method: The study was conducted on 33 PE (mean age = 30 ± 5 years), 33 GDM (mean age = ...

    Abstract Introduction: To assess renal and hepatic functions along with the redox state in preeclampsia (PE) and gestational diabetes mellitus (GDM) pregnancies.
    Design and method: The study was conducted on 33 PE (mean age = 30 ± 5 years), 33 GDM (mean age = 30 ± 6 years) and age, gravida, parity, and ethnicity matched 25 normal pregnancies (NP). Biomarkers of redox status, renal and hepatic functions; aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), bilirubin, urea, blood urea nitrogen (BUN), creatinine, uric acid, lipid peroxidation (MDA), total thiols (TSH), radical scavenging activities and ferric reducing antioxidant potentials of serum were measured.
    Results: Higher urea, BUN, uric acid, creatinine and overexpressed AST, ALT, ALP was observed in PE (p <0.03-p<0.001), whereas in GDM elevation in creatinine and ALT activity were only statistically significant (p <0.01) in comparison to NP. Diminished antioxidant/radical scavenging potentials, TSH content and increased MDA were noted in both the diseased pregnancies when compared with NP with statistically significant variables ranged from p <0.04-p <0.0001.
    Conclusion: Our data suggest that PE has detrimental effects on renal and hepatic functions while GDM are prone to malfunctioned liver and kidney performances. Impaired redox state may be one of the reasons of altered physiological process in PE and GDM pregnancies. Results may be used to monitor the efficiency and efficacy of antioxidant supplementation, recently suggested for PE and GDM patients.
    MeSH term(s) Adult ; Alanine Transaminase/metabolism ; Aspartate Aminotransferases/metabolism ; Diabetes, Gestational/metabolism ; Diabetes, Gestational/physiopathology ; Female ; Humans ; Kidney/physiopathology ; Lipid Peroxidation ; Liver/physiopathology ; Pre-Eclampsia/metabolism ; Pre-Eclampsia/physiopathology ; Pregnancy ; Young Adult
    Chemical Substances Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2021.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Role of red grape polyphenols as antidiabetic agents.

    Pandey, Kanti Bhooshan / Rizvi, Syed Ibrahim

    Integrative medicine research

    2014  Volume 3, Issue 3, Page(s) 119–125

    Abstract: The worldwide incidence of diabetes mellitus has reached alarming proportions. Persistent hyperglycemia due to impaired insulin activity and/or insulin resistance inversely affects the retina, cerebrovascular system, kidney, peripheral limbs, and other ... ...

    Abstract The worldwide incidence of diabetes mellitus has reached alarming proportions. Persistent hyperglycemia due to impaired insulin activity and/or insulin resistance inversely affects the retina, cerebrovascular system, kidney, peripheral limbs, and other parts of the body, which leads to life-threatening complications. The causal role of oxidative stress in the development and progression of diabetic complications has been emphasized. Polyphenols present in natural products have gained much attention in recent decades in preventive studies against diabetes-associated pathologies. In the present review, we provide a comparative update on the role of quercetin, myricetin, and resveratrol-the major polyphenols present in red grapes-in intervening with diabetic complications, and a brief highlight on the molecular mechanisms underlying oxidative stress mediated hyperglycemia.
    Language English
    Publishing date 2014-07-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2213-4220
    ISSN 2213-4220
    DOI 10.1016/j.imr.2014.06.001
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  6. Article ; Online: Resveratrol in vitro ameliorates tert-butyl hydroperoxide-induced alterations in erythrocyte membranes from young and older humans.

    Pandey, Kanti Bhooshan / Rizvi, Syed Ibrahim

    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

    2014  Volume 39, Issue 10, Page(s) 1093–1097

    Abstract: Implication of reactive oxygen species/oxidative stress has been readily reported in etiology of aging and related manifestations. Plasma membrane as a regulator of numerous aspects of cell physiology including cell-cell interaction, solute transport, ... ...

    Abstract Implication of reactive oxygen species/oxidative stress has been readily reported in etiology of aging and related manifestations. Plasma membrane as a regulator of numerous aspects of cell physiology including cell-cell interaction, solute transport, and signal transduction, provides structural integrity to the cells. The aim of the present study was to determine the effect of resveratrol administration in vitro, to evaluate the biological effect of this phytoalexin in oxidatively injured erythrocytes during aging. This study, carried out on 91 normal healthy subjects, provides experimental evidence that erythrocytes have increased oxidative damage with age. In vitro administration of resveratrol significantly attenuated deleterious effects of oxidative injury in erythrocytes from humans of all ages.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cells, Cultured ; Erythrocyte Membrane/drug effects ; Female ; Humans ; Male ; Middle Aged ; Oxidation-Reduction/drug effects ; Stilbenes/pharmacology ; Young Adult ; tert-Butylhydroperoxide/adverse effects
    Chemical Substances Stilbenes ; tert-Butylhydroperoxide (955VYL842B) ; resveratrol (Q369O8926L)
    Language English
    Publishing date 2014-10
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2236708-1
    ISSN 1715-5320 ; 1715-5312
    ISSN (online) 1715-5320
    ISSN 1715-5312
    DOI 10.1139/apnm-2014-0064
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    Zs.A 1717: Show issues Location:
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  7. Article ; Online: Role of resveratrol in regulation of membrane transporters and integrity of human erythrocytes.

    Pandey, Kanti Bhooshan / Rizvi, Syed Ibrahim

    Biochemical and biophysical research communications

    2014  Volume 453, Issue 3, Page(s) 521–526

    Abstract: An altered ion homeostasis due to impaired membrane transporters is known to be involved in the pathophysiology of many chronic diseases. Resveratrol, a phytoalexin, has been reported to elicit pleiotropic health-promoting effects, however, the mechanism( ...

    Abstract An altered ion homeostasis due to impaired membrane transporters is known to be involved in the pathophysiology of many chronic diseases. Resveratrol, a phytoalexin, has been reported to elicit pleiotropic health-promoting effects, however, the mechanism(s) which underlie these effects remain speculative. The present study investigate the modulatory role of resveratrol on erythrocyte membrane Ca(2+)ATPase (PMCA pump), Na(+)/K(+)-ATPase (NKA pump), and Na(+)/H(+) exchanger (NHE) in control and experimental-oxidative stress conditions. Results suggest that resveratrol is a potent modulator of membrane transporters evidenced by stimulation of PMCA and NKA pumps and down-regulation of NHE. The observed effects on membrane transporters correlated with susceptibility of erythrocyte membrane to oxidative damage. The findings provide an insight into the role of membrane transporters and their involvement in the health beneficial effects of resveratrol.
    MeSH term(s) Erythrocytes/drug effects ; Erythrocytes/metabolism ; Humans ; Membrane Transport Proteins/metabolism ; Oxidative Stress ; Stilbenes/pharmacology
    Chemical Substances Membrane Transport Proteins ; Stilbenes ; resveratrol (Q369O8926L)
    Language English
    Publishing date 2014-10-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2014.09.117
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    Zs.A 116: Show issues Location:
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  8. Article ; Online: Erythrocyte senescence and membrane transporters in young and old rats.

    Singh, Sandeep / Pandey, Kanti Bhooshan / Rizvi, Syed Ibrahim

    Archives of physiology and biochemistry

    2016  Volume 122, Issue 4, Page(s) 228–234

    Abstract: Alterations at the level of plasma membrane are reported to play an important role in cellular senescence. The present study was undertaken to correlate cellular senescence, membrane transport processes and organismal aging. To achieve this objective ... ...

    Abstract Alterations at the level of plasma membrane are reported to play an important role in cellular senescence. The present study was undertaken to correlate cellular senescence, membrane transport processes and organismal aging. To achieve this objective activities of membrane linked Na
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Cell Membrane/pathology ; Cellular Senescence/physiology ; Erythrocytes/metabolism ; Erythrocytes/pathology ; Immunoblotting ; Lipid Peroxides/metabolism ; Male ; Membrane Proteins/metabolism ; Protein Carbonylation ; Rats ; Rats, Wistar ; Sodium-Hydrogen Exchangers/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
    Chemical Substances Lipid Peroxides ; Membrane Proteins ; Sodium-Hydrogen Exchangers ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9)
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1238320-x
    ISSN 1744-4160 ; 1381-3455
    ISSN (online) 1744-4160
    ISSN 1381-3455
    DOI 10.1080/13813455.2016.1190761
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    Uc I Zs.99: Show issues Location:
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  9. Article ; Online: Resveratrol up-regulates the erythrocyte plasma membrane redox system and mitigates oxidation-induced alterations in erythrocytes during aging in humans.

    Pandey, Kanti Bhooshan / Rizvi, Syed Ibrahim

    Rejuvenation research

    2013  Volume 16, Issue 3, Page(s) 232–240

    Abstract: Reactive oxygen/nitrogen species (ROS/RNS)-mediated oxidative damage followed by disturbed cellular homeostasis is involved in aging and related consequences. Lipid peroxidation, post-translational modifications of proteins, and an impaired defense ... ...

    Abstract Reactive oxygen/nitrogen species (ROS/RNS)-mediated oxidative damage followed by disturbed cellular homeostasis is involved in aging and related consequences. Lipid peroxidation, post-translational modifications of proteins, and an impaired defense system due to increased oxidative stress jeopardize cell fate and functions, resulting in cell senescence. Resveratrol, a natural stilbene, has extensively been reported to elicit a plethora of health-promoting effects. The present study carried out on 97 healthy human subjects (62 males and 35 females) of both sexes provides experimental evidence that resveratrol confers ability to up-regulate the plasma membrane redox system (PMRS) along with ascorbate free radical reductase, a compensatory system operating in the cell to maintain cellular redox state. Furthermore, resveratrol provided significant protection against lipid peroxidation and protein carbonylation and restored the cellular redox homeostasis measured in terms of glutathione (GSH) and sulfhydryl (-SH) group levels during oxidation injury in erythrocytes of different age groups in humans. Findings suggest a possible role of resveratrol in retardation of age-dependent oxidative stress.
    MeSH term(s) Aging/blood ; Antioxidants/pharmacology ; Erythrocyte Membrane/drug effects ; Erythrocyte Membrane/metabolism ; Humans ; Oxidation-Reduction ; Stilbenes/pharmacology ; Up-Regulation/drug effects
    Chemical Substances Antioxidants ; Stilbenes ; resveratrol (Q369O8926L)
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2150779-X
    ISSN 1557-8577 ; 1549-1684
    ISSN (online) 1557-8577
    ISSN 1549-1684
    DOI 10.1089/rej.2013.1419
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    Zs.A 5215: Show issues Location:
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  10. Article ; Online: Effect of oral supplementation of composite leaf extract of medicinal plants on biomarkers of oxidative stress in induced diabetic Wistar rats.

    Tiwari, Brahm Kumar / Abidi, Abu Baker / Rizvi, Syed Ibrahim / Pandey, Kanti Bhooshan

    Archives of physiology and biochemistry

    2017  Volume 124, Issue 4, Page(s) 361–366

    Abstract: Present study was conducted to evaluate the effect of oral supplementation of composite extract of leaves (CLE) of four medicinal plants; Aegle marmelos, Ocimum sanctum, Murraya koenigii and Azadirachta indica on markers of oxidative stress in brain ... ...

    Abstract Present study was conducted to evaluate the effect of oral supplementation of composite extract of leaves (CLE) of four medicinal plants; Aegle marmelos, Ocimum sanctum, Murraya koenigii and Azadirachta indica on markers of oxidative stress in brain tissues of alloxan-induced diabetic rats in vivo. Enhanced lipid peroxidation, protein oxidation and reduced antioxidative defence systems were measured in brain tissues of diabetic rats. Supplementation of CLE, once in a day for 35 days significantly (p < .05) protected the peroxidation of lipid, oxidation of protein and ameliorated the antioxidant defence in brain tissue of diabetic rats. It was observed that the insulin-like effect of CLE was dose dependent; higher effect at higher doses. The results of the study suggest that supplementation CLE may provide an overall homeostasis and significant neuro-protection through rescuing brain cells from oxidative abuse and accelerating brain antioxidative defence during advanced stage of hyperglycaemia.
    MeSH term(s) Animals ; Antioxidants/administration & dosage ; Antioxidants/therapeutic use ; Biomarkers/blood ; Biomarkers/metabolism ; Brain/drug effects ; Brain/enzymology ; Brain/metabolism ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/diet therapy ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Dietary Supplements ; Hyperglycemia/prevention & control ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/therapeutic use ; India ; Isophane Insulin, Human/therapeutic use ; Lipid Peroxidation/drug effects ; Male ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism ; Neurons/drug effects ; Neurons/enzymology ; Neurons/metabolism ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/therapeutic use ; Oxidation-Reduction ; Oxidative Stress/drug effects ; Oxidoreductases/metabolism ; Plant Extracts/administration & dosage ; Plant Extracts/therapeutic use ; Plant Leaves/chemistry ; Plant Leaves/growth & development ; Plants, Medicinal/chemistry ; Plants, Medicinal/growth & development ; Rats, Wistar
    Chemical Substances Antioxidants ; Biomarkers ; Hypoglycemic Agents ; Isophane Insulin, Human ; Nerve Tissue Proteins ; Neuroprotective Agents ; Plant Extracts ; Oxidoreductases (EC 1.-)
    Language English
    Publishing date 2017-12-06
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1238320-x
    ISSN 1744-4160 ; 1381-3455
    ISSN (online) 1744-4160
    ISSN 1381-3455
    DOI 10.1080/13813455.2017.1411369
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