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  1. Article ; Online: Commentary-child and adolescent development in the focus of emerging developmental science.

    Kornilov, Sergey A

    New directions for child and adolescent development

    2015  Volume 2015, Issue 147, Page(s) 117–121

    Abstract: In this brief essay, I comment on the constellation of papers published in the current issue. I argue that it represents the new beginning of the new era for the journal, driven by several considerations. Among these, three are key. First, the collection ...

    Abstract In this brief essay, I comment on the constellation of papers published in the current issue. I argue that it represents the new beginning of the new era for the journal, driven by several considerations. Among these, three are key. First, the collection of articles in this issue is explicitly concerned with the multivariate and multidisciplinary nature of development and developmental science. Second, they explicate this point by providing an overview of several cross-disciplinary methodological approaches and the ways they can be used to study development. Finally, a common thread among the papers appearing in this issue is to attempt to relate and integrate research, practice, and policy in child and adolescent development.
    MeSH term(s) Adolescent ; Adolescent Development ; Behavioral Research ; Child ; Child Development ; Humans
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article
    ISSN 1534-8687 ; 1520-3247
    ISSN (online) 1534-8687
    ISSN 1520-3247
    DOI 10.1002/cad.20079
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  2. Article ; Online: Structural basis for the ligand promiscuity of the neofunctionalized, carotenoid-binding fasciclin domain protein AstaP.

    Kornilov, Fedor D / Slonimskiy, Yury B / Lunegova, Daria A / Egorkin, Nikita A / Savitskaya, Anna G / Kleymenov, Sergey Yu / Maksimov, Eugene G / Goncharuk, Sergey A / Mineev, Konstantin S / Sluchanko, Nikolai N

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 471

    Abstract: Fasciclins (FAS1) are ancient adhesion protein domains with no common small ligand binding reported. A unique microalgal FAS1-containing astaxanthin (AXT)-binding protein (AstaP) binds a broad repertoire of carotenoids by a largely unknown mechanism. ... ...

    Abstract Fasciclins (FAS1) are ancient adhesion protein domains with no common small ligand binding reported. A unique microalgal FAS1-containing astaxanthin (AXT)-binding protein (AstaP) binds a broad repertoire of carotenoids by a largely unknown mechanism. Here, we explain the ligand promiscuity of AstaP-orange1 (AstaPo1) by determining its NMR structure in complex with AXT and validating this structure by SAXS, calorimetry, optical spectroscopy and mutagenesis. α1-α2 helices of the AstaPo1 FAS1 domain embrace the carotenoid polyene like a jaw, forming a hydrophobic tunnel, too short to cap the AXT β-ionone rings and dictate specificity. AXT-contacting AstaPo1 residues exhibit different conservation in AstaPs with the tentative carotenoid-binding function and in FAS1 proteins generally, which supports the idea of AstaP neofunctionalization within green algae. Intriguingly, a cyanobacterial homolog with a similar domain structure cannot bind carotenoids under identical conditions. These structure-activity relationships provide the first step towards the sequence-based prediction of the carotenoid-binding FAS1 members.
    MeSH term(s) Carrier Proteins ; Ligands ; Scattering, Small Angle ; X-Ray Diffraction ; Cell Adhesion Molecules/metabolism ; Carotenoids/metabolism
    Chemical Substances Carrier Proteins ; Ligands ; Cell Adhesion Molecules ; Carotenoids (36-88-4)
    Language English
    Publishing date 2023-04-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-04832-z
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  3. Article ; Online: What Reading Disability? Evidence for Multiple Latent Profiles of Struggling Readers in a Large Russian Sibpair Sample With at Least One Sibling at Risk for Reading Difficulties.

    Kornilov, Sergey A / Grigorenko, Elena L

    Journal of learning disabilities

    2017  Volume 51, Issue 5, Page(s) 434–443

    Abstract: In this study, we performed a latent profile analysis of reading and related skills in a large ( n = 733) sibpair sample of Russian readers at risk for reading difficulties. The analysis suggested the presence of seven latent profiles, of which two were ... ...

    Abstract In this study, we performed a latent profile analysis of reading and related skills in a large ( n = 733) sibpair sample of Russian readers at risk for reading difficulties. The analysis suggested the presence of seven latent profiles, of which two were characterized by relatively high performance on measures of spelling and reading comprehension and the remaining five included severely as well as moderately affected readers with deficits in the domains of phonological, orthographic, and morphological processing. The results suggest that the development and manifestation of reading difficulties in Russian is mappable on a complex pattern of interactions between different types and severities of processing deficits. The results point to the psychological reality of multiple different suboptimal patterns of deficits in reading and reading-related skills and support the multifactorial view of the disorder, with intriguing implications for future neurobiological studies.
    MeSH term(s) Adolescent ; Child ; Dyslexia/classification ; Dyslexia/physiopathology ; Female ; Humans ; Male ; Psycholinguistics ; Reading ; Russia ; Siblings
    Language English
    Publishing date 2017-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217619-1
    ISSN 1538-4780 ; 0022-2194
    ISSN (online) 1538-4780
    ISSN 0022-2194
    DOI 10.1177/0022219417718833
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  4. Book ; Online: Robust representations of oil wells' intervals via sparse attention mechanism

    Ermilova, Alina / Baramiia, Nikita / Kornilov, Valerii / Petrakov, Sergey / Zaytsev, Alexey

    2022  

    Abstract: Transformer-based neural network architectures achieve state-of-the-art results in different domains, from natural language processing (NLP) to computer vision (CV). The key idea of Transformers, the attention mechanism, has already led to significant ... ...

    Abstract Transformer-based neural network architectures achieve state-of-the-art results in different domains, from natural language processing (NLP) to computer vision (CV). The key idea of Transformers, the attention mechanism, has already led to significant breakthroughs in many areas. The attention has found their implementation for time series data as well. However, due to the quadratic complexity of the attention calculation regarding input sequence length, the application of Transformers is limited by high resource demands. Moreover, their modifications for industrial time series need to be robust to missing or noised values, which complicates the expansion of the horizon of their application. To cope with these issues, we introduce the class of efficient Transformers named Regularized Transformers (Reguformers). We implement the regularization technique inspired by the dropout ideas to improve robustness and reduce computational expenses. The focus in our experiments is on oil&gas data, namely, well logs, a prominent example of multivariate time series. The goal is to solve the problems of similarity and representation learning for them. To evaluate our models for such problems, we work with an industry-scale open dataset consisting of well logs of more than 20 wells. The experiments show that all variations of Reguformers outperform the previously developed RNNs, classical Transformer model, and robust modifications of it like Informer and Performer in terms of well-intervals' classification and the quality of the obtained well-intervals' representations. Moreover, the sustainability to missing and incorrect data in our models exceeds that of others by a significant margin. The best result that the Reguformer achieves on well-interval similarity task is the mean PR~AUC score equal to 0.983, which is comparable to the classical Transformer and outperforms the previous models.
    Keywords Computer Science - Machine Learning
    Subject code 006
    Publishing date 2022-12-29
    Publishing country us
    Document type Book ; Online
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  5. Article ; Online: Neonatal and clinical outcomes after transfer of a mosaic embryo identified by preimplantation genetic testing for aneuploidies.

    Yakovlev, Pavel / Vyatkina, Svetlana / Polyakov, Alex / Pavlova, Marina / Volkomorov, Victor / Yakovlev, Maksim / Filimonov, Sergey / Kazaryn, Liya / Aizikovich, Asia / Kornilov, Nikolay

    Reproductive biomedicine online

    2022  Volume 45, Issue 1, Page(s) 88–100

    Abstract: Research question: Do clinical and neonatal outcomes differ between mosaic embryo transfers (MET) and euploid embryo transfers (EET)?: Design: This retrospective cohort study compared the implantation rate, live birth rate (LBR) and miscarriage rate ... ...

    Abstract Research question: Do clinical and neonatal outcomes differ between mosaic embryo transfers (MET) and euploid embryo transfers (EET)?
    Design: This retrospective cohort study compared the implantation rate, live birth rate (LBR) and miscarriage rate between 513 euploid embryos and 118 mosaic embryos (72 whole chromosome mosaic [WCM], 40 segmental mosaic and six complex mosaic). Blastocysts were analysed using preimplantation genetic testing for aneuploidies with next-generation sequencing, followed by a single vitrified-warmed embryo transfer. Trophectoderm biopsies were classified as mosaic if they had 20-80% abnormal cells.
    Results: Overall, EET resulted in a significantly higher implantation rate (47.0%) and LBR (40.7%) than MET (implantation rate 39.0%, P = 0.005; LBR 28.8%, P = 0.008) and WCM embryos (implantation rate 37.5%, P = 0.01; LBR 22.2%, P = 0.007) after covariate adjustment. Segmental mosaic embryos had an implantation rate (47.5%) and LBR (45.0%) comparable to those of euploid embryos. Mosaic embryos with a high percentage of aneuploid cells (≥60%) showed a significantly lower LBR (10.5% versus 40.7%, P = 0.03) than euploid embryos after covariate adjustment, with three of the five implantations of mosaic embryos resulting in miscarriage. Neonatal outcomes did not differ significantly between the mosaic and euploid groups. Of the 34 women with a live birth after MET, 13 had a prenatal or postnatal genetic testing result, and no abnormalities were found.
    Conclusions: Mosaic embryos were associated with a lower LBR, while segmental mosaic embryos had similar clinical outcomes to euploid embryos. Mosaic embryos with a high aneuploidy percentage (≥60%) should be assigned a low transfer priority. Neonatal outcomes did not differ significantly between the euploid and mosaic groups.
    MeSH term(s) Abortion, Spontaneous ; Aneuploidy ; Blastocyst/pathology ; Female ; Genetic Testing/methods ; Humans ; Infant, Newborn ; Mosaicism ; Pregnancy ; Preimplantation Diagnosis/methods ; Retrospective Studies
    Language English
    Publishing date 2022-01-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2113823-0
    ISSN 1472-6491 ; 1472-6483
    ISSN (online) 1472-6491
    ISSN 1472-6483
    DOI 10.1016/j.rbmo.2022.01.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5792: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19.

    Kornilov, Sergey A / Lucas, Isabelle / Jade, Kathleen / Dai, Chengzhen L / Lovejoy, Jennifer C / Magis, Andrew T

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 452

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Angiotensin-Converting Enzyme 2 ; Biomarkers/blood ; COVID-19 ; Cohort Studies ; Coronavirus Infections/enzymology ; Coronavirus Infections/mortality ; Female ; Humans ; Male ; Metabolic Syndrome/epidemiology ; Middle Aged ; Pandemics ; Peptidyl-Dipeptidase A/blood ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/mortality ; Severity of Illness Index ; Sex Factors ; Young Adult
    Chemical Substances Biomarkers ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03141-9
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    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Structural insights into thrombolytic activity of destabilase from medicinal leech.

    Marin, Egor / Kornilov, Daniil A / Bukhdruker, Sergey S / Aleksenko, Vladimir A / Manuvera, Valentin A / Zinovev, Egor V / Kovalev, Kirill V / Shevtsov, Mikhail B / Talyzina, Anna A / Bobrovsky, Pavel A / Kuzmichev, Pavel K / Mishin, Alexey V / Gushchin, Ivan Y / Lazarev, Vassili N / Borshchevskiy, Valentin I

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 6641

    Abstract: Destabilase from the medical leech Hirudo medicinalis belongs to the family of i-type lysozymes. It has two different enzymatic activities: microbial cell walls destruction (muramidase activity), and dissolution of the stabilized fibrin (isopeptidase ... ...

    Abstract Destabilase from the medical leech Hirudo medicinalis belongs to the family of i-type lysozymes. It has two different enzymatic activities: microbial cell walls destruction (muramidase activity), and dissolution of the stabilized fibrin (isopeptidase activity). Both activities are known to be inhibited by sodium chloride at near physiological concentrations, but the structural basis remains unknown. Here we present two crystal structures of destabilase, including a 1.1 Å-resolution structure in complex with sodium ion. Our structures reveal the location of sodium ion between Glu34/Asp46 residues, which were previously recognized as a glycosidase active site. While sodium coordination with these amino acids may explain inhibition of the muramidase activity, its influence on previously suggested Ser49/Lys58 isopeptidase activity dyad is unclear. We revise the Ser49/Lys58 hypothesis and compare sequences of i-type lysozymes with confirmed destabilase activity. We suggest that the general base for the isopeptidase activity is His112 rather than Lys58. pKa calculations of these amino acids, assessed through the 1 μs molecular dynamics simulation, confirm the hypothesis. Our findings highlight the ambiguity of destabilase catalytic residues identification and build foundations for further research of structure-activity relationship of isopeptidase activity as well as structure-based protein design for potential anticoagulant drug development.
    MeSH term(s) Animals ; Hirudo medicinalis/chemistry ; Muramidase/chemistry ; Endopeptidases/metabolism ; Leeches/metabolism ; Fibrinolytic Agents/therapeutic use
    Chemical Substances fibrin destabilase (EC 3.4.99.-) ; Muramidase (EC 3.2.1.17) ; Endopeptidases (EC 3.4.-) ; Fibrinolytic Agents
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32459-x
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  8. Article: Ambulatory Risk Models for the Long-Term Prevention of Sepsis: Retrospective Study.

    Lee, Jewel Y / Molani, Sevda / Fang, Chen / Jade, Kathleen / O'Mahony, D Shane / Kornilov, Sergey A / Mico, Lindsay T / Hadlock, Jennifer J

    JMIR medical informatics

    2021  Volume 9, Issue 7, Page(s) e29986

    Abstract: Background: Sepsis is a life-threatening condition that can rapidly lead to organ damage and death. Existing risk scores predict outcomes for patients who have already become acutely ill.: Objective: We aimed to develop a model for identifying ... ...

    Abstract Background: Sepsis is a life-threatening condition that can rapidly lead to organ damage and death. Existing risk scores predict outcomes for patients who have already become acutely ill.
    Objective: We aimed to develop a model for identifying patients at risk of getting sepsis within 2 years in order to support the reduction of sepsis morbidity and mortality.
    Methods: Machine learning was applied to 2,683,049 electronic health records (EHRs) with over 64 million encounters across five states to develop models for predicting a patient's risk of getting sepsis within 2 years. Features were selected to be easily obtainable from a patient's chart in real time during ambulatory encounters.
    Results: The models showed consistent prediction scores, with the highest area under the receiver operating characteristic curve of 0.82 and a positive likelihood ratio of 2.9 achieved with gradient boosting on all features combined. Predictive features included age, sex, ethnicity, average ambulatory heart rate, standard deviation of BMI, and the number of prior medical conditions and procedures. The findings identified both known and potential new risk factors for long-term sepsis. Model variations also illustrated trade-offs between incrementally higher accuracy, implementability, and interpretability.
    Conclusions: Accurate implementable models were developed to predict the 2-year risk of sepsis, using EHR data that is easy to obtain from ambulatory encounters. These results help advance the understanding of sepsis and provide a foundation for future trials of risk-informed preventive care.
    Language English
    Publishing date 2021-07-08
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2798261-0
    ISSN 2291-9694
    ISSN 2291-9694
    DOI 10.2196/29986
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  9. Article: Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia.

    Kornilov, Sergey A / Tan, Mei / Aljughaiman, Abdullah / Naumova, Oxana Yu / Grigorenko, Elena L

    Frontiers in genetics

    2019  Volume 10, Page(s) 888

    Abstract: Recent studies of the genetic foundations of cognitive ability rely on large samples (in extreme, hundreds of thousands) of individuals from relatively outbred populations of mostly European ancestry. Hypothesizing that the genetic foundation of ... ...

    Abstract Recent studies of the genetic foundations of cognitive ability rely on large samples (in extreme, hundreds of thousands) of individuals from relatively outbred populations of mostly European ancestry. Hypothesizing that the genetic foundation of cognitive ability depends on the broader population-specific genetic context, we performed a genome-wide association study and homozygosity mapping of cognitive ability estimates obtained through latent variable modeling in a sample of 354 children from a consanguineous population of Saudi Arabia. Approximately half of the sample demonstrated significantly elevated homozygosity levels indicative of inbreeding, and among those with elevated levels, homozygosity was negatively associated with cognitive ability. Further homozygosity mapping identified a specific run, inclusive of the
    Language English
    Publishing date 2019-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2019.00888
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  10. Article ; Online: The Cross-Cultural Invariance of Creative Cognition: A Case Study of Creative Writing in U.S. and Russian College Students.

    Kornilov, Sergey A / Kornilova, Tatiana V / Grigorenko, Elena L

    New directions for child and adolescent development

    2016  Volume 2016, Issue 151, Page(s) 47–59

    Abstract: Unlike intelligence, creativity has rarely been investigated from the standpoint of cross-cultural invariance of the structure of the instruments used to measure it. In the study reported in this article, we investigated the cross-cultural invariance of ... ...

    Abstract Unlike intelligence, creativity has rarely been investigated from the standpoint of cross-cultural invariance of the structure of the instruments used to measure it. In the study reported in this article, we investigated the cross-cultural invariance of expert ratings of creative stories written by undergraduate students from the Russian Federation and the United States. Analyses of differential rater and item functioning using Many-Facet Rasch Measurement and multiple levels of invariance using confirmatory factor analyses suggested partial measurement invariance of creative ability estimates obtained using this method in two cultures. Russian and U.S. students demonstrated similar overall levels of creativity; however, U.S. students received higher emotionality ratings than Russian students did. The findings are discussed in the context of viewing creativity as at least a partially culturally invariant trait whose manifestation is moderated by culture-specific semantic knowledge and patterns of linguistic behavior.
    MeSH term(s) Adolescent ; Adult ; Creativity ; Cross-Cultural Comparison ; Female ; Humans ; Male ; Middle Aged ; Russia ; Students ; United States ; Universities ; Writing ; Young Adult
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1534-8687 ; 1520-3247
    ISSN (online) 1534-8687
    ISSN 1520-3247
    DOI 10.1002/cad.20149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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