Article ; Online: In-vitro external fixation pin-site model proof of concept: A novel approach to studying wound healing in transcutaneous implants.
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
2024 Volume 238, Issue 4, Page(s) 403–411
Abstract: ... and skin and an increase in the patient's risk of infection, however, currently no studies have ...
| Abstract | External fixation is an essential surgical technique for treating trauma, limb lengthening and deformity correction, however infection is common, with infection rates ranging from 4.5 to 100% of cases. Throughout the literature researchers and clinicians have highlighted a relationship between excessive movement of the pin and skin and an increase in the patient's risk of infection, however, currently no studies have addressed this role of pin-movement on pin-site wounds. This preliminary study describes a novel in vitro pin-site model, developed using a full-thickness human skin equivalent (HSE) model in conjunction with a bespoke mechanical system which simulates pin-movement. The effect of pin-movement on the wound healing response of the skin equivalents was assessed by measuring the expression of pro-inflammatory cytokines. Six human skin equivalent models were divided into three test groups: no pin as the control, static pin-site wound and dynamic pin-site wound ( |
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| MeSH term(s) | Humans ; External Fixators ; Fracture Fixation/methods ; Surgical Wound Infection/therapy ; Interleukin-8 ; Bone Nails ; Wound Healing/physiology |
| Chemical Substances | Interleukin-8 |
| Language | English |
| Publishing date | 2024-03-03 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1065942-0 |
| ISSN | 2041-3033 ; 0046-2039 ; 0954-4119 |
| ISSN (online) | 2041-3033 |
| ISSN | 0046-2039 ; 0954-4119 |
| DOI | 10.1177/09544119241234154 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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