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Book: ECTO-NOX proteins

Morré, Durward James / Morré, Dorothy M.

growth, cancer, and aging

2013

Author's details	D. James Morré ; Dorothy M. Morré
Language	English
Size	XVI, 507 S. : Ill., graph. Darst.
Publisher	Springer
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT017388094
ISBN	978-1-4614-3957-8 ; 9781461439585 ; 1-4614-3957-4 ; 1461439582
Database	Catalogue ZB MED Medicine, Health

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2012 A 3785	order for loan	Magazin

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Article ; Online: Endomembrane System of Plants and Fungi

MORRÉ, D. JAMES

Tip Growth In Plant and Fungal Cells

Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1016/b978-0-12-335845-5.50010-0
Database	COVID19

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Article ; Online: Non-mitochondrial coenzyme Q.

Morré, D James / Morré, Dorothy M

BioFactors (Oxford, England)

2011 Volume 37, Issue 5, Page(s) 355–360

Abstract: The key role of coenzyme Q (ubiquinone or Q) is in mitochondrial and prokaryotic energetics. Less well investigated is the basis for its presence in eukaryotic membrane locations other than mitochondria and in plasma where both antioxidant and ... ...

Abstract	The key role of coenzyme Q (ubiquinone or Q) is in mitochondrial and prokaryotic energetics. Less well investigated is the basis for its presence in eukaryotic membrane locations other than mitochondria and in plasma where both antioxidant and potentially more targeted roles are indicated. Included in the latter is that of a lipid-soluble electron transfer intermediate that serves as the transmembrane component of plasma membrane and Golgi apparatus electron transport, which regulates cytosolic NAD(+) /NADH ratios and is involved in vectorial membrane displacements and in the regulation of cell growth. Important protective effects on circulating lipoproteins and in the prevention of coronary artery disease ensue not only from the antioxidant role of CoQ(10) but also from its ability to directly block protein oxidation and superoxide generation of the TM-9 family of membrane proteins known as age-related NADH oxidase or arNOX (ENOX3) and their shed forms that appear after age 30 and some of which associate specifically with low-density lipoprotein particles to catalyze protein oxidation and crosslinking.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Biological Transport ; Cell Membrane/metabolism ; Electron Transport ; Endoplasmic Reticulum/metabolism ; Golgi Apparatus/metabolism ; Humans ; Mitochondria/metabolism ; NADH, NADPH Oxidoreductases/metabolism ; Oxidative Stress ; Superoxide Dismutase/metabolism ; Ubiquinone/biosynthesis ; Ubiquinone/metabolism
Chemical Substances	Antioxidants ; Ubiquinone (1339-63-5) ; Superoxide Dismutase (EC 1.15.1.1) ; NADH, NADPH Oxidoreductases (EC 1.6.-) ; tumor-associated NADH oxidase (EC 1.6.-)
Language	English
Publishing date	2011-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	59230-4
ISSN	1872-8081 ; 0951-6433
ISSN (online)	1872-8081
ISSN	0951-6433
DOI	10.1002/biof.156
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Article: Cancer prevention trial of a synergistic mixture of green tea concentrate plus Capsicum (CAPSOL-T) in a random population of subjects ages 40-84.

Hanau, Claudia / Morré, D James / Morré, Dorothy M

Clinical proteomics

2014 Volume 11, Issue 1, Page(s) 2

Abstract: ... subjects were tested for cancer presence using the ONCOblot® Tissue of Origin 2-D gel/western blot protocol ...

Abstract	Background: Experts agree that one of the more promising strategies in cancer management is early detection coupled with early intervention. In this study, we evaluated an early cancer detection strategy of cancer presence based on serum levels of the cancer-specific transcript variants of ENOX2 in serum coupled with an ENOX2-targeted nutraceutical preparation of green tea concentrate plus Capsicum (Capsol-T®) as a strategy of Curative Prevention® involving early detection coupled with early intervention in early stage cancer when in its most susceptible and manageable stages. Experimental design: One hundred ten (110) subjects were tested for cancer presence using the ONCOblot® Tissue of Origin 2-D gel/western blot protocol for detection of serum presence of transcript variants of the ENOX2 protein. Subjects testing positive for ENOX2 received 350 mg of Capsol-T® in capsule form every 4 h including during the night for periods of at least 3 to 6 months or longer after which they were again tested for ENOX2 presence using the ONCOblot® Tissue of Origin Cancer Test protocol. Results: Of the 110 subjects, both male and female, ages 40 to 84, with no evidence of clinical symptoms of cancer, 40% were positive for ENOX2 presence in the ONCOblot® Tissue of Origin Cancer Test. After completion of 3 to 17 months of Capsol-T® use, 94% of subjects subsequently tested negative for ENOX2 presence. Conclusions: Oral Capsol-T® is well tolerated and, for ENOX2 presence in serum in the absence of clinical cancer symptoms, is consistently effective in reducing the serum ENOX2 levels to below detectable limits.
Language	English
Publishing date	2014-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2205154-5
ISSN	1542-6416
ISSN	1542-6416
DOI	10.1186/1559-0275-11-2
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Article ; Online: Oxidative stress reduced by a green tea concentrate and Capsicum combination: synergistic effects.

Forney, Greg B / Morré, D James / Morré, Dorothy M

Journal of dietary supplements

2013 Volume 10, Issue 4, Page(s) 318–324

Abstract: Reactive oxygen species that are produced by aerobic metabolism and signaling cascades have the potential to play important roles in maintaining homeostatic redox and cell proliferation. When the balance between the production and elimination of reactive ...

Abstract	Reactive oxygen species that are produced by aerobic metabolism and signaling cascades have the potential to play important roles in maintaining homeostatic redox and cell proliferation. When the balance between the production and elimination of reactive oxygen species is perturbed toward production, the result is oxidative stress. High levels of oxidative stress are a general characteristic of cancer. The altered redox state within a tumor microenvironment confers a growth advantage through increased proliferation rates, evasion of apoptosis, and increased resistance to therapeutic compounds. We have tested a synergistic combination of green tea-Camellia sinensis-concentrate and powdered Capsicum powder (TeaFense™/Capsol-T™) as a dietary supplement to reduce oxidative stress as an approach to elimination of malignant cells. Here, we demonstrate that the green tea-powdered Capsicum mixture effectively reduces levels of oxidative stress in both cancer (HeLa) and noncancer (MCF-10A) cells as determined from measurements of levels of the oxidative stress indicator Nrf-2 by western blot analysis. Nrf-2 is a transcription factor that controls an antioxidant response element. Increased expression of Nrf-2 is linked to high levels of oxidative stress and vice versa. Based on levels of Nrf-2, the mixture of green tea concentrate plus powdered Capsicum reduced oxidative stress by more than 50% compared with 15% by the green tea concentrate alone.
MeSH term(s)	Antioxidants/pharmacology ; Camellia sinensis ; Capsicum ; Dietary Supplements ; Drug Synergism ; HeLa Cells ; Humans ; NF-E2-Related Factor 2/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Oxidative Stress/drug effects ; Plant Preparations/pharmacology ; Reactive Oxygen Species/metabolism ; Tea
Chemical Substances	Antioxidants ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Plant Preparations ; Reactive Oxygen Species ; Tea
Language	English
Publishing date	2013-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.3109/19390211.2013.830673
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Synchronous Oscillations Intrinsic to Water: Applications to Cellular Time Keeping and Water Treatment

Morré, D. James / Morré, Dorothy M

Water. 2015 May 07, v. 7, no. 5

2015

Abstract: A homodimeric, growth-related and time-keeping hydroquinone oxidase (ENOX1) of the eukaryotic cell surface capable of oxidizing intracellular NADH exhibits properties of the ultradian driver of the biological 24 h circadian clock by exhibiting a complex ... ...

Abstract	A homodimeric, growth-related and time-keeping hydroquinone oxidase (ENOX1) of the eukaryotic cell surface capable of oxidizing intracellular NADH exhibits properties of the ultradian driver of the biological 24 h circadian clock by exhibiting a complex 2 + 3 set of oscillations of copper salts and appear to derive from periodic variations in the ratio of ortho and para nuclear spins of the paired hydrogen atoms of the elongated octahedral structure of the ENOX1 protein bound copper II hexahydrates. A corollary of these observations is that the ortho/para oscillations must occur in a highly synchronized matter. Our findings suggest that water molecules communicate with each other via very low frequency electromagnetic fields and that these fields also appear to be generated by the energetics of the synchronous ortho to para interconversions of the nuclear spin pairs of the water hydrogens. Further evidence for energy absorbed and emitted by water and correlated with ortho/para oscillations of ortho/para spin pairs of water hydrogens is indicated from the auto-oscillations in water luminescence. The emissions oscillate with period lengths of 18.8 min that agree with our previously found period of oscillation of about 18 min for pure water, reflective of ortho to para spin isomers based on measurements of redox potential. The period length of pure water (increased by about 25% in D2O) and varies depending on the dominant cation present (copper salts in solution are unique in that the period length is exactly 24 min). Synchrony is maintained through generation of and response to LFEMF generated by the ortho-para spin pairs. Changes in redox potential sufficient to catalyze NADH oxidation were used to monitor synchronous water oscillations that appear to extend indefinitely over great distances in contiguous bodies of either still or flowing water. Adjacent out-of-phase water samples contained in thin plastic cuvettes auto-synchronize in a matter of seconds when placed side by side. Potential applications from water treatment along with opportunity related to human health are anticipated to derive from a better understanding of how water synchrony is generated and maintained, and to be aided by methodological advances in measurement and analysis.
Keywords	cations ; circadian clocks ; copper ; deuterium oxide ; electromagnetic field ; emissions ; energy ; enzymes ; eukaryotic cells ; human health ; hydrogen ; hydroquinone ; isomers ; luminescence ; NAD (coenzyme) ; oxidation ; quinones ; redox potential ; salts ; water treatment
Language	English
Dates of publication	2015-0507
Size	p. 2082-2100.
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	Journal Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
DOI	10.3390/w7052082
Database	NAL-Catalogue (AGRICOLA)

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Article: arNOX activity of saliva as a non-invasive measure of coenzyme Q10 response in human trials.

Morré, D James / Morré, Dorothy M

BioFactors (Oxford, England)

2008 Volume 32, Issue 1-4, Page(s) 231–235

Abstract: arNOX is a coenzyme Q10-inhibited, aging-related ECTO-NOX protein of the cell surface also present in sera. It is capable of superoxide generation measured as superoxide dismutase-inhibited reduction of ferricytochrome c and is a potential contributor to ...

Abstract	arNOX is a coenzyme Q10-inhibited, aging-related ECTO-NOX protein of the cell surface also present in sera. It is capable of superoxide generation measured as superoxide dismutase-inhibited reduction of ferricytochrome c and is a potential contributor to atherogenic risk. Here, we report an arNOX activity of saliva of older individuals also inhibited by coenzyme Q10. The activity first appears after age 30 to a near maximum at about age 55. Those surviving beyond age 55 usually have reduced arNOX activities. Our studies demonstrate significant (25 to 30%) reduction of arNOX levels with coenzyme Q10 supplementation of 60 mg (2 x 30 mg) per day for 28 days. Activity correlated with age. Response to coenzyme Q10 increased with age being greatest between ages 60 and 65. Saliva arNOX levels varied in a regular pattern throughout the day so it was important that samples be collected at approximately the same time each day for comparative purposes. The coenzyme Q10 response was reversible and within 12 h after the last intake of coenzyme Q10, the salivary arNOX levels returned to base line. The findings suggest that salivary arNOX provides a convenient and non-invasive method to monitor arNOX levels in clinical coenzyme Q10 intervention trials with the response levels paralleling those seen with serum and cellular arNOX.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; NADH, NADPH Oxidoreductases/antagonists & inhibitors ; NADH, NADPH Oxidoreductases/drug effects ; NADH, NADPH Oxidoreductases/metabolism ; Saliva/enzymology ; Superoxides/metabolism ; Ubiquinone/analogs & derivatives ; Ubiquinone/pharmacology
Chemical Substances	Superoxides (11062-77-4) ; Ubiquinone (1339-63-5) ; NADH, NADPH Oxidoreductases (EC 1.6.-) ; tumor-associated NADH oxidase (EC 1.6.-) ; coenzyme Q10 (EJ27X76M46)
Language	English
Publishing date	2008-11-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	59230-4
ISSN	1872-8081 ; 0951-6433
ISSN (online)	1872-8081
ISSN	0951-6433
DOI	10.1002/biof.5520320127
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Article: Spectroscopic Analyses of Oscillations in ECTO-NOX-Catalyzed Oxidation of NADH.

Morré, D James / Morré, Dorothy M

Nonlinearity in biology, toxicology, medicine

2008 Volume 1, Issue 3, Page(s) 345–362

Abstract: Spectroscopic strategies that substantiate periodic oscillations in low rates of NADH oxidation exhibited by ECTO-NOX proteins at the animal and plant cell surface are described. Both continuous display and discontinuous rate determinations exhibit the ... ...

Abstract	Spectroscopic strategies that substantiate periodic oscillations in low rates of NADH oxidation exhibited by ECTO-NOX proteins at the animal and plant cell surface are described. Both continuous display and discontinuous rate determinations exhibit the oscillations but continuous displays lack sufficient resolution to discern details. A procedure is documented where rates are determined by least squares analyses of traces recorded over 1 min at intervals of 1.5 min. These traces recapitulate the continuous displays but offer an opportunity to reliably estimate changes in reaction rates over short time intervals not afforded by the continuous traces. Results from previously used rate determination over 5 min intervals are included for comparison. Turbidity is identified as the major contributor to losses in resolution. Even highly purified NOX preparations tend to aggregate to form turbid suspensions. With turbid suspensions, double beam or dual wavelength instrumentation where the sample is placed immediately adjacent to the photomultiplier tube are required to reduce losses in resolution from turbidity. Also required are high levels of synchronous ECTO-NOX function. Blue or red (plants) light, small molecules (i.e., melatonin) and autosynchrony alone or in combination were used to synchronize the oscillations. Special problems posed by preparations containing more than one ECTO-NOX form and where the different ECTO-NOX forms do not cross entrain are discussed.
Language	English
Publishing date	2008-11-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2174817-2
ISSN	1540-143X ; 1540-1421
ISSN (online)	1540-143X
ISSN	1540-1421
DOI	10.1080/15401420390249916
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: ECTO-NOX proteins

Morré, D. James / Morré, Dorothy M

growth, cancer, and aging

2013

Author's details	D. James Morré, Dorothy M. Morré
MeSH term(s)	Membrane Proteins ; Neoplasm Proteins
Language	English
Size	xvi, 507 p. :, ill. (some col.) ;, 24 cm.
Publisher	Springer Science+Business Media
Publishing place	New York
Document type	Book
ISBN	9781461439578 ; 1461439574
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Golgi apparatus mediated polysaccharide secretion by outer root cap cells of Zea mays : I. Kinetics and secretory pathway.

James Morré, D / Jones, D D / Mollenhauer, H H

Planta

2014 Volume 74, Issue 3, Page(s) 286–301

Abstract: In the outer cap cells of roots of Zea mays, secretion is accompanied by hypertrophy of dictyosome cisternae with formation of large secretory vesicles. Vesicle contents are subsequently released from the protoplast by fusion of the vesicle membrane with ...

Abstract	In the outer cap cells of roots of Zea mays, secretion is accompanied by hypertrophy of dictyosome cisternae with formation of large secretory vesicles. Vesicle contents are subsequently released from the protoplast by fusion of the vesicle membrane with the plasma membrane. The secreted material, a highly hydrated polysaccharide, was localized intracellularly by the periodic acid-Schiff reaction. Under appropriate conditions, the product moves outward through the cell wall after discharge from the protoplast, and appears as a droplet adhering to the root tip. Under conditions where the secretory product accumulates at the inner wall surfaces, no external droplet is formed.The secretory activity has an active phase that is sensitive to metabolic inhibitors and influenced by temperature (Q10>2), and a passive phase that is independent of temperature, insensitive to metabolic inhibitors but sensitive to osmotic agents. The active phase is characterized by a temperature-independent periodicity (3 hours). Sucrose supplied to the growth medium increases the amount of polysaccharide secreted. Polysaccharide synthesis, segregation into vesicles, and discharge from the protoplast are assumed to require active metabolism; the step involving extrusion of polysaccharide through the cell wall region appears to be a passive process influenced by the degree of hydration of the polysaccharide and by cell turgor.
Language	English
Publishing date	2014-02-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	208909-9
ISSN	1432-2048 ; 0032-0935 ; 1866-2749
ISSN (online)	1432-2048
ISSN	0032-0935 ; 1866-2749
DOI	10.1007/BF00384849
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