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Article: Short Course of Antibiotic Therapy for Gram-Negative Bacilli Bacteremia in Patients with Cancer and Hematopoietic Stem Cell Transplantation: Less Is Possible.

Herrera, Fabián / Torres, Diego / Carena, Alberto / Nicola, Federico / Rearte, Andrés / Temporiti, Elena / Jorge, Laura / Valentini, Ricardo / Bues, Florencia / Relloso, Silvia / Bonvehí, Pablo

Microorganisms

2023 Volume 11, Issue 2

Abstract: Data about short courses of antibiotic therapy for Gram-negative bacilli (GNB) bacteremia in immunosuppressed patients are limited. This is a prospective observational study performed on adult patients with cancer and hematopoietic stem cell transplant ( ... ...

Abstract	Data about short courses of antibiotic therapy for Gram-negative bacilli (GNB) bacteremia in immunosuppressed patients are limited. This is a prospective observational study performed on adult patients with cancer and hematopoietic stem cell transplant (HSCT) who developed GNB bacteremia and received appropriate empirical antibiotic therapy (EAT), had a clinical response within 7 days and survived 48 h after the end of therapy. They received antibiotic therapy in the range of 7-15 days and were divided into short course, with a median of 7 days (SC), or long course, with a median of 14 days (LC). Seventy-four patients were included (SC: 36 and LC: 38). No differences were observed in baseline characteristics or in the presence of neutropenia: 58.3% vs. 60.5% (
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11020511
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Article ; Online: Prevalence of Chagas Disease and Associated Factors in an Endemic Area of Northeastern Argentina.

Baeck, Maria / Mando, Pablo / Virasoro, Belén / Martinez, Alfredo / Zarate, Soledad / Valentini, Ricardo / Lopez Saubidet, Ignacio

The American journal of tropical medicine and hygiene

2022

Abstract: Chagas disease caused by Trypanosoma cruzi, remains one of the leading public health problems in Latin America. The number of infections in nonendemic countries continues to rise as a consequence of migratory flows. Updated information on prevalence, ... ...

Abstract	Chagas disease caused by Trypanosoma cruzi, remains one of the leading public health problems in Latin America. The number of infections in nonendemic countries continues to rise as a consequence of migratory flows. Updated information on prevalence, especially in treatable stages, together with vector eradication programs are key factors in an attempt to control the disease. We aim to estimate the prevalence of T. cruzi infection in an endemic area of Argentina and to describe epidemiological and clinical factors related to the disease. This is a cross-sectional study in an endemic rural area of Argentina. Our target population was people between 10 and 20 years of age, collecting demographic, clinical, and electrocardiographic data and seroprevalence against T. cruzi. We included 460 subjects; 76.7% did not have drinking water; 49.3% reported the presence of Triatoma infestans at home; 79.1% had pets or birds; 72.6% lived close to a chicken coop; 24.6% lived in adobe houses; 27.8% lived in overcrowded conditions. Seroprevalence was 9.33%. In the multivariate analysis, the presence of Triatoma infestans at home (OR 2.08, P = 0.03) had an association with seropositivity. No relevant findings indicating acute or chronic organ involvement were detected. We found no correlation of right bundle branch block (RBBB) and Chagas disease in our population. None of the infected patients were previously aware of their condition, highlighting the importance of active surveillance to detect infection in a potentially treatable stage, especially in areas with difficult access to health programs.
Language	English
Publishing date	2022-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.21-0646
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Article ; Online: Budget impact analysis of using procalcitonin to optimize antimicrobial treatment for patients with suspected sepsis in the intensive care unit and hospitalized lower respiratory tract infections in Argentina.

Garay, Osvaldo Ulises / Guiñazú, Gonzalo / Cornistein, Wanda / Farina, Javier / Valentini, Ricardo / Levy Hara, Gabriel

PloS one

2021 Volume 16, Issue 4, Page(s) e0250711

Abstract: Background: Inappropriate antibiotic use represents a major global threat. Sepsis and bacterial lower respiratory tract infections (LRTIs) have been linked to antimicrobial resistance, carrying important consequences for patients and health systems. ... ...

Abstract	Background: Inappropriate antibiotic use represents a major global threat. Sepsis and bacterial lower respiratory tract infections (LRTIs) have been linked to antimicrobial resistance, carrying important consequences for patients and health systems. Procalcitonin-guided algorithms may represent helpful tools to reduce antibiotic overuse but the financial burden is unclear. The aim of this study was to estimate the healthcare and budget impact in Argentina of using procalcitonin-guided algorithms to guide antibiotic prescription. Methods: A decision tree was used to model health and cost outcomes for the Argentinean health system, over a one-year duration. Patients with suspected sepsis in the intensive care unit and hospitalized patients with LRTI were included. Model parameters were obtained from a focused, non-systematic, local and international bibliographic search, and validated by a panel of local experts. Deterministic and probabilistic sensitivity analyses were performed to analyze the uncertainty of parameters. Results: The model predicted that using procalcitonin-guided algorithms would result in 734.5 [95% confidence interval (CI): 1,105.2;438.8] thousand fewer antibiotic treatment days, 7.9 [95% CI: 18.5;8.5] thousand antibiotic-resistant cases avoided, and 5.1 [95% CI: 6.7;4.2] thousand fewer Clostridioides difficile cases. In total, this would save $422.4 US dollars (USD) [95% CI: $935;$267] per patient per year, meaning cost savings of $83.0 [95% CI: $183.6;$57.7] million USD for the entire health system and $0.4 [95% CI: $0.9;$0.3] million USD for a healthcare provider with 1,000 cases per year of sepsis and LRTI patients. The sensitivity analysis showed that the probability of cost-saving for the sepsis patient group was lower than for the LRTI patient group (85% vs. 100%). Conclusions: Healthcare and financial benefits can be obtained by implementing procalcitonin-guided algorithms in Argentina. Although we found results to be robust on an aggregate level, some caution must be used when focusing only on sepsis patients in the intensive care unit.
MeSH term(s)	Anti-Infective Agents/therapeutic use ; Antimicrobial Stewardship/economics ; Argentina/epidemiology ; Clostridioides difficile/isolation & purification ; Cost-Benefit Analysis ; Hospitalization/statistics & numerical data ; Humans ; Intensive Care Units ; Procalcitonin/therapeutic use ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/microbiology ; Sepsis/drug therapy ; Sepsis/epidemiology
Chemical Substances	Anti-Infective Agents ; Procalcitonin
Language	English
Publishing date	2021-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0250711
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Article ; Online: Association of cardiovascular risk factors and myocardial hypertrophy in women with preeclampsia history.

Ferreira, Ricardo Mattos / Ferron, Fabiane Valentini Francisqueti / Borges, Vera Therezinha Medeiros / Peraçoli, José Carlos / Ferron, Artur Junio Togneri / Roscani, Meliza Goi / Hueb, João Carlos / Bazan, Rodrigo / Martin, Luis Cuadrado / Bazan, Silméia Garcia Zanati

Life sciences

2024 Volume 346, Page(s) 122646

Abstract: Aims: A historic of preeclampsia (PE) has been associated with cardiovascular disease (CVD) in women. There are substantial evidences that cardiovascular changes resulting from PE can persist even after pregnancy end. Therefore, the aims was to evaluate ...

Abstract	Aims: A historic of preeclampsia (PE) has been associated with cardiovascular disease (CVD) in women. There are substantial evidences that cardiovascular changes resulting from PE can persist even after pregnancy end. Therefore, the aims was to evaluate the prevalence of myocardial hypertrophy in young women 12 months after PE event as well as try to identify risk factors for these changes. Materials and methods: Single-center observational prospective cross-sectional study that included 118 consecutive patients after 12 months of PE. Clinical and laboratory evaluations, echocardiogram were performed. Myocardial hypertrophy (LVH) was defined as an index myocardial mass ≥ 45 g/m Key findings: Systemic arterial hypertension (SAH) was identified in 52 patients (44 %), overweight/obesity (OOB) in 82 (69 %), dyslipidemia in 68 (57 %) and metabolic syndrome in 47 patients (40 %). LVH was present in 35 cases (29 %) and associated with OOB (OR = 4.51; CI95%:1.18-17.17, p < 0.001), in a model corrected for age and SAH diagnosis. When only the metabolic syndrome components were analyzed, in the multiple logistic regression model, the abdominal circumference was the only clinical variable associated with LVH (OR = 17.65; CI95%:3.70-84.17; p < 0.001). Significance: It was observed a high prevalence of ventricular hypertrophy in young women with a history of pre-eclampsia. This condition was associated with the presence of obesity.
MeSH term(s)	Humans ; Female ; Pre-Eclampsia/epidemiology ; Pregnancy ; Adult ; Cross-Sectional Studies ; Prospective Studies ; Heart Disease Risk Factors ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiomegaly/epidemiology ; Cardiomegaly/etiology ; Prevalence ; Obesity/complications ; Obesity/epidemiology ; Hypertrophy, Left Ventricular/epidemiology ; Hypertrophy, Left Ventricular/etiology ; Young Adult ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Hypertension/epidemiology ; Hypertension/complications
Language	English
Publishing date	2024-04-16
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2024.122646
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Article ; Online: Impact of Rigorous Clinical and Laboratory Screening for COVID-19 in a Teaching Hospital in Inner Brazil.

Valentini Ferreira Proença, Stephanie / Castelo Branco Fortaleza, Carlos Magno / Atique Sawazaki, Jonas / de Souza Cavalcante, Ricardo / Cardoso de Macedo, Bruno / Mara Queiroz, Sandra / Pires Ferreira Filho, Sebastião / Berg de Almeida, Gabriel

Infection control and hospital epidemiology

2022 , Page(s) 1–5

Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2022.59
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Article ; Online: Coagulopatía y COVID-19. Recomendaciones para una realidad cambiante.

Riveros, Dardo / Maymó, Daniela / Laviano, Julia / Fornillo, Florencia Fornillo / Fernández, José / Benzadon, Ricardo / Solimano, Jorge / Cacchione, Roberto / Riera, Leandro / Duarte, Patricio / Cazap, Nicolás / Gotta, Daniel / García Altuve, Juan / Valentini, Ricardo / Dupont, Juan

Medicina

2021 Volume 80, Issue 5, Page(s) 505–511

Abstract: The coronavirus disease 2019 (COVID-19) pandemic requires rapid medical responses. The risk of venous and arterial thromboembolism increases in critically ill patients with SARS-CoV-2 infection. There is a hypercoagulable state that includes elevated ... ...

Title translation	Coagulopathy and COVID-19. Recommendations for a changing reality.
Abstract	The coronavirus disease 2019 (COVID-19) pandemic requires rapid medical responses. The risk of venous and arterial thromboembolism increases in critically ill patients with SARS-CoV-2 infection. There is a hypercoagulable state that includes elevated levels of D-dimer, with an increased risk of organ failure and increased mortality. The abnormalities described in hemostasis should be considered for therapeutic decision making. We analyzed the available scientific evidence for the therapeutic approach of coagulopathy in the course of the disease with the objective of designing realistic therapeutic recommendations aimed at reducing morbidity and mortality in patients with COVID-19.
MeSH term(s)	Argentina/epidemiology ; Betacoronavirus ; Blood Coagulation Disorders/diagnosis ; Blood Coagulation Disorders/epidemiology ; Blood Coagulation Disorders/etiology ; Blood Coagulation Disorders/prevention & control ; COVID-19 ; Coronavirus ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Cytokines ; Disseminated Intravascular Coagulation ; Heparin ; Humans ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Sepsis ; Thromboembolism/complications
Chemical Substances	Cytokines ; Heparin (9005-49-6)
Keywords	covid19
Language	Spanish
Publishing date	2021-01-01
Publishing country	Argentina
Document type	Journal Article
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
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Article ; Online: Análisis descriptivo de 4776 pacientes internados en servicios de clínica médica por COVID-19. Resultados del Registro Multicéntrico Argentino - REMA-COVID-19.

Boietti, Bruno R / Mirofsky, Matias / Valentini, Ricardo / Peuchot, Verónica A / Cámera, Luis A / Pollán, Javier A / Zylberman, Marcelo / Valdez, Pascual

Medicina

2021 Volume 81, Issue 5, Page(s) 703–714

Abstract: A multicenter registry that included adults hospitalized for COVID-19 was carried out in various provinces of Argentina, from March to October 2020. The objectives were to describe the epidemiological characteristics, clinical manifestations, treatments, ...

Title translation	Descriptive analysis of 4776 patients admitted to medical clinic services for COVID-19. Results of the Argentine Multi-Center Registry - REMA-COVID-19.
Abstract	A multicenter registry that included adults hospitalized for COVID-19 was carried out in various provinces of Argentina, from March to October 2020. The objectives were to describe the epidemiological characteristics, clinical manifestations, treatments, complications and risk factors, need for admission to critical care units and mortality. The registry included information on 4776 patients in 37 health centers in Argentina. Of them, 70.2% came from the city of Buenos Aires and from Buenos Aires Province; 52.3% were men. The mean age was 56 years (SD 20.3). Of them, 13.1% stated that they were health personnel. The median time of symptoms at the time of hospitalization was 3 days (CI 1-6). The most frequent comorbidities were hypertension in 32.4% and diabetes mellitus in 15.8%. The most frequent symptoms were: cough 58%, odynophagia 23.3%, myalgia 20.5% and fever / low-grade fever 19.9%. The hospital stay had a median of 8 days (CI 4-15). A 14.8% of the patients required critical care, while 3.2% who also required it, were not transferred to a closed unit due to adequacy of the therapeutic effort. The most frequent complications in critical care were: cardiovascular events (54.1%), septic shock (33.3%), renal failure (9.7%) and pneumonia associated with mechanical ventilation (12.5%). Overall mortality was 12.3%. Old age, dementia and COPD behaved as independent predictors of mortality (p < 0.001, 0.007 and 0.002 respectively) in the multivariate analysis.
MeSH term(s)	Adult ; COVID-19 ; Hospitalization ; Humans ; Length of Stay ; Male ; Middle Aged ; Registries ; SARS-CoV-2
Language	Spanish
Publishing date	2021-10-13
Publishing country	Argentina
Document type	Journal Article ; Multicenter Study
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
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Article: Neuroblastoma olfatorio.

Rodríguez Giambagli, Nerina / Laviano, Julia / Kotsias, Sophia / Valentini, Ricardo

Medicina

2016 Volume 76, Issue 1, Page(s) 43

Title translation	Olfactory neuroblastoma.
MeSH term(s)	Aged ; Esthesioneuroblastoma, Olfactory/diagnosis ; Humans ; Magnetic Resonance Imaging ; Male ; Nasal Cavity ; Nose Neoplasms/diagnosis
Language	Spanish
Publishing date	2016
Publishing country	Argentina
Document type	Case Reports ; Journal Article
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
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Article ; Online: Transpulmonary pressure in acute respiratory distress syndrome.

Rodriguez, Pablo O / Esperanza, José Aquino / Valentini, Ricardo

Critical care medicine

2013 Volume 41, Issue 1, Page(s) e9–10

MeSH term(s)	Animals ; Positive-Pressure Respiration/methods
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0b013e318270e569
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Article ; Online: Coagulopathy and COVID-19. Recommendations for a changing reality

Dardo Riveros / Daniela Maymó / Julia Laviano / Florencia Fornillo / José Fernández / Ricardo Benzadon / Jorge Solimano / Roberto Cacchione / Leandro Riera / Patricio Duarte / Nicolás Cazap / Daniel Gotta / Juan García Altuve / Ricardo Valentini / Juan Dupont

Medicina (Buenos Aires), Vol 80, Iss 5, Pp 505-

2020 Volume 511

Abstract	The coronavirus disease 2019 (COVID-19) pandemic requires rapid medical responses. The risk of venous and arterial thromboembolism increases in critically ill patients with SARS-CoV-2 infection. There is a hypercoagulable state that includes elevated levels of D-dimer, with an increased risk of organ failure and increased mortality. The abnormalities described in hemostasis should be considered for therapeutic decision making. We analyzed the available scientific evidence for the therapeutic approach of coagulopathy in the course of the disease with the objective of designing realistic therapeutic recommendations aimed at reducing morbidity and mortality in patients with COVID-19.
Keywords	covid-19 ; thromboembolism ; sepsis induced coagulopathy ; disseminated intravascular coagulation ; cytokine storm ; heparin ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607 ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Fundación Revista Medicina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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