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Article ; Online: New insights into cell death induced by long chain bases in Arabidopsis.

Michaelson, Louise V

2011 Volume 191, Issue 4, Page(s) 909–911

MeSH term(s)	Arabidopsis/genetics ; Arabidopsis Proteins/metabolism ; Cell Death ; Mitogen-Activated Protein Kinases/metabolism ; Serine C-Palmitoyltransferase/metabolism ; Signal Transduction ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism
Chemical Substances	Arabidopsis Proteins ; Lcb2 protein, Arabidopsis (EC 2.3.1.50) ; Serine C-Palmitoyltransferase (EC 2.3.1.50) ; MPK6 protein, Arabidopsis (EC 2.7.11.24) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Sphingosine (NGZ37HRE42) ; safingol (OWA98U788S)
Language	English
Publishing date	2011-08-05
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/j.1469-8137.2011.03843.x
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Article: Using

Dobermann, Darja / Field, Lin M / Michaelson, Louise V

Journal of cleaner production

2018 Volume 211, Page(s) 303–308

Abstract: Waragi, a form of homemade gin, is produced throughout Uganda in both legal and illegal breweries. Waste produced during the illegal brewing process is predominantly disposed of via indiscriminate dumping into surrounding environments and reports from ... ...

Abstract	Waragi, a form of homemade gin, is produced throughout Uganda in both legal and illegal breweries. Waste produced during the illegal brewing process is predominantly disposed of via indiscriminate dumping into surrounding environments and reports from local communities have indicated this to be harmful to crops and livestock. The larvae of
Language	English
Publishing date	2018-10-03
Publishing country	Netherlands
Document type	Journal Article
ISSN	0959-6526
ISSN	0959-6526
DOI	10.1016/j.jclepro.2018.11.176
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Article ; Online: Production of the infant formula ingredient 1,3-olein-2-palmitin in Arabidopsis thaliana seeds.

van Erp, Harrie / Bryant, Fiona M / Martin-Moreno, Jose / Michaelson, Louise V / Eastmond, Peter J

Metabolic engineering

2021 Volume 67, Page(s) 67–74

Abstract: In human milk fat, palmitic acid (16:0) is esterified to the middle (sn-2 or β) position on the glycerol backbone and oleic acid (18:1) predominantly to the outer positions, giving the triacylglycerol (TG) a distinctive stereoisomeric structure that is ... ...

Abstract	In human milk fat, palmitic acid (16:0) is esterified to the middle (sn-2 or β) position on the glycerol backbone and oleic acid (18:1) predominantly to the outer positions, giving the triacylglycerol (TG) a distinctive stereoisomeric structure that is believed to assist nutrient absorption in the infant gut. However, the fat used in most infant formulas is derived from plants, which preferentially esterify 16:0 to the outer positions. We have previously showed that the metabolism of the model oilseed Arabidopsis thaliana can be engineered to incorporate 16:0 into the middle position of TG. However, the fatty acyl composition of Arabidopsis seed TG does not mimic human milk, which is rich in both 16:0 and 18:1 and is defined by the high abundance of the TG molecular species 1,3-olein-2-palmitin (OPO). Here we have constructed an Arabidopsis fatty acid biosynthesis 1-1 fatty acid desaturase 2 fatty acid elongase 1 mutant with around 20% 16:0 and 70% 18:1 in its seeds and we have engineered it to esterify more than 80% of the 16:0 to the middle position of TG, using heterologous expression of the human lysophosphatidic acid acyltransferase isoform AGPAT1, combined with suppression of LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE 2 and PHOSPHATIDYLCHOLINE:DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE. Our data show that oilseeds can be engineered to produce TG that is rich in OPO, which is a structured fat ingredient used in infant formulas.
MeSH term(s)	Arabidopsis/genetics ; Fatty Acids ; Humans ; Infant ; Infant Formula ; Milk, Human ; Seeds/genetics ; Triglycerides
Chemical Substances	Fatty Acids ; Triglycerides
Language	English
Publishing date	2021-06-04
Publishing country	Belgium
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1470383-x
ISSN	1096-7184 ; 1096-7176
ISSN (online)	1096-7184
ISSN	1096-7176
DOI	10.1016/j.ymben.2021.05.009
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Article ; Online: Increased bioavailability of phenolic acids and enhanced vascular function following intake of feruloyl esterase-processed high fibre bread: A randomized, controlled, single blind, crossover human intervention trial.

Turner, Alice L / Michaelson, Louise V / Shewry, Peter R / Lovegrove, Alison / Spencer, Jeremy P E

Clinical nutrition (Edinburgh, Scotland)

2020 Volume 40, Issue 3, Page(s) 788–795

Abstract: Background & aims: Clinical trial data have indicated an association between wholegrain consumption and a reduction in surrogate markers of cardiovascular disease. Phenolics present in wholegrain bound to arabinoxylan fibre may contribute these effects, ...

Abstract	Background & aims: Clinical trial data have indicated an association between wholegrain consumption and a reduction in surrogate markers of cardiovascular disease. Phenolics present in wholegrain bound to arabinoxylan fibre may contribute these effects, particularly when released enzymatically from the fiber prior to ingestion. The aim of the present study was therefore to determine whether the intake of high fibre bread containing higher free ferulic acid (FA) levels (enzymatically released during processing) enhances human endothelium-dependent vascular function. Methods: A randomized, single masked, controlled, crossover, human intervention study was conducted on 19 healthy men. Individuals consumed either a high fibre flatbread with enzymatically released free FA (14.22 mg), an equivalent standard high fibre bread (2.34 mg), or a white bread control (0.48 mg) and markers of vascular function and plasma phenolic acid concentrations were measured at baseline, 2, 5 and 7 h post consumption. Results: Significantly increased brachial arterial dilation was observed following consumption of the high free FA ('enzyme-treated') high fibre bread verses both a white bread (2 h: p < 0.05; 5 h: p < 0.01) and a standard high fibre bread (5 h: p < 0.05). Concurrently, significant increases in plasma FA levels were observed, at 2 h (p < 0.01) after consumption of the enzyme-treated bread, relative to control treatments. Blood pressure, heart rate, DVP-SI and DVP-RI were not significantly altered following intake of any of the breads (p > 0.05). Conclusion: Dietary intake of bread, processed enzymatically to release FA from arabinoxylan fiber during production increases the bioavailability of FA, and induces acute endothelium-dependent vasodilation. Clinical trial registry: NO: NCT03946293. WEBSITE: www.clinicaltrials.gov.
MeSH term(s)	Adult ; Biological Availability ; Blood Pressure ; Bread ; Carboxylic Ester Hydrolases/metabolism ; Coumaric Acids/blood ; Coumaric Acids/pharmacokinetics ; Cross-Over Studies ; Dietary Fiber/administration & dosage ; Food Handling ; Heart Rate ; Humans ; Male ; Single-Blind Method ; Vasodilation ; Xylans/metabolism
Chemical Substances	Coumaric Acids ; Dietary Fiber ; Xylans ; arabinoxylan (9040-27-1) ; ferulic acid (AVM951ZWST) ; Carboxylic Ester Hydrolases (EC 3.1.1.-) ; feruloyl esterase (EC 3.1.1.73)
Language	English
Publishing date	2020-08-08
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2020.07.026
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Article: Defining lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins.

Wang, Rui / Ghumra, Ashfaq / Cochrane, Stella / Fairclough, Lucy / Broughton, Richard / Michaelson, Louise V / Beaudoin, Frederic / Alcocer, Marcos J C

Clinical and translational allergy

2020 Volume 10, Issue 1, Page(s) 54

Language	English
Publishing date	2020-11-25
Publishing country	England
Document type	Letter
ZDB-ID	2630865-4
ISSN	2045-7022
ISSN	2045-7022
DOI	10.1186/s13601-020-00358-3
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Article: Using Hermetia illucens to process Ugandan waragi waste

Dobermann, Darja / Field, Lin M / Michaelson, Louise V

Journal of cleaner production. 2019 Feb. 20, v. 211

2019

Abstract	Waragi, a form of homemade gin, is produced throughout Uganda in both legal and illegal breweries. Waste produced during the illegal brewing process is predominantly disposed of via indiscriminate dumping into surrounding environments and reports from local communities have indicated this to be harmful to crops and livestock. The larvae of Hermetia illucens are documented to consume a wide range of otherwise unappealing waste products. In addition to this, the prepupal stages of the larvae can serve as a high-quality protein feed for animal livestock. Therefore, the feasibility of the larvae of H. illucens to digest waragi waste was evaluated. A dietary toxicity trial was run to establish an LC50 value for waragi inclusion in larval diets. This was followed by a larger scale trial utilising waragi waste in combination with various in situ available feed stuffs to further assess the viability of processing waragi waste using H. illucens. Larvae were able to eat diets composed of up to 85% waragi waste without any significant impact (p > .01) on survival or growth. When combined with locally available feed sources, e.g. chicken offal, cottonseed cake, sunflower meal or groundnut cake, larvae showed high survival (>95%) and growth rates on diets including 25% waragi waste. Results indicate that H. illucens larvae may be a useful tool in processing waragi waste.
Keywords	Hermetia illucens ; brewing ; brewing industry ; chickens ; cottonseed cake ; crops ; diet ; larvae ; lethal concentration 50 ; peanut cake ; prepupae ; sunflower meal ; toxicity ; viability ; wastes ; Uganda
Language	English
Dates of publication	2019-0220
Size	p. 303-308.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2018.11.176
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Article ; Online: Sphingolipids: towards an integrated view of metabolism during the plant stress response.

Huby, Eloïse / Napier, Johnathan A / Baillieul, Fabienne / Michaelson, Louise V / Dhondt-Cordelier, Sandrine

The New phytologist

2019 Volume 225, Issue 2, Page(s) 659–670

Abstract: Plants exist in an environment of changing abiotic and biotic stresses. They have developed a complex set of strategies to respond to these stresses and over recent years it has become clear that sphingolipids are a key player in these responses. ... ...

Abstract	Plants exist in an environment of changing abiotic and biotic stresses. They have developed a complex set of strategies to respond to these stresses and over recent years it has become clear that sphingolipids are a key player in these responses. Sphingolipids are not universally present in all three domains of life. Many bacteria and archaea do not produce sphingolipids but they are ubiquitous in eukaryotes and have been intensively studied in yeast and mammals. During the last decade there has been a steadily increasing interest in plant sphingolipids. Plant sphingolipids exhibit structural differences when compared with their mammalian counterparts and it is now clear that they perform some unique functions. Sphingolipids are recognised as critical components of the plant plasma membrane and endomembrane system. Besides being important structural elements of plant membranes, their particular structure contributes to the fluidity and biophysical order. Sphingolipids are also involved in multiple cellular and regulatory processes including vesicle trafficking, plant development and defence. This review will focus on our current knowledge as to the function of sphingolipids during plant stress responses, not only as structural components of biological membranes, but also as signalling mediators.
MeSH term(s)	Oxidative Stress ; Plant Growth Regulators/metabolism ; Plants/metabolism ; Signal Transduction ; Sphingolipids/chemistry ; Sphingolipids/metabolism ; Stress, Physiological
Chemical Substances	Plant Growth Regulators ; Sphingolipids
Language	English
Publishing date	2019-07-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.15997
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Article ; Online: Lipid remodelling: Unravelling the response to cold stress in Arabidopsis and its extremophile relative Eutrema salsugineum.

Barrero-Sicilia, Cristina / Silvestre, Susana / Haslam, Richard P / Michaelson, Louise V

Plant science : an international journal of experimental plant biology

2017 Volume 263, Page(s) 194–200

Abstract: Environmental constraints limit the geographic distribution of many economically important crops. Cold stress is an important abiotic stress that affects plant growth and development, resulting in loss of vigour and surface lesions. These symptoms are ... ...

Abstract	Environmental constraints limit the geographic distribution of many economically important crops. Cold stress is an important abiotic stress that affects plant growth and development, resulting in loss of vigour and surface lesions. These symptoms are caused by, among other metabolic processes, the altered physical and chemical composition of cell membranes. As a major component of cell membranes lipids have been recognized as having a significant role in cold stress, both as a mechanical defence through leaf surface protection and plasma membrane remodelling, and as signal transduction molecules. We present an overview integrating gene expression and lipidomic data published so far in Arabidopsis and its relative the extremophile Eutrema salsugineum. This data enables a better understanding of the contribution of the lipidome in determining the ability to tolerate suboptimal temperature conditions. Collectively this information will allow us to identify the key lipids and pathways responsible for resilience, enabling the development of new approaches for crop tolerance to stress.
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis/physiology
Language	English
Publishing date	2017-07-27
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2017.07.017
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Article: Sphingolipids: towards an integrated view of metabolism during the plant stress response

Huby, Eloïse / Napier, Johnathan A / Baillieul, Fabienne / Michaelson, Louise V / Dhondt‐Cordelier, Sandrine

new phytologist. 2020 Jan., v. 225, no. 2

2020

Abstract	Plants exist in an environment of changing abiotic and biotic stresses. They have developed a complex set of strategies to respond to these stresses and over recent years it has become clear that sphingolipids are a key player in these responses. Sphingolipids are not universally present in all three domains of life. Many bacteria and archaea do not produce sphingolipids but they are ubiquitous in eukaryotes and have been intensively studied in yeast and mammals. During the last decade there has been a steadily increasing interest in plant sphingolipids. Plant sphingolipids exhibit structural differences when compared with their mammalian counterparts and it is now clear that they perform some unique functions. Sphingolipids are recognised as critical components of the plant plasma membrane and endomembrane system. Besides being important structural elements of plant membranes, their particular structure contributes to the fluidity and biophysical order. Sphingolipids are also involved in multiple cellular and regulatory processes including vesicle trafficking, plant development and defence. This review will focus on our current knowledge as to the function of sphingolipids during plant stress responses, not only as structural components of biological membranes, but also as signalling mediators.
Keywords	Archaea ; abiotic stress ; bacteria ; biotic stress ; endomembrane system ; eukaryotic cells ; mammals ; metabolism ; physiological transport ; plant development ; plant stress ; plasma membrane ; sphingolipids ; stress response ; yeasts
Language	English
Dates of publication	2020-01
Size	p. 659-670.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.15997
Database	NAL-Catalogue (AGRICOLA)

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Article: Production of the infant formula ingredient 1,3-olein-2-palmitin in Arabidopsis thaliana seeds

van Erp, Harrie / Bryant, Fiona M / Martin-Moreno, Jose / Michaelson, Louise V / Eastmond, Peter J

Metabolic engineering. 2021 Sept., v. 67

2021

Abstract	In human milk fat, palmitic acid (16:0) is esterified to the middle (sn-2 or β) position on the glycerol backbone and oleic acid (18:1) predominantly to the outer positions, giving the triacylglycerol (TG) a distinctive stereoisomeric structure that is believed to assist nutrient absorption in the infant gut. However, the fat used in most infant formulas is derived from plants, which preferentially esterify 16:0 to the outer positions. We have previously showed that the metabolism of the model oilseed Arabidopsis thaliana can be engineered to incorporate 16:0 into the middle position of TG. However, the fatty acyl composition of Arabidopsis seed TG does not mimic human milk, which is rich in both 16:0 and 18:1 and is defined by the high abundance of the TG molecular species 1,3-olein-2-palmitin (OPO). Here we have constructed an Arabidopsis fatty acid biosynthesis 1-1 fatty acid desaturase 2 fatty acid elongase 1 mutant with around 20% 16:0 and 70% 18:1 in its seeds and we have engineered it to esterify more than 80% of the 16:0 to the middle position of TG, using heterologous expression of the human lysophosphatidic acid acyltransferase isoform AGPAT1, combined with suppression of LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE 2 and PHOSPHATIDYLCHOLINE:DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE. Our data show that oilseeds can be engineered to produce TG that is rich in OPO, which is a structured fat ingredient used in infant formulas.
Keywords	Arabidopsis thaliana ; biosynthesis ; digestive system ; esterification ; fatty acid desaturase ; fatty acid elongase ; glycerol ; heterologous gene expression ; human milk fat ; humans ; infant formulas ; ingredients ; lysophospholipids ; mutants ; nutrient uptake ; oilseeds ; oleic acid ; palmitic acid ; triacylglycerols
Language	English
Dates of publication	2021-09
Size	p. 67-74.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1470383-x
ISSN	1096-7184 ; 1096-7176
ISSN (online)	1096-7184
ISSN	1096-7176
DOI	10.1016/j.ymben.2021.05.009
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