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  1. Article ; Online: A unique case of Fusobacterium nucleatum spondylodiscitis communicating with a pleural empyema through a fistula.

    Bonnesen, Barbara / Sivapalan, Pradeesh / Naghavi, Hadi / Back Holmgaard, Dennis / Sloth, Carsten / Wiese, Lothar / Kolekar, Shailesh

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2021  Volume 129, Issue 11, Page(s) 626–630

    Abstract: Species (spp.) belonging to the genus Fusobacterium are anaerobic commensals colonizing the upper respiratory tract, the gastrointestinal tract, and the genitals. Infections with Fusobacterium spp. have been reported at many anatomical sites, including ... ...

    Abstract Species (spp.) belonging to the genus Fusobacterium are anaerobic commensals colonizing the upper respiratory tract, the gastrointestinal tract, and the genitals. Infections with Fusobacterium spp. have been reported at many anatomical sites, including pneumonias and pleural empyemas; however, there are very few published cases of Fusobacterium spp. causing spondylodiscitis or fistulas. Bone infections with Fusobacterium can spread directly to surrounding muscular tissue or by hematogenous transmission to any other tissue including pleurae and lungs. Similarly, pleural infections can spread Fusobacterium spp. to any other tissue including fistulas and bone. Concomitant pleural empyema and spondylodiscitis are rare; however, there are a few published cases with concomitant disease, although none caused by Fusobacterium spp. A 77-year-old female patient was assessed using computed tomography (CT) scanning of the thorax and abdomen, as well as analyses of fluid drained from the region affected by the pleural empyema. A diagnosis of Fusobacterium empyema, fistula, bacteremia, and spondylodiscitis was made, and the patient's condition improved significantly after drainage of the pleural empyema and relevant long-term antibiotic treatment. We describe the first confirmed case with concomitant infection with Fusobacterium nucleatum as spondylodiscitis and pleural empyema connected by a fistula.
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Bacteremia/etiology ; Discitis/diagnosis ; Discitis/drug therapy ; Discitis/etiology ; Empyema, Pleural/diagnosis ; Empyema, Pleural/drug therapy ; Empyema, Pleural/etiology ; Female ; Fistula/diagnosis ; Fistula/drug therapy ; Fistula/etiology ; Fusobacterium Infections/complications ; Fusobacterium Infections/diagnosis ; Fusobacterium Infections/drug therapy ; Fusobacterium nucleatum/drug effects ; Fusobacterium nucleatum/pathogenicity ; Humans ; Pleura/diagnostic imaging ; Pleura/microbiology ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-09-09
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.73: Show issues Location:
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  2. Article ; Online: Aspergilloma complicating previous COVID-19 pneumonitis - a case report.

    Banke, Gry / Kjeldgaard, Peter / Shaker, Saher Burhan / Sivapalan, Pradeesh / Søholm, Jacob / Back Holmgaard, Dennis / Thyssen Astvad, Karen Marie / Bangsborg, Jette / Brun Andersen, Michael / Bonnesen, Barbara

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2022  Volume 130, Issue 7, Page(s) 397–403

    Abstract: Aspergillomas are found in pre-existing cavities in pulmonary parenchyma. To the best of our knowledge, aspergilloma has not previously been reported in COVID-19-associated pulmonary architecture distortion combined with barotrauma from invasive ... ...

    Abstract Aspergillomas are found in pre-existing cavities in pulmonary parenchyma. To the best of our knowledge, aspergilloma has not previously been reported in COVID-19-associated pulmonary architecture distortion combined with barotrauma from invasive mechanical ventilation therapy. We present a case of a 67-year-old woman, who suffered from severe COVID-19 in the summer of 2020 with no suspicion of infection with Aspergillus in the acute phase. Ten months after discharge from her COVID-related admission, she developed bilateral aspergillomas diagnosed by image diagnostics, bronchoscopy, and blood samples, and she now receives antifungal therapy. We would like to raise awareness on aspergilloma in post-COVID-19 patients, since it is an expected long-term complication to COVID-19 patients with pulmonary architectural distortion.
    MeSH term(s) Aged ; Bronchoscopy ; COVID-19/complications ; Female ; Humans ; Lung/diagnostic imaging ; Pneumonia ; Pulmonary Aspergillosis/complications ; Pulmonary Aspergillosis/diagnosis
    Language English
    Publishing date 2022-05-16
    Publishing country Denmark
    Document type Case Reports
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.73: Show issues Location:
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  3. Article ; Online: Trefoil factor 3 in perinatal pancreas is increased by gestational low protein diet and associated with accelerated β-cell maturation.

    Winkel, Louise / Bagge, Annika / Larsen, Louise / Haase, Tobias N / Rasmussen, Morten / Lykke, Jeanette / Holmgaard, Dennis B / Thim, Lars / Nielsen, Jens H / Dalgaard, Louise T

    Islets

    2018  Volume 10, Issue 3, Page(s) e1472186

    Abstract: The endocrine pancreas expands markedly in the first postnatal days and the insulin producing β-cells initiate a functional maturation preceded by a morphological change of the islets of Langerhans. Trefoil factor 3 (TFF3) is a secreted peptide expressed ...

    Abstract The endocrine pancreas expands markedly in the first postnatal days and the insulin producing β-cells initiate a functional maturation preceded by a morphological change of the islets of Langerhans. Trefoil factor 3 (TFF3) is a secreted peptide expressed in intestinal epithelia, where it promotes migration, but its role in the pancreas is not characterized. The aim of this study was to examine the expression and function of TFF3 in perinatal rat pancreas, ex vivo cultured fetal rat pancreas and in the rat β-cell line INS-1E. Control or gestational low-protein diet perinatal rat pancreas was harvested at embryonic day 20 (E20), day of birth (P0) and postnatal day 2 (P2). TFF3 mRNA was upregulated 4.5-fold at P0 vs. E20 and downregulated again at P2. In protein-undernourished pups induction of TFF3 at P0 was further increased to 9.7-fold and was increased at P2. TFF3 caused tyrosine phosphorylation of EGFR in INS-1E β-cells, and purified recombinant TFF3 increased both attachment and spreading of INS-1E β-cells. In ex vivo cultures of collagenase digested fetal rat pancreas, a model of perinatal β-cell maturation, TFF3 increased cellular spreading as well as insulin mRNA levels. TFF3 also increased the expression of Pref1/Dlk1 that shares similarities in expression and regulation with TFF3. These results suggest that TFF3 may promote adhesion and spreading of cells to accelerate β-cell maturation. This study indicates a functional role for TFF3 in pancreatic β-cell maturation in the perinatal period, which is altered by low protein diet during gestation.
    MeSH term(s) Animals ; Cell Line ; Diet, Protein-Restricted ; Female ; Gene Expression Regulation ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/metabolism ; Maternal Nutritional Physiological Phenomena/physiology ; Pregnancy ; Rats ; Trefoil Factor-3/genetics ; Trefoil Factor-3/metabolism
    Chemical Substances Trefoil Factor-3
    Language English
    Publishing date 2018-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1938-2022
    ISSN (online) 1938-2022
    DOI 10.1080/19382014.2018.1472186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Calprotectin--a marker of mortality in COPD? Results from a prospective cohort study.

    Holmgaard, Dennis B / Mygind, Lone H / Titlestad, Ingrid / Madsen, Hanne / Pedersen, Svend Stenvang / Mortensen, Ole H / Pedersen, Court

    COPD

    2013  Volume 10, Issue 5, Page(s) 581–587

    Abstract: Calprotectin comprises more than 45% of the cytosolic content of neutrophil granulocytes. Because pathogenesis, disease activity and disease progression in COPD are believed to be partly dependent of neutrophil driven inflammation we decided to ... ...

    Abstract Calprotectin comprises more than 45% of the cytosolic content of neutrophil granulocytes. Because pathogenesis, disease activity and disease progression in COPD are believed to be partly dependent of neutrophil driven inflammation we decided to investigate whether plasma level of calprotectin (p-calprotectin) was associated with all-cause mortality in patients with COPD. We measured p-calprotectin in blood samples from 460 patients with moderate to very severe COPD in stable phase. Patients were stratified into three groups according to p-calprotectin level. Outcome measure was all-cause mortality. Analyses were adjusted for factors known to influence mortality using a Cox regression analysis. We found a time dependent correlation between p-calprotectin levels and mortality during the first 5 years of follow-up. Increasing levels of p-calprotectin were associated with concomitant increases in mortality from HR 1.56 (CI 95%: 1.03 -2.38) at calprotectin between 100 -200 ng/ml to HR 2.02 (CI 95%: 1.27-3.19) at calprotectin >200 ng/ml. P-calprotectin could be a useful marker of all-cause mortality in patients suffering from moderate to very severe COPD.
    MeSH term(s) Aged ; Biomarkers/blood ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Leukocyte L1 Antigen Complex/blood ; Male ; Middle Aged ; Multivariate Analysis ; Neutrophils/immunology ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/immunology ; Pulmonary Disease, Chronic Obstructive/mortality ; Severity of Illness Index
    Chemical Substances Biomarkers ; Leukocyte L1 Antigen Complex
    Language English
    Publishing date 2013-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2171107-0
    ISSN 1541-2563 ; 1541-2555
    ISSN (online) 1541-2563
    ISSN 1541-2555
    DOI 10.3109/15412555.2013.781580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5990: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Plasma YKL-40 and all-cause mortality in patients with chronic obstructive pulmonary disease.

    Holmgaard, Dennis B / Mygind, Lone H / Titlestad, Ingrid L / Madsen, Hanne / Pedersen, Svend Stenvang / Johansen, Julia S / Pedersen, Court

    BMC pulmonary medicine

    2013  Volume 13, Page(s) 77

    Abstract: Background: Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 is a potential biomarker of inflammation and mortality in patients suffering from inflammatory lung ... ...

    Abstract Background: Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 is a potential biomarker of inflammation and mortality in patients suffering from inflammatory lung disease, but its prognostic value in patients with COPD remains unknown. We investigated whether high plasma YKL-40 was associated with increased mortality in patients with moderate to very severe COPD.
    Methods: Four hundred and ninety-three patients with moderate to very severe COPD were followed prospectively for up to 10 years. Patients were divided into two groups according to plasma YKL-40: concentration higher than the 75th percentile for age-matched healthy subjects (i.e. high levels) and normal levels. Outcome was overall survival (OS) and was evaluated in uni- and multivariate proportional hazards Cox regression analyses and adjusted for factors affecting mortality.
    Results: Median plasma YKL-40 was increased in patients with COPD (81 ng/ml, p < 0.001) compared to healthy subjects (40 ng/ml). Patients with high plasma YKL-40 had a hazard ratio (HR) of 1.42 (95% CI: 1.15-1.75, p = 0.001) for all-cause mortality. Multivariate analysis showed that YKL-40 (HR 1.38; 95% CI: 1.11-1.72, p = 0.004), age (HR 1.05; 95% CI: 1.03-1.06, p < 0.0001), Severe COPD (HR 1.35; 95 CI: 1.03-1.76, p = 0.03) very severe COPD (HR 2.19; 95% CI: 1.60 - 2.99 < 0.0001), neutrophil granulocyte count (HR 1.05; 95% CI: 1.01-1.08, p = 0.01), and a smoking history of > 40 years (HR 1.38; 95% CI: 1.11-1.71, p = 0.003) were independent prognostic markers of OS.
    Conclusion: High plasmaYKL-40 is associated with increased mortality in patients with moderate to very severe COPD, suggesting a role for YKL-40 as a potential biomarker of mortality in this patient group.
    MeSH term(s) Adipokines/blood ; Age Factors ; Aged ; Biomarkers/blood ; Case-Control Studies ; Chitinase-3-Like Protein 1 ; Female ; Granulocytes ; Humans ; Lectins/blood ; Leukocyte Count ; Longitudinal Studies ; Male ; Neutrophils ; Proportional Hazards Models ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/mortality ; Severity of Illness Index ; Smoking/mortality
    Chemical Substances Adipokines ; Biomarkers ; CHI3L1 protein, human ; Chitinase-3-Like Protein 1 ; Lectins
    Language English
    Publishing date 2013-12-30
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/1471-2466-13-77
    Database MEDical Literature Analysis and Retrieval System OnLINE

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