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  1. Book ; Thesis: The immunosupressive tumor microenvironment and its modulation in head and neck squamous cell carcinoma

    Theodoraki, Marie-Nicole

    2018  

    Author's details vorgelegt von Dr. med. Marie-Nicole Theodoraki
    Keywords Head and neck neoplasms ; Carcinoma, Squamous cell ; Neoplasms ; Immunology ; Immunosuppression ; Immunity, Cellular
    Language English
    Size 1 Band (verschiedene Seitenzählungen), Illustrationen, Diagramme
    Publishing place Ulm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kumulative Habilitationsschrift, Universität Ulm, 2019
    Note Enthält Zeitschriftenaufsätze
    HBZ-ID HT020240183
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 E 1262 order for loan Magazin

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  2. Article ; Online: Immuntherapie von Kopf-Hals-Tumoren : Highlights der ASCO- und ESMO-Jahrestagung 2021.

    Theodoraki, Marie-Nicole / Laban, Simon / Hoffmann, Thomas K

    HNO

    2022  Volume 70, Issue 4, Page(s) 271–277

    Abstract: Background: This year's American Society of Clinical Oncology (ASCO) meeting included interesting data on first-line therapy of nasopharyngeal carcinomas with PD‑1 inhibitors and on checkpoint inhibition in various clinical constellations. At the ... ...

    Title translation Immunotherapy of head and neck cancer : Highlights of the ASCO and ESMO annual meetings 2021.
    Abstract Background: This year's American Society of Clinical Oncology (ASCO) meeting included interesting data on first-line therapy of nasopharyngeal carcinomas with PD‑1 inhibitors and on checkpoint inhibition in various clinical constellations. At the European Society of Medical Oncology (ESMO) meeting, the results of the CheckMate-651 study were presented.
    Materials and methods: All abstracts and presentations from the ASCO and ESMO meetings 2021 on immunotherapy in head and neck cancer (HNSCC) were evaluated for their relevance. The most interesting studies are elaborated upon herein.
    Results: Studies on locally advanced HNSCC showed an improved response after neoadjuvant pembrolizumab administration. A second cycle did not improve the response rate, but the proportion of patients with a good response was almost doubled. The CheckRad CD8 study showed an improvement in progression-free survival by induction chemoimmunotherapy with tremelimumab and durvalumab followed by stratification according to the CD8 immune cell infiltrate. Two studies were presented on first-line treatment of recurrent/metastatic nasopharyngeal carcinomas. Chemoimmunotherapy showed a higher response rate and prolonged progression-free survival with a similar adverse event profile. In recurrent/metastatic HNSCC, the CheckMate 651 study showed an increased duration of response with nivolumab and ipilimumab and higher response rates than pembrolizumab alone. The primary endpoints for overall survival were not achieved.
    Conclusion: PD‑1 inhibition has great potential to change the therapeutic landscape for nasopharyngeal carcinomas in the future. In HNSCC, CD8 tumor infiltrate presents a promising predictive marker for selecting patients who can benefit from radioimmunotherapy. The combination of nivolumab and ipilimumab did not improve overall survival in palliative first-line therapy; thus, no change in the current standard is expected.
    MeSH term(s) Head and Neck Neoplasms/therapy ; Humans ; Immunotherapy/methods ; Medical Oncology ; Neoplasm Recurrence, Local ; Squamous Cell Carcinoma of Head and Neck/therapy
    Language German
    Publishing date 2022-01-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 200040-4
    ISSN 1433-0458 ; 0017-6192
    ISSN (online) 1433-0458
    ISSN 0017-6192
    DOI 10.1007/s00106-021-01142-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exosomen: potenzielle Flüssigbiopsie bei Kopf-Hals-Karzinomen.

    Theodoraki, Marie-Nicole / Ludwig, Sonja

    HNO

    2020  Volume 68, Issue 2, Page(s) 106–110

    Abstract: Due to late diagnosis and poor treatment response, advanced head and neck squamous cell carcinoma (HNSCC) belongs to the tumor diseases with highest mortality worldwide. Although many biomarkers have been investigated over the past years, none have yet ... ...

    Title translation Exosomes: potential liquid biopsy in head and neck cancer.
    Abstract Due to late diagnosis and poor treatment response, advanced head and neck squamous cell carcinoma (HNSCC) belongs to the tumor diseases with highest mortality worldwide. Although many biomarkers have been investigated over the past years, none have yet become established in clinical practice. There is thus an urgent need to introduce noninvasive liquid biopsies that not only give information about cancer activity but also enable early conclusions regarding treatment response. This underlines the biological importance of exosomes from the blood of HNSCC patients. Isolation of exosomes from cell line supernatants and human plasma can easily be performed by size-exclusion chromatography. Thus, protein content, expression patterns, and immunomodulatory effects on immune cells can be evaluated. Further separation of exosomes by cell of origin enables more detailed examination of tumor-derived exosomes (TEX) and exosomes from immune cells. The etiology of the disease, e.g., human papillomavirus (HPV) status, disease activity (active vs. no evident disease), and response to immunotherapies can be detected by exosomal protein expression and immunosuppressive effects of exosomes on different immune cell subtypes. In conclusion, the presented studies can make an essential contribution to the establishment of exosomes as liquid biopsies for head and neck cancer diagnosis and treatment monitoring.
    MeSH term(s) Exosomes ; Head and Neck Neoplasms/diagnosis ; Humans ; Liquid Biopsy ; Squamous Cell Carcinoma of Head and Neck/diagnosis
    Language German
    Publishing date 2020-01-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 200040-4
    ISSN 1433-0458 ; 0017-6192
    ISSN (online) 1433-0458
    ISSN 0017-6192
    DOI 10.1007/s00106-019-00806-y
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  4. Article ; Online: Optimization of extracellular vesicles preparation from saliva of head and neck cancer patients.

    Tengler, Luisa / Tiedtke, Moritz / Schütz, Julia / Bieback, Karen / Uhlig, Stefanie / Theodoraki, Marie-Nicole / Nitschke, Katja / Worst, Thomas Stefan / Seiz, Elena / Scherl, Claudia / Rotter, Nicole / Ludwig, Sonja

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 946

    Abstract: Small extracellular vesicles from saliva (SEVs) have high potential as biomarkers in Head and Neck cancer (HNC). However, there is no common consensus on the ideal method for their isolation. This study compared different ultracentrifugation (UC) methods ...

    Abstract Small extracellular vesicles from saliva (SEVs) have high potential as biomarkers in Head and Neck cancer (HNC). However, there is no common consensus on the ideal method for their isolation. This study compared different ultracentrifugation (UC) methods (durations and + /- additional purification) with size exclusion chromatography (SEC) and investigated the potential of SEVs as diagnostic biomarkers and their biological activity on NK and CD8
    MeSH term(s) Humans ; Saliva ; B7-H1 Antigen ; CD8-Positive T-Lymphocytes ; Extracellular Vesicles ; Head and Neck Neoplasms ; Biomarkers
    Chemical Substances B7-H1 Antigen ; Biomarkers
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50610-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Optimization of extracellular vesicles preparation from saliva of head and neck cancer patients

    Luisa Tengler / Moritz Tiedtke / Julia Schütz / Karen Bieback / Stefanie Uhlig / Marie-Nicole Theodoraki / Katja Nitschke / Thomas Stefan Worst / Elena Seiz / Claudia Scherl / Nicole Rotter / Sonja Ludwig

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Volume 9

    Abstract: Abstract Small extracellular vesicles from saliva (SEVs) have high potential as biomarkers in Head and Neck cancer (HNC). However, there is no common consensus on the ideal method for their isolation. This study compared different ultracentrifugation (UC) ...

    Abstract Abstract Small extracellular vesicles from saliva (SEVs) have high potential as biomarkers in Head and Neck cancer (HNC). However, there is no common consensus on the ideal method for their isolation. This study compared different ultracentrifugation (UC) methods (durations and + /− additional purification) with size exclusion chromatography (SEC) and investigated the potential of SEVs as diagnostic biomarkers and their biological activity on NK and CD8+ T cells. SEVs from 19 HNC patients and 8 healthy donors (HDs) were thoroughly characterized. Transmission electron microscopy confirmed the isolation of vesicles by all methods. The average size determined via nanoparticle-tracking analysis was smaller for SEVs isolated by SEC than UC. The highest particle-to-protein yield was achieved by UC (3 h + 3 h) (UCopt) and SEC. However, SEC yielded considerably fewer SEVs. Comparing the surface marker cargo, SEVs isolated by UCopt from HNC patients carried more PD-L1, FasL, and TGF-β than SEVs from HDs. These levels correlated with tumor stage and HPV status. SEVs downregulated NKG2D expression on primary NK cells. HNC SEVs accelerated CD8+ T cell death compared to HD SEVs. This study suggests that UCopt is preferable when isolation of a high particle-to-protein load is required. Especially PD-L1 and FasL on SEVs hold substantial potential as diagnostic biomarkers.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Plasma‑derived CD16 exosomes and peripheral blood monocytes as correlating biomarkers in head and neck cancer.

    Theodoraki, Marie-Nicole / Hofmann, Linda / Huber, Diana / Brunner, Cornelia / Hoffmann, Thomas K / Idel, Christian / Fleckner, Jonas / Bruchhage, Karl-Ludwig / Pries, Ralph

    Oncology letters

    2023  Volume 25, Issue 5, Page(s) 200

    Abstract: Exosomes play an important role in the individual immune regulation in patients with head and neck squamous cell carcinoma (HNSCC) as part of the tumor microenvironment. Patients with HNSCC with advanced tumor stages reveal significantly increased levels ...

    Abstract Exosomes play an important role in the individual immune regulation in patients with head and neck squamous cell carcinoma (HNSCC) as part of the tumor microenvironment. Patients with HNSCC with advanced tumor stages reveal significantly increased levels of plasma derived CD16
    Language English
    Publishing date 2023-04-04
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2023.13786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Conference proceedings: Nasoseptale Schleimhautverschiebelappen: Postoperative Befunde und Lebensqualität

    Sommer, Fabian / Theodoraki, Marie-Nicole / Waldhauer, Julian / Hoffmann, Karl Thomas / Pala, Andrej

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766945
    Database Thieme publisher's database

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  8. Article ; Conference proceedings: Nasoseptal flaps: Postoperative findings and quality of life

    Sommer, Fabian / Theodoraki, Marie-Nicole / Waldhauer, Julian / Hoffmann, Karl Thomas / Pala, Andrej

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language English
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1767605
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  9. Article ; Conference proceedings: Analyse von Effektor- und Suppressor-B-Zellpopulationen in Kopf-Hals-Plattenepithelkarzinomen in der Maus

    Sonntag, Michael / Laban, Simon / Theodoraki, Marie-Nicole / Schuler, Patrick / Hoffmann, Thomas / Brunner, Cornelia

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766673
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  10. Article ; Conference proceedings: Effect of plasma-derived exosomes from HNSCC patients on NF-κB signaling in macrophages

    Huber, Diana / Hofmann, Linda / Lotfi, Ramin / Hoffmann, ThomasK. / Brunner, Cornelia / Theodoraki, Marie-Nicole

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language English
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1767256
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