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  1. Article ; Online: Reply to the Letter: "Malnutrition in COVID-19 survivors: comment".

    Calvani, Riccardo / Tosato, Matteo / Landi, Francesco

    Aging clinical and experimental research

    2023  Volume 35, Issue 12, Page(s) 3251–3252

    MeSH term(s) Humans ; COVID-19 ; Malnutrition ; Survivors
    Language English
    Publishing date 2023-11-10
    Publishing country Germany
    Document type Letter
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-023-02592-8
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    Zs.A 3343: Show issues Location:
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  2. Article ; Online: Molecular Mechanism and Pathogenesis of Sarcopenia: An Overview.

    Picca, Anna / Calvani, Riccardo

    International journal of molecular sciences

    2021  Volume 22, Issue 6

    Abstract: Sarcopenia involves a progressive age-related decline of skeletal muscle mass and strength/function [ ... ]. ...

    Abstract Sarcopenia involves a progressive age-related decline of skeletal muscle mass and strength/function [...].
    MeSH term(s) Dysbiosis/complications ; Dysbiosis/pathology ; Humans ; Inflammation/pathology ; Mitochondria/metabolism ; Muscles/pathology ; Sarcopenia/complications ; Sarcopenia/pathology
    Language English
    Publishing date 2021-03-16
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22063032
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  3. Article ; Online: Translation of Research on Sarcopenia Into Clinical Practice.

    Cesari, Matteo / Calvani, Riccardo / Canevelli, Marco / Marzetti, Emanuele

    Journal of the American Medical Directors Association

    2022  Volume 23, Issue 5, Page(s) 705–706

    MeSH term(s) Humans ; Sarcopenia/diagnosis ; Sarcopenia/therapy ; Translations
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2022.03.006
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  4. Article ; Online: Biomarkers of frailty: Moving the field forward.

    Picca, Anna / Calvani, Riccardo

    Experimental gerontology

    2020  Volume 133, Page(s) 110868

    MeSH term(s) Aged ; Biomarkers ; Frail Elderly ; Frailty ; Humans
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-02-06
    Publishing country England
    Document type Editorial
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2020.110868
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    Zs.A 579: Show issues Location:
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  5. Article ; Online: Mitochondrial Quantity and Quality in Age-Related Sarcopenia.

    Marzetti, Emanuele / Calvani, Riccardo / Coelho-Júnior, Hélio José / Landi, Francesco / Picca, Anna

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Sarcopenia, the age-associated decline in skeletal muscle mass and strength, is a condition with a complex pathophysiology. Among the factors underlying the development of sarcopenia are the progressive demise of motor neurons, the transition from fast ... ...

    Abstract Sarcopenia, the age-associated decline in skeletal muscle mass and strength, is a condition with a complex pathophysiology. Among the factors underlying the development of sarcopenia are the progressive demise of motor neurons, the transition from fast to slow myosin isoform (type II to type I fiber switch), and the decrease in satellite cell number and function. Mitochondrial dysfunction has been indicated as a key contributor to skeletal myocyte decline and loss of physical performance with aging. Several systems have been implicated in the regulation of muscle plasticity and trophism such as the fine-tuned and complex regulation between the stimulator of protein synthesis, mechanistic target of rapamycin (mTOR), and the inhibitor of mTOR, AMP-activated protein kinase (AMPK), that promotes muscle catabolism. Here, we provide an overview of the molecular mechanisms linking mitochondrial signaling and quality with muscle homeostasis and performance and discuss the main pathways elicited by their imbalance during age-related muscle wasting. We also discuss lifestyle interventions (i.e., physical exercise and nutrition) that may be exploited to preserve mitochondrial function in the aged muscle. Finally, we illustrate the emerging possibility of rescuing muscle tissue homeostasis through mitochondrial transplantation.
    MeSH term(s) Humans ; Aged ; Sarcopenia/metabolism ; Mitochondria/metabolism ; Muscle Fibers, Skeletal/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Muscle, Skeletal/metabolism
    Chemical Substances TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042052
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  6. Article ; Online: Are sit-to-stand and isometric handgrip tests comparable assessment tools to identify dynapenia in sarcopenic people?

    Coelho-Júnior, Hélio José / Calvani, Riccardo / Picca, Anna / Marzetti, Emanuele

    Archives of gerontology and geriatrics

    2023  Volume 114, Page(s) 105059

    Abstract: Sarcopenia is a neuromuscular disease characterized by the simultaneous existence of reduced muscle strength and muscle atrophy. The current recommendations for the diagnosis of sarcopenia suggest dynapenia be operationalized using either isometric ... ...

    Abstract Sarcopenia is a neuromuscular disease characterized by the simultaneous existence of reduced muscle strength and muscle atrophy. The current recommendations for the diagnosis of sarcopenia suggest dynapenia be operationalized using either isometric handgrip strength (IHG) or sit-to-stand (STS) tests. However, specific associations between each of these assessment tools and sarcopenia-related parameters have been observed. In addition, important neuromuscular and biomechanical aspects differ between IHG and STS. This scenario has important clinical implications and calls for detailed studies to refine the current recommendations for sarcopenia identification. The present communication presents evidence to foster a constructive debate on the matter.
    MeSH term(s) Humans ; Sarcopenia/diagnosis ; Sarcopenia/pathology ; Hand Strength/physiology ; Muscle, Skeletal/physiology ; Muscle Weakness ; Muscle Strength/physiology
    Language English
    Publishing date 2023-05-08
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2023.105059
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    Zs.A 1729: Show issues Location:
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  7. Article ; Online: Molecular Mechanism and Pathogenesis of Sarcopenia

    Anna Picca / Riccardo Calvani

    International Journal of Molecular Sciences, Vol 22, Iss 3032, p

    An Overview

    2021  Volume 3032

    Abstract: Sarcopenia involves a progressive age‐related decline of skeletal muscle mass and strength/function [.] ...

    Abstract Sarcopenia involves a progressive age‐related decline of skeletal muscle mass and strength/function [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Multisystem derangements in frailty and sarcopenia: a source for biomarker discovery.

    Picca, Anna / Calvani, Riccardo / Marzetti, Emanuele

    Current opinion in clinical nutrition and metabolic care

    2022  Volume 25, Issue 3, Page(s) 173–177

    Abstract: Purpose of review: Multisystem derangements, encompassing metabolic, musculoskeletal and stress-response systems, occur during aging and are associated with the development of physical frailty and sarcopenia. These modular changes are relevant sources ... ...

    Abstract Purpose of review: Multisystem derangements, encompassing metabolic, musculoskeletal and stress-response systems, occur during aging and are associated with the development of physical frailty and sarcopenia. These modular changes are relevant sources for the identification of biomarkers for the two conditions. Here, we provide an up-to-date overview on existing biomarkers of physical frailty and sarcopenia and discuss emerging approaches for biomarker discovery.
    Recent findings: Inflammatory, metabolic and hematologic markers are shared between physical frailty and sarcopenia. Gut microbial derivatives and damage-associated molecular patterns transferred via extracellular vesicles have been indicated as possible gut-muscle axis regulators and candidate markers of physical frailty and sarcopenia.
    Summary: Mediators of metabolic, musculoskeletal and stress-response system dysregulation are shared by physical frailty and sarcopenia and indicate the existence of common pathophysiological pathways. Multiplatform biomarker analyses have been proposed as an innovating approach for tracking the multifaceted and dynamic nature of physical frailty and sarcopenia. Upon validation, the identified biomarkers may support diagnostic makeup and tracking of the two conditions in both research and clinical settings.
    MeSH term(s) Aged ; Aging/physiology ; Biomarkers ; Biomedical Research ; Frail Elderly ; Frailty/diagnosis ; Humans ; Sarcopenia
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000000828
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5586: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Sarcopenia and SARC-F: "Perfect is the Enemy of Good".

    Cesari, Matteo / Marzetti, Emanuele / Calvani, Riccardo

    Journal of the American Medical Directors Association

    2021  Volume 22, Issue 9, Page(s) 1862–1863

    MeSH term(s) Aged ; Geriatric Assessment ; Humans ; Sarcopenia/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2021.07.030
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  10. Article ; Online: Body composition parameters and sarcopenia in adults with Down syndrome: a case-control study.

    Villani, Emanuele Rocco / Onder, Graziano / Marzetti, Emanuele / Coelho-Junior, Helio / Calvani, Riccardo / Di Paola, Antonella / Carfì, Angelo

    Aging clinical and experimental research

    2024  Volume 36, Issue 1, Page(s) 81

    Abstract: Background: Individuals with Down syndrome (DS) experience premature aging. Whether accelerated aging involves changes in body composition parameters and is associated with early development of sarcopenia is unclear.: Aims: To compare parameters of ... ...

    Abstract Background: Individuals with Down syndrome (DS) experience premature aging. Whether accelerated aging involves changes in body composition parameters and is associated with early development of sarcopenia is unclear.
    Aims: To compare parameters of body composition and the prevalence of sarcopenia between adults with DS and the general population.
    Methods: Body composition was assessed by whole-body dual-energy X-ray absorptiometry (DXA). Fat mass (FMI) and skeletal mass indices (SMI) were calculated as the ratio between total body fat mass and appendicular lean mass and the square of height, respectively. Fat mass distribution was assessed by the android/gynoid fat ratio (A/G). Sarcopenia was defined according to the criteria and cut-points recommended by the European Working Group on Sarcopenia in Older People 2 (EWGSOP2). Data on age- and sex-matched non-DS controls were retrieved from the 2001-2002 National Health and Nutrition Examination Survey (NHANES) population.
    Results: Sixty-four DS adults (mean age 37.2 ± 12.0 years, 20.3% women) were enrolled and compared with age- and sex-matched NHANES participants (n = 256), in a 1:4 ratio. FMI (7.96 ± 3.18 kg/m
    Conclusions: Adults with DS have a higher prevalence of sarcopenia compared with the general population. This finding suggests that DS is associated with early muscle aging and calls for the design of interventions targeting the skeletal muscle to prevent or treat sarcopenia.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Sarcopenia/complications ; Sarcopenia/epidemiology ; Sarcopenia/diagnosis ; Nutrition Surveys ; Case-Control Studies ; Down Syndrome/complications ; Body Mass Index ; Body Composition ; Absorptiometry, Photon
    Language English
    Publishing date 2024-03-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-023-02680-9
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